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The map label for this gene is proY [H]

Identifier: 152969354

GI number: 152969354

Start: 889828

End: 891210

Strand: Direct

Name: proY [H]

Synonym: KPN_00797

Alternate gene names: 152969354

Gene position: 889828-891210 (Clockwise)

Preceding gene: 152969353

Following gene: 152969357

Centisome position: 16.74

GC content: 60.38

Gene sequence:

>1383_bases
ATGCAACAACAACACAAGCCACATCTGCTGCGCGGGCTCAATGCCCGACACATTCGGTTTATTGCGCTCGGCTCCGCTAT
CGGCACCGGGCTGTTCTATGGCTCGGCCTCAGCCATCAAAGCGGCGGGCCCGGCGGTGCTGCTGGCCTATCTGATTGGCG
GCGCGGCGGTGTTTATCGTCATGCGCGCGCTGGGCGAGATGGCGGTGCGCAACCCGGTTTCCGGCTCCTTCGGCAGCTAT
GCCCGCCAGTATCTCGGGCCGCTGGCCGGGTTTATTACCGGCTGGACCTACACCTTTGAAATGGTGATCGTCGCCCTGGC
CGACGTCACCGCCTTCGGTATCTATATGGGGTTGTGGTACCCCGATGTGCCGCGCTGGATCTGGATCCTCAGCATCATCT
TCTTTATCGGCGCGATGAATCTGTGCAACGTGCGGGTATTTGGCGAGATGGAGTTCTGGCTGTCTCTGGTGAAGGTGGTG
GCGATTATCGCCATGATGCTGGCGGGGGCGGGGATCATCTTCTTTGGCTTTGGCCACAGCTTCCCGGCCACCGGGCTGGA
AAACCTCTGGAGCCACGGCGGCTTTGCCCCTAACGGCTGGCAGGGCGTTATCGCCTCGCTTGGCATCGTGATGTTCGCCT
TCGGCGGGGTGGAGATTATCGGCGTCACCGCCGCGGAAGCGAAGGATCCTAAGAAGGTGATCCCGCAGGCCATCAATACC
ATTCCGCTGCGCATTATCCTGTTCTACGTCTGCACCCTGGCGGTACTGATGGCGATCTTCCCGTGGAACAGCTTTGGCGA
ACAGGGGAGTCCGTTTGTGCTTATTTTCGACGGTCTGGGGATCCCGGCGGCGGCGACCATCCTTAACATCATCGTGATCA
GCGCCAGCATCTCGGCGATTAACAGCGATATTTTTGGCGCCGGACGCATGATGTACGGCATGTCGAAAGAGGGGCTGGCG
CCGAAAAGCTTCCAGCGCATCGCCAGCAACGGTGTGCCCTGGATGACGGTGGTGGTCATGGGCGGCGCGCTGCTGGCGGC
GGTGGTATTGAACTATCTGATCCCCGAGCAGGTATTTGTGCTAATTGCTTCGCTGGCGGCATTCGCCACGGTATGGGTGT
GGCTGATGATTCTGCTATCCCATTTTGCCATGCGCCGCGGTTTGTCTGCCGAAGAGCGCAGCCAGATCGCCTTTCCCATT
CCGTTCTGGCCGGTTGCGCCGCTGTTGACGCTACTGTTTATGGGGCTGGTCATCGCCGTACTAGGGATGTTTGCCGAAAC
GCGGATGGCGCTGATCGCCGGCCTGGTCTGGCTCGGGCTGCTGACGGTGGTGTGGTATGCGCGGGTGCGTAAAACGGCGC
TGCAGGTAGCCACTGAACAGTAA

Upstream 100 bases:

>100_bases
AATCACCGTTGTTCTCTGTACCCGCGTCGGGGGAAGTCATTCCCCCGACCGCCCTACACCGCATATTTGTCGTCATATAA
AAAAATCAGGACACCTGTAT

Downstream 100 bases:

>100_bases
GATCAATTTCCCCGGTGGCGCTGCGCTTACCGGGGCTACAAATGGCACGGACCGTAGGCCGGGCAAGGCGTCAGCCGCCG
CCCGGCATAAAAGCGGCTCC

Product: putative amino acid permease

Products: Proton [Cytoplasm]; L-proline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MQQQHKPHLLRGLNARHIRFIALGSAIGTGLFYGSASAIKAAGPAVLLAYLIGGAAVFIVMRALGEMAVRNPVSGSFGSY
ARQYLGPLAGFITGWTYTFEMVIVALADVTAFGIYMGLWYPDVPRWIWILSIIFFIGAMNLCNVRVFGEMEFWLSLVKVV
AIIAMMLAGAGIIFFGFGHSFPATGLENLWSHGGFAPNGWQGVIASLGIVMFAFGGVEIIGVTAAEAKDPKKVIPQAINT
IPLRIILFYVCTLAVLMAIFPWNSFGEQGSPFVLIFDGLGIPAAATILNIIVISASISAINSDIFGAGRMMYGMSKEGLA
PKSFQRIASNGVPWMTVVVMGGALLAAVVLNYLIPEQVFVLIASLAAFATVWVWLMILLSHFAMRRGLSAEERSQIAFPI
PFWPVAPLLTLLFMGLVIAVLGMFAETRMALIAGLVWLGLLTVVWYARVRKTALQVATEQ

Sequences:

>Translated_460_residues
MQQQHKPHLLRGLNARHIRFIALGSAIGTGLFYGSASAIKAAGPAVLLAYLIGGAAVFIVMRALGEMAVRNPVSGSFGSY
ARQYLGPLAGFITGWTYTFEMVIVALADVTAFGIYMGLWYPDVPRWIWILSIIFFIGAMNLCNVRVFGEMEFWLSLVKVV
AIIAMMLAGAGIIFFGFGHSFPATGLENLWSHGGFAPNGWQGVIASLGIVMFAFGGVEIIGVTAAEAKDPKKVIPQAINT
IPLRIILFYVCTLAVLMAIFPWNSFGEQGSPFVLIFDGLGIPAAATILNIIVISASISAINSDIFGAGRMMYGMSKEGLA
PKSFQRIASNGVPWMTVVVMGGALLAAVVLNYLIPEQVFVLIASLAAFATVWVWLMILLSHFAMRRGLSAEERSQIAFPI
PFWPVAPLLTLLFMGLVIAVLGMFAETRMALIAGLVWLGLLTVVWYARVRKTALQVATEQ
>Mature_460_residues
MQQQHKPHLLRGLNARHIRFIALGSAIGTGLFYGSASAIKAAGPAVLLAYLIGGAAVFIVMRALGEMAVRNPVSGSFGSY
ARQYLGPLAGFITGWTYTFEMVIVALADVTAFGIYMGLWYPDVPRWIWILSIIFFIGAMNLCNVRVFGEMEFWLSLVKVV
AIIAMMLAGAGIIFFGFGHSFPATGLENLWSHGGFAPNGWQGVIASLGIVMFAFGGVEIIGVTAAEAKDPKKVIPQAINT
IPLRIILFYVCTLAVLMAIFPWNSFGEQGSPFVLIFDGLGIPAAATILNIIVISASISAINSDIFGAGRMMYGMSKEGLA
PKSFQRIASNGVPWMTVVVMGGALLAAVVLNYLIPEQVFVLIASLAAFATVWVWLMILLSHFAMRRGLSAEERSQIAFPI
PFWPVAPLLTLLFMGLVIAVLGMFAETRMALIAGLVWLGLLTVVWYARVRKTALQVATEQ

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of proline [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI181337167, Length=341, Percent_Identity=24.633431085044, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI110347453, Length=349, Percent_Identity=26.9340974212034, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI258614005, Length=412, Percent_Identity=23.0582524271845, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI258614003, Length=412, Percent_Identity=23.0582524271845, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI258645169, Length=378, Percent_Identity=22.4867724867725, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1786602, Length=457, Percent_Identity=57.7680525164114, Blast_Score=504, Evalue=1e-144,
Organism=Escherichia coli, GI1786789, Length=449, Percent_Identity=42.9844097995546, Blast_Score=382, Evalue=1e-107,
Organism=Escherichia coli, GI1786302, Length=457, Percent_Identity=42.6695842450766, Blast_Score=369, Evalue=1e-103,
Organism=Escherichia coli, GI48994972, Length=446, Percent_Identity=41.7040358744395, Blast_Score=344, Evalue=9e-96,
Organism=Escherichia coli, GI1790653, Length=461, Percent_Identity=38.177874186551, Blast_Score=328, Evalue=4e-91,
Organism=Escherichia coli, GI87081708, Length=461, Percent_Identity=38.3947939262473, Blast_Score=297, Evalue=1e-81,
Organism=Escherichia coli, GI87081915, Length=458, Percent_Identity=34.2794759825328, Blast_Score=285, Evalue=3e-78,
Organism=Escherichia coli, GI1789017, Length=462, Percent_Identity=35.9307359307359, Blast_Score=270, Evalue=2e-73,
Organism=Escherichia coli, GI1788480, Length=445, Percent_Identity=34.8314606741573, Blast_Score=237, Evalue=1e-63,
Organism=Escherichia coli, GI87081869, Length=417, Percent_Identity=23.021582733813, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87082023, Length=419, Percent_Identity=24.582338902148, Blast_Score=81, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17532491, Length=430, Percent_Identity=22.7906976744186, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17540018, Length=398, Percent_Identity=26.1306532663317, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324061, Length=444, Percent_Identity=32.2072072072072, Blast_Score=204, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6320772, Length=445, Percent_Identity=31.2359550561798, Blast_Score=195, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6324990, Length=498, Percent_Identity=30.3212851405622, Blast_Score=183, Evalue=6e-47,
Organism=Saccharomyces cerevisiae, GI6324924, Length=416, Percent_Identity=31.0096153846154, Blast_Score=172, Evalue=8e-44,
Organism=Saccharomyces cerevisiae, GI6319824, Length=409, Percent_Identity=28.6063569682152, Blast_Score=166, Evalue=6e-42,
Organism=Saccharomyces cerevisiae, GI6321629, Length=414, Percent_Identity=26.3285024154589, Blast_Score=163, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6324553, Length=399, Percent_Identity=30.8270676691729, Blast_Score=163, Evalue=7e-41,
Organism=Saccharomyces cerevisiae, GI6322892, Length=411, Percent_Identity=27.9805352798054, Blast_Score=160, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6324059, Length=454, Percent_Identity=27.9735682819383, Blast_Score=159, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6320717, Length=407, Percent_Identity=24.5700245700246, Blast_Score=150, Evalue=5e-37,
Organism=Saccharomyces cerevisiae, GI6321053, Length=429, Percent_Identity=26.8065268065268, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6319543, Length=406, Percent_Identity=26.8472906403941, Blast_Score=142, Evalue=8e-35,
Organism=Saccharomyces cerevisiae, GI6319542, Length=402, Percent_Identity=25.3731343283582, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6320251, Length=408, Percent_Identity=24.5098039215686, Blast_Score=136, Evalue=9e-33,
Organism=Saccharomyces cerevisiae, GI6322967, Length=395, Percent_Identity=26.8354430379747, Blast_Score=133, Evalue=7e-32,
Organism=Saccharomyces cerevisiae, GI6319608, Length=446, Percent_Identity=25.5605381165919, Blast_Score=128, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6324981, Length=395, Percent_Identity=26.8354430379747, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6320364, Length=504, Percent_Identity=24.6031746031746, Blast_Score=103, Evalue=4e-23,
Organism=Drosophila melanogaster, GI161077963, Length=398, Percent_Identity=24.8743718592965, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI221512776, Length=419, Percent_Identity=23.6276849642005, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24666159, Length=419, Percent_Identity=23.6276849642005, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24667468, Length=406, Percent_Identity=25.8620689655172, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24668806, Length=407, Percent_Identity=24.3243243243243, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI21356285, Length=407, Percent_Identity=24.3243243243243, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24668802, Length=407, Percent_Identity=24.3243243243243, Blast_Score=76, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 49664; Mature: 49664

Theoretical pI: Translated: 9.75; Mature: 9.75

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQQHKPHLLRGLNARHIRFIALGSAIGTGLFYGSASAIKAAGPAVLLAYLIGGAAVFIV
CCCCCCCHHHHCCCCCCEEEEEEHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHH
MRALGEMAVRNPVSGSFGSYARQYLGPLAGFITGWTYTFEMVIVALADVTAFGIYMGLWY
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PDVPRWIWILSIIFFIGAMNLCNVRVFGEMEFWLSLVKVVAIIAMMLAGAGIIFFGFGHS
CCHHHHHHHHHHHHHHCCHHHCCEEEECCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
FPATGLENLWSHGGFAPNGWQGVIASLGIVMFAFGGVEIIGVTAAEAKDPKKVIPQAINT
CCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHH
IPLRIILFYVCTLAVLMAIFPWNSFGEQGSPFVLIFDGLGIPAAATILNIIVISASISAI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHH
NSDIFGAGRMMYGMSKEGLAPKSFQRIASNGVPWMTVVVMGGALLAAVVLNYLIPEQVFV
HHHHHCCCHHHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIASLAAFATVWVWLMILLSHFAMRRGLSAEERSQIAFPIPFWPVAPLLTLLFMGLVIAV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCEECCCCCCCHHHHHHHHHHHHHHHH
LGMFAETRMALIAGLVWLGLLTVVWYARVRKTALQVATEQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQQQHKPHLLRGLNARHIRFIALGSAIGTGLFYGSASAIKAAGPAVLLAYLIGGAAVFIV
CCCCCCCHHHHCCCCCCEEEEEEHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHH
MRALGEMAVRNPVSGSFGSYARQYLGPLAGFITGWTYTFEMVIVALADVTAFGIYMGLWY
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PDVPRWIWILSIIFFIGAMNLCNVRVFGEMEFWLSLVKVVAIIAMMLAGAGIIFFGFGHS
CCHHHHHHHHHHHHHHCCHHHCCEEEECCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
FPATGLENLWSHGGFAPNGWQGVIASLGIVMFAFGGVEIIGVTAAEAKDPKKVIPQAINT
CCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHH
IPLRIILFYVCTLAVLMAIFPWNSFGEQGSPFVLIFDGLGIPAAATILNIIVISASISAI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHH
NSDIFGAGRMMYGMSKEGLAPKSFQRIASNGVPWMTVVVMGGALLAAVVLNYLIPEQVFV
HHHHHCCCHHHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIASLAAFATVWVWLMILLSHFAMRRGLSAEERSQIAFPIPFWPVAPLLTLLFMGLVIAV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCEECCCCCCCHHHHHHHHHHHHHHHH
LGMFAETRMALIAGLVWLGLLTVVWYARVRKTALQVATEQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-proline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-proline [Periplasm] = Proton [Cytoplasm] + L-proline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]