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The map label for this gene is pcp [H]

Identifier: 152969289

GI number: 152969289

Start: 814721

End: 815368

Strand: Direct

Name: pcp [H]

Synonym: KPN_00725

Alternate gene names: 152969289

Gene position: 814721-815368 (Clockwise)

Preceding gene: 152969288

Following gene: 152969290

Centisome position: 15.33

GC content: 58.64

Gene sequence:

>648_bases
ATGATGGCTGGCGTATTGATTACCGGTTTTGAGCCGTTCGGCGGCGAAACGGTTAATCCTTCATGGGAAGTGGTTAAGCA
GTTGGATGACATGATTATTCGCGGACAGCAGGTGGTGGCTAAACAATTACCCTGCGTATTCGGCGAAGCGCTGACGGTGC
TGAAGGCGGCGCTGGAAACCTATCAACCGCGGCTGACGATTGCCGTCGGACAGGCCGGCGGCCGTGTAGATATTACCGTC
GAACGTGTAGCGATCAATGTCGATGATGCGCGGATCCCCGACAATAAAGGCCAGCAACCGATCGATGAGCCGATCGTCGC
TAATGGCCCTGCGGCCTGCTTCAGTACGCTGCCGATCAAAGCGATCGTCAGCGCGCTGCGCCAGCAGGGGATCCCGGCCT
CGGTGTCGCAAACCGCGGGCACCTTCGTCTGCAATCACGTGATGTATGGTTTGCTGCATCAGCTGCAGGGAAAACGCGGA
CAGAAGGGCGGTTTTATCCATATTCCGTATCTGCCTGAACAGGCGGCGGCCCACCCGGGGCAGGCGAGTATGTCGGTCGC
GACGGTACGCGCGGCGCTGGAAACGGCGATTGCCGTCGCTCTTGAACAGGATGACGATGTCAAAATTGGCGGCGGCGCCA
CCCATTAA

Upstream 100 bases:

>100_bases
GGATAAAAACGCGGTAATTAAAGCCCAGATACCGACCGGTATCCTGCTGCTTATCGTCAATGTATTCTTACTCTATTTCC
TGATGTTCCTGTAAGGAGGG

Downstream 100 bases:

>100_bases
CAGAAGGATGACAGTATGCCGGAAGGTCCGGAGATCCGCCGTGCGGCGGATAAACTGGAGGCGGCAATCAAAGGCGAACC
CTTAACCAACGTTTGGTTCG

Product: pyrrolidone-carboxylate peptidase

Products: NA

Alternate protein names: 5-oxoprolyl-peptidase; Pyroglutamyl-peptidase I; PGP-I; Pyrase [H]

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MMAGVLITGFEPFGGETVNPSWEVVKQLDDMIIRGQQVVAKQLPCVFGEALTVLKAALETYQPRLTIAVGQAGGRVDITV
ERVAINVDDARIPDNKGQQPIDEPIVANGPAACFSTLPIKAIVSALRQQGIPASVSQTAGTFVCNHVMYGLLHQLQGKRG
QKGGFIHIPYLPEQAAAHPGQASMSVATVRAALETAIAVALEQDDDVKIGGGATH

Sequences:

>Translated_215_residues
MMAGVLITGFEPFGGETVNPSWEVVKQLDDMIIRGQQVVAKQLPCVFGEALTVLKAALETYQPRLTIAVGQAGGRVDITV
ERVAINVDDARIPDNKGQQPIDEPIVANGPAACFSTLPIKAIVSALRQQGIPASVSQTAGTFVCNHVMYGLLHQLQGKRG
QKGGFIHIPYLPEQAAAHPGQASMSVATVRAALETAIAVALEQDDDVKIGGGATH
>Mature_215_residues
MMAGVLITGFEPFGGETVNPSWEVVKQLDDMIIRGQQVVAKQLPCVFGEALTVLKAALETYQPRLTIAVGQAGGRVDITV
ERVAINVDDARIPDNKGQQPIDEPIVANGPAACFSTLPIKAIVSALRQQGIPASVSQTAGTFVCNHVMYGLLHQLQGKRG
QKGGFIHIPYLPEQAAAHPGQASMSVATVRAALETAIAVALEQDDDVKIGGGATH

Specific function: Removes 5-oxoproline from various penultimate amino acid residues except L-proline [H]

COG id: COG2039

COG function: function code O; Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C15 family [H]

Homologues:

Organism=Homo sapiens, GI8923198, Length=204, Percent_Identity=27.9411764705882, Blast_Score=75, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000816
- InterPro:   IPR016125 [H]

Pfam domain/function: PF01470 Peptidase_C15 [H]

EC number: =3.4.19.3 [H]

Molecular weight: Translated: 22642; Mature: 22642

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS01333 PYRASE_GLU ; PS01334 PYRASE_CYS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMAGVLITGFEPFGGETVNPSWEVVKQLDDMIIRGQQVVAKQLPCVFGEALTVLKAALET
CCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHH
YQPRLTIAVGQAGGRVDITVERVAINVDDARIPDNKGQQPIDEPIVANGPAACFSTLPIK
CCCEEEEEEECCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCHH
AIVSALRQQGIPASVSQTAGTFVCNHVMYGLLHQLQGKRGQKGGFIHIPYLPEQAAAHPG
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHCCCC
QASMSVATVRAALETAIAVALEQDDDVKIGGGATH
CCHHHHHHHHHHHHHHHHHEECCCCCEEECCCCCC
>Mature Secondary Structure
MMAGVLITGFEPFGGETVNPSWEVVKQLDDMIIRGQQVVAKQLPCVFGEALTVLKAALET
CCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHH
YQPRLTIAVGQAGGRVDITVERVAINVDDARIPDNKGQQPIDEPIVANGPAACFSTLPIK
CCCEEEEEEECCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCHH
AIVSALRQQGIPASVSQTAGTFVCNHVMYGLLHQLQGKRGQKGGFIHIPYLPEQAAAHPG
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHCCCC
QASMSVATVRAALETAIAVALEQDDDVKIGGGATH
CCHHHHHHHHHHHHHHHHHEECCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA