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The map label for this gene is dnaX [H]

Identifier: 152969025

GI number: 152969025

Start: 496362

End: 498269

Strand: Direct

Name: dnaX [H]

Synonym: KPN_00452

Alternate gene names: 152969025

Gene position: 496362-498269 (Clockwise)

Preceding gene: 152969024

Following gene: 152969026

Centisome position: 9.34

GC content: 63.68

Gene sequence:

>1908_bases
ATGAGTTATCAGGTCTTAGCCCGTAAATGGCGCCCACAAACCTTTGCTGACGTCGTCGGCCAGGAACATGTGCTGACCGC
ACTGGCGAACGGCTTGTCGTTAGGGCGCATTCATCACGCTTATCTTTTTTCCGGTACCCGCGGGGTCGGGAAGACCTCCA
TCGCCCGTCTGCTGGCGAAAGGGTTAAACTGTGAAACCGGCATCACCGCCACCCCCTGCGGCGTGTGCGATAACTGCCGG
GAAATTGAACAGGGGCGCTTTGTCGATCTGATTGAGATTGACGCCGCCTCGCGAACCAAAGTCGAAGATACCCGCGATCT
GCTGGACAACGTCCAGTACGCGCCGGCCCGCGGCCGCTTTAAGGTCTATCTCATCGACGAAGTCCATATGCTGTCGCGTC
ACAGCTTCAACGCGTTGTTAAAAACGCTGGAGGAGCCGCCGGCGCACGTCAAATTCCTGCTGGCGACGACGGATCCGCAG
AAGTTGCCGGTAACGATCTTATCCCGCTGCCTGCAGTTCCACCTGAAGGCGCTGGACGTTGAACAGATCCGCCATCAGCT
GGAGCATATTCTTGGCGAAGAGCAGATTGCCTTTGAGCCCCGCGCGCTGCAGCTGTTGTCGCGGGCGGCCGATGGCAGCC
TGCGCGATGCCTTAAGCCTGACCGATCAGGCGATTGCCAGTGGGGAAGGGCAGCTGACGGCCGCATCGGTGAGCACCATG
CTCGGCACCCTTGATGACGATCAGGCGCTGTCGCTGATTGAAGCGCTGGTTGCTGCCGACGGCGAGCGGGTCATGGCGGG
CGTCAATGACGCCGCCGCACGCGGCGTCGAGTGGGAGGCGCTGCTGGTCGAGATGCAGAGCCTGCTGCACCGCATCGCCA
TGGTTCAGCTGTCGCCTTCGGCGCTGGGCGCCGACATGGCCGCGGTCGAAGTGCGGATGCGCGAACTGGCGCGAACCGTA
CCGCCCGGCGACGTTCAGCTCTACTACCAAACGCTGCTGATTGGCCGCAAAGAGCTGCCTTACGCCCCGGACCGGCGGAT
GGGCGTCGAAATGACGCTGCTGCGTGCCCTGGCGTTTCATCCGCGTAAGCCGCTGCCGGAGCCGGAGGTGCAGCCGGCAC
AGGCCGCCGCGCCCGCGCCGCGTCAGCCGGTTGCCCCCGCCGCGCCGCCGCCACAGTCGCCGCAGAGTTTGCCGCCGACC
ACCAGCCAGGTGCTGGCGGCCCGCAGCCACCTGCAGCGCAGTCAGGGAGCAACCACCCCAAAAAAGAGTGAACCGGCAGC
CGCTTCCCGCGCGCGGCCGGTGAATAACGCTGCGCTGGAGCGACTGAGTTCGATTACCGAGCGCGTCCAGGCTCGTCCGG
CCGCGGCCGCGCTGGAGCAGGCCCCGGCGAAGAAAGAGGCCTATCGCTGGAAGGCGACGACGGTGGTGGAAGAGACCAAA
GTCGAAGTCGCCACGCCCAAAGCGCTGAAAAAGGCGCTGGAGCATGAGAAGACGCCGGAGCTGGCGGCCAAGCTCGCCGA
AGAAGCGGTCGAGCGCGACAGCTGGGCGGCGGAAGTGAGCCAGCTGGCGGTACCGAAGCTGGTCGAGCAGGTGGCGCTCA
ACGCGTGGAAAGAGCAGGAGGGCAGCCGCGTCTGTCTGCATCTGCGTCCCAGCCAGCGCCACCTCAATTCCGCCAGCGCG
CAGCAAAAGCTGGCTGAAGCGCTGGGGGTGTTGTACGGTACGCCGGTTGAATTGACCATCGTGGAAGACGATAATCCCGC
GATGCGTACGCCGCTGGAGTGGCGGCAGGCTATTTATGAAGAGAAGCTCGCGCAGGCGCGCGAAGCCATTATCGCGGATA
ATAACATTCAGACCCTGCGTCGTTTCTTCGACGCCGATCTGGATGAAGAGAGTATTCGCCCCATTTGA

Upstream 100 bases:

>100_bases
GCCACTAAGCAAATCCCTCCACATAGCCTCGCCGATCGGGCGGGGCTGTGATAGCATGACCCCTTCGTGATTTCACCTTC
CAGCGTTTCAGAGCCAGCCC

Downstream 100 bases:

>100_bases
ATGCCAGTCTGACTGGCATTCAGTACCTTTAACGATGACTGACTGAGAGAGAAGCCTATGTTTGGTGGAAAAGGCGGCCT
GGGTAACCTGATGAAGCAGG

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 635; Mature: 634

Protein sequence:

>635_residues
MSYQVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNCETGITATPCGVCDNCR
EIEQGRFVDLIEIDAASRTKVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPAHVKFLLATTDPQ
KLPVTILSRCLQFHLKALDVEQIRHQLEHILGEEQIAFEPRALQLLSRAADGSLRDALSLTDQAIASGEGQLTAASVSTM
LGTLDDDQALSLIEALVAADGERVMAGVNDAAARGVEWEALLVEMQSLLHRIAMVQLSPSALGADMAAVEVRMRELARTV
PPGDVQLYYQTLLIGRKELPYAPDRRMGVEMTLLRALAFHPRKPLPEPEVQPAQAAAPAPRQPVAPAAPPPQSPQSLPPT
TSQVLAARSHLQRSQGATTPKKSEPAAASRARPVNNAALERLSSITERVQARPAAAALEQAPAKKEAYRWKATTVVEETK
VEVATPKALKKALEHEKTPELAAKLAEEAVERDSWAAEVSQLAVPKLVEQVALNAWKEQEGSRVCLHLRPSQRHLNSASA
QQKLAEALGVLYGTPVELTIVEDDNPAMRTPLEWRQAIYEEKLAQAREAIIADNNIQTLRRFFDADLDEESIRPI

Sequences:

>Translated_635_residues
MSYQVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNCETGITATPCGVCDNCR
EIEQGRFVDLIEIDAASRTKVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPAHVKFLLATTDPQ
KLPVTILSRCLQFHLKALDVEQIRHQLEHILGEEQIAFEPRALQLLSRAADGSLRDALSLTDQAIASGEGQLTAASVSTM
LGTLDDDQALSLIEALVAADGERVMAGVNDAAARGVEWEALLVEMQSLLHRIAMVQLSPSALGADMAAVEVRMRELARTV
PPGDVQLYYQTLLIGRKELPYAPDRRMGVEMTLLRALAFHPRKPLPEPEVQPAQAAAPAPRQPVAPAAPPPQSPQSLPPT
TSQVLAARSHLQRSQGATTPKKSEPAAASRARPVNNAALERLSSITERVQARPAAAALEQAPAKKEAYRWKATTVVEETK
VEVATPKALKKALEHEKTPELAAKLAEEAVERDSWAAEVSQLAVPKLVEQVALNAWKEQEGSRVCLHLRPSQRHLNSASA
QQKLAEALGVLYGTPVELTIVEDDNPAMRTPLEWRQAIYEEKLAQAREAIIADNNIQTLRRFFDADLDEESIRPI
>Mature_634_residues
SYQVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNCETGITATPCGVCDNCRE
IEQGRFVDLIEIDAASRTKVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPAHVKFLLATTDPQK
LPVTILSRCLQFHLKALDVEQIRHQLEHILGEEQIAFEPRALQLLSRAADGSLRDALSLTDQAIASGEGQLTAASVSTML
GTLDDDQALSLIEALVAADGERVMAGVNDAAARGVEWEALLVEMQSLLHRIAMVQLSPSALGADMAAVEVRMRELARTVP
PGDVQLYYQTLLIGRKELPYAPDRRMGVEMTLLRALAFHPRKPLPEPEVQPAQAAAPAPRQPVAPAAPPPQSPQSLPPTT
SQVLAARSHLQRSQGATTPKKSEPAAASRARPVNNAALERLSSITERVQARPAAAALEQAPAKKEAYRWKATTVVEETKV
EVATPKALKKALEHEKTPELAAKLAEEAVERDSWAAEVSQLAVPKLVEQVALNAWKEQEGSRVCLHLRPSQRHLNSASAQ
QKLAEALGVLYGTPVELTIVEDDNPAMRTPLEWRQAIYEEKLAQAREAIIADNNIQTLRRFFDADLDEESIRPI

Specific function: The gamma chain seems to interact with the delta subunit to transfer the beta subunit on the DNA [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI6677723, Length=311, Percent_Identity=23.7942122186495, Blast_Score=79, Evalue=2e-14,
Organism=Homo sapiens, GI194306571, Length=314, Percent_Identity=23.5668789808917, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI194306567, Length=314, Percent_Identity=23.5668789808917, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1786676, Length=652, Percent_Identity=83.282208588957, Blast_Score=1071, Evalue=0.0,
Organism=Escherichia coli, GI1787341, Length=139, Percent_Identity=32.3741007194245, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324039, Length=217, Percent_Identity=25.8064516129032, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322528, Length=278, Percent_Identity=24.4604316546763, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI18859927, Length=268, Percent_Identity=23.8805970149254, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022001
- InterPro:   IPR022754
- InterPro:   IPR012763
- InterPro:   IPR021029 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3; PF12168 DNA_pol3_tau_4; PF12170 DNA_pol3_tau_5 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 69606; Mature: 69475

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYQVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAK
CCHHHHHHHCCCCHHHHHHCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHH
GLNCETGITATPCGVCDNCREIEQGRFVDLIEIDAASRTKVEDTRDLLDNVQYAPARGRF
CCCCCCCCCCCCCCCHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCE
KVYLIDEVHMLSRHSFNALLKTLEEPPAHVKFLLATTDPQKLPVTILSRCLQFHLKALDV
EEEEECHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCH
EQIRHQLEHILGEEQIAFEPRALQLLSRAADGSLRDALSLTDQAIASGEGQLTAASVSTM
HHHHHHHHHHHCCCHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LGTLDDDQALSLIEALVAADGERVMAGVNDAAARGVEWEALLVEMQSLLHRIAMVQLSPS
HHCCCCHHHHHHHHHHHHCCCCCEEECCCHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHH
ALGADMAAVEVRMRELARTVPPGDVQLYYQTLLIGRKELPYAPDRRMGVEMTLLRALAFH
HHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHC
PRKPLPEPEVQPAQAAAPAPRQPVAPAAPPPQSPQSLPPTTSQVLAARSHLQRSQGATTP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCC
KKSEPAAASRARPVNNAALERLSSITERVQARPAAAALEQAPAKKEAYRWKATTVVEETK
CCCCCCHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHH
VEVATPKALKKALEHEKTPELAAKLAEEAVERDSWAAEVSQLAVPKLVEQVALNAWKEQE
HEECCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GSRVCLHLRPSQRHLNSASAQQKLAEALGVLYGTPVELTIVEDDNPAMRTPLEWRQAIYE
CCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHH
EKLAQAREAIIADNNIQTLRRFFDADLDEESIRPI
HHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SYQVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAK
CHHHHHHHCCCCHHHHHHCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHH
GLNCETGITATPCGVCDNCREIEQGRFVDLIEIDAASRTKVEDTRDLLDNVQYAPARGRF
CCCCCCCCCCCCCCCHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCE
KVYLIDEVHMLSRHSFNALLKTLEEPPAHVKFLLATTDPQKLPVTILSRCLQFHLKALDV
EEEEECHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCH
EQIRHQLEHILGEEQIAFEPRALQLLSRAADGSLRDALSLTDQAIASGEGQLTAASVSTM
HHHHHHHHHHHCCCHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LGTLDDDQALSLIEALVAADGERVMAGVNDAAARGVEWEALLVEMQSLLHRIAMVQLSPS
HHCCCCHHHHHHHHHHHHCCCCCEEECCCHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHH
ALGADMAAVEVRMRELARTVPPGDVQLYYQTLLIGRKELPYAPDRRMGVEMTLLRALAFH
HHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHC
PRKPLPEPEVQPAQAAAPAPRQPVAPAAPPPQSPQSLPPTTSQVLAARSHLQRSQGATTP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCC
KKSEPAAASRARPVNNAALERLSSITERVQARPAAAALEQAPAKKEAYRWKATTVVEETK
CCCCCCHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHH
VEVATPKALKKALEHEKTPELAAKLAEEAVERDSWAAEVSQLAVPKLVEQVALNAWKEQE
HEECCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GSRVCLHLRPSQRHLNSASAQQKLAEALGVLYGTPVELTIVEDDNPAMRTPLEWRQAIYE
CCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHH
EKLAQAREAIIADNNIQTLRRFFDADLDEESIRPI
HHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3534795; 3018672; 9278503; 2186364; 2187190; 2181440; 1575709 [H]