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The map label for this gene is apt [H]

Identifier: 152969024

GI number: 152969024

Start: 495718

End: 496269

Strand: Direct

Name: apt [H]

Synonym: KPN_00451

Alternate gene names: 152969024

Gene position: 495718-496269 (Clockwise)

Preceding gene: 152969023

Following gene: 152969025

Centisome position: 9.33

GC content: 57.43

Gene sequence:

>552_bases
ATGACCGCAACTGCACAGCAGCTTGAATATCTGAAGAACAGCATCCAGAGTATCGAGGATTATCCAAAACCTGGCATTCT
TTTCCGCGATGTCACCAGCTTACTGGAAGACCCGAAGGCCTACGCGCTTAGCATTGAACTGCTGACCGAGCGCTACAAAG
ACGCGGGTATTACCAAAGTGGTAGGGACTGAGGCGCGTGGCTTCCTGTTCGGCGCACCGGTTGCGCTGGCGCTGGGCGTG
GGCTTTGTTCCGGTACGCAAGCCGCGTAAGTTGCCGCGTGAAACCATTGCCGAGACCTATGAGCTGGAGTATGGCACCGA
TCAGCTGGAGATCCACGTTGACGCCATTAAACCGGGCGATAAAGTGCTGGTGGTTGACGATCTGCTGGCGACCGGCGGCA
CTATCGACGCCACGGTCAAACTGATCCGCCGCCTCGGTGGCGAAGTGCACGATGCCGCTTTCATTATCAATCTCTTCGAT
CTGGGCGGCGAACAGCGCCTGGAGAAGCTGGGGATCCACTGCTACAGTCTGGTGCCGTTCCCGGGCCACTAA

Upstream 100 bases:

>100_bases
GTTTTCGAGCGCGGGCAAGCCTGGTCAAAGGTTAAACAAATGTTTCTTTGGCCCCTTTTGCACGCCCGTGGGTAATACCG
TTTCAATCAGGCATACACTT

Downstream 100 bases:

>100_bases
GCAAATCCCTCCACATAGCCTCGCCGATCGGGCGGGGCTGTGATAGCATGACCCCTTCGTGATTTCACCTTCCAGCGTTT
CAGAGCCAGCCCATGAGTTA

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT [H]

Number of amino acids: Translated: 183; Mature: 182

Protein sequence:

>183_residues
MTATAQQLEYLKNSIQSIEDYPKPGILFRDVTSLLEDPKAYALSIELLTERYKDAGITKVVGTEARGFLFGAPVALALGV
GFVPVRKPRKLPRETIAETYELEYGTDQLEIHVDAIKPGDKVLVVDDLLATGGTIDATVKLIRRLGGEVHDAAFIINLFD
LGGEQRLEKLGIHCYSLVPFPGH

Sequences:

>Translated_183_residues
MTATAQQLEYLKNSIQSIEDYPKPGILFRDVTSLLEDPKAYALSIELLTERYKDAGITKVVGTEARGFLFGAPVALALGV
GFVPVRKPRKLPRETIAETYELEYGTDQLEIHVDAIKPGDKVLVVDDLLATGGTIDATVKLIRRLGGEVHDAAFIINLFD
LGGEQRLEKLGIHCYSLVPFPGH
>Mature_182_residues
TATAQQLEYLKNSIQSIEDYPKPGILFRDVTSLLEDPKAYALSIELLTERYKDAGITKVVGTEARGFLFGAPVALALGVG
FVPVRKPRKLPRETIAETYELEYGTDQLEIHVDAIKPGDKVLVVDDLLATGGTIDATVKLIRRLGGEVHDAAFIINLFDL
GGEQRLEKLGIHCYSLVPFPGH

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4502171, Length=165, Percent_Identity=42.4242424242424, Blast_Score=137, Evalue=7e-33,
Organism=Homo sapiens, GI71773201, Length=130, Percent_Identity=44.6153846153846, Blast_Score=114, Evalue=4e-26,
Organism=Escherichia coli, GI1786675, Length=183, Percent_Identity=92.3497267759563, Blast_Score=338, Evalue=1e-94,
Organism=Caenorhabditis elegans, GI17509087, Length=159, Percent_Identity=44.0251572327044, Blast_Score=127, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6323619, Length=170, Percent_Identity=40, Blast_Score=111, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6320649, Length=171, Percent_Identity=35.672514619883, Blast_Score=89, Evalue=5e-19,
Organism=Drosophila melanogaster, GI17136334, Length=168, Percent_Identity=42.2619047619048, Blast_Score=133, Evalue=8e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005764
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.7 [H]

Molecular weight: Translated: 20077; Mature: 19946

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATAQQLEYLKNSIQSIEDYPKPGILFRDVTSLLEDPKAYALSIELLTERYKDAGITKV
CCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHEEHHHHHHHHHHHCCCEEE
VGTEARGFLFGAPVALALGVGFVPVRKPRKLPRETIAETYELEYGTDQLEIHVDAIKPGD
ECCCCCCEEEHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEEEEECCCC
KVLVVDDLLATGGTIDATVKLIRRLGGEVHDAAFIINLFDLGGEQRLEKLGIHCYSLVPF
EEEEEEHHHHCCCCHHHHHHHHHHHCCCHHHHHHEEHHHHCCCHHHHHHHCCEEEEECCC
PGH
CCC
>Mature Secondary Structure 
TATAQQLEYLKNSIQSIEDYPKPGILFRDVTSLLEDPKAYALSIELLTERYKDAGITKV
CCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHEEHHHHHHHHHHHCCCEEE
VGTEARGFLFGAPVALALGVGFVPVRKPRKLPRETIAETYELEYGTDQLEIHVDAIKPGD
ECCCCCCEEEHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEEEEECCCC
KVLVVDDLLATGGTIDATVKLIRRLGGEVHDAAFIINLFDLGGEQRLEKLGIHCYSLVPF
EEEEEEHHHHCCCCHHHHHHHHHHHCCCHHHHHHEEHHHHCCCHHHHHHHCCEEEEECCC
PGH
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA