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The map label for this gene is ldcC [H]

Identifier: 152968780

GI number: 152968780

Start: 235411

End: 237600

Strand: Direct

Name: ldcC [H]

Synonym: KPN_00199

Alternate gene names: 152968780

Gene position: 235411-237600 (Clockwise)

Preceding gene: 152968779

Following gene: 152968781

Centisome position: 4.43

GC content: 57.76

Gene sequence:

>2190_bases
ATGATGCTTGACTTAGGTGAATACCAGGAGGAAAGCGTGAATATCATCGCCATCATGGGGCCTCACGGCGTCTATCACAA
AGACGAACCGATCAAAGAACTGGAAGCGGCGCTGCAGCGCCAGGGTTTCCAGACCATCTGGCCGCAAAACAGCGCCGACC
TGCTGCAGTTTATCGAGCACAACCCGCGCATCTGCGGGGTGATCTTCGACTGGGATGAATACAGCGTCGATCTGTGCAGC
GATATCAATCAGCTCAATGAATACCTCCCCCTGTACGCCTTTATTAACGCCCACTCGACGATGGACGTCAGCAGTCAGGA
TCTGCGCATGACGCTGTGGTTCTTCGAATATGCGCTGGGACTCTCCGAAGAGATCGCCACCCGCATTGGGCAGTACACCC
GCGAGTACCTGGAGAATATCACTCCGCCGTTTACCCGCGCGCTGTTCAACTATGTCCAGGAGGGAAAATATACCTTCTGT
ACGCCGGGCCATATGGGCGGCAGCGCCTATCAGAAAAGCCCGGTGGGCTGCCTGTTCTATGATTTTTTTGGCGGGAATAC
GCTGAAGGCGGATGTCTCGATTTCGGTCACCGAGCTGGGCTCCCTGCTGGATCATACCGGCCCGCACCTGGAGGCGGAGG
AGTATATCGCGCGCGCCTTTGGCGCCGAGCAAAGCTATATGGTGACCAACGGCACCTCGACGTCCAATAAAATTGTCGGC
ATGTACTCGGCGCCCGCCGGCAGCACCCTGCTGATTGACCGTAACTGTCACAAATCGCTGGCCCACCTGCTGATGATGAG
CGATGTGGTTCCCCTGTGGCTGAAGCCGACCCGCAACGCGCTGGGGATCCTCGGCGGTATCCCCCGGCGCGAGTTCACCC
GCGACAGCATTCAACAGAAAGTGCGCGACACGGGCGGGGCGCAGTGGCCCGTGCATGCGGTGATCACCAACTCTACCTAC
GATGGACTGCTCTATAACACCACCTGGCTTAAGGAGACGCTCGATGTCCCGTCGATCCATTTCGATTCCGCCTGGGTGCC
CTATACCCATTTCCATCCGATATATCAGGGGAAAAGCGGCATGAGCGGGGAGCGGATCCCCGGGAAAGTTATCTTCGAGA
CGCAGTCGACGCATAAAATGCTGGCCGCGCTGTCGCAGGCCTCGCTGATCCACATTAAGGGCAACTATGATGAAGAGACC
TTTAATGAAGCCTTTATGATGCATACCTCGACCTCGCCGAGCTACCCCATCGTCGCGTCGATTGAGACCGCGGCGGCGAT
GCTGCGCGGTAACTCCGGTAAACGTCTGATCCAGCGCTCCATTGAGCGGGCGCTGGACTTCCGCAAAGAGGTGCAGCGAC
TGCGCGAGGAGTCGGACGGCTGGTTCTTTGATATCTGGCAGCCGGAAGCGGTGGATAAAGCCGAATGCTGGCCGGTGGCG
CCGGGCGAAGACTGGCATGGTTTCAAAGATGCCGATGCGGATCATATGTATCTCGATCCGGTGAAGGTCACCATTCTGAC
GCCGGGCATGGACGAGCAGGGGAATATGGATGAAGAGGGGATCCCGGCGGCGCTGGTGGCGAAGTTCCTCGACGAGCGGG
GCGTGGTGGTGGAAAAAACGGGCCCCTATAACCTGCTGTTCCTGTTCAGCATCGGCATTGATAAAACCAGGGCGATGGGG
CTACTGCGCGGTCTGACTGAGTTCAAACGCGCCTACGATCTCAATCTGCGGGTGAAAAATATGCTGCCGGATCTGTACGC
CGAAGATCCCGACTTCTACCGCAACATGCGGATCCAGGATCTGGCGCAGGGGATCCACCGCTTGATCCGTCAGCACCAGC
TGCCGCAGCTGATGCTCAGCGCCTTTGACGTCCTGCCGGAAATGAAAATGACGCCGCATCACGCCTGGCAGCGCCAGATC
AAGGGTGAGGTAGAAACTATTGAACTGGAGAACCTGGTGGGGCGGATTTCGGCCAACATGATCCTCCCTTATCCGCCGGG
GGTTCCGCTGCTGATGCCGGGAGAGATGATCACCGAGGAAAGCCGGGCGGTGCTCGATTTTCTGCTGATGCTTTGCTCTA
TCGGCCGTCATTACCCGGGCTTTGAGACCGATATTCACGGCGCCAAGCGCGATGAGGACGGTGTGTATCGGGTACGAGTC
TTAAAAAATGACGAAAGGCTTGCGCGTTAA

Upstream 100 bases:

>100_bases
TGATGAGCTACGGTTACGCTTAACTTTTTCGCTAGGACTAAACACTAAGGGCCGGATTTTCCGGCCCTTTTTTTATGTGC
GATGCGCCCGGGGGATTGCT

Downstream 100 bases:

>100_bases
CGGCGCACACGCGTAACGTGGCTGGCTTAACAGAAGGAGTTTAACCATGCTGGGTTTGAAACGGGTTCACCATATTGCCA
TCATTGCGACGGATTACGCC

Product: lysine decarboxylase 2, constitutive

Products: NA

Alternate protein names: LDC [H]

Number of amino acids: Translated: 729; Mature: 729

Protein sequence:

>729_residues
MMLDLGEYQEESVNIIAIMGPHGVYHKDEPIKELEAALQRQGFQTIWPQNSADLLQFIEHNPRICGVIFDWDEYSVDLCS
DINQLNEYLPLYAFINAHSTMDVSSQDLRMTLWFFEYALGLSEEIATRIGQYTREYLENITPPFTRALFNYVQEGKYTFC
TPGHMGGSAYQKSPVGCLFYDFFGGNTLKADVSISVTELGSLLDHTGPHLEAEEYIARAFGAEQSYMVTNGTSTSNKIVG
MYSAPAGSTLLIDRNCHKSLAHLLMMSDVVPLWLKPTRNALGILGGIPRREFTRDSIQQKVRDTGGAQWPVHAVITNSTY
DGLLYNTTWLKETLDVPSIHFDSAWVPYTHFHPIYQGKSGMSGERIPGKVIFETQSTHKMLAALSQASLIHIKGNYDEET
FNEAFMMHTSTSPSYPIVASIETAAAMLRGNSGKRLIQRSIERALDFRKEVQRLREESDGWFFDIWQPEAVDKAECWPVA
PGEDWHGFKDADADHMYLDPVKVTILTPGMDEQGNMDEEGIPAALVAKFLDERGVVVEKTGPYNLLFLFSIGIDKTRAMG
LLRGLTEFKRAYDLNLRVKNMLPDLYAEDPDFYRNMRIQDLAQGIHRLIRQHQLPQLMLSAFDVLPEMKMTPHHAWQRQI
KGEVETIELENLVGRISANMILPYPPGVPLLMPGEMITEESRAVLDFLLMLCSIGRHYPGFETDIHGAKRDEDGVYRVRV
LKNDERLAR

Sequences:

>Translated_729_residues
MMLDLGEYQEESVNIIAIMGPHGVYHKDEPIKELEAALQRQGFQTIWPQNSADLLQFIEHNPRICGVIFDWDEYSVDLCS
DINQLNEYLPLYAFINAHSTMDVSSQDLRMTLWFFEYALGLSEEIATRIGQYTREYLENITPPFTRALFNYVQEGKYTFC
TPGHMGGSAYQKSPVGCLFYDFFGGNTLKADVSISVTELGSLLDHTGPHLEAEEYIARAFGAEQSYMVTNGTSTSNKIVG
MYSAPAGSTLLIDRNCHKSLAHLLMMSDVVPLWLKPTRNALGILGGIPRREFTRDSIQQKVRDTGGAQWPVHAVITNSTY
DGLLYNTTWLKETLDVPSIHFDSAWVPYTHFHPIYQGKSGMSGERIPGKVIFETQSTHKMLAALSQASLIHIKGNYDEET
FNEAFMMHTSTSPSYPIVASIETAAAMLRGNSGKRLIQRSIERALDFRKEVQRLREESDGWFFDIWQPEAVDKAECWPVA
PGEDWHGFKDADADHMYLDPVKVTILTPGMDEQGNMDEEGIPAALVAKFLDERGVVVEKTGPYNLLFLFSIGIDKTRAMG
LLRGLTEFKRAYDLNLRVKNMLPDLYAEDPDFYRNMRIQDLAQGIHRLIRQHQLPQLMLSAFDVLPEMKMTPHHAWQRQI
KGEVETIELENLVGRISANMILPYPPGVPLLMPGEMITEESRAVLDFLLMLCSIGRHYPGFETDIHGAKRDEDGVYRVRV
LKNDERLAR
>Mature_729_residues
MMLDLGEYQEESVNIIAIMGPHGVYHKDEPIKELEAALQRQGFQTIWPQNSADLLQFIEHNPRICGVIFDWDEYSVDLCS
DINQLNEYLPLYAFINAHSTMDVSSQDLRMTLWFFEYALGLSEEIATRIGQYTREYLENITPPFTRALFNYVQEGKYTFC
TPGHMGGSAYQKSPVGCLFYDFFGGNTLKADVSISVTELGSLLDHTGPHLEAEEYIARAFGAEQSYMVTNGTSTSNKIVG
MYSAPAGSTLLIDRNCHKSLAHLLMMSDVVPLWLKPTRNALGILGGIPRREFTRDSIQQKVRDTGGAQWPVHAVITNSTY
DGLLYNTTWLKETLDVPSIHFDSAWVPYTHFHPIYQGKSGMSGERIPGKVIFETQSTHKMLAALSQASLIHIKGNYDEET
FNEAFMMHTSTSPSYPIVASIETAAAMLRGNSGKRLIQRSIERALDFRKEVQRLREESDGWFFDIWQPEAVDKAECWPVA
PGEDWHGFKDADADHMYLDPVKVTILTPGMDEQGNMDEEGIPAALVAKFLDERGVVVEKTGPYNLLFLFSIGIDKTRAMG
LLRGLTEFKRAYDLNLRVKNMLPDLYAEDPDFYRNMRIQDLAQGIHRLIRQHQLPQLMLSAFDVLPEMKMTPHHAWQRQI
KGEVETIELENLVGRISANMILPYPPGVPLLMPGEMITEESRAVLDFLLMLCSIGRHYPGFETDIHGAKRDEDGVYRVRV
LKNDERLAR

Specific function: LDC is constitutively but weakly expressed under various conditions [H]

COG id: COG1982

COG function: function code E; Arginine/lysine/ornithine decarboxylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-I family [H]

Homologues:

Organism=Escherichia coli, GI1786384, Length=710, Percent_Identity=88.7323943661972, Blast_Score=1345, Evalue=0.0,
Organism=Escherichia coli, GI1790573, Length=714, Percent_Identity=69.187675070028, Blast_Score=1086, Evalue=0.0,
Organism=Escherichia coli, GI221142684, Length=735, Percent_Identity=35.5102040816327, Blast_Score=468, Evalue=1e-133,
Organism=Escherichia coli, GI87082193, Length=620, Percent_Identity=34.6774193548387, Blast_Score=337, Evalue=2e-93,
Organism=Escherichia coli, GI1786909, Length=691, Percent_Identity=31.548480463097, Blast_Score=309, Evalue=5e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005308
- InterPro:   IPR011193
- InterPro:   IPR000310
- InterPro:   IPR008286
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01276 OKR_DC_1; PF03711 OKR_DC_1_C; PF03709 OKR_DC_1_N [H]

EC number: =4.1.1.18 [H]

Molecular weight: Translated: 82646; Mature: 82646

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00703 OKR_DC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMLDLGEYQEESVNIIAIMGPHGVYHKDEPIKELEAALQRQGFQTIWPQNSADLLQFIEH
CCCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCEECCCCHHHHHHHHHC
NPRICGVIFDWDEYSVDLCSDINQLNEYLPLYAFINAHSTMDVSSQDLRMTLWFFEYALG
CCCEEEEEECCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHC
LSEEIATRIGQYTREYLENITPPFTRALFNYVQEGKYTFCTPGHMGGSAYQKSPVGCLFY
CCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCEEEE
DFFGGNTLKADVSISVTELGSLLDHTGPHLEAEEYIARAFGAEQSYMVTNGTSTSNKIVG
EECCCCEEEEEEEEEHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCEEEE
MYSAPAGSTLLIDRNCHKSLAHLLMMSDVVPLWLKPTRNALGILGGIPRREFTRDSIQQK
EEECCCCCEEEEECCHHHHHHHHHHHHCCCCEEECCCCHHHHHHCCCCCHHHHHHHHHHH
VRDTGGAQWPVHAVITNSTYDGLLYNTTWLKETLDVPSIHFDSAWVPYTHFHPIYQGKSG
HHHCCCCCCCEEEEEECCCCCCEEEEHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCCC
MSGERIPGKVIFETQSTHKMLAALSQASLIHIKGNYDEETFNEAFMMHTSTSPSYPIVAS
CCCCCCCCEEEEECCHHHHHHHHHCCCCEEEEECCCCHHHHCCEEEEEECCCCCCCEEEE
IETAAAMLRGNSGKRLIQRSIERALDFRKEVQRLREESDGWFFDIWQPEAVDKAECWPVA
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCC
PGEDWHGFKDADADHMYLDPVKVTILTPGMDEQGNMDEEGIPAALVAKFLDERGVVVEKT
CCCCCCCCCCCCCCCEEECCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEECC
GPYNLLFLFSIGIDKTRAMGLLRGLTEFKRAYDLNLRVKNMLPDLYAEDPDFYRNMRIQD
CCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCEEHHHHCCHHHCCCCHHHHCCCHHH
LAQGIHRLIRQHQLPQLMLSAFDVLPEMKMTPHHAWQRQIKGEVETIELENLVGRISANM
HHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEHHHHHHHHHCCE
ILPYPPGVPLLMPGEMITEESRAVLDFLLMLCSIGRHYPGFETDIHGAKRDEDGVYRVRV
EEECCCCCCEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEE
LKNDERLAR
EECHHHHCC
>Mature Secondary Structure
MMLDLGEYQEESVNIIAIMGPHGVYHKDEPIKELEAALQRQGFQTIWPQNSADLLQFIEH
CCCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCEECCCCHHHHHHHHHC
NPRICGVIFDWDEYSVDLCSDINQLNEYLPLYAFINAHSTMDVSSQDLRMTLWFFEYALG
CCCEEEEEECCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHC
LSEEIATRIGQYTREYLENITPPFTRALFNYVQEGKYTFCTPGHMGGSAYQKSPVGCLFY
CCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCEEEE
DFFGGNTLKADVSISVTELGSLLDHTGPHLEAEEYIARAFGAEQSYMVTNGTSTSNKIVG
EECCCCEEEEEEEEEHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCEEEE
MYSAPAGSTLLIDRNCHKSLAHLLMMSDVVPLWLKPTRNALGILGGIPRREFTRDSIQQK
EEECCCCCEEEEECCHHHHHHHHHHHHCCCCEEECCCCHHHHHHCCCCCHHHHHHHHHHH
VRDTGGAQWPVHAVITNSTYDGLLYNTTWLKETLDVPSIHFDSAWVPYTHFHPIYQGKSG
HHHCCCCCCCEEEEEECCCCCCEEEEHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCCC
MSGERIPGKVIFETQSTHKMLAALSQASLIHIKGNYDEETFNEAFMMHTSTSPSYPIVAS
CCCCCCCCEEEEECCHHHHHHHHHCCCCEEEEECCCCHHHHCCEEEEEECCCCCCCEEEE
IETAAAMLRGNSGKRLIQRSIERALDFRKEVQRLREESDGWFFDIWQPEAVDKAECWPVA
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCC
PGEDWHGFKDADADHMYLDPVKVTILTPGMDEQGNMDEEGIPAALVAKFLDERGVVVEKT
CCCCCCCCCCCCCCCEEECCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEECC
GPYNLLFLFSIGIDKTRAMGLLRGLTEFKRAYDLNLRVKNMLPDLYAEDPDFYRNMRIQD
CCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCEEHHHHCCHHHCCCCHHHHCCCHHH
LAQGIHRLIRQHQLPQLMLSAFDVLPEMKMTPHHAWQRQIKGEVETIELENLVGRISANM
HHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEHHHHHHHHHCCE
ILPYPPGVPLLMPGEMITEESRAVLDFLLMLCSIGRHYPGFETDIHGAKRDEDGVYRVRV
EEECCCCCCEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEE
LKNDERLAR
EECHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9226257; 9339543; 9278503; 9723924 [H]