| Definition | Klebsiella pneumoniae subsp. pneumoniae MGH 78578 chromosome, complete genome. |
|---|---|
| Accession | NC_009648 |
| Length | 5,315,120 |
Click here to switch to the map view.
The map label for this gene is ftsI [H]
Identifier: 152968669
GI number: 152968669
Start: 103152
End: 104918
Strand: Direct
Name: ftsI [H]
Synonym: KPN_00088
Alternate gene names: 152968669
Gene position: 103152-104918 (Clockwise)
Preceding gene: 152968668
Following gene: 152968670
Centisome position: 1.94
GC content: 56.31
Gene sequence:
>1767_bases ATGAAAGCAGCGCCAAAAACGCCTAAAGCAAAACGTCAGGAAGAACAGGCCAACTTTATCAGTTGGCGTTTTGCGTTGCT GTGCGGCTGTATTCTGCTGGCGCTGGCTTTTCTGCTGGGTCGCGTCGCCTGGTTACAGGTGATCAGCCCCGATATGCTGG TGCGCCAGGGCGATATGCGTTCTCTGCGCGTACAGGAAGTGTCCACCGCGCGCGGGATGATTACCGATCGCTCCGGACGT CCGCTGGCGGTCAGCGTGCCGGTGAAGGCTATCTGGGCCGACCCGAAAGAGCTCCATGACGCCGGTGGGGTTACCCTGGA TACGCGCTGGAAAGCGCTGGCGGATGCCCTCAATATGCCGCTGGATCAGCTGGCGACGCGCATCAATACCAATCCGCGGA TGCGGTTTATCTATCTGGCGCGTCAGGTTAATCCTGACATGGCCGATTACATCAAGAAGCTGAAGCTGCCGGGCATTCAT CTGCGCGAAGAATCCCGTCGTTACTACCCTTCCGGGGAAGTAACCGCTCACCTCATCGGCTTTACCAACGTCGATAGCCA GGGGATTGAAGGGGTTGAGAAAAGCTTTGATAAATGGCTTACCGGTCAGCCGGGCGAGCGTATCGTACGTAAAGACCGCT ATGGCCGGGTAATTGAAGACATCTCTTCTACCGATAGCCAGGCAGCGCACAACCTGGCGCTGAGTATCGACGAACGCCTG CAGGCGCTGGTCTATCGCGAGCTGAACAACGCCGTGGCCTTTAACAAAGCCGAGTCGGGCAGCGCCGTGTTAGTGGATGT TAACACCGGTGAAGTGCTGGCGATGGCCAACAGCCCATCCTATAACCCGAACAACTTCGCCGGTACGGCAAAAGACACCA TGCGTAACCGTGCGATTACCGACGTGTTTGAACCGGGTTCGACGGTGAAACCGATGGTGGTCATGACGGCGCTGCAGCGC GGTATCGTCAACGAAAATACCGTGCTCAATACCGTGCCTTATCGAATTAACGGCCACGAAATCAAAGACGTGGCGCGCTA CAGCGAATTGACCCTGACCGGGGTGCTACAGAAGTCGAGTAACGTCGGTGTTTCTAAGCTGGCGTTAGCGATGCCGTCCT CAGCGTTAGTAGATACTTACTCACGTTTTGGGCTTGGAAAGGCGACCAATTTGGGGTTGGTCGGAGAACGCAGTGGCTTA TATCCTCAAAAACAACGGTGGTCTGACATAGAGAGGGCCACCTTTTCTTTCGGCTATGGGCTAATGGTAACCCCGTTACA GTTAGCGCGAGTCTACGCAACGATTGGCAGCTATGGCATCTATCGCCCGTTGTCGATTACCAAGGTTGATCCTCCGGTTC CGGGCGAGCGCGTCTTCCCGGAATCACTCGTTCGTACCGTCGTTCATATGATGGAAAGCGTGGCGCTGCCCGGCGGCGGC GGTGTGAAAGCGGCGATCAAAGGCTATCGCATCGCGATTAAAACCGGTACGGCGAAAAAAGTGGGGCCGGATGGCCGCTA TATCAACAAATATATTGCTTACACCGCAGGCGTTGCGCCCGCCAGCCATCCGCGCTTCGCGCTGGTGGTGGTGATCAACG ACCCGCAGGCAGGTAAATACTACGGTGGCGCCGTTTCCGCGCCGGTCTTCGGTGCCATCATGGGCGGCGTATTGCGCACC ATGAACATCGAGCCGGATGCGCTGGCAACGGGCGAAAAAAGTGAATTTGTAATTAATCAAGGCGAGGGAACAGGTGGCAG ATCGTAA
Upstream 100 bases:
>100_bases CAGTCGGGTTGAGCGGATCGCGACCGAGAAGTTACAGATGCAACACGTCGATCCATCACAAGAAAATATCGTTGTACAGA AATAAGGATTATTGCGACGG
Downstream 100 bases:
>100_bases TTTGCGCGACCTACTCGCTCCATGGGTGCCAAACGCACCGGAGCGCATTCTGCGAGAGATGACGCTGGACAGCCGGGTGG CTGCTTCCGGCGATCTCTTT
Product: division-specific transpeptidase, penicillin-binding protein 3
Products: NA
Alternate protein names: Penicillin-binding protein 3; PBP-3; Peptidoglycan glycosyltransferase 3 [H]
Number of amino acids: Translated: 588; Mature: 588
Protein sequence:
>588_residues MKAAPKTPKAKRQEEQANFISWRFALLCGCILLALAFLLGRVAWLQVISPDMLVRQGDMRSLRVQEVSTARGMITDRSGR PLAVSVPVKAIWADPKELHDAGGVTLDTRWKALADALNMPLDQLATRINTNPRMRFIYLARQVNPDMADYIKKLKLPGIH LREESRRYYPSGEVTAHLIGFTNVDSQGIEGVEKSFDKWLTGQPGERIVRKDRYGRVIEDISSTDSQAAHNLALSIDERL QALVYRELNNAVAFNKAESGSAVLVDVNTGEVLAMANSPSYNPNNFAGTAKDTMRNRAITDVFEPGSTVKPMVVMTALQR GIVNENTVLNTVPYRINGHEIKDVARYSELTLTGVLQKSSNVGVSKLALAMPSSALVDTYSRFGLGKATNLGLVGERSGL YPQKQRWSDIERATFSFGYGLMVTPLQLARVYATIGSYGIYRPLSITKVDPPVPGERVFPESLVRTVVHMMESVALPGGG GVKAAIKGYRIAIKTGTAKKVGPDGRYINKYIAYTAGVAPASHPRFALVVVINDPQAGKYYGGAVSAPVFGAIMGGVLRT MNIEPDALATGEKSEFVINQGEGTGGRS
Sequences:
>Translated_588_residues MKAAPKTPKAKRQEEQANFISWRFALLCGCILLALAFLLGRVAWLQVISPDMLVRQGDMRSLRVQEVSTARGMITDRSGR PLAVSVPVKAIWADPKELHDAGGVTLDTRWKALADALNMPLDQLATRINTNPRMRFIYLARQVNPDMADYIKKLKLPGIH LREESRRYYPSGEVTAHLIGFTNVDSQGIEGVEKSFDKWLTGQPGERIVRKDRYGRVIEDISSTDSQAAHNLALSIDERL QALVYRELNNAVAFNKAESGSAVLVDVNTGEVLAMANSPSYNPNNFAGTAKDTMRNRAITDVFEPGSTVKPMVVMTALQR GIVNENTVLNTVPYRINGHEIKDVARYSELTLTGVLQKSSNVGVSKLALAMPSSALVDTYSRFGLGKATNLGLVGERSGL YPQKQRWSDIERATFSFGYGLMVTPLQLARVYATIGSYGIYRPLSITKVDPPVPGERVFPESLVRTVVHMMESVALPGGG GVKAAIKGYRIAIKTGTAKKVGPDGRYINKYIAYTAGVAPASHPRFALVVVINDPQAGKYYGGAVSAPVFGAIMGGVLRT MNIEPDALATGEKSEFVINQGEGTGGRS >Mature_588_residues MKAAPKTPKAKRQEEQANFISWRFALLCGCILLALAFLLGRVAWLQVISPDMLVRQGDMRSLRVQEVSTARGMITDRSGR PLAVSVPVKAIWADPKELHDAGGVTLDTRWKALADALNMPLDQLATRINTNPRMRFIYLARQVNPDMADYIKKLKLPGIH LREESRRYYPSGEVTAHLIGFTNVDSQGIEGVEKSFDKWLTGQPGERIVRKDRYGRVIEDISSTDSQAAHNLALSIDERL QALVYRELNNAVAFNKAESGSAVLVDVNTGEVLAMANSPSYNPNNFAGTAKDTMRNRAITDVFEPGSTVKPMVVMTALQR GIVNENTVLNTVPYRINGHEIKDVARYSELTLTGVLQKSSNVGVSKLALAMPSSALVDTYSRFGLGKATNLGLVGERSGL YPQKQRWSDIERATFSFGYGLMVTPLQLARVYATIGSYGIYRPLSITKVDPPVPGERVFPESLVRTVVHMMESVALPGGG GVKAAIKGYRIAIKTGTAKKVGPDGRYINKYIAYTAGVAPASHPRFALVVVINDPQAGKYYGGAVSAPVFGAIMGGVLRT MNIEPDALATGEKSEFVINQGEGTGGRS
Specific function: Cell wall formation. Essential for the formation of a septum of the murein sacculus. Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]
COG id: COG0768
COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2
Gene ontology:
Cell location: Cell inner membrane; Single-pass membrane protein; Periplasmic side. Note=The bulk of the molecule, except for the N-terminal membrane anchor region, protrudes into the periplasmic space, where it acts on murein (By similarity) [H]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the transpeptidase family [H]
Homologues:
Organism=Escherichia coli, GI1786272, Length=588, Percent_Identity=93.8775510204082, Blast_Score=1141, Evalue=0.0, Organism=Escherichia coli, GI1786854, Length=621, Percent_Identity=25.9259259259259, Blast_Score=140, Evalue=2e-34,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR012338 - InterPro: IPR005311 - InterPro: IPR001460 [H]
Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]
EC number: =2.4.1.129 [H]
Molecular weight: Translated: 64003; Mature: 64003
Theoretical pI: Translated: 10.03; Mature: 10.03
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.3 %Cys (Translated Protein) 2.9 %Met (Translated Protein) 3.2 %Cys+Met (Translated Protein) 0.3 %Cys (Mature Protein) 2.9 %Met (Mature Protein) 3.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKAAPKTPKAKRQEEQANFISWRFALLCGCILLALAFLLGRVAWLQVISPDMLVRQGDMR CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEECCCCH SLRVQEVSTARGMITDRSGRPLAVSVPVKAIWADPKELHDAGGVTLDTRWKALADALNMP HHHHHHHHHHCCEEECCCCCCEEEECCHHEEECCHHHHHHCCCCEEEHHHHHHHHHHCCC LDQLATRINTNPRMRFIYLARQVNPDMADYIKKLKLPGIHLREESRRYYPSGEVTAHLIG HHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHCCCCCEECCCCCCCCCCCCCEEEEEE FTNVDSQGIEGVEKSFDKWLTGQPGERIVRKDRYGRVIEDISSTDSQAAHNLALSIDERL EECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHEEEHHHHH QALVYRELNNAVAFNKAESGSAVLVDVNTGEVLAMANSPSYNPNNFAGTAKDTMRNRAIT HHHHHHHHHCCEEECCCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCCHHHHHHHCCHH DVFEPGSTVKPMVVMTALQRGIVNENTVLNTVPYRINGHEIKDVARYSELTLTGVLQKSS HHCCCCCCCCHHHHHHHHHHCCCCCCCEEECCCEEECCCHHHHHHHHHHHHHEEEHHCCC NVGVSKLALAMPSSALVDTYSRFGLGKATNLGLVGERSGLYPQKQRWSDIERATFSFGYG CCCHHHHHHHCCCHHHHHHHHHHCCCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHCCCC LMVTPLQLARVYATIGSYGIYRPLSITKVDPPVPGERVFPESLVRTVVHMMESVALPGGG HHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCC GVKAAIKGYRIAIKTGTAKKVGPDGRYINKYIAYTAGVAPASHPRFALVVVINDPQAGKY CCCEEECCEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCC YGGAVSAPVFGAIMGGVLRTMNIEPDALATGEKSEFVINQGEGTGGRS CCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCC >Mature Secondary Structure MKAAPKTPKAKRQEEQANFISWRFALLCGCILLALAFLLGRVAWLQVISPDMLVRQGDMR CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEECCCCH SLRVQEVSTARGMITDRSGRPLAVSVPVKAIWADPKELHDAGGVTLDTRWKALADALNMP HHHHHHHHHHCCEEECCCCCCEEEECCHHEEECCHHHHHHCCCCEEEHHHHHHHHHHCCC LDQLATRINTNPRMRFIYLARQVNPDMADYIKKLKLPGIHLREESRRYYPSGEVTAHLIG HHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHCCCCCEECCCCCCCCCCCCCEEEEEE FTNVDSQGIEGVEKSFDKWLTGQPGERIVRKDRYGRVIEDISSTDSQAAHNLALSIDERL EECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHEEEHHHHH QALVYRELNNAVAFNKAESGSAVLVDVNTGEVLAMANSPSYNPNNFAGTAKDTMRNRAIT HHHHHHHHHCCEEECCCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCCHHHHHHHCCHH DVFEPGSTVKPMVVMTALQRGIVNENTVLNTVPYRINGHEIKDVARYSELTLTGVLQKSS HHCCCCCCCCHHHHHHHHHHCCCCCCCEEECCCEEECCCHHHHHHHHHHHHHEEEHHCCC NVGVSKLALAMPSSALVDTYSRFGLGKATNLGLVGERSGLYPQKQRWSDIERATFSFGYG CCCHHHHHHHCCCHHHHHHHHHHCCCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHCCCC LMVTPLQLARVYATIGSYGIYRPLSITKVDPPVPGERVFPESLVRTVVHMMESVALPGGG HHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCC GVKAAIKGYRIAIKTGTAKKVGPDGRYINKYIAYTAGVAPASHPRFALVVVINDPQAGKY CCCEEECCEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCC YGGAVSAPVFGAIMGGVLRTMNIEPDALATGEKSEFVINQGEGTGGRS CCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 11206551; 11258796 [H]