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The map label for this gene is cimH [H]

Identifier: 152968636

GI number: 152968636

Start: 61194

End: 62558

Strand: Direct

Name: cimH [H]

Synonym: KPN_00055

Alternate gene names: 152968636

Gene position: 61194-62558 (Clockwise)

Preceding gene: 152968633

Following gene: 152968637

Centisome position: 1.15

GC content: 59.85

Gene sequence:

>1365_bases
ATGAGCACCACAGACAATGCATTCTCTGCAACCCTTGAACCGATCGATACGCCGAAAACCACGCTCAAGCAGCGCTGGTG
GCATATTATGGATAACTGGAAGGTGGGGATCGTCCCGCTGCCGCTGTTTCTGCTGGCCGGAGGACTGATTGCCCTCGACT
GCCTTGGCGGCAAACTGCCGAGCGATATCGTGGTGATGGTGGCCACCCTGGCTTTCTTTGGCTTCGCCTGCGGCGAGTTT
GGTAAACGCCTCCCGGTGCTGGGGAAACTCGGTGCGGCGGCGATCTGCGCCACCTTTATTCCTTCCGCGCTGGTCCACTA
TGGTCTGCTGCCTGACGTGGTTATTGAATCCACGACCAAATTCTATAAATCCACTAACATCCTCTATCTCTATATCTGCT
GCATCATTGTCGGCAGCATCATGAGTATGAACCGCACCACGCTGATTCAGGGCTTTCTGAAGATCTTCTTCCCGATGCTG
TGCGGCGAAGTGGTCGGCATGCTGGTGGGCATCGGCGTCGGCACGCTGCTGGGCATGGAGCCGTTCCAGGTGTTCTTCTT
TATCGTGCTGCCGATTATGGCCGGCGGCGTGGGAGAGGGGGCGATCCCGCTGTCAATGGGTTATGCCGCGCTGATGCATA
TGGAGCAGGGCGTGGCCCTGGGCCGGGTATTGCCGATGGTGATGCTTGGCAGCCTGACGGCGATCGTCATCTCCGGCTGC
CTCAACCAGCTCGGCAAGCGCTTCCCGCATCTGACCGGCGAAGGGCAACTGATGCCGAACCGCAGCCATGAAACCCGCAG
CCTCAGCGAGAGCGAAGGCGTGAGCGGTAAGACCGACGTTGGGACCCTCGCCTCCGGCGCGCTGCTGGCGGTACTGCTGT
ATATGATGGGGATGCTCGGCCACAAACTGATTGGTCTGCCGGCGCCGGTAGGCATGCTGTTCCTCGCGGTGCTGTTAAAG
CTGGCTAACGTGGTGTCTCCGCGTCTGCAGGAGGGGTCGCAGATGGTGTATAAATTCTTCCGCACCGCGGTCACCTACCC
GATCCTCTTTGCCGTCGGCGTGGCGATCACCCCGTGGCAGGAACTGGTAAACGCCTTCACTTTAACCAACCTGCTGGTGA
TCGTCAGTACCGTCTCCGCGCTGGTGGCGACCGGTTTCCTGGTTGGTAAAAAGATAGGGATGCACCCGATCGATGTGGCG
ATTGTTTCCTGTTGCCAGAGCGGGCAGGGCGGCACCGGCGATGTGGCGATCCTGACCGCCGGCAACCGCATGAGCCTGAT
GCCGTTCGCGCAGATCGCTACCCGCATCGGCGGGGCGATAAATGTCTCGCTGGGGTTGCTGTTCCTCAGCCACTATCTGG
CGTGA

Upstream 100 bases:

>100_bases
AGTGACCATTAAAACTTCTTTTTTAATTTGGGAAGCTTCACATTAACGACGCCGCTGTCCCTTTACGCTGAAAATGAATA
ATAACGACAGGGCTGAATTT

Downstream 100 bases:

>100_bases
TATAACGCTACGCTCAGCGATAAATCTGCTATTTTCCGCTACAGAACGCCGAAAATATCTGCGTTCTGTATCCTAAATGC
TCCGCATTTAGCGTTACAAT

Product: citrate/acetate antiporter

Products: NA

Alternate protein names: Citrate/malate-proton symporter [H]

Number of amino acids: Translated: 454; Mature: 453

Protein sequence:

>454_residues
MSTTDNAFSATLEPIDTPKTTLKQRWWHIMDNWKVGIVPLPLFLLAGGLIALDCLGGKLPSDIVVMVATLAFFGFACGEF
GKRLPVLGKLGAAAICATFIPSALVHYGLLPDVVIESTTKFYKSTNILYLYICCIIVGSIMSMNRTTLIQGFLKIFFPML
CGEVVGMLVGIGVGTLLGMEPFQVFFFIVLPIMAGGVGEGAIPLSMGYAALMHMEQGVALGRVLPMVMLGSLTAIVISGC
LNQLGKRFPHLTGEGQLMPNRSHETRSLSESEGVSGKTDVGTLASGALLAVLLYMMGMLGHKLIGLPAPVGMLFLAVLLK
LANVVSPRLQEGSQMVYKFFRTAVTYPILFAVGVAITPWQELVNAFTLTNLLVIVSTVSALVATGFLVGKKIGMHPIDVA
IVSCCQSGQGGTGDVAILTAGNRMSLMPFAQIATRIGGAINVSLGLLFLSHYLA

Sequences:

>Translated_454_residues
MSTTDNAFSATLEPIDTPKTTLKQRWWHIMDNWKVGIVPLPLFLLAGGLIALDCLGGKLPSDIVVMVATLAFFGFACGEF
GKRLPVLGKLGAAAICATFIPSALVHYGLLPDVVIESTTKFYKSTNILYLYICCIIVGSIMSMNRTTLIQGFLKIFFPML
CGEVVGMLVGIGVGTLLGMEPFQVFFFIVLPIMAGGVGEGAIPLSMGYAALMHMEQGVALGRVLPMVMLGSLTAIVISGC
LNQLGKRFPHLTGEGQLMPNRSHETRSLSESEGVSGKTDVGTLASGALLAVLLYMMGMLGHKLIGLPAPVGMLFLAVLLK
LANVVSPRLQEGSQMVYKFFRTAVTYPILFAVGVAITPWQELVNAFTLTNLLVIVSTVSALVATGFLVGKKIGMHPIDVA
IVSCCQSGQGGTGDVAILTAGNRMSLMPFAQIATRIGGAINVSLGLLFLSHYLA
>Mature_453_residues
STTDNAFSATLEPIDTPKTTLKQRWWHIMDNWKVGIVPLPLFLLAGGLIALDCLGGKLPSDIVVMVATLAFFGFACGEFG
KRLPVLGKLGAAAICATFIPSALVHYGLLPDVVIESTTKFYKSTNILYLYICCIIVGSIMSMNRTTLIQGFLKIFFPMLC
GEVVGMLVGIGVGTLLGMEPFQVFFFIVLPIMAGGVGEGAIPLSMGYAALMHMEQGVALGRVLPMVMLGSLTAIVISGCL
NQLGKRFPHLTGEGQLMPNRSHETRSLSESEGVSGKTDVGTLASGALLAVLLYMMGMLGHKLIGLPAPVGMLFLAVLLKL
ANVVSPRLQEGSQMVYKFFRTAVTYPILFAVGVAITPWQELVNAFTLTNLLVIVSTVSALVATGFLVGKKIGMHPIDVAI
VSCCQSGQGGTGDVAILTAGNRMSLMPFAQIATRIGGAINVSLGLLFLSHYLA

Specific function: Proton motive force-driven secondary transporter that catalyzes the uptake of both citrate and malate. Appears to be an electroneutral proton-solute symporter; the number of protons transported is equal to the valence of the transported anions. Is strictl

COG id: COG3493

COG function: function code C; Na+/citrate symporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:citrate (SCF) symporter family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004679
- InterPro:   IPR018025 [H]

Pfam domain/function: PF03390 2HCT [H]

EC number: NA

Molecular weight: Translated: 48153; Mature: 48021

Theoretical pI: Translated: 8.48; Mature: 8.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
STTDNAFSATLEPIDTPKTTLKQRWWHIMDNWKVGIVPLPLFLLAGGLIALDCLGGKLP
CCCCCCHHCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCHHHHHHHHCCCCC
SDIVVMVATLAFFGFACGEFGKRLPVLGKLGAAAICATFIPSALVHYGLLPDVVIESTTK
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
FYKSTNILYLYICCIIVGSIMSMNRTTLIQGFLKIFFPMLCGEVVGMLVGIGVGTLLGME
HHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PFQVFFFIVLPIMAGGVGEGAIPLSMGYAALMHMEQGVALGRVLPMVMLGSLTAIVISGC
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
LNQLGKRFPHLTGEGQLMPNRSHETRSLSESEGVSGKTDVGTLASGALLAVLLYMMGMLG
HHHHHHHCCCCCCCCCCCCCCCCHHHCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
HKLIGLPAPVGMLFLAVLLKLANVVSPRLQEGSQMVYKFFRTAVTYPILFAVGVAITPWQ
HHHHCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
ELVNAFTLTNLLVIVSTVSALVATGFLVGKKIGMHPIDVAIVSCCQSGQGGTGDVAILTA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCEEEEEC
GNRMSLMPFAQIATRIGGAINVSLGLLFLSHYLA
CCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969509; 9384377; 11566984 [H]