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The map label for this gene is nhaA

Identifier: 152968598

GI number: 152968598

Start: 16915

End: 18102

Strand: Direct

Name: nhaA

Synonym: KPN_00016

Alternate gene names: 152968598

Gene position: 16915-18102 (Clockwise)

Preceding gene: 152968597

Following gene: 152968599

Centisome position: 0.32

GC content: 59.85

Gene sequence:

>1188_bases
ATGAAAGTAAAAGTGAAACATCTGCAACGATTCTTTAGTAGCGATGCTTCCGGCGGCATTGTCTTAATTATCGCCGCCGC
GCTGGCGATGGTGATGGCCAATACCAGCGTGACCAGTGGTCTGTATCACTCCTTCCTTGAGACGCCAGTACAGCTGCGTG
TGGGCGCGCTGGAGATCAACAAGAACATGCTGTTATGGATCAATGATGCTCTGATGGCGGTGTTCTTTTTGCTGATTGGC
CTGGAGGTCAAGCGTGAGCTGATTCAGGGGTCGCTGGCGAGCCGCCGTCAGGCGGTCTTCCCGGTGATAGCCGCGCTGGG
CGGGATGATCGTCCCGGCCCTGGTCTACCTGGCCTTTAACGCCCAGGATCCTGTCGCCAGAGAAGGGTGGGCGATCCCGG
CGGCGACGGATATTGCCTTTGCCCTCGGCGTGCTGGCGCTGTTAGGTAGCCGGGTCCCGACGGCGCTGAAGATTTTCCTG
ATGGCGCTGGCGATTATTGATGACCTCGGGGCTATCGTGATTATCGCGCTGTTTTATACCCACGACCTGTCCATGCTCTC
GCTGGGCGTGGCGGCGGCGGCGATCGCGGTGCTGATGGCCCTGAATCTGAGCGGCGTGCGGCGTACCGGGATCTATATTC
TGGTTGGCGCGGTGCTGTGGACGGCGGTGCTGAAGTCTGGCGTTCACGCGACCCTTGCCGGGGTGATTGTCGGCTTTATG
ATCCCGCTCGAAGAAAAGCATGGCAAGTCGCCGGCCAAAGCGCTTGAGCATGTCCTGCACCCGTGGGTGGCGTTTATGAT
CCTGCCGCTGTTTGCCTTCGCGAACGCGGGGGTCTCACTGCAGGGGGTCACCCTTGCCGGGCTGACGTCGCTCCTGCCGC
TGGGCATTATGGCTGGCCTGTTTATCGGTAAGCCGCTGGGGATTAGCCTGTTCTGCTGGCTGGCCCTGAAGCTGAAGTGG
GCTTCGCTGCCGGAGGGAACCACCTGCAAGCAAATTATGGCGGTGGGGATCCTGTGCGGGATTGGCTTTACGATGTCGAT
TTTCATCGCCACCCTGGCCTTTGGCAGCGTGGATCCCGCGTTGATCAACTGGGCCAAGCTTGGCATCCTGATCGGCTCAG
TGCTATCAGCGGTCGTCGGCTACCTCATACTGCGTCAGCGCGTGACGGATACTCGCCTCGCGGTATAA

Upstream 100 bases:

>100_bases
CCTTTAACTCGTAAAAAGCGAATATTAGCGCAACTTAAATCTGATTTTTTCGAGTTATCAGTATGTGTATTATGCTTTTA
TCGAGTTATTCACCAACAGG

Downstream 100 bases:

>100_bases
CCTTTCTGCAGGAGAGCCCGTCAGGCTCTCCTGGACATTATCAGGGAGAGAAGCATGTCACATATTAACTACAATCATCT
GTACTACTTCTGGCACGTGT

Product: pH-dependent sodium/proton antiporter

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA 1

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MKVKVKHLQRFFSSDASGGIVLIIAAALAMVMANTSVTSGLYHSFLETPVQLRVGALEINKNMLLWINDALMAVFFLLIG
LEVKRELIQGSLASRRQAVFPVIAALGGMIVPALVYLAFNAQDPVAREGWAIPAATDIAFALGVLALLGSRVPTALKIFL
MALAIIDDLGAIVIIALFYTHDLSMLSLGVAAAAIAVLMALNLSGVRRTGIYILVGAVLWTAVLKSGVHATLAGVIVGFM
IPLEEKHGKSPAKALEHVLHPWVAFMILPLFAFANAGVSLQGVTLAGLTSLLPLGIMAGLFIGKPLGISLFCWLALKLKW
ASLPEGTTCKQIMAVGILCGIGFTMSIFIATLAFGSVDPALINWAKLGILIGSVLSAVVGYLILRQRVTDTRLAV

Sequences:

>Translated_395_residues
MKVKVKHLQRFFSSDASGGIVLIIAAALAMVMANTSVTSGLYHSFLETPVQLRVGALEINKNMLLWINDALMAVFFLLIG
LEVKRELIQGSLASRRQAVFPVIAALGGMIVPALVYLAFNAQDPVAREGWAIPAATDIAFALGVLALLGSRVPTALKIFL
MALAIIDDLGAIVIIALFYTHDLSMLSLGVAAAAIAVLMALNLSGVRRTGIYILVGAVLWTAVLKSGVHATLAGVIVGFM
IPLEEKHGKSPAKALEHVLHPWVAFMILPLFAFANAGVSLQGVTLAGLTSLLPLGIMAGLFIGKPLGISLFCWLALKLKW
ASLPEGTTCKQIMAVGILCGIGFTMSIFIATLAFGSVDPALINWAKLGILIGSVLSAVVGYLILRQRVTDTRLAV
>Mature_395_residues
MKVKVKHLQRFFSSDASGGIVLIIAAALAMVMANTSVTSGLYHSFLETPVQLRVGALEINKNMLLWINDALMAVFFLLIG
LEVKRELIQGSLASRRQAVFPVIAALGGMIVPALVYLAFNAQDPVAREGWAIPAATDIAFALGVLALLGSRVPTALKIFL
MALAIIDDLGAIVIIALFYTHDLSMLSLGVAAAAIAVLMALNLSGVRRTGIYILVGAVLWTAVLKSGVHATLAGVIVGFM
IPLEEKHGKSPAKALEHVLHPWVAFMILPLFAFANAGVSLQGVTLAGLTSLLPLGIMAGLFIGKPLGISLFCWLALKLKW
ASLPEGTTCKQIMAVGILCGIGFTMSIFIATLAFGSVDPALINWAKLGILIGSVLSAVVGYLILRQRVTDTRLAV

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family

Homologues:

Organism=Escherichia coli, GI1786201, Length=387, Percent_Identity=84.2377260981912, Blast_Score=608, Evalue=1e-175,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NHAA1_KLEP7 (A6T4F6)

Other databases:

- EMBL:   CP000647
- RefSeq:   YP_001333707.1
- ProteinModelPortal:   A6T4F6
- SMR:   A6T4F6
- STRING:   A6T4F6
- GeneID:   5338438
- GenomeReviews:   CP000647_GR
- KEGG:   kpn:KPN_00016
- eggNOG:   COG3004
- HOGENOM:   HBG665619
- OMA:   LIHWIND
- ProtClustDB:   PRK09561
- HAMAP:   MF_01844
- InterPro:   IPR023171
- InterPro:   IPR004670
- TIGRFAMs:   TIGR00773

Pfam domain/function: PF06965 Na_H_antiport_1

EC number: NA

Molecular weight: Translated: 41744; Mature: 41744

Theoretical pI: Translated: 10.11; Mature: 10.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x453113a8)-; HASH(0x4567f46c)-; HASH(0x4567fc34)-; HASH(0x4567bdb8)-; HASH(0x4567a390)-; HASH(0x136a2d8c)-; HASH(0x4567bf8c)-; HASH(0x4567f5f8)-; HASH(0x4567fa60)-; HASH(0x45666c80)-; HASH(0x4567f874)-;

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVKVKHLQRFFSSDASGGIVLIIAAALAMVMANTSVTSGLYHSFLETPVQLRVGALEIN
CCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHEEEEEEEC
KNMLLWINDALMAVFFLLIGLEVKRELIQGSLASRRQAVFPVIAALGGMIVPALVYLAFN
CCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AQDPVAREGWAIPAATDIAFALGVLALLGSRVPTALKIFLMALAIIDDLGAIVIIALFYT
CCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HDLSMLSLGVAAAAIAVLMALNLSGVRRTGIYILVGAVLWTAVLKSGVHATLAGVIVGFM
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
IPLEEKHGKSPAKALEHVLHPWVAFMILPLFAFANAGVSLQGVTLAGLTSLLPLGIMAGL
CCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHH
FIGKPLGISLFCWLALKLKWASLPEGTTCKQIMAVGILCGIGFTMSIFIATLAFGSVDPA
HHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
LINWAKLGILIGSVLSAVVGYLILRQRVTDTRLAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
>Mature Secondary Structure
MKVKVKHLQRFFSSDASGGIVLIIAAALAMVMANTSVTSGLYHSFLETPVQLRVGALEIN
CCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHEEEEEEEC
KNMLLWINDALMAVFFLLIGLEVKRELIQGSLASRRQAVFPVIAALGGMIVPALVYLAFN
CCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AQDPVAREGWAIPAATDIAFALGVLALLGSRVPTALKIFLMALAIIDDLGAIVIIALFYT
CCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HDLSMLSLGVAAAAIAVLMALNLSGVRRTGIYILVGAVLWTAVLKSGVHATLAGVIVGFM
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
IPLEEKHGKSPAKALEHVLHPWVAFMILPLFAFANAGVSLQGVTLAGLTSLLPLGIMAGL
CCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHH
FIGKPLGISLFCWLALKLKWASLPEGTTCKQIMAVGILCGIGFTMSIFIATLAFGSVDPA
HHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
LINWAKLGILIGSVLSAVVGYLILRQRVTDTRLAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA