| Definition | Klebsiella pneumoniae subsp. pneumoniae MGH 78578 chromosome, complete genome. |
|---|---|
| Accession | NC_009648 |
| Length | 5,315,120 |
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The map label for this gene is thrA [H]
Identifier: 152968584
GI number: 152968584
Start: 340
End: 2802
Strand: Direct
Name: thrA [H]
Synonym: KPN_00002
Alternate gene names: 152968584
Gene position: 340-2802 (Clockwise)
Preceding gene: 152968583
Following gene: 152968585
Centisome position: 0.01
GC content: 59.6
Gene sequence:
>2463_bases ATGCGAGTGTTGAAGTTCGGCGGTACATCAGTGGCAAATGCGGAACGGTTTCTGCGGGTTGCCGATATTCTGGAGAGTAA TGCCAGGCAGGGGCAGGTAGCGACGGTCCTGTCTGCCCCGGCGAAGATCACTAACCACCTGGTAGCGATGATTGAAAAGA CCATTGGCGGCCAGGATGCCCTCCCCAATATTGCCGACGCCGAACGCATTTTTGCCGAACTTCTTCAGGGCCTTGCCGAC GCCCAGCCCGCTTTCCCGCTTGCCCAGTTAAAAGCCTTCGTGGAGCAGGAATTTGCTCAGATTAAGCATGTTCTGCACGG CATCAGCCTGCTGGGTCAGTGCCCGGACAGCGTCAATGCCGCGCTGATCTGCCGCGGCGAAAAGCTCTCCATCGCCATCA TGGCGGGTCTGCTGGAAGCCCGTGGACATAAAGTCAGTGTCATTAACCCGGTCGAAAAACTGCTCGCCGTGGGCCACTAT CTGGAATCCACCGTCGATATCGCCGAATCCACCCGCCGCATTGCCGCCAGCCAGATCCCGGCAGACCATATGATCCTGAT GGCCGGGTTTACCGCCGGCAATGAGAAAGGCGAGCTGGTGGTGCTGGGGCGTAACGGCTCCGACTACTCGGCTGCGGTAC TGGCCGCCTGCCTGCGCGCTGACTGCTGCGAAATCTGGACCGATGTCGACGGAGTGTACACCTGCGATCCGCGTCAGGTG CCGGATGCGCGCCTGCTGAAATCGATGTCTTATCAGGAGGCGATGGAGCTCTCCTACTTTGGCGCGAAAGTGCTGCACCC GCGCACCATCGCCCCTATCGCCCAGTTCCAAATCCCATGCCTGATTAAAAATACCGGCAACCCACAGGCGCCGGGAACGC TTATCGGCGCCAGCCGCGACGAGGACGATTTGCCGGTGAAAGGCATCTCTAACCTCAACAACATGGCGATGTTCAACGTC TCCGGGCCGGGGATGAAAGGGATGGTCGGCATGGCGGCCCGCGTCTTCGCCACCATGTCCCGCGCCGGCATCTCGGTGGT GTTGATCACTCAATCTTCTTCGGAGTACAGCATCAGTTTCTGCGTGCCGCAGAGCGACTGCGCACGTGCCAAACGGGCGA TGGAAGATGAGTTTTATCTGGAGCTGAAAGAGGGGCTGCTGGAGCCGCTGGCGATTATGGAGCGTCTGGCGATCATCTCC GTGGTGGGCGACGGAATGCGTACCCTGCGCGGTATCTCGGCGAAATTCTTTGCGGCACTGGCCCGTGCCAATATCAATAT CGTGGCGATTGCCCAGGGCTCTTCCGAGCGCTCAATTTCGGTAGTGGTCAGCAATGACGACGCCACCACCGGCGTGCGCG TGACCCATCAGATGCTGTTCAACACCGATCAGGTGATTGAAGTGTTTGTCATCGGCGTCGGCGGCGTCGGCGGCGCGCTG CTAGAGCAGATCAAGCGCCAGCAGGGGTGGCTGAAGAACAAACATATCGATCTGCGCGTCTGCGGTGTAGCCAATTCTCA GGCGCTGCTGACCAGCGTGCATGGCCTGAATCTGGAAAACTGGAGTGCGGAACTGGCGGAGGCGAAAGAGCCGTTTAATC TTGGCCGCCTGATCCGCCTGGTGAAAGAGTACCACCTGCTCAATCCGGTGATCGTCGACTGTACCTCCAGCCAGGCGGTC GCCGATCAGTATGCCGACTTCCTGCGCGAAGGTTTCCATGTGGTGACGCCGAACAAAAAGGCCAATACCTTTTCGCTGGA TTACTATCACCAGCTGCGCCATGCGGCCAGCAGCTCGCGGCGTAAGTTCCTCTATGACACTAACGTTGGCGCGGGCCTGC CGGTGATTGAGAACCTGCAGAACCTGCTCAACGCCGGCGATGAGCTGCGCCATTTCTCCGGGATCCTGTCCGGCTCCCTG TCGTTTATCTTCGGCAAGCTGGACGAGGGGGTGAGTTTCTCCGCGGCGACGGCGATGGCCCGTGAGATGGGGTATACCGA GCCGGATCCGCGCGACGATTTATCCGGGGTGGATGTGGCGCGTAAACTGCTGATTCTGGCCCGCGAGACCGGGCGTGAAC TGGAGCTGGCGGACATTATCGTCGAGTCGGCGCTGCCGCCGGACTTCGACGCCAGCGGCGATGTCGAGACCTTTATGGCC CGCCTGCCGTCGCTGGACGATGGTTTTGCCTCGCGGGTTGCTAAGGCGCGCGATGAAGGTAAAGTCTTGCGCTACGTCGG TAACATCGAAGAGGATGGTACCTGCCGGGTAAAAATAGCCGCGGTTGACGGCAACGATCCGCTGTTCAAAGTTAAGAATG GTGAGAACGCGCTGGCTTTTTATAGCCATTATTATCAGCCATTGCCGCTGGTGCTGCGCGGCTATGGCGCCGGGAACGAC GTCACGGCGGCCGGCGTATTCGCCGACCTGCTGCGCACCCTGTCCTGGAAGTTAGGAGTTTAA
Upstream 100 bases:
>100_bases AGGTAACGGTGCGGGCTGACGCGTACAGGAAACACAGAAAAAAGCCCGCACCTGAACAGTGCGGGCTTTTTTTTTGACAA GAGATCAAGGGGTAAGAACC
Downstream 100 bases:
>100_bases GATGGTCAAAGTATATGCCCCGGCTTCCAGTGCCAATATGAGCGTCGGGTTTGATGTGTTGGGCGCGGCGGTCACGCCGG TCGATGGCACGCTGCTTGGC
Product: bifunctional aspartokinase I/homoserine dehydrogenase I
Products: NA
Alternate protein names: Aspartokinase I/homoserine dehydrogenase I; AKI-HDI; Aspartokinase; Homoserine dehydrogenase [H]
Number of amino acids: Translated: 820; Mature: 820
Protein sequence:
>820_residues MRVLKFGGTSVANAERFLRVADILESNARQGQVATVLSAPAKITNHLVAMIEKTIGGQDALPNIADAERIFAELLQGLAD AQPAFPLAQLKAFVEQEFAQIKHVLHGISLLGQCPDSVNAALICRGEKLSIAIMAGLLEARGHKVSVINPVEKLLAVGHY LESTVDIAESTRRIAASQIPADHMILMAGFTAGNEKGELVVLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYTCDPRQV PDARLLKSMSYQEAMELSYFGAKVLHPRTIAPIAQFQIPCLIKNTGNPQAPGTLIGASRDEDDLPVKGISNLNNMAMFNV SGPGMKGMVGMAARVFATMSRAGISVVLITQSSSEYSISFCVPQSDCARAKRAMEDEFYLELKEGLLEPLAIMERLAIIS VVGDGMRTLRGISAKFFAALARANINIVAIAQGSSERSISVVVSNDDATTGVRVTHQMLFNTDQVIEVFVIGVGGVGGAL LEQIKRQQGWLKNKHIDLRVCGVANSQALLTSVHGLNLENWSAELAEAKEPFNLGRLIRLVKEYHLLNPVIVDCTSSQAV ADQYADFLREGFHVVTPNKKANTFSLDYYHQLRHAASSSRRKFLYDTNVGAGLPVIENLQNLLNAGDELRHFSGILSGSL SFIFGKLDEGVSFSAATAMAREMGYTEPDPRDDLSGVDVARKLLILARETGRELELADIIVESALPPDFDASGDVETFMA RLPSLDDGFASRVAKARDEGKVLRYVGNIEEDGTCRVKIAAVDGNDPLFKVKNGENALAFYSHYYQPLPLVLRGYGAGND VTAAGVFADLLRTLSWKLGV
Sequences:
>Translated_820_residues MRVLKFGGTSVANAERFLRVADILESNARQGQVATVLSAPAKITNHLVAMIEKTIGGQDALPNIADAERIFAELLQGLAD AQPAFPLAQLKAFVEQEFAQIKHVLHGISLLGQCPDSVNAALICRGEKLSIAIMAGLLEARGHKVSVINPVEKLLAVGHY LESTVDIAESTRRIAASQIPADHMILMAGFTAGNEKGELVVLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYTCDPRQV PDARLLKSMSYQEAMELSYFGAKVLHPRTIAPIAQFQIPCLIKNTGNPQAPGTLIGASRDEDDLPVKGISNLNNMAMFNV SGPGMKGMVGMAARVFATMSRAGISVVLITQSSSEYSISFCVPQSDCARAKRAMEDEFYLELKEGLLEPLAIMERLAIIS VVGDGMRTLRGISAKFFAALARANINIVAIAQGSSERSISVVVSNDDATTGVRVTHQMLFNTDQVIEVFVIGVGGVGGAL LEQIKRQQGWLKNKHIDLRVCGVANSQALLTSVHGLNLENWSAELAEAKEPFNLGRLIRLVKEYHLLNPVIVDCTSSQAV ADQYADFLREGFHVVTPNKKANTFSLDYYHQLRHAASSSRRKFLYDTNVGAGLPVIENLQNLLNAGDELRHFSGILSGSL SFIFGKLDEGVSFSAATAMAREMGYTEPDPRDDLSGVDVARKLLILARETGRELELADIIVESALPPDFDASGDVETFMA RLPSLDDGFASRVAKARDEGKVLRYVGNIEEDGTCRVKIAAVDGNDPLFKVKNGENALAFYSHYYQPLPLVLRGYGAGND VTAAGVFADLLRTLSWKLGV >Mature_820_residues MRVLKFGGTSVANAERFLRVADILESNARQGQVATVLSAPAKITNHLVAMIEKTIGGQDALPNIADAERIFAELLQGLAD AQPAFPLAQLKAFVEQEFAQIKHVLHGISLLGQCPDSVNAALICRGEKLSIAIMAGLLEARGHKVSVINPVEKLLAVGHY LESTVDIAESTRRIAASQIPADHMILMAGFTAGNEKGELVVLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYTCDPRQV PDARLLKSMSYQEAMELSYFGAKVLHPRTIAPIAQFQIPCLIKNTGNPQAPGTLIGASRDEDDLPVKGISNLNNMAMFNV SGPGMKGMVGMAARVFATMSRAGISVVLITQSSSEYSISFCVPQSDCARAKRAMEDEFYLELKEGLLEPLAIMERLAIIS VVGDGMRTLRGISAKFFAALARANINIVAIAQGSSERSISVVVSNDDATTGVRVTHQMLFNTDQVIEVFVIGVGGVGGAL LEQIKRQQGWLKNKHIDLRVCGVANSQALLTSVHGLNLENWSAELAEAKEPFNLGRLIRLVKEYHLLNPVIVDCTSSQAV ADQYADFLREGFHVVTPNKKANTFSLDYYHQLRHAASSSRRKFLYDTNVGAGLPVIENLQNLLNAGDELRHFSGILSGSL SFIFGKLDEGVSFSAATAMAREMGYTEPDPRDDLSGVDVARKLLILARETGRELELADIIVESALPPDFDASGDVETFMA RLPSLDDGFASRVAKARDEGKVLRYVGNIEEDGTCRVKIAAVDGNDPLFKVKNGENALAFYSHYYQPLPLVLRGYGAGND VTAAGVFADLLRTLSWKLGV
Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]
COG id: COG0527
COG function: function code E; Aspartokinases
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 2 ACT domains [H]
Homologues:
Organism=Escherichia coli, GI1786183, Length=820, Percent_Identity=92.0731707317073, Blast_Score=1537, Evalue=0.0, Organism=Escherichia coli, GI1790376, Length=822, Percent_Identity=30.6569343065693, Blast_Score=332, Evalue=6e-92, Organism=Escherichia coli, GI1790455, Length=465, Percent_Identity=29.4623655913978, Blast_Score=156, Evalue=6e-39, Organism=Saccharomyces cerevisiae, GI6320893, Length=502, Percent_Identity=28.0876494023904, Blast_Score=167, Evalue=7e-42, Organism=Saccharomyces cerevisiae, GI6322599, Length=340, Percent_Identity=33.2352941176471, Blast_Score=160, Evalue=9e-40,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002912 - InterPro: IPR001048 - InterPro: IPR005106 - InterPro: IPR001341 - InterPro: IPR018042 - InterPro: IPR011147 - InterPro: IPR001342 - InterPro: IPR019811 - InterPro: IPR016040 [H]
Pfam domain/function: PF00696 AA_kinase; PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]
EC number: =2.7.2.4; =1.1.1.3 [H]
Molecular weight: Translated: 88582; Mature: 88582
Theoretical pI: Translated: 5.78; Mature: 5.78
Prosite motif: PS01042 HOMOSER_DHGENASE ; PS00324 ASPARTOKINASE
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.5 %Cys (Translated Protein) 2.4 %Met (Translated Protein) 3.9 %Cys+Met (Translated Protein) 1.5 %Cys (Mature Protein) 2.4 %Met (Mature Protein) 3.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MRVLKFGGTSVANAERFLRVADILESNARQGQVATVLSAPAKITNHLVAMIEKTIGGQDA CEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCEEHHHHCCHHHHHHHHHHHHHHCCCCCC LPNIADAERIFAELLQGLADAQPAFPLAQLKAFVEQEFAQIKHVLHGISLLGQCPDSVNA CCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE ALICRGEKLSIAIMAGLLEARGHKVSVINPVEKLLAVGHYLESTVDIAESTRRIAASQIP EEEECCCCEEHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC ADHMILMAGFTAGNEKGELVVLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYTCDPRQV CCCEEEEEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCC PDARLLKSMSYQEAMELSYFGAKVLHPRTIAPIAQFQIPCLIKNTGNPQAPGTLIGASRD CHHHHHHHCCHHHHHHHHHHCHHHCCCCHHCCHHHEECCEEEECCCCCCCCCEEEECCCC EDDLPVKGISNLNNMAMFNVSGPGMKGMVGMAARVFATMSRAGISVVLITQSSSEYSISF CCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCEEEEEEEECCCCEEEEE CVPQSDCARAKRAMEDEFYLELKEGLLEPLAIMERLAIISVVGDGMRTLRGISAKFFAAL ECCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH ARANINIVAIAQGSSERSISVVVSNDDATTGVRVTHQMLFNTDQVIEVFVIGVGGVGGAL HHCCCEEEEEECCCCCCEEEEEEECCCCCCCHHHHHHHHHCHHHEEEEEEEECCCCCHHH LEQIKRQQGWLKNKHIDLRVCGVANSQALLTSVHGLNLENWSAELAEAKEPFNLGRLIRL HHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHH VKEYHLLNPVIVDCTSSQAVADQYADFLREGFHVVTPNKKANTFSLDYYHQLRHAASSSR HHHHHHCCCEEEECCCCHHHHHHHHHHHHCCCEEECCCCCCCEEEHHHHHHHHHHHHCCC RKFLYDTNVGAGLPVIENLQNLLNAGDELRHFSGILSGSLSFIFGKLDEGVSFSAATAMA CEEEEECCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHH REMGYTEPDPRDDLSGVDVARKLLILARETGRELELADIIVESALPPDFDASGDVETFMA HHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHH RLPSLDDGFASRVAKARDEGKVLRYVGNIEEDGTCRVKIAAVDGNDPLFKVKNGENALAF HCCCCCCHHHHHHHHHCCCCCHHHHHCCCCCCCEEEEEEEEECCCCCEEEEECCCCHHHH YSHYYQPLPLVLRGYGAGNDVTAAGVFADLLRTLSWKLGV HHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCC >Mature Secondary Structure MRVLKFGGTSVANAERFLRVADILESNARQGQVATVLSAPAKITNHLVAMIEKTIGGQDA CEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCEEHHHHCCHHHHHHHHHHHHHHCCCCCC LPNIADAERIFAELLQGLADAQPAFPLAQLKAFVEQEFAQIKHVLHGISLLGQCPDSVNA CCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE ALICRGEKLSIAIMAGLLEARGHKVSVINPVEKLLAVGHYLESTVDIAESTRRIAASQIP EEEECCCCEEHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC ADHMILMAGFTAGNEKGELVVLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYTCDPRQV CCCEEEEEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCC PDARLLKSMSYQEAMELSYFGAKVLHPRTIAPIAQFQIPCLIKNTGNPQAPGTLIGASRD CHHHHHHHCCHHHHHHHHHHCHHHCCCCHHCCHHHEECCEEEECCCCCCCCCEEEECCCC EDDLPVKGISNLNNMAMFNVSGPGMKGMVGMAARVFATMSRAGISVVLITQSSSEYSISF CCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCEEEEEEEECCCCEEEEE CVPQSDCARAKRAMEDEFYLELKEGLLEPLAIMERLAIISVVGDGMRTLRGISAKFFAAL ECCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH ARANINIVAIAQGSSERSISVVVSNDDATTGVRVTHQMLFNTDQVIEVFVIGVGGVGGAL HHCCCEEEEEECCCCCCEEEEEEECCCCCCCHHHHHHHHHCHHHEEEEEEEECCCCCHHH LEQIKRQQGWLKNKHIDLRVCGVANSQALLTSVHGLNLENWSAELAEAKEPFNLGRLIRL HHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHH VKEYHLLNPVIVDCTSSQAVADQYADFLREGFHVVTPNKKANTFSLDYYHQLRHAASSSR HHHHHHCCCEEEECCCCHHHHHHHHHHHHCCCEEECCCCCCCEEEHHHHHHHHHHHHCCC RKFLYDTNVGAGLPVIENLQNLLNAGDELRHFSGILSGSLSFIFGKLDEGVSFSAATAMA CEEEEECCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHH REMGYTEPDPRDDLSGVDVARKLLILARETGRELELADIIVESALPPDFDASGDVETFMA HHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHH RLPSLDDGFASRVAKARDEGKVLRYVGNIEEDGTCRVKIAAVDGNDPLFKVKNGENALAF HCCCCCCHHHHHHHHHCCCCCHHHHHCCCCCCCEEEEEEEEECCCCCEEEEECCCCHHHH YSHYYQPLPLVLRGYGAGNDVTAAGVFADLLRTLSWKLGV HHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 7003595; 1630901; 7610040; 9278503; 6277952; 2410621; 387092; 6298218; 390305 [H]