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The map label for this gene is rot [H]

Identifier: 151221867

GI number: 151221867

Start: 1851286

End: 1851786

Strand: Reverse

Name: rot [H]

Synonym: NWMN_1655

Alternate gene names: 151221867

Gene position: 1851786-1851286 (Counterclockwise)

Preceding gene: 151221868

Following gene: 151221864

Centisome position: 64.32

GC content: 31.54

Gene sequence:

>501_bases
ATGCATAAGTTAGCACGTACAAGTTTTGGGATTGTTGGGATGTTTGTTAATACTTGTATAGTAGCTAAATATGTGATTAT
TAATTGGGAGATGTTTAGCATGAAAAAAGTAAATAACGACACTGTATTTGGAATTTTGCAATTAGAAACACTTTTGGGTG
ACATTAACTCAATTTTCAGCGAGATTGAAAGCGAATACAAAATGTCTAGAGAAGAAATTTTAATTTTACTAACTTTATGG
CAAAAAGGTTCTATGACGCTTAAAGAAATGGACAGATTTGTTGAAGTTAAACCGTATAAGCGTACGAGAACGTATAATAA
TTTAGTTGAATTAGAATGGATTTACAAAGAGCGTCCTGTTGACGATGAAAGAACAGTTATTATTCATTTCAATGAAAAGT
TACAACAAGAGAAAGTAGAGTTGTTGAATTTCATCAGTGATGCGATTGCAAGTAGAGCAACAGCAATGCAAAATAGTTTA
AACGCAATTATTGCTGTGTAA

Upstream 100 bases:

>100_bases
CTAAATATTAACTCTATTGATTATTGGTTTTTATACTTATTTAATTTTATTCAACTTTGACAATTGAATAGAAAGCAAGT
TTATTTACACTTGTAGTTTT

Downstream 100 bases:

>100_bases
GTTTAATAGCATAAAAAGAGGTTTTCATTAAGTTGAAAACCTCTTTTTGTTGTTGGCATTAATTTTTCAAATGTTGACTA
CTCAATCCTAAATTATAAAT

Product: accessory regulator Rot

Products: NA

Alternate protein names: Repressor of toxins [H]

Number of amino acids: Translated: 166; Mature: 166

Protein sequence:

>166_residues
MHKLARTSFGIVGMFVNTCIVAKYVIINWEMFSMKKVNNDTVFGILQLETLLGDINSIFSEIESEYKMSREEILILLTLW
QKGSMTLKEMDRFVEVKPYKRTRTYNNLVELEWIYKERPVDDERTVIIHFNEKLQQEKVELLNFISDAIASRATAMQNSL
NAIIAV

Sequences:

>Translated_166_residues
MHKLARTSFGIVGMFVNTCIVAKYVIINWEMFSMKKVNNDTVFGILQLETLLGDINSIFSEIESEYKMSREEILILLTLW
QKGSMTLKEMDRFVEVKPYKRTRTYNNLVELEWIYKERPVDDERTVIIHFNEKLQQEKVELLNFISDAIASRATAMQNSL
NAIIAV
>Mature_166_residues
MHKLARTSFGIVGMFVNTCIVAKYVIINWEMFSMKKVNNDTVFGILQLETLLGDINSIFSEIESEYKMSREEILILLTLW
QKGSMTLKEMDRFVEVKPYKRTRTYNNLVELEWIYKERPVDDERTVIIHFNEKLQQEKVELLNFISDAIASRATAMQNSL
NAIIAV

Specific function: Global regulator with both positive and negative effects that mediates modulation of several genes involved in virulence. Negatively regulates the transcription of several known virulence factors such as lipase (geh), hemolysins (hla and hlb) and protease

COG id: COG1846

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the rot family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010166
- InterPro:   IPR000835
- InterPro:   IPR016998
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01047 MarR [H]

EC number: NA

Molecular weight: Translated: 19390; Mature: 19390

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHKLARTSFGIVGMFVNTCIVAKYVIINWEMFSMKKVNNDTVFGILQLETLLGDINSIFS
CCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEHEEEECCCCEEEHHHHHHHHHHHHHHHHH
EIESEYKMSREEILILLTLWQKGSMTLKEMDRFVEVKPYKRTRTYNNLVELEWIYKERPV
HHHHHHHCCHHHEEEEEEECCCCCCCHHHHHHHHCCCCCHHHHHHCCCEEEEEEECCCCC
DDERTVIIHFNEKLQQEKVELLNFISDAIASRATAMQNSLNAIIAV
CCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEC
>Mature Secondary Structure
MHKLARTSFGIVGMFVNTCIVAKYVIINWEMFSMKKVNNDTVFGILQLETLLGDINSIFS
CCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEHEEEECCCCEEEHHHHHHHHHHHHHHHHH
EIESEYKMSREEILILLTLWQKGSMTLKEMDRFVEVKPYKRTRTYNNLVELEWIYKERPV
HHHHHHHCCHHHEEEEEEECCCCCCCHHHHHHHHCCCCCHHHHHHCCCEEEEEEECCCCC
DDERTVIIHFNEKLQQEKVELLNFISDAIASRATAMQNSLNAIIAV
CCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10809700; 12511508 [H]