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The map label for this gene is lexA

Identifier: 151221463

GI number: 151221463

Start: 1375014

End: 1375637

Strand: Reverse

Name: lexA

Synonym: NWMN_1251

Alternate gene names: 151221463

Gene position: 1375637-1375014 (Counterclockwise)

Preceding gene: 151221472

Following gene: 151221457

Centisome position: 47.78

GC content: 36.54

Gene sequence:

>624_bases
ATGAGAGAATTAACAAAACGACAAAGCGAAATATATAACTATATTAAACAAGTTGTTCAAACGAAAGGTTATCCGCCTAG
TGTTCGCGAAATTGGTGAAGCAGTTGGCTTAGCATCCAGTTTCACTGTTCATGGGCACCTTTCACGTCTTGAAGAAAAAG
GCTATATAGAAGGAGATCCAACGAAACCACGTGCTATAGAAATTGTAAGTGATCAAACAAATGATAATATTAATATGGAA
GAAACGATTCATGTGCCAGTTATTGGTAAAGTCACAGCAGGTGTTCCTATTACCGCAGTAGAAAATATTGAAGAATATTT
TCCATTACCTGAACACTTAACATCGACACACAATAGCGACATATTCATATTAAACGTCGTAGGCGACAGTATGATTGAGG
CTGGTATATTAGACGGAGACAAAGTAATTGTTCGCAGTCAAACCATAGCAGAAAATGGAGACATTATTGTTGCTATGACT
GAGGAAGATGAAGCAACTGTCAAACGCTTCTATAAAGAAAAAAATCGTTATCGATTACAACCTGAAAATAGTACAATGGA
GCCAATTTACCTAGACAATGTTGCTGTAATTGGGAAAGTAATTGGTTTGTACCGCGAAATGTAA

Upstream 100 bases:

>100_bases
AGAACTTATGTTCTGTGTCAATATTTTAACGAACAAATGTTTGTTTTGGTTTCAAATTAATGATATACTGTATTTAAATT
AATTTAGGGAGTGCCTATAT

Downstream 100 bases:

>100_bases
TATTTTAAACCGTTATATATTATCGTAATTGTTAAGCCCTCATTTTTATAAATTTTGGACCTCTTGAAAAAGTTACGTTT
TCAAGAGGTTTTATTTATTC

Product: LexA repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 207; Mature: 207

Protein sequence:

>207_residues
MRELTKRQSEIYNYIKQVVQTKGYPPSVREIGEAVGLASSFTVHGHLSRLEEKGYIEGDPTKPRAIEIVSDQTNDNINME
ETIHVPVIGKVTAGVPITAVENIEEYFPLPEHLTSTHNSDIFILNVVGDSMIEAGILDGDKVIVRSQTIAENGDIIVAMT
EEDEATVKRFYKEKNRYRLQPENSTMEPIYLDNVAVIGKVIGLYREM

Sequences:

>Translated_207_residues
MRELTKRQSEIYNYIKQVVQTKGYPPSVREIGEAVGLASSFTVHGHLSRLEEKGYIEGDPTKPRAIEIVSDQTNDNINME
ETIHVPVIGKVTAGVPITAVENIEEYFPLPEHLTSTHNSDIFILNVVGDSMIEAGILDGDKVIVRSQTIAENGDIIVAMT
EEDEATVKRFYKEKNRYRLQPENSTMEPIYLDNVAVIGKVIGLYREM
>Mature_207_residues
MRELTKRQSEIYNYIKQVVQTKGYPPSVREIGEAVGLASSFTVHGHLSRLEEKGYIEGDPTKPRAIEIVSDQTNDNINME
ETIHVPVIGKVTAGVPITAVENIEEYFPLPEHLTSTHNSDIFILNVVGDSMIEAGILDGDKVIVRSQTIAENGDIIVAMT
EEDEATVKRFYKEKNRYRLQPENSTMEPIYLDNVAVIGKVIGLYREM

Specific function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, lea

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family [H]

Homologues:

Organism=Escherichia coli, GI1790476, Length=209, Percent_Identity=34.4497607655502, Blast_Score=111, Evalue=3e-26,
Organism=Escherichia coli, GI1787431, Length=134, Percent_Identity=33.5820895522388, Blast_Score=62, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006199
- InterPro:   IPR006200
- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01726 LexA_DNA_bind; PF00717 Peptidase_S24 [H]

EC number: =3.4.21.88 [H]

Molecular weight: Translated: 23236; Mature: 23236

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS00228 TUBULIN_B_AUTOREG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRELTKRQSEIYNYIKQVVQTKGYPPSVREIGEAVGLASSFTVHGHLSRLEEKGYIEGDP
CCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEHHHHHHHHHCCCCCCCC
TKPRAIEIVSDQTNDNINMEETIHVPVIGKVTAGVPITAVENIEEYFPLPEHLTSTHNSD
CCCEEEEEEECCCCCCCCCCEEEEEEEEEEECCCCCHHHHHHHHHHCCCCHHHHCCCCCC
IFILNVVGDSMIEAGILDGDKVIVRSQTIAENGDIIVAMTEEDEATVKRFYKEKNRYRLQ
EEEEEECCCHHHHHCCCCCCEEEEEECEECCCCCEEEEEECCCHHHHHHHHHHCCCEEEC
PENSTMEPIYLDNVAVIGKVIGLYREM
CCCCCCCCEEECCHHHHHHHHHHHHCC
>Mature Secondary Structure
MRELTKRQSEIYNYIKQVVQTKGYPPSVREIGEAVGLASSFTVHGHLSRLEEKGYIEGDP
CCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEHHHHHHHHHCCCCCCCC
TKPRAIEIVSDQTNDNINMEETIHVPVIGKVTAGVPITAVENIEEYFPLPEHLTSTHNSD
CCCEEEEEEECCCCCCCCCCEEEEEEEEEEECCCCCHHHHHHHHHHCCCCHHHHCCCCCC
IFILNVVGDSMIEAGILDGDKVIVRSQTIAENGDIIVAMTEEDEATVKRFYKEKNRYRLQ
EEEEEECCCHHHHHCCCCCCEEEEEECEECCCCCEEEEEECCCHHHHHHHHHHCCCEEEC
PENSTMEPIYLDNVAVIGKVIGLYREM
CCCCCCCCEEECCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA