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The map label for this gene is saeS

Identifier: 151220886

GI number: 151220886

Start: 756620

End: 757675

Strand: Reverse

Name: saeS

Synonym: NWMN_0674

Alternate gene names: 151220886

Gene position: 757675-756620 (Counterclockwise)

Preceding gene: 151220887

Following gene: 151220875

Centisome position: 26.32

GC content: 30.59

Gene sequence:

>1056_bases
ATGGTGTTATCAATTAGAAGTCAAATCATTATTGGCGTCGTATCGAGTATACCATTAACTTCAACTATTTTAGCAATTGC
ATATATTTTAATGTGGTTTAACGGCCATATGACACTAACTTTGACCTTAACGACAATAATTACAAGCTGTTTAACCTTAT
TAATATGTAGTATTTTTATTAATCCACTTATACAAAAAATTAAGCAGTTTAATATAAAAACTAAGCAATTTGCTAACGGA
AATTACGCAAGCAATGATAAAACGTTTAATTCACCAAAAGAAATTTATGAATTAAATCAATCTTTTAATAAAATGGCTTC
TGAAATTACGCAACAAATGAATCAAATTAAATCCGAACAACAAGAAAAAACAGAACTGATTCAAAACTTAGCCCATGATT
TAAAAACACCTTTAGCAAGCATTATTTCATATTCTGAAGGACTACGTGATGGTATAATCACTAAGGATCATGAGATTAAA
GAGTCATACGACATATTAATTAAACAAGCAAACAGATTATCAACATTATTTGATGATATGACTCATATTATCACTTTAAA
TACAGGTAAAACATATCCCCCAGAATTAATACAACTAGACCAATTACTTGTATCAATATTGCAACCATATGAGCAACGTA
TCAAACATGAAAACCGCACATTAGAAGTGAATTTCTGTAACGAAATTGATGCATTTTATCAATATCGAACGCCACTTGAG
CGTATTTTAACAAACTTACTTGATAATGCGCTAAAATTTTCAAATGTTGGTAGTCGCATTGATATTAATATTAGTGAAAA
CGAAGATCAAGATACTATCGACATTGCTATTAGCGATGAAGGTATTGGCATTATACCAGAACTACAAGAACGTATATTCG
AACGTACATTCAGAGTAGAAAACTCTCGTAATACAAAAACGGGTGGTTCTGGATTAGGCTTATATATAGCTAATGAACTC
GCGCAACAAAATAACGCAAAAATCAGTGTAAGCAGTGATATAGATGTAGGAACTACGATGACTGTAACATTACACAAATT
AGACATTACGTCATAA

Upstream 100 bases:

>100_bases
ATATACACCGTATTAGAGAAAAATTAGAAAAAGAGAGCTTTACAACATATACCATCACAACTGTATGGGGATTAGGATAT
AAATTTGAAAGGAGCCGATA

Downstream 100 bases:

>100_bases
TCCGATTTATTTATAAAATAAAATGCAAAGACTAAAAAGAAGCTCCCATTAATGAGGGCTTCTTTTTTTGTTTATTTAGA
ATAAACTTTATGGGTATCCT

Product: sensor histidine kinase SaeS

Products: NA

Alternate protein names: Sensor protein saeS; Staphylococcus exoprotein expression protein S [H]

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MVLSIRSQIIIGVVSSIPLTSTILAIAYILMWFNGHMTLTLTLTTIITSCLTLLICSIFINPLIQKIKQFNIKTKQFANG
NYASNDKTFNSPKEIYELNQSFNKMASEITQQMNQIKSEQQEKTELIQNLAHDLKTPLASIISYSEGLRDGIITKDHEIK
ESYDILIKQANRLSTLFDDMTHIITLNTGKTYPPELIQLDQLLVSILQPYEQRIKHENRTLEVNFCNEIDAFYQYRTPLE
RILTNLLDNALKFSNVGSRIDINISENEDQDTIDIAISDEGIGIIPELQERIFERTFRVENSRNTKTGGSGLGLYIANEL
AQQNNAKISVSSDIDVGTTMTVTLHKLDITS

Sequences:

>Translated_351_residues
MVLSIRSQIIIGVVSSIPLTSTILAIAYILMWFNGHMTLTLTLTTIITSCLTLLICSIFINPLIQKIKQFNIKTKQFANG
NYASNDKTFNSPKEIYELNQSFNKMASEITQQMNQIKSEQQEKTELIQNLAHDLKTPLASIISYSEGLRDGIITKDHEIK
ESYDILIKQANRLSTLFDDMTHIITLNTGKTYPPELIQLDQLLVSILQPYEQRIKHENRTLEVNFCNEIDAFYQYRTPLE
RILTNLLDNALKFSNVGSRIDINISENEDQDTIDIAISDEGIGIIPELQERIFERTFRVENSRNTKTGGSGLGLYIANEL
AQQNNAKISVSSDIDVGTTMTVTLHKLDITS
>Mature_351_residues
MVLSIRSQIIIGVVSSIPLTSTILAIAYILMWFNGHMTLTLTLTTIITSCLTLLICSIFINPLIQKIKQFNIKTKQFANG
NYASNDKTFNSPKEIYELNQSFNKMASEITQQMNQIKSEQQEKTELIQNLAHDLKTPLASIISYSEGLRDGIITKDHEIK
ESYDILIKQANRLSTLFDDMTHIITLNTGKTYPPELIQLDQLLVSILQPYEQRIKHENRTLEVNFCNEIDAFYQYRTPLE
RILTNLLDNALKFSNVGSRIDINISENEDQDTIDIAISDEGIGIIPELQERIFERTFRVENSRNTKTGGSGLGLYIANEL
AQQNNAKISVSSDIDVGTTMTVTLHKLDITS

Specific function: Member of the two-component regulatory system saeR/saeS involved in the regulation of staphylococcal virulence factors in a strain-dependent fashion. Probably functions as a membrane- associated protein kinase that upon sensing the appropriate signal, aut

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=283, Percent_Identity=26.8551236749117, Blast_Score=104, Evalue=9e-24,
Organism=Escherichia coli, GI1790346, Length=270, Percent_Identity=27.037037037037, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1786783, Length=325, Percent_Identity=23.0769230769231, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI48994928, Length=254, Percent_Identity=26.7716535433071, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI1789149, Length=266, Percent_Identity=25.5639097744361, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1786600, Length=252, Percent_Identity=24.2063492063492, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1788713, Length=233, Percent_Identity=24.8927038626609, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI87081816, Length=241, Percent_Identity=24.896265560166, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1790861, Length=269, Percent_Identity=25.6505576208178, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1787374, Length=260, Percent_Identity=25.7692307692308, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1789808, Length=256, Percent_Identity=23.4375, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI145693157, Length=259, Percent_Identity=26.2548262548263, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI87082128, Length=292, Percent_Identity=23.2876712328767, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 39726; Mature: 39726

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLSIRSQIIIGVVSSIPLTSTILAIAYILMWFNGHMTLTLTLTTIITSCLTLLICSIFI
CEEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHH
NPLIQKIKQFNIKTKQFANGNYASNDKTFNSPKEIYELNQSFNKMASEITQQMNQIKSEQ
HHHHHHHHHCCCCHHEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QEKTELIQNLAHDLKTPLASIISYSEGLRDGIITKDHEIKESYDILIKQANRLSTLFDDM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
THIITLNTGKTYPPELIQLDQLLVSILQPYEQRIKHENRTLEVNFCNEIDAFYQYRTPLE
HHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHCCHHH
RILTNLLDNALKFSNVGSRIDINISENEDQDTIDIAISDEGIGIIPELQERIFERTFRVE
HHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCC
NSRNTKTGGSGLGLYIANELAQQNNAKISVSSDIDVGTTMTVTLHKLDITS
CCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEEEEEECCC
>Mature Secondary Structure
MVLSIRSQIIIGVVSSIPLTSTILAIAYILMWFNGHMTLTLTLTTIITSCLTLLICSIFI
CEEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHH
NPLIQKIKQFNIKTKQFANGNYASNDKTFNSPKEIYELNQSFNKMASEITQQMNQIKSEQ
HHHHHHHHHCCCCHHEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QEKTELIQNLAHDLKTPLASIISYSEGLRDGIITKDHEIKESYDILIKQANRLSTLFDDM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
THIITLNTGKTYPPELIQLDQLLVSILQPYEQRIKHENRTLEVNFCNEIDAFYQYRTPLE
HHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHCCHHH
RILTNLLDNALKFSNVGSRIDINISENEDQDTIDIAISDEGIGIIPELQERIFERTFRVE
HHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCC
NSRNTKTGGSGLGLYIANELAQQNNAKISVSSDIDVGTTMTVTLHKLDITS
CCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA