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The map label for this gene is mutM

Identifier: 150398756

GI number: 150398756

Start: 3780080

End: 3781000

Strand: Direct

Name: mutM

Synonym: Smed_3573

Alternate gene names: 150398756

Gene position: 3780080-3781000 (Clockwise)

Preceding gene: 150398751

Following gene: 150398757

Centisome position: 99.95

GC content: 64.17

Gene sequence:

>921_bases
ATGCCGGAATTGCCCGAGGTGGAAACGGTCAAGCGCGGACTGGCGCCGACGATGGAGGGAGCACTTCTCGTGCGCGCCGA
ATTGCGCCGTCCCGATCTGCGCTTTCCCTTTCCCGAGAATTTCGAGGACGCAGTCGCCGGCCGGCGTATCGTCGCGCTCT
CGCGCCGCGCCAAATATCTGACGATCGAGCTGGAGGGCGGCGACGTCATCATCGCCCATCTCGGCATGTCCGGCTCGTTC
AGGATCGAGTTTGACGGTCCCGGGGAGGGCCGCATCAAGGAGAGCGCCGATCCCGCCGTCCCCGGCGATTTCCACCGTCC
GCGCAGCAAGGACGAGAAACACGACCATGTCGTCTTCCATCTCGATGCCTCCTGCGGCCCGGCCCGGGTCATCTATAACG
ATCCACGCCGCTTCGGCTTCATGGCTCTGGCGCGGCGCGAAGCGCTTGCCGAGCACGTCTTTCTTCGCGGCCTCGGCGAG
GAGCCGACCGGCAACGCTCTCGATGCGGCCTATCTCGCCGCCCGGTTCTCCGGCAAAGCGCAGCCGCTGAAAGCCGCTCT
TCTCGATCAAAGGACGATCGCCGGCCTCGGCAATATATACGTTTGCGAGGCATTGTGGCGTTCGGGCCTTTCGCCGAAAA
GGGCGGCAGGTACGCTCGTCGACAAGCGGGCTCGCCCGAAGCAGGCGCTGGTTCAGCTGACGGATGCGATCCGCGCCGTC
ATCGCAGATGCGATCGCCGCCGGCGGTTCCTCGCTCAAGGATCACATTCAGGCGGATGGCAGTCTTGGCTATTTCCAGCA
CAGCTTCTCCGTCTATGACAGAGAAGGCGAGGCTTGCCGCACGTCCGGCTGCCGCGGTACGGTTGAGCGCATCGTTCAGG
CAGGGCGTTCGACCTTTTACTGTCCGCACTGCCAGAAATAG

Upstream 100 bases:

>100_bases
GCCGCATGCAGCGGGATATAGGCCATCGATGTCGCTATGGGAATGGCGAGACGCTCACGCGGGCCAACGCGATGAACAAA
GGATTGAAGGAAGTCAGCCG

Downstream 100 bases:

>100_bases
CGCGCGGCAAGGCACATTTCGCTCCCGGATCTGCCGGGCGCTCGATTCCGAAAATGCGTGAAGGAGACGGGAATGGGTTA
CGAGACGTTGCTGGTGGAAA

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MPELPEVETVKRGLAPTMEGALLVRAELRRPDLRFPFPENFEDAVAGRRIVALSRRAKYLTIELEGGDVIIAHLGMSGSF
RIEFDGPGEGRIKESADPAVPGDFHRPRSKDEKHDHVVFHLDASCGPARVIYNDPRRFGFMALARREALAEHVFLRGLGE
EPTGNALDAAYLAARFSGKAQPLKAALLDQRTIAGLGNIYVCEALWRSGLSPKRAAGTLVDKRARPKQALVQLTDAIRAV
IADAIAAGGSSLKDHIQADGSLGYFQHSFSVYDREGEACRTSGCRGTVERIVQAGRSTFYCPHCQK

Sequences:

>Translated_306_residues
MPELPEVETVKRGLAPTMEGALLVRAELRRPDLRFPFPENFEDAVAGRRIVALSRRAKYLTIELEGGDVIIAHLGMSGSF
RIEFDGPGEGRIKESADPAVPGDFHRPRSKDEKHDHVVFHLDASCGPARVIYNDPRRFGFMALARREALAEHVFLRGLGE
EPTGNALDAAYLAARFSGKAQPLKAALLDQRTIAGLGNIYVCEALWRSGLSPKRAAGTLVDKRARPKQALVQLTDAIRAV
IADAIAAGGSSLKDHIQADGSLGYFQHSFSVYDREGEACRTSGCRGTVERIVQAGRSTFYCPHCQK
>Mature_305_residues
PELPEVETVKRGLAPTMEGALLVRAELRRPDLRFPFPENFEDAVAGRRIVALSRRAKYLTIELEGGDVIIAHLGMSGSFR
IEFDGPGEGRIKESADPAVPGDFHRPRSKDEKHDHVVFHLDASCGPARVIYNDPRRFGFMALARREALAEHVFLRGLGEE
PTGNALDAAYLAARFSGKAQPLKAALLDQRTIAGLGNIYVCEALWRSGLSPKRAAGTLVDKRARPKQALVQLTDAIRAVI
ADAIAAGGSSLKDHIQADGSLGYFQHSFSVYDREGEACRTSGCRGTVERIVQAGRSTFYCPHCQK

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger

Homologues:

Organism=Escherichia coli, GI1790066, Length=307, Percent_Identity=37.785016286645, Blast_Score=181, Evalue=5e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FPG_SINMW (A6UFF8)

Other databases:

- EMBL:   CP000738
- RefSeq:   YP_001329223.1
- ProteinModelPortal:   A6UFF8
- SMR:   A6UFF8
- STRING:   A6UFF8
- GeneID:   5324461
- GenomeReviews:   CP000738_GR
- KEGG:   smd:Smed_3573
- eggNOG:   COG0266
- HOGENOM:   HBG690070
- OMA:   RSTFYCA
- ProtClustDB:   PRK01103
- BioCyc:   SMED366394:SMED_3573-MONOMER
- HAMAP:   MF_00103
- InterPro:   IPR015886
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663
- SMART:   SM00898
- TIGRFAMs:   TIGR00577

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS; SSF81624 Form_DNAglyc_cat; SSF46946 Ribosomal_H2TH

EC number: =3.2.2.23; =4.2.99.18

Molecular weight: Translated: 33449; Mature: 33317

Theoretical pI: Translated: 8.59; Mature: 8.59

Prosite motif: PS51068 FPG_CAT; PS01242 ZF_FPG_1; PS51066 ZF_FPG_2

Important sites: ACT_SITE 2-2 ACT_SITE 3-3 ACT_SITE 58-58 ACT_SITE 296-296 BINDING 114-114 BINDING 136-136 BINDING 179-179

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETVKRGLAPTMEGALLVRAELRRPDLRFPFPENFEDAVAGRRIVALSRRAKYL
CCCCCCHHHHHHCCCCCCCCCEEEEEHHCCCCCCCCCCCCHHHHHHCCEEEEEECCCEEE
TIELEGGDVIIAHLGMSGSFRIEFDGPGEGRIKESADPAVPGDFHRPRSKDEKHDHVVFH
EEEECCCCEEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEE
LDASCGPARVIYNDPRRFGFMALARREALAEHVFLRGLGEEPTGNALDAAYLAARFSGKA
EECCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCC
QPLKAALLDQRTIAGLGNIYVCEALWRSGLSPKRAAGTLVDKRARPKQALVQLTDAIRAV
CHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
IADAIAAGGSSLKDHIQADGSLGYFQHSFSVYDREGEACRTSGCRGTVERIVQAGRSTFY
HHHHHHCCCCHHHHHHHCCCCCCCHHHCCCEECCCCCHHHCCCCHHHHHHHHHCCCCEEC
CPHCQK
CCCCCC
>Mature Secondary Structure 
PELPEVETVKRGLAPTMEGALLVRAELRRPDLRFPFPENFEDAVAGRRIVALSRRAKYL
CCCCCHHHHHHCCCCCCCCCEEEEEHHCCCCCCCCCCCCHHHHHHCCEEEEEECCCEEE
TIELEGGDVIIAHLGMSGSFRIEFDGPGEGRIKESADPAVPGDFHRPRSKDEKHDHVVFH
EEEECCCCEEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEE
LDASCGPARVIYNDPRRFGFMALARREALAEHVFLRGLGEEPTGNALDAAYLAARFSGKA
EECCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCC
QPLKAALLDQRTIAGLGNIYVCEALWRSGLSPKRAAGTLVDKRARPKQALVQLTDAIRAV
CHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
IADAIAAGGSSLKDHIQADGSLGYFQHSFSVYDREGEACRTSGCRGTVERIVQAGRSTFY
HHHHHHCCCCHHHHHHHCCCCCCCHHHCCCEECCCCCHHHCCCCHHHHHHHHHCCCCEEC
CPHCQK
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA