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The map label for this gene is trxB [H]

Identifier: 150398751

GI number: 150398751

Start: 3775013

End: 3775918

Strand: Direct

Name: trxB [H]

Synonym: Smed_3568

Alternate gene names: 150398751

Gene position: 3775013-3775918 (Clockwise)

Preceding gene: 150398750

Following gene: 150398756

Centisome position: 99.82

GC content: 64.13

Gene sequence:

>906_bases
ATGTCGGTTGATGCGGCGCCAGTTGATGTAACGATTGTGGGAGGAAGCTATGCGGGTCTTTCCGCGGCATTGCAGCTGGC
AAGGGCGAGGCGCTCCGTGGTGGTCGTCGATTCGGGCGCGCGCAGGAACCGCTTCGCCGACACGTCGCATGGGTTCCTCA
GCCGCGACGGCGAAGCGCCGGCGGTGATCGCGGCGCACGGGCGGGAGCAGTTGATGGCCTATCCCAATGTGCGATTCGTC
GAAGGAATGGCTGACACGGTAAGCCGCGGCGGCGCGAATCTCATCGTCTCGATACAGGGTGAAAAGATCGCCGCGCGGCG
GTTGATCCTGGCCACCGGGGTGATCGATGAATTGCCGTCGCTGCCGGGACTTCAGGAACGATGGGGCCGTGCCGTCTTTC
ATTGCCCCTATTGCCACGGCTACGAGCTCGGGCAGGGGCGAATCGGCGTTCTCGCGACCGGTGAGAACAGTTTTCACCAG
GCTATGATGCTGCCGGACTGGGGACCGACCACCTTGTTTGCCAATGATGTATTCGAGCCCGATGCCGCCCAGGCCGCCAT
GCTCGAGGCACGCGGCGTGGAGATCGAAAGGCAGAAGGTCGTCGCTCTCGACGGGCCGAAGGCGACCTTGGTGCTGGAAG
GCGGTCGGACTGTTTCCCTCGAAGGTCTTTTCGTTGCGTCCCGTACCCGCATGGCAAGCGGCCTGCCCGCAGCGCTCGGA
TGCGCTTTCGAGGAAGGCCCGCTCGGGCCTTTTATACGGACGAATGAGGCAAAGGAGACGAGCGTGGAGGGCGTCTACGC
CTGCGGCGATGCGGCGCGCTCGGCGGGCTCGGTCTCCCATGCGGTGGGCGACGGCGTCACGGCAGCCGTGGCTGCCCATA
AATCGTTGATTTTCGACGTGCATTGA

Upstream 100 bases:

>100_bases
CTCCTCCTCCAGCGACTGGGAACGATAAGTCTGGCAGATCTTTCGCGTGATTTTCAGCAACGGATGGCGCTCGGTCGCCA
GAAAACGAAGGAGCAAAATC

Downstream 100 bases:

>100_bases
GGCCGTCTTCCCGGACGGAAAACCCTACACGCTTCTCCTGAAAGTGCTCCGGTCAGCGGGCGCCGGCGGCGGTAAGCAGG
CGTTCGATGGCGCGAAAGCC

Product: FAD-dependent pyridine nucleotide-disulfide oxidoreductase

Products: NA

Alternate protein names: TR; TRXR [H]

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MSVDAAPVDVTIVGGSYAGLSAALQLARARRSVVVVDSGARRNRFADTSHGFLSRDGEAPAVIAAHGREQLMAYPNVRFV
EGMADTVSRGGANLIVSIQGEKIAARRLILATGVIDELPSLPGLQERWGRAVFHCPYCHGYELGQGRIGVLATGENSFHQ
AMMLPDWGPTTLFANDVFEPDAAQAAMLEARGVEIERQKVVALDGPKATLVLEGGRTVSLEGLFVASRTRMASGLPAALG
CAFEEGPLGPFIRTNEAKETSVEGVYACGDAARSAGSVSHAVGDGVTAAVAAHKSLIFDVH

Sequences:

>Translated_301_residues
MSVDAAPVDVTIVGGSYAGLSAALQLARARRSVVVVDSGARRNRFADTSHGFLSRDGEAPAVIAAHGREQLMAYPNVRFV
EGMADTVSRGGANLIVSIQGEKIAARRLILATGVIDELPSLPGLQERWGRAVFHCPYCHGYELGQGRIGVLATGENSFHQ
AMMLPDWGPTTLFANDVFEPDAAQAAMLEARGVEIERQKVVALDGPKATLVLEGGRTVSLEGLFVASRTRMASGLPAALG
CAFEEGPLGPFIRTNEAKETSVEGVYACGDAARSAGSVSHAVGDGVTAAVAAHKSLIFDVH
>Mature_300_residues
SVDAAPVDVTIVGGSYAGLSAALQLARARRSVVVVDSGARRNRFADTSHGFLSRDGEAPAVIAAHGREQLMAYPNVRFVE
GMADTVSRGGANLIVSIQGEKIAARRLILATGVIDELPSLPGLQERWGRAVFHCPYCHGYELGQGRIGVLATGENSFHQA
MMLPDWGPTTLFANDVFEPDAAQAAMLEARGVEIERQKVVALDGPKATLVLEGGRTVSLEGLFVASRTRMASGLPAALGC
AFEEGPLGPFIRTNEAKETSVEGVYACGDAARSAGSVSHAVGDGVTAAVAAHKSLIFDVH

Specific function: Serves To Protect The Cell Against DNA Damage By Alkyl Hydroperoxides. It Can Use Either NADH Or NADPH As Electron Donor For Direct Reduction Of Redox Dyes Or Of Alkyl Hydroperoxides When Combined With The Ahpc Protein. [C]

COG id: COG0492

COG function: function code O; Thioredoxin reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR008255
- InterPro:   IPR001327
- InterPro:   IPR000103
- InterPro:   IPR005982 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.8.1.9 [H]

Molecular weight: Translated: 31522; Mature: 31391

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVDAAPVDVTIVGGSYAGLSAALQLARARRSVVVVDSGARRNRFADTSHGFLSRDGEAP
CCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCC
AVIAAHGREQLMAYPNVRFVEGMADTVSRGGANLIVSIQGEKIAARRLILATGVIDELPS
EEEEECCCHHEEECCCCEEEHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCC
LPGLQERWGRAVFHCPYCHGYELGQGRIGVLATGENSFHQAMMLPDWGPTTLFANDVFEP
CCCHHHHHCCEEEECCCCCCEEECCCCEEEEEECCCCCEEEEECCCCCCCEEEECCCCCC
DAAQAAMLEARGVEIERQKVVALDGPKATLVLEGGRTVSLEGLFVASRTRMASGLPAALG
CHHHHHHHHHCCCEEECEEEEEECCCCEEEEEECCCEEEEEEEEEECHHHHHCCCCHHHC
CAFEEGPLGPFIRTNEAKETSVEGVYACGDAARSAGSVSHAVGDGVTAAVAAHKSLIFDV
CCCCCCCCCCCEECCCCCCCCCCEEEECCHHHHCCCCHHHHHCCCHHHHHHHCCEEEEEC
H
C
>Mature Secondary Structure 
SVDAAPVDVTIVGGSYAGLSAALQLARARRSVVVVDSGARRNRFADTSHGFLSRDGEAP
CCCCCCEEEEEECCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCC
AVIAAHGREQLMAYPNVRFVEGMADTVSRGGANLIVSIQGEKIAARRLILATGVIDELPS
EEEEECCCHHEEECCCCEEEHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCC
LPGLQERWGRAVFHCPYCHGYELGQGRIGVLATGENSFHQAMMLPDWGPTTLFANDVFEP
CCCHHHHHCCEEEECCCCCCEEECCCCEEEEEECCCCCEEEEECCCCCCCEEEECCCCCC
DAAQAAMLEARGVEIERQKVVALDGPKATLVLEGGRTVSLEGLFVASRTRMASGLPAALG
CHHHHHHHHHCCCEEECEEEEEECCCCEEEEEECCCEEEEEEEEEECHHHHHCCCCHHHC
CAFEEGPLGPFIRTNEAKETSVEGVYACGDAARSAGSVSHAVGDGVTAAVAAHKSLIFDV
CCCCCCCCCCCEECCCCCCCCCCEEEECCHHHHCCCCHHHHHCCCHHHHHHHCCEEEEEC
H
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]