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The map label for this gene is tatA [H]

Identifier: 150398695

GI number: 150398695

Start: 3713117

End: 3714286

Strand: Reverse

Name: tatA [H]

Synonym: Smed_3509

Alternate gene names: 150398695

Gene position: 3714286-3713117 (Counterclockwise)

Preceding gene: 150398696

Following gene: 150398694

Centisome position: 98.21

GC content: 66.75

Gene sequence:

>1170_bases
ATGTTCGACGCCCTCACCCGCCAAGCCGACGACCCCTTGCTGGCCCTTATCGGCCTGTTCAGGAAGGATGAGCGCCCAGG
CAAGGTGGACCTCGGCGTCGGCGTCTATCGTGACGAAGCCGGCCGCACGCCGATCTTCCGAGCGGTCAAGGCCGCGGAAA
AGCGACTTCTCGAAACGCAGGACAGCAAGGCCTATGTCGGACCCGAGGGAGACCTCGATTTTCTTGATCGCCTCTGGCAG
CTCGTCGGCGGGGATATAGTCGAGCGCAGCCATGTGGCGGGCGTCCAGACGCCCGGCGGCTCCGGCGCGCTCCGTCTGGC
GGCGGACCTCATCGCCCGCATGGGCGGCCGGGGCATCTGGCTCGGGCTGCCGAGCTGGCCGAACCACGCGCCGATCTTCA
AGGCGGCCGGGCTCAATATAGCCACCTACGATTTTTTCGACATTCCGTCGCAATCGGTAATCTTCGATAATCTCGTGAGC
GCGCTGGAAGGCGCTGCACCCGGCGATGCGGTGCTGCTGCATGCCAGCTGCCACAATCCGACCGGCGGCGTGCTCAGCGA
AGCGCAATGGATGGAGATCGCCGCGCTGGTGGCCGAGCGCGGCCTGCTGCCGCTCGTCGATCTCGCCTATCAAGGGCTCG
GCCGCGGCCTCGATCAGGATGTCGCCGGCCTCAGACATCTTCTCGGCGTCGTGCCGGAAGCGCTCATGGCGGTTTCCTGC
TCGAAATCCTTCGGGCTTTATCGCGAGCGCACGGGCGCGATCTTCGCCCGCACCAGCTCATCCGCATCGGCGGACAGGGT
GCGCTCCAATCTCGCGGGCCTCGCCCGCACCAGCTATTCCATGCCGCCGGATCACGGCGCAGCCGTCGTGCGGACGATCC
TTGGCGACCCGGAACTCAGACGCGACTGGGCGGAGGAGCTGGAGACGATGCGGCTCAGGATGACCGGCCTCCGGCGGTCG
CTTGCCGAGGGGCTCCGCACCCGCTGGCAGAGCCTCGGCGCGGTCGCCGATCAGGAGGGCATGTTCTCGATGCTGCCGCT
TTCCGAAGCGGAGGTGATGCGGCTCAGGACCGAGCACGCCATCTATATGCCCTCCTCCGGCCGCATCAACATCGCCGGGC
TGAAGACCACGGAAGCCGCCGAGGTTGCCGGCAAGTTCACCAGTCTCTGA

Upstream 100 bases:

>100_bases
TGAACCGCTCTCCGGGGACGGGCGCAAGCTCGATCCGGCTTGCCTTTCCGGCCGTGGGAAACGACTATGGTTCCATGCAG
CTTCTCATTGGGGAATAACC

Downstream 100 bases:

>100_bases
TCTCAAGTCTTGTTTCCGGGTCTTTTCCGGGGCGCAGCGTCCGGCTATGTCTTCCCACATCCGGAAGAACGGGAAGATTC
GGCATGACGGTTACGATCTA

Product: aromatic amino acid aminotransferase

Products: NA

Alternate protein names: TAT; L-tyrosine:2-oxoglutarate aminotransferase [H]

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MFDALTRQADDPLLALIGLFRKDERPGKVDLGVGVYRDEAGRTPIFRAVKAAEKRLLETQDSKAYVGPEGDLDFLDRLWQ
LVGGDIVERSHVAGVQTPGGSGALRLAADLIARMGGRGIWLGLPSWPNHAPIFKAAGLNIATYDFFDIPSQSVIFDNLVS
ALEGAAPGDAVLLHASCHNPTGGVLSEAQWMEIAALVAERGLLPLVDLAYQGLGRGLDQDVAGLRHLLGVVPEALMAVSC
SKSFGLYRERTGAIFARTSSSASADRVRSNLAGLARTSYSMPPDHGAAVVRTILGDPELRRDWAEELETMRLRMTGLRRS
LAEGLRTRWQSLGAVADQEGMFSMLPLSEAEVMRLRTEHAIYMPSSGRINIAGLKTTEAAEVAGKFTSL

Sequences:

>Translated_389_residues
MFDALTRQADDPLLALIGLFRKDERPGKVDLGVGVYRDEAGRTPIFRAVKAAEKRLLETQDSKAYVGPEGDLDFLDRLWQ
LVGGDIVERSHVAGVQTPGGSGALRLAADLIARMGGRGIWLGLPSWPNHAPIFKAAGLNIATYDFFDIPSQSVIFDNLVS
ALEGAAPGDAVLLHASCHNPTGGVLSEAQWMEIAALVAERGLLPLVDLAYQGLGRGLDQDVAGLRHLLGVVPEALMAVSC
SKSFGLYRERTGAIFARTSSSASADRVRSNLAGLARTSYSMPPDHGAAVVRTILGDPELRRDWAEELETMRLRMTGLRRS
LAEGLRTRWQSLGAVADQEGMFSMLPLSEAEVMRLRTEHAIYMPSSGRINIAGLKTTEAAEVAGKFTSL
>Mature_389_residues
MFDALTRQADDPLLALIGLFRKDERPGKVDLGVGVYRDEAGRTPIFRAVKAAEKRLLETQDSKAYVGPEGDLDFLDRLWQ
LVGGDIVERSHVAGVQTPGGSGALRLAADLIARMGGRGIWLGLPSWPNHAPIFKAAGLNIATYDFFDIPSQSVIFDNLVS
ALEGAAPGDAVLLHASCHNPTGGVLSEAQWMEIAALVAERGLLPLVDLAYQGLGRGLDQDVAGLRHLLGVVPEALMAVSC
SKSFGLYRERTGAIFARTSSSASADRVRSNLAGLARTSYSMPPDHGAAVVRTILGDPELRRDWAEELETMRLRMTGLRRS
LAEGLRTRWQSLGAVADQEGMFSMLPLSEAEVMRLRTEHAIYMPSSGRINIAGLKTTEAAEVAGKFTSL

Specific function: Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate [H]

COG id: COG1448

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI73486658, Length=384, Percent_Identity=34.1145833333333, Blast_Score=225, Evalue=4e-59,
Organism=Homo sapiens, GI4504067, Length=386, Percent_Identity=34.1968911917098, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI117414139, Length=381, Percent_Identity=24.6719160104987, Blast_Score=110, Evalue=3e-24,
Organism=Escherichia coli, GI1787159, Length=380, Percent_Identity=42.3684210526316, Blast_Score=323, Evalue=1e-89,
Organism=Escherichia coli, GI1790488, Length=396, Percent_Identity=36.6161616161616, Blast_Score=259, Evalue=3e-70,
Organism=Caenorhabditis elegans, GI71981858, Length=380, Percent_Identity=33.6842105263158, Blast_Score=246, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI25147133, Length=383, Percent_Identity=32.6370757180157, Blast_Score=225, Evalue=3e-59,
Organism=Caenorhabditis elegans, GI17569539, Length=391, Percent_Identity=30.4347826086957, Blast_Score=184, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI17569537, Length=376, Percent_Identity=24.7340425531915, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI25147136, Length=209, Percent_Identity=31.5789473684211, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17550384, Length=260, Percent_Identity=29.6153846153846, Blast_Score=119, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6323055, Length=401, Percent_Identity=31.4214463840399, Blast_Score=206, Evalue=7e-54,
Organism=Saccharomyces cerevisiae, GI6322743, Length=414, Percent_Identity=29.7101449275362, Blast_Score=186, Evalue=4e-48,
Organism=Drosophila melanogaster, GI19920542, Length=381, Percent_Identity=34.1207349081365, Blast_Score=224, Evalue=9e-59,
Organism=Drosophila melanogaster, GI24580970, Length=381, Percent_Identity=34.1207349081365, Blast_Score=224, Evalue=9e-59,
Organism=Drosophila melanogaster, GI24580972, Length=381, Percent_Identity=34.1207349081365, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24654046, Length=384, Percent_Identity=34.6354166666667, Blast_Score=215, Evalue=5e-56,
Organism=Drosophila melanogaster, GI19922362, Length=384, Percent_Identity=34.6354166666667, Blast_Score=215, Evalue=5e-56,

Paralogues:

None

Copy number: 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR000796
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.5 [H]

Molecular weight: Translated: 41917; Mature: 41917

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDALTRQADDPLLALIGLFRKDERPGKVDLGVGVYRDEAGRTPIFRAVKAAEKRLLETQ
CCCCHHHCCCCHHHHHHHHHHCCCCCCEEEECCEEEECCCCCCHHHHHHHHHHHHHHHCC
DSKAYVGPEGDLDFLDRLWQLVGGDIVERSHVAGVQTPGGSGALRLAADLIARMGGRGIW
CCCEEECCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCEEE
LGLPSWPNHAPIFKAAGLNIATYDFFDIPSQSVIFDNLVSALEGAAPGDAVLLHASCHNP
EECCCCCCCCCCEEECCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCC
TGGVLSEAQWMEIAALVAERGLLPLVDLAYQGLGRGLDQDVAGLRHLLGVVPEALMAVSC
CCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
SKSFGLYRERTGAIFARTSSSASADRVRSNLAGLARTSYSMPPDHGAAVVRTILGDPELR
HHHHCCHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHH
RDWAEELETMRLRMTGLRRSLAEGLRTRWQSLGAVADQEGMFSMLPLSEAEVMRLRTEHA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHCE
IYMPSSGRINIAGLKTTEAAEVAGKFTSL
EECCCCCCEEEEECCCCHHHHHHHHHCCC
>Mature Secondary Structure
MFDALTRQADDPLLALIGLFRKDERPGKVDLGVGVYRDEAGRTPIFRAVKAAEKRLLETQ
CCCCHHHCCCCHHHHHHHHHHCCCCCCEEEECCEEEECCCCCCHHHHHHHHHHHHHHHCC
DSKAYVGPEGDLDFLDRLWQLVGGDIVERSHVAGVQTPGGSGALRLAADLIARMGGRGIW
CCCEEECCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCEEE
LGLPSWPNHAPIFKAAGLNIATYDFFDIPSQSVIFDNLVSALEGAAPGDAVLLHASCHNP
EECCCCCCCCCCEEECCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCC
TGGVLSEAQWMEIAALVAERGLLPLVDLAYQGLGRGLDQDVAGLRHLLGVVPEALMAVSC
CCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
SKSFGLYRERTGAIFARTSSSASADRVRSNLAGLARTSYSMPPDHGAAVVRTILGDPELR
HHHHCCHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHH
RDWAEELETMRLRMTGLRRSLAEGLRTRWQSLGAVADQEGMFSMLPLSEAEVMRLRTEHA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHCE
IYMPSSGRINIAGLKTTEAAEVAGKFTSL
EECCCCCCEEEEECCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2019560; 8096210; 11481430 [H]