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The map label for this gene is tktB [C]

Identifier: 150398322

GI number: 150398322

Start: 3277164

End: 3278009

Strand: Direct

Name: tktB [C]

Synonym: Smed_3128

Alternate gene names: 150398322

Gene position: 3277164-3278009 (Clockwise)

Preceding gene: 150398317

Following gene: 150398323

Centisome position: 86.65

GC content: 59.46

Gene sequence:

>846_bases
ATGATCAGTAGCATATTTATTCACAATGAGGATTTCATGCAGCCGAACGATCTCGACCGCATCGCTCAACAGATCCGACT
TCGCGATCTGCAAGCGGTTTTCGAAGCCGGCGCCGGCCACATCGGCGGAGAGATGTCCGCCATCGACATTCTGACGGCGC
TCTATTTTCGCGTGCTGCGCATCTGGCCCGAACAGCCGAAGCACCCGGACCGCGACCGTTTCGTGCTGTCGAAAGGCCAT
GTGGCGCTGGCGCTCTATGTGACGCTGGCCAAGCGAGGCTTCATTCCAGAGGAAGAAATCGGCACATTCCTGAAGCCGCA
TTCGCGCCTCAACGGGCATCCGAACTGCACCAAGGTGCCGGGCATCGAGACGAATACCGGCCCGCTCGGCCACGGGCTGC
CGGTGGCGGTGGGCATGGCGAAGGCGGCAAAGCTGACCCGCGCGAAATATCACACCTATGCTTTGACCGGTGACGGCGAA
ATGCAGGAAGGATCCAACTGGGAGGCCATCTCATCGGCCGCGCAATTCGGTCTCGACAACCTGACCCTGATCATCGACCA
CAACCGCTTCCAGCAGGGCGCCGCTCTGAAGGATACCAACAATCTCGCTCCATTCCCCGCCAAACTCGAAGCCTTCGGCT
GGGATGTGACCGAGATCAACGGCAATGCCATGGATGAAGTCGTTCCGGCGCTGGAAAAGCGCGGCAGTCGCCCGCACTGT
ATCGTCGCCCATACGAACAAGGGCCACGGCATATCCTTCATGCAGGACAAGGTCGACTGGCACCACAAGGTGCCGAACGA
CGAACAATACAAGATTGCCGTGGCTGAGCTTTCGGAGGCCCTGTGA

Upstream 100 bases:

>100_bases
ATACACGACCAATCCTGAGGCTGTCAATACGAGGGAGGCTGCAATCTCGCGGTTGCTATTGCGGAATTCCGCTTGACTTG
CGAGAGGGGCGTGCAAATAT

Downstream 100 bases:

>100_bases
TGAACGCCGTGACATCGTCTGCCAAGTTGCACGATTGCCGTGACGCCTTCGTTACGGTGCTGGAGCGCCTCAGTGCGGAT
AACCCCAGGATCGTGGCCGT

Product: transketolase domain-containing protein

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MISSIFIHNEDFMQPNDLDRIAQQIRLRDLQAVFEAGAGHIGGEMSAIDILTALYFRVLRIWPEQPKHPDRDRFVLSKGH
VALALYVTLAKRGFIPEEEIGTFLKPHSRLNGHPNCTKVPGIETNTGPLGHGLPVAVGMAKAAKLTRAKYHTYALTGDGE
MQEGSNWEAISSAAQFGLDNLTLIIDHNRFQQGAALKDTNNLAPFPAKLEAFGWDVTEINGNAMDEVVPALEKRGSRPHC
IVAHTNKGHGISFMQDKVDWHHKVPNDEQYKIAVAELSEAL

Sequences:

>Translated_281_residues
MISSIFIHNEDFMQPNDLDRIAQQIRLRDLQAVFEAGAGHIGGEMSAIDILTALYFRVLRIWPEQPKHPDRDRFVLSKGH
VALALYVTLAKRGFIPEEEIGTFLKPHSRLNGHPNCTKVPGIETNTGPLGHGLPVAVGMAKAAKLTRAKYHTYALTGDGE
MQEGSNWEAISSAAQFGLDNLTLIIDHNRFQQGAALKDTNNLAPFPAKLEAFGWDVTEINGNAMDEVVPALEKRGSRPHC
IVAHTNKGHGISFMQDKVDWHHKVPNDEQYKIAVAELSEAL
>Mature_281_residues
MISSIFIHNEDFMQPNDLDRIAQQIRLRDLQAVFEAGAGHIGGEMSAIDILTALYFRVLRIWPEQPKHPDRDRFVLSKGH
VALALYVTLAKRGFIPEEEIGTFLKPHSRLNGHPNCTKVPGIETNTGPLGHGLPVAVGMAKAAKLTRAKYHTYALTGDGE
MQEGSNWEAISSAAQFGLDNLTLIIDHNRFQQGAALKDTNNLAPFPAKLEAFGWDVTEINGNAMDEVVPALEKRGSRPHC
IVAHTNKGHGISFMQDKVDWHHKVPNDEQYKIAVAELSEAL

Specific function: Unknown

COG id: COG3959

COG function: function code G; Transketolase, N-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=257, Percent_Identity=38.5214007782101, Blast_Score=181, Evalue=7e-46,
Organism=Homo sapiens, GI4507521, Length=257, Percent_Identity=38.5214007782101, Blast_Score=181, Evalue=7e-46,
Organism=Homo sapiens, GI133778974, Length=267, Percent_Identity=34.4569288389513, Blast_Score=163, Evalue=1e-40,
Organism=Homo sapiens, GI225637459, Length=267, Percent_Identity=29.5880149812734, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI225637461, Length=236, Percent_Identity=30.5084745762712, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI225637463, Length=234, Percent_Identity=30.3418803418803, Blast_Score=110, Evalue=1e-24,
Organism=Escherichia coli, GI1788808, Length=281, Percent_Identity=32.7402135231317, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI48994911, Length=250, Percent_Identity=34.8, Blast_Score=123, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17539652, Length=252, Percent_Identity=36.1111111111111, Blast_Score=164, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6325331, Length=254, Percent_Identity=33.0708661417323, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6319593, Length=257, Percent_Identity=32.6848249027237, Blast_Score=103, Evalue=4e-23,
Organism=Drosophila melanogaster, GI45551847, Length=269, Percent_Identity=34.2007434944238, Blast_Score=160, Evalue=6e-40,
Organism=Drosophila melanogaster, GI45550715, Length=269, Percent_Identity=34.2007434944238, Blast_Score=160, Evalue=6e-40,
Organism=Drosophila melanogaster, GI24666278, Length=237, Percent_Identity=35.8649789029536, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24645119, Length=226, Percent_Identity=35.8407079646018, Blast_Score=144, Evalue=5e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 31084; Mature: 31084

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISSIFIHNEDFMQPNDLDRIAQQIRLRDLQAVFEAGAGHIGGEMSAIDILTALYFRVLR
CCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
IWPEQPKHPDRDRFVLSKGHVALALYVTLAKRGFIPEEEIGTFLKPHSRLNGHPNCTKVP
HCCCCCCCCCCCCEEEECCCEEEHHHHHHHHHCCCCHHHHHHHHCCHHHCCCCCCCCCCC
GIETNTGPLGHGLPVAVGMAKAAKLTRAKYHTYALTGDGEMQEGSNWEAISSAAQFGLDN
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCHHHHHHHHHCCCCC
LTLIIDHNRFQQGAALKDTNNLAPFPAKLEAFGWDVTEINGNAMDEVVPALEKRGSRPHC
EEEEEECCCCCCCCCCCCCCCCCCCCCHHHHCCCEEEECCCCHHHHHHHHHHHCCCCCEE
IVAHTNKGHGISFMQDKVDWHHKVPNDEQYKIAVAELSEAL
EEEECCCCCCCHHHHHHHHHHCCCCCCCCEEEEHHHHHHCC
>Mature Secondary Structure
MISSIFIHNEDFMQPNDLDRIAQQIRLRDLQAVFEAGAGHIGGEMSAIDILTALYFRVLR
CCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
IWPEQPKHPDRDRFVLSKGHVALALYVTLAKRGFIPEEEIGTFLKPHSRLNGHPNCTKVP
HCCCCCCCCCCCCEEEECCCEEEHHHHHHHHHCCCCHHHHHHHHCCHHHCCCCCCCCCCC
GIETNTGPLGHGLPVAVGMAKAAKLTRAKYHTYALTGDGEMQEGSNWEAISSAAQFGLDN
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCHHHHHHHHHCCCCC
LTLIIDHNRFQQGAALKDTNNLAPFPAKLEAFGWDVTEINGNAMDEVVPALEKRGSRPHC
EEEEEECCCCCCCCCCCCCCCCCCCCCHHHHCCCEEEECCCCHHHHHHHHHHHCCCCCEE
IVAHTNKGHGISFMQDKVDWHHKVPNDEQYKIAVAELSEAL
EEEECCCCCCCHHHHHHHHHHCCCCCCCCEEEEHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]