Click here to switch to the map view.

The map label for this gene is phbA [H]

Identifier: 150398311

GI number: 150398311

Start: 3266553

End: 3267734

Strand: Reverse

Name: phbA [H]

Synonym: Smed_3117

Alternate gene names: 150398311

Gene position: 3267734-3266553 (Counterclockwise)

Preceding gene: 150398313

Following gene: 150398310

Centisome position: 86.4

GC content: 65.82

Gene sequence:

>1182_bases
ATGAGCAATCCCTCGATCGTCATCGCCAGCGCCGCCCGCACGGCCGTCGGCTCCTTCAATGGCGCCTTCGGCAATACGCC
TGCGCACGAATTGGGCGCGGCCGCGGTCAAGGCGGTTCTGGAGCGGGCCGGTGTCGAAGCCGGCGAAGTGGACGAGGTGA
TCCTCGGGCAGGTGCTGCCGGCGGGCGAGGGGCAGAATCCGGCGCGCCAGGCGGCGATGAAAGCCGGAGTCCCGCAGGAA
AAGACCGCCTGGGGCATGAATCAGCTCTGCGGCTCCGGCCTGCGCGCCGTGGCGCTCGGCATGCAGCAGATCGCAACCGG
TGATGCGAAGGTCATCGTCGCCGGCGGCATGGAGTCGATGTCCATGGCGCCGCATTGCGCGCACTTGCGGGGCGGCGTGA
AAATGGGCGATTACAAGATGATCGACACGATGATCAAGGACGGCCTGACGGACGCCTTCTATGGATATCACATGGGCACT
ACCGCGGAGAACGTCGCGCGGAAATGGCAGCTTACGCGCGAGGAGCAGGACGAATTCGCGCTGGCCTCCCAGAACAAGGC
CGAAGCCGCCCAGAAAGCCGGCCGCTTCGCCGACGAGATCGTTCCTTTCGTCGTCAAGACGCGGAAAGGCGACGTCACTG
TCGACCAGGACGAATACATACGTCACGGCGCCACGCTGGAATCGATTGCGAAGCTTCGCCCGGCTTTCGACAAGGAAGGC
ACCGTCACTGCCGCCAACGCGTCGGGCCTCAATGACGGCGCCGCCGCCGCTCTGCTGATGACCGAGGCCGAGGCCGGCCG
GCGCGGCATCCAGCCGCTTGCCCGCATCGTCTCCTGGGCCACGGCGGGCGTCGACCCGCAGATCATGGGCACGGGCCCGA
TCCCCGCATCGCGCAAGGCACTTGAAAAAGCCGGCTGGTCGGTCGCCGAAATTGAACTCGTAGAGGCCAACGAGGCCTTC
GCGGCCCAGGCATGCGCCGTCAACAAGGATCTCGGTTGGGACCCGTCGATCGTCAACGTCAATGGCGGCGCGATCGCCAT
CGGACATCCGATCGGCGCGTCCGGAGCCCGCGTGCTGAACACGCTTCTTTTTGAAATGAAGCGGCGCAACGTCTCGAAGG
GCCTTGCGACACTCTGCATCGGCGGCGGCATGGGGGTCGCCATGTGCGTGGAACGCCTTTAG

Upstream 100 bases:

>100_bases
CCTCCTGAAGCTTTTGCGGCAGTGCAACTCGCCGTTTGACTTGCGCCCCTCCCTTTGCCAGTCTGCCTCCATCAGGCAAA
GCAAATATGAGGAACGTCCC

Downstream 100 bases:

>100_bases
CCGACGCCCGGTGAGCCGGGCGACTTCCAGATCCGGATATGCACAGGCGGCCCGGGCTCCGGGCCGCGGAAGGACGATTT
TCGCCAATTTGGCTTAACAG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MSNPSIVIASAARTAVGSFNGAFGNTPAHELGAAAVKAVLERAGVEAGEVDEVILGQVLPAGEGQNPARQAAMKAGVPQE
KTAWGMNQLCGSGLRAVALGMQQIATGDAKVIVAGGMESMSMAPHCAHLRGGVKMGDYKMIDTMIKDGLTDAFYGYHMGT
TAENVARKWQLTREEQDEFALASQNKAEAAQKAGRFADEIVPFVVKTRKGDVTVDQDEYIRHGATLESIAKLRPAFDKEG
TVTAANASGLNDGAAAALLMTEAEAGRRGIQPLARIVSWATAGVDPQIMGTGPIPASRKALEKAGWSVAEIELVEANEAF
AAQACAVNKDLGWDPSIVNVNGGAIAIGHPIGASGARVLNTLLFEMKRRNVSKGLATLCIGGGMGVAMCVERL

Sequences:

>Translated_393_residues
MSNPSIVIASAARTAVGSFNGAFGNTPAHELGAAAVKAVLERAGVEAGEVDEVILGQVLPAGEGQNPARQAAMKAGVPQE
KTAWGMNQLCGSGLRAVALGMQQIATGDAKVIVAGGMESMSMAPHCAHLRGGVKMGDYKMIDTMIKDGLTDAFYGYHMGT
TAENVARKWQLTREEQDEFALASQNKAEAAQKAGRFADEIVPFVVKTRKGDVTVDQDEYIRHGATLESIAKLRPAFDKEG
TVTAANASGLNDGAAAALLMTEAEAGRRGIQPLARIVSWATAGVDPQIMGTGPIPASRKALEKAGWSVAEIELVEANEAF
AAQACAVNKDLGWDPSIVNVNGGAIAIGHPIGASGARVLNTLLFEMKRRNVSKGLATLCIGGGMGVAMCVERL
>Mature_392_residues
SNPSIVIASAARTAVGSFNGAFGNTPAHELGAAAVKAVLERAGVEAGEVDEVILGQVLPAGEGQNPARQAAMKAGVPQEK
TAWGMNQLCGSGLRAVALGMQQIATGDAKVIVAGGMESMSMAPHCAHLRGGVKMGDYKMIDTMIKDGLTDAFYGYHMGTT
AENVARKWQLTREEQDEFALASQNKAEAAQKAGRFADEIVPFVVKTRKGDVTVDQDEYIRHGATLESIAKLRPAFDKEGT
VTAANASGLNDGAAAALLMTEAEAGRRGIQPLARIVSWATAGVDPQIMGTGPIPASRKALEKAGWSVAEIELVEANEAFA
AQACAVNKDLGWDPSIVNVNGGAIAIGHPIGASGARVLNTLLFEMKRRNVSKGLATLCIGGGMGVAMCVERL

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=393, Percent_Identity=57.2519083969466, Blast_Score=471, Evalue=1e-133,
Organism=Homo sapiens, GI167614485, Length=389, Percent_Identity=43.9588688946015, Blast_Score=318, Evalue=4e-87,
Organism=Homo sapiens, GI4557237, Length=398, Percent_Identity=42.964824120603, Blast_Score=310, Evalue=1e-84,
Organism=Homo sapiens, GI4501853, Length=393, Percent_Identity=40.4580152671756, Blast_Score=244, Evalue=9e-65,
Organism=Homo sapiens, GI4504327, Length=423, Percent_Identity=33.3333333333333, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI194353979, Length=389, Percent_Identity=29.8200514138817, Blast_Score=140, Evalue=2e-33,
Organism=Escherichia coli, GI1788554, Length=389, Percent_Identity=57.0694087403599, Blast_Score=425, Evalue=1e-120,
Organism=Escherichia coli, GI87082165, Length=388, Percent_Identity=54.1237113402062, Blast_Score=422, Evalue=1e-119,
Organism=Escherichia coli, GI1787663, Length=396, Percent_Identity=43.9393939393939, Blast_Score=304, Evalue=8e-84,
Organism=Escherichia coli, GI48994986, Length=396, Percent_Identity=43.1818181818182, Blast_Score=263, Evalue=2e-71,
Organism=Escherichia coli, GI1788683, Length=422, Percent_Identity=33.6492890995261, Blast_Score=192, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI133906874, Length=395, Percent_Identity=43.2911392405063, Blast_Score=323, Evalue=6e-89,
Organism=Caenorhabditis elegans, GI25147385, Length=393, Percent_Identity=41.4758269720102, Blast_Score=303, Evalue=9e-83,
Organism=Caenorhabditis elegans, GI17535921, Length=396, Percent_Identity=40.9090909090909, Blast_Score=282, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI17551802, Length=425, Percent_Identity=33.4117647058824, Blast_Score=188, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI17535917, Length=400, Percent_Identity=32.25, Blast_Score=185, Evalue=5e-47,
Organism=Saccharomyces cerevisiae, GI6325229, Length=398, Percent_Identity=42.2110552763819, Blast_Score=284, Evalue=1e-77,
Organism=Saccharomyces cerevisiae, GI6322031, Length=388, Percent_Identity=37.3711340206186, Blast_Score=214, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24655093, Length=388, Percent_Identity=58.5051546391753, Blast_Score=468, Evalue=1e-132,
Organism=Drosophila melanogaster, GI24640423, Length=390, Percent_Identity=42.5641025641026, Blast_Score=294, Evalue=9e-80,
Organism=Drosophila melanogaster, GI17648125, Length=389, Percent_Identity=41.3881748071979, Blast_Score=291, Evalue=4e-79,
Organism=Drosophila melanogaster, GI17137578, Length=425, Percent_Identity=34.1176470588235, Blast_Score=191, Evalue=8e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40867; Mature: 40736

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNPSIVIASAARTAVGSFNGAFGNTPAHELGAAAVKAVLERAGVEAGEVDEVILGQVLP
CCCCCEEEEECHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCC
AGEGQNPARQAAMKAGVPQEKTAWGMNQLCGSGLRAVALGMQQIATGDAKVIVAGGMESM
CCCCCCHHHHHHHHCCCCCHHHHCCHHHHHHCCHHHHHHHHHHHCCCCCEEEEECCCHHH
SMAPHCAHLRGGVKMGDYKMIDTMIKDGLTDAFYGYHMGTTAENVARKWQLTREEQDEFA
CCCCHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHH
LASQNKAEAAQKAGRFADEIVPFVVKTRKGDVTVDQDEYIRHGATLESIAKLRPAFDKEG
HHCCCHHHHHHHHHHHHHHHHHHHHEECCCCEEECHHHHHHCCCCHHHHHHHCCCCCCCC
TVTAANASGLNDGAAAALLMTEAEAGRRGIQPLARIVSWATAGVDPQIMGTGPIPASRKA
CEEECCCCCCCCCHHHHHEEHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHH
LEKAGWSVAEIELVEANEAFAAQACAVNKDLGWDPSIVNVNGGAIAIGHPIGASGARVLN
HHHCCCCEEEEEEEECCCHHHHHHHHCCCCCCCCCCEEEECCCEEEECCCCCCCHHHHHH
TLLFEMKRRNVSKGLATLCIGGGMGVAMCVERL
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCC
>Mature Secondary Structure 
SNPSIVIASAARTAVGSFNGAFGNTPAHELGAAAVKAVLERAGVEAGEVDEVILGQVLP
CCCCEEEEECHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCC
AGEGQNPARQAAMKAGVPQEKTAWGMNQLCGSGLRAVALGMQQIATGDAKVIVAGGMESM
CCCCCCHHHHHHHHCCCCCHHHHCCHHHHHHCCHHHHHHHHHHHCCCCCEEEEECCCHHH
SMAPHCAHLRGGVKMGDYKMIDTMIKDGLTDAFYGYHMGTTAENVARKWQLTREEQDEFA
CCCCHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHH
LASQNKAEAAQKAGRFADEIVPFVVKTRKGDVTVDQDEYIRHGATLESIAKLRPAFDKEG
HHCCCHHHHHHHHHHHHHHHHHHHHEECCCCEEECHHHHHHCCCCHHHHHHHCCCCCCCC
TVTAANASGLNDGAAAALLMTEAEAGRRGIQPLARIVSWATAGVDPQIMGTGPIPASRKA
CEEECCCCCCCCCHHHHHEEHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHH
LEKAGWSVAEIELVEANEAFAAQACAVNKDLGWDPSIVNVNGGAIAIGHPIGASGARVLN
HHHCCCCEEEEEEEECCCHHHHHHHHCCCCCCCCCCEEEECCCEEEECCCCCCCHHHHHH
TLLFEMKRRNVSKGLATLCIGGGMGVAMCVERL
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7582015; 11481430 [H]