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The map label for this gene is metH [H]

Identifier: 150398068

GI number: 150398068

Start: 3003180

End: 3006953

Strand: Reverse

Name: metH [H]

Synonym: Smed_2870

Alternate gene names: 150398068

Gene position: 3006953-3003180 (Counterclockwise)

Preceding gene: 150398069

Following gene: 150398061

Centisome position: 79.51

GC content: 62.98

Gene sequence:

>3774_bases
ATGTCCGCCTCCGACGACCTCTTTGGACACGTTTCGCCCAAGCCGGATGGCTCGGAAATCTTCCGCCAGCTCGCACAGGC
GGCCGCCGAGCGTATCCTCATCATGGACGGCGCAATGGGGACGGAGATCCAGCAGCTGGGTTTCGTCGAGGATCACTTCC
GGGGCGAGCGTTTCGGCGCCTGCAATTGCCATCAGCAGGGCAACAACGACCTTCTGACGCTCACGCAACCGAAGGCGATT
GAAGAGATACATTATCATTACGCAATCGCCGGTGCCGACATTCTGGAGACCAACACCTTCTCCTCGACCCGGATCGCCCA
GGCCGATTACGGCATGGAGGACATGGTCTACGACCTCAATCGCGATGGCGCGCGGTTGGCGCGGCGTGCTGCGCGGCGGG
CCGAGGCAGAGGACGGCAGGCGGCGCTTCGTGGCTGGCGCACTCGGGCCGACCAACCGCACAGCCTCGATCTCGCCGGAC
GTCAACAATCCCGGTTATCGTGCCGTCAGCTTCGATGATCTGAGGCTTGCCTATTCCGAGCAGGTGCGTGGTCTGATCGA
TGGCGGTGCCGACATCATCCTGATCGAGACTATTTTCGACACACTGAATGCCAAAGCCGCGATCTTTGCGACGCAGGAAG
TGTTCGCGGAGAAAGCTGTTCACCTGCCGATAATGATATCAGGCACGATCACCGATCTTTCCGGCCGCACACTCTCGGGA
CAGACGCCAACGGCTTTCTGGTATTCGGTGCGTCATGCATCGCCGTTTACGATCGGCCTCAACTGCGCGCTCGGGGCCAA
TGCGATGCGTGCCCATATCGACGAGCTCTCGGCGATAGCCGATACGCTGGTCTGCGCCTATCCCAATGCGGGCCTGCCCA
ACGAATTCGGCCAGTACGACGAAAGCCCCGAGCAGATGGCGGCGCAGATCGAGGGCTTCGCCCGGGACGGCCTCGTCAAT
GTCGTCGGTGGCTGTTGCGGCTCGACCCCGGCTCATATCCGCGCCATCGCCGAAGCGGTTGCCAAATATCCGCCGCGCCG
GGTGCCGGAGACCGAACGCCTGATGCGGCTTTCCGGCCTCGAGCCCTTCACGCTCACCGACGAGATCCCCTTCGTCAATG
TGGGAGAACGCACCAATGTCACCGGCTCGGCGAAGTTCCGCAAGCTGATCACTGCCGGGGACTACGCCGCCGCACTCGAA
GTCGCGCGCGATCAGGTGGCGAACGGCGCCCAGATCATCGACGTCAACATGGACGAAGGCCTCATCGATTCGAAGCAGGT
CATGGTCGAGTTCCTGAACCTCGTTGCCTCGGAGCCGGATATCGCGCGCGTGCCCGTGATGATCGACTCGTCCAAGTGGG
AGGTCATCGAAGCAGGACTCAAATGCGTCCAGGGCAAGGCGCTGGTGAACTCCATCTCGCTCAAGGAAGGCGAGGAAGCG
TTCCTGTATCACGCCCGTCTCGTGCGCGCCTATGGCGCCGCCGTCGTGGTGATGGCGTTCGACGAGAAAGGGCAGGCCGA
CACGAAGACCCGCAAGGTGGAGATCTGCCGCCGCGCCTACCGCTTGCTGACGGAAGAGGTGGGCTTTCCGCCGGAGGACA
TCATCTTCGACCCGAATATCTTCGCGGTCGCGACCGGCATCGAGGAGCACGACAATTACGGCGTCGACTTCATCGAGGCG
ACGCACGAGATCGTCGCGGCGCTGCCGCACGTCCATATCTCCGGCGGCGTGTCGAACCTGTCCTTCTCCTTCCGCGGCAA
CGAGCCCGTGCGCGAGGCGATGCACGCCGTTTTTCTCTACCATGCGATCCAGGCCGGCATGGACATGGGCATCGTCAATG
CCGGGCAGCTCGCCGTCTATGATGCGATCGACGCGGAGCTGCGCGAAGCCTGCGAGGATGTCGTGCTCAATCGCCGGTCC
GATGGAACCGAGCGCCTGTTGGAAATCGCCGAACGCTATCGCGGGCAGGGCGGGAGCCAGGGCAGGGAGAAGGATCTAGC
CTGGCGCGAATGGCCGGTCGAGAAAAGGCTCGAGCATGCCCTCGTCTACGGCATTACCGAATTCATCGAAGCCGATACCG
AGGAAGCCCGGCTCTCTGCCGAGCGGCCGCTGCATGTCATCGAAGGGCCGCTGATGGCCGGGATGAACGTGGTGGGCGAC
CTCTTCGGCTCGGGGAAGATGTTTCTGCCGCAGGTGGTCAAATCCGCGCGCGTGATGAAGCAGGCCGTTGCGGTGCTGCT
CCCCCATATGGAGGCGGAAAAGCGTGCCAATGGCGGCGGCGAGGCGCGCGAGAGCGCCGGCAAGATCCTGATGGCGACCG
TCAAGGGCGACGTGCACGATATCGGCAAGAACATCGTCGGCGTCGTGCTCGCCTGTAACAACTACGAGATCATCGATCTC
GGCGTCATGGTATCCTCGGCCAGGATTCTCGAAGTGGCGCGCGAGCAGAAGGTTGATATCATCGGCCTTTCCGGCCTCAT
TACGCCATCGCTGGACGAGATGGCGCATGTCGCTTCCGAGCTGGAACGGGAGGGCTTCGACCTGCCATTGCTGATTGGCG
GCGCGACGACCAGCCGCGTGCACACGGCGGTAAAGATCAATCCGCGCTACAGCCTCGGCCAGACGGTCTATGTCACGGAC
GCAAGCCGTGCCGTCGGCGTCGTATCGAGCCTGCTCTCGCCGGAGGTCCGCGACGGCTACAAGGAAACCATCCGCGCGGA
ATATCTCAAGGTTGCCGAGGCGCATGCGCGCAACGAAGCCGAGAAGCGTCGTCTGCCTCTCTCGCAGGCACGCGCGAACG
CGGTAAAGATCGATTGGGAGGCGCATCGGCCGAAAGTGCCGTCCTTCCTCGGCACGCGCGTTTTCGACGGATGGGATCTT
GCCGAACTCGCCCGCTATATCGACTGGACGCCCTTCTTCCAGACCTGGGAAATGAAGGGCGTTTATCCACGCATCCTCGA
CGACGAGCATCAAGGGGCGGCTGCCCGCCAGCTCTTCGAAGACGCGCAGGCGATGCTGGCGCAGATCGTGGCGGAAAAAT
GGTTCGCCCCCAAAGCCGTGGTCGGCTTCTGGCCGGCCGGCAGCGTCGGCGACGACGTCCGCCTCTTCACAGATGAGACG
CGCAAAGGTGAGCTTGCCACCTTGTTCACGCTCCGCCAGCAACTGGTGAAAAGAGACGGACGTCCGAATGTCGCCCTGGC
CGATTTCGTTGCTCCGGCCGAGAGCGGCAAGCGGGACTATGCCGGCGCTTTCGTCGTCACCGCCGGTATCGAGGAGGTGG
CGATCGCCGAACGCTTCGAGCGCGCCAACGACGACTATTCTTCGATCATGGTCAAGGCGCTGGCCGACCGCTTCGCCGAG
GCCTTCGCCGAGCGGATGCATGAATATGTGCGCAAGGAGCTTTGGGGCTATGCCGCGGATGAAGCCTTCACGCCGCAGGA
ATTGATCGGCGAGCCCTATGCCGGCATTCGGCCTGCTCCCGGCTATCCGGCACAGCCCGACCATACCGAGAAGGAGACGC
TTTTCCGGCTCCTGAATGCCGAGGCAGCGATCGGCGTGAAGCTCACCGAGAGCTATGCCATGTGGCCGGGCTCCTCTGTA
TCTGGCCTCTATATCGGTCACCCCGATTCCTACTATTTCGGCGTCGCCAAGATCGAGCGCGATCAGGTGGAAGACTATGC
CGAGCGCAAGCAGATGAGCGTGCGGGAAGTCGAGCGCTGGCTGTCGCCGGTCCTCAACTACGTGCCGGCCCCGGAGGCCG
AGGCGGCGGAATAG

Upstream 100 bases:

>100_bases
GTCCGGTCTCCAAACGTGACCGACACGTATGTTGACATAAAGATATGTTTATGTGAGTAAATCAATAATCATTTGTCGTT
TTCAGAACGGGAGATCTCCC

Downstream 100 bases:

>100_bases
ACTGAACGGGCAGCGGAAAACGGCTACGCACTTTTCCTAGTTGCTCTAGCGATCTGCAGCCAGGATCATCTCGGCTGCCT
TTTCCGCGATCATGATCGTC

Product: B12-dependent methionine synthase

Products: NA

Alternate protein names: 5-methyltetrahydrofolate--homocysteine methyltransferase; Methionine synthase, vitamin-B12 dependent; MS [H]

Number of amino acids: Translated: 1257; Mature: 1256

Protein sequence:

>1257_residues
MSASDDLFGHVSPKPDGSEIFRQLAQAAAERILIMDGAMGTEIQQLGFVEDHFRGERFGACNCHQQGNNDLLTLTQPKAI
EEIHYHYAIAGADILETNTFSSTRIAQADYGMEDMVYDLNRDGARLARRAARRAEAEDGRRRFVAGALGPTNRTASISPD
VNNPGYRAVSFDDLRLAYSEQVRGLIDGGADIILIETIFDTLNAKAAIFATQEVFAEKAVHLPIMISGTITDLSGRTLSG
QTPTAFWYSVRHASPFTIGLNCALGANAMRAHIDELSAIADTLVCAYPNAGLPNEFGQYDESPEQMAAQIEGFARDGLVN
VVGGCCGSTPAHIRAIAEAVAKYPPRRVPETERLMRLSGLEPFTLTDEIPFVNVGERTNVTGSAKFRKLITAGDYAAALE
VARDQVANGAQIIDVNMDEGLIDSKQVMVEFLNLVASEPDIARVPVMIDSSKWEVIEAGLKCVQGKALVNSISLKEGEEA
FLYHARLVRAYGAAVVVMAFDEKGQADTKTRKVEICRRAYRLLTEEVGFPPEDIIFDPNIFAVATGIEEHDNYGVDFIEA
THEIVAALPHVHISGGVSNLSFSFRGNEPVREAMHAVFLYHAIQAGMDMGIVNAGQLAVYDAIDAELREACEDVVLNRRS
DGTERLLEIAERYRGQGGSQGREKDLAWREWPVEKRLEHALVYGITEFIEADTEEARLSAERPLHVIEGPLMAGMNVVGD
LFGSGKMFLPQVVKSARVMKQAVAVLLPHMEAEKRANGGGEARESAGKILMATVKGDVHDIGKNIVGVVLACNNYEIIDL
GVMVSSARILEVAREQKVDIIGLSGLITPSLDEMAHVASELEREGFDLPLLIGGATTSRVHTAVKINPRYSLGQTVYVTD
ASRAVGVVSSLLSPEVRDGYKETIRAEYLKVAEAHARNEAEKRRLPLSQARANAVKIDWEAHRPKVPSFLGTRVFDGWDL
AELARYIDWTPFFQTWEMKGVYPRILDDEHQGAAARQLFEDAQAMLAQIVAEKWFAPKAVVGFWPAGSVGDDVRLFTDET
RKGELATLFTLRQQLVKRDGRPNVALADFVAPAESGKRDYAGAFVVTAGIEEVAIAERFERANDDYSSIMVKALADRFAE
AFAERMHEYVRKELWGYAADEAFTPQELIGEPYAGIRPAPGYPAQPDHTEKETLFRLLNAEAAIGVKLTESYAMWPGSSV
SGLYIGHPDSYYFGVAKIERDQVEDYAERKQMSVREVERWLSPVLNYVPAPEAEAAE

Sequences:

>Translated_1257_residues
MSASDDLFGHVSPKPDGSEIFRQLAQAAAERILIMDGAMGTEIQQLGFVEDHFRGERFGACNCHQQGNNDLLTLTQPKAI
EEIHYHYAIAGADILETNTFSSTRIAQADYGMEDMVYDLNRDGARLARRAARRAEAEDGRRRFVAGALGPTNRTASISPD
VNNPGYRAVSFDDLRLAYSEQVRGLIDGGADIILIETIFDTLNAKAAIFATQEVFAEKAVHLPIMISGTITDLSGRTLSG
QTPTAFWYSVRHASPFTIGLNCALGANAMRAHIDELSAIADTLVCAYPNAGLPNEFGQYDESPEQMAAQIEGFARDGLVN
VVGGCCGSTPAHIRAIAEAVAKYPPRRVPETERLMRLSGLEPFTLTDEIPFVNVGERTNVTGSAKFRKLITAGDYAAALE
VARDQVANGAQIIDVNMDEGLIDSKQVMVEFLNLVASEPDIARVPVMIDSSKWEVIEAGLKCVQGKALVNSISLKEGEEA
FLYHARLVRAYGAAVVVMAFDEKGQADTKTRKVEICRRAYRLLTEEVGFPPEDIIFDPNIFAVATGIEEHDNYGVDFIEA
THEIVAALPHVHISGGVSNLSFSFRGNEPVREAMHAVFLYHAIQAGMDMGIVNAGQLAVYDAIDAELREACEDVVLNRRS
DGTERLLEIAERYRGQGGSQGREKDLAWREWPVEKRLEHALVYGITEFIEADTEEARLSAERPLHVIEGPLMAGMNVVGD
LFGSGKMFLPQVVKSARVMKQAVAVLLPHMEAEKRANGGGEARESAGKILMATVKGDVHDIGKNIVGVVLACNNYEIIDL
GVMVSSARILEVAREQKVDIIGLSGLITPSLDEMAHVASELEREGFDLPLLIGGATTSRVHTAVKINPRYSLGQTVYVTD
ASRAVGVVSSLLSPEVRDGYKETIRAEYLKVAEAHARNEAEKRRLPLSQARANAVKIDWEAHRPKVPSFLGTRVFDGWDL
AELARYIDWTPFFQTWEMKGVYPRILDDEHQGAAARQLFEDAQAMLAQIVAEKWFAPKAVVGFWPAGSVGDDVRLFTDET
RKGELATLFTLRQQLVKRDGRPNVALADFVAPAESGKRDYAGAFVVTAGIEEVAIAERFERANDDYSSIMVKALADRFAE
AFAERMHEYVRKELWGYAADEAFTPQELIGEPYAGIRPAPGYPAQPDHTEKETLFRLLNAEAAIGVKLTESYAMWPGSSV
SGLYIGHPDSYYFGVAKIERDQVEDYAERKQMSVREVERWLSPVLNYVPAPEAEAAE
>Mature_1256_residues
SASDDLFGHVSPKPDGSEIFRQLAQAAAERILIMDGAMGTEIQQLGFVEDHFRGERFGACNCHQQGNNDLLTLTQPKAIE
EIHYHYAIAGADILETNTFSSTRIAQADYGMEDMVYDLNRDGARLARRAARRAEAEDGRRRFVAGALGPTNRTASISPDV
NNPGYRAVSFDDLRLAYSEQVRGLIDGGADIILIETIFDTLNAKAAIFATQEVFAEKAVHLPIMISGTITDLSGRTLSGQ
TPTAFWYSVRHASPFTIGLNCALGANAMRAHIDELSAIADTLVCAYPNAGLPNEFGQYDESPEQMAAQIEGFARDGLVNV
VGGCCGSTPAHIRAIAEAVAKYPPRRVPETERLMRLSGLEPFTLTDEIPFVNVGERTNVTGSAKFRKLITAGDYAAALEV
ARDQVANGAQIIDVNMDEGLIDSKQVMVEFLNLVASEPDIARVPVMIDSSKWEVIEAGLKCVQGKALVNSISLKEGEEAF
LYHARLVRAYGAAVVVMAFDEKGQADTKTRKVEICRRAYRLLTEEVGFPPEDIIFDPNIFAVATGIEEHDNYGVDFIEAT
HEIVAALPHVHISGGVSNLSFSFRGNEPVREAMHAVFLYHAIQAGMDMGIVNAGQLAVYDAIDAELREACEDVVLNRRSD
GTERLLEIAERYRGQGGSQGREKDLAWREWPVEKRLEHALVYGITEFIEADTEEARLSAERPLHVIEGPLMAGMNVVGDL
FGSGKMFLPQVVKSARVMKQAVAVLLPHMEAEKRANGGGEARESAGKILMATVKGDVHDIGKNIVGVVLACNNYEIIDLG
VMVSSARILEVAREQKVDIIGLSGLITPSLDEMAHVASELEREGFDLPLLIGGATTSRVHTAVKINPRYSLGQTVYVTDA
SRAVGVVSSLLSPEVRDGYKETIRAEYLKVAEAHARNEAEKRRLPLSQARANAVKIDWEAHRPKVPSFLGTRVFDGWDLA
ELARYIDWTPFFQTWEMKGVYPRILDDEHQGAAARQLFEDAQAMLAQIVAEKWFAPKAVVGFWPAGSVGDDVRLFTDETR
KGELATLFTLRQQLVKRDGRPNVALADFVAPAESGKRDYAGAFVVTAGIEEVAIAERFERANDDYSSIMVKALADRFAEA
FAERMHEYVRKELWGYAADEAFTPQELIGEPYAGIRPAPGYPAQPDHTEKETLFRLLNAEAAIGVKLTESYAMWPGSSVS
GLYIGHPDSYYFGVAKIERDQVEDYAERKQMSVREVERWLSPVLNYVPAPEAEAAE

Specific function: Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate [H]

COG id: COG1410

COG function: function code E; Methionine synthase I, cobalamin-binding domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Homo sapiens, GI169790923, Length=1241, Percent_Identity=56.2449637389202, Blast_Score=1365, Evalue=0.0,
Organism=Escherichia coli, GI1790450, Length=1227, Percent_Identity=62.0211898940505, Blast_Score=1509, Evalue=0.0,
Organism=Escherichia coli, GI1786456, Length=320, Percent_Identity=26.25, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17535405, Length=1247, Percent_Identity=53.4883720930233, Blast_Score=1296, Evalue=0.0,

Paralogues:

None

Copy number: 513 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 1320 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006158
- InterPro:   IPR011005
- InterPro:   IPR003759
- InterPro:   IPR011822
- InterPro:   IPR000489
- InterPro:   IPR003726
- InterPro:   IPR004223 [H]

Pfam domain/function: PF02310 B12-binding; PF02607 B12-binding_2; PF02965 Met_synt_B12; PF00809 Pterin_bind; PF02574 S-methyl_trans [H]

EC number: =2.1.1.13 [H]

Molecular weight: Translated: 138095; Mature: 137964

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS50974 ADOMET_ACTIVATION ; PS50970 HCY ; PS50972 PTERIN_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASDDLFGHVSPKPDGSEIFRQLAQAAAERILIMDGAMGTEIQQLGFVEDHFRGERFGA
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHCEEEEECCCCCCHHHHHCCHHHHHCCCCCCC
CNCHQQGNNDLLTLTQPKAIEEIHYHYAIAGADILETNTFSSTRIAQADYGMEDMVYDLN
CCCCCCCCCCEEEECCCHHHHHHHHHHEEECCHHEECCCCCCCEEECCCCCHHHHHHHCC
RDGARLARRAARRAEAEDGRRRFVAGALGPTNRTASISPDVNNPGYRAVSFDDLRLAYSE
CCHHHHHHHHHHHCCHHCCHHEEEEECCCCCCCCEEECCCCCCCCCEEEEHHHHHHHHHH
QVRGLIDGGADIILIETIFDTLNAKAAIFATQEVFAEKAVHLPIMISGTITDLSGRTLSG
HHHHHHCCCCCEEEHHHHHHHHCCCEEEEEHHHHHHHHHCCCEEEEECEEECCCCCEECC
QTPTAFWYSVRHASPFTIGLNCALGANAMRAHIDELSAIADTLVCAYPNAGLPNEFGQYD
CCCCEEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHCCC
ESPEQMAAQIEGFARDGLVNVVGGCCGSTPAHIRAIAEAVAKYPPRRVPETERLMRLSGL
CCHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCC
EPFTLTDEIPFVNVGERTNVTGSAKFRKLITAGDYAAALEVARDQVANGAQIIDVNMDEG
CCEEECCCCCEEECCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEECCCCC
LIDSKQVMVEFLNLVASEPDIARVPVMIDSSKWEVIEAGLKCVQGKALVNSISLKEGEEA
CCCHHHHHHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHCCHHHHHHCCCCCCCHH
FLYHARLVRAYGAAVVVMAFDEKGQADTKTRKVEICRRAYRLLTEEVGFPPEDIIFDPNI
HHHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHEEECCCE
FAVATGIEEHDNYGVDFIEATHEIVAALPHVHISGGVSNLSFSFRGNEPVREAMHAVFLY
EEEEECCHHCCCCCCHHHHHHHHHHHHCCCEEEECCCCEEEEEECCCCHHHHHHHHHHHH
HAIQAGMDMGIVNAGQLAVYDAIDAELREACEDVVLNRRSDGTERLLEIAERYRGQGGSQ
HHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCC
GREKDLAWREWPVEKRLEHALVYGITEFIEADTEEARLSAERPLHVIEGPLMAGMNVVGD
CCCCCCCHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHCCHHHHHHHHHHH
LFGSGKMFLPQVVKSARVMKQAVAVLLPHMEAEKRANGGGEARESAGKILMATVKGDVHD
HHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHCCCCEEEEEECCCHHH
IGKNIVGVVLACNNYEIIDLGVMVSSARILEVAREQKVDIIGLSGLITPSLDEMAHVASE
HHHHHEEEEEEECCEEEEEEHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHH
LEREGFDLPLLIGGATTSRVHTAVKINPRYSLGQTVYVTDASRAVGVVSSLLSPEVRDGY
HHHCCCCCEEEECCCCCCCEEEEEEECCCCCCCCEEEEECCHHHHHHHHHHHCCHHHCCH
KETIRAEYLKVAEAHARNEAEKRRLPLSQARANAVKIDWEAHRPKVPSFLGTRVFDGWDL
HHHHHHHHHHHHHHHHHCHHHHHCCCHHHHCCCEEEEEECCCCCCCCHHHHHHHCCCCCH
AELARYIDWTPFFQTWEMKGVYPRILDDEHQGAAARQLFEDAQAMLAQIVAEKWFAPKAV
HHHHHHCCCCCCHHCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCE
VGFWPAGSVGDDVRLFTDETRKGELATLFTLRQQLVKRDGRPNVALADFVAPAESGKRDY
EEECCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEHHHHHCCCCCCCCCC
AGAFVVTAGIEEVAIAERFERANDDYSSIMVKALADRFAEAFAERMHEYVRKELWGYAAD
CCEEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
EAFTPQELIGEPYAGIRPAPGYPAQPDHTEKETLFRLLNAEAAIGVKLTESYAMWPGSSV
CCCCCHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHEEEEEECCEEECCCCCC
SGLYIGHPDSYYFGVAKIERDQVEDYAERKQMSVREVERWLSPVLNYVPAPEAEAAE
CEEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SASDDLFGHVSPKPDGSEIFRQLAQAAAERILIMDGAMGTEIQQLGFVEDHFRGERFGA
CCCCCCCCCCCCCCCHHHHHHHHHHHHHCEEEEECCCCCCHHHHHCCHHHHHCCCCCCC
CNCHQQGNNDLLTLTQPKAIEEIHYHYAIAGADILETNTFSSTRIAQADYGMEDMVYDLN
CCCCCCCCCCEEEECCCHHHHHHHHHHEEECCHHEECCCCCCCEEECCCCCHHHHHHHCC
RDGARLARRAARRAEAEDGRRRFVAGALGPTNRTASISPDVNNPGYRAVSFDDLRLAYSE
CCHHHHHHHHHHHCCHHCCHHEEEEECCCCCCCCEEECCCCCCCCCEEEEHHHHHHHHHH
QVRGLIDGGADIILIETIFDTLNAKAAIFATQEVFAEKAVHLPIMISGTITDLSGRTLSG
HHHHHHCCCCCEEEHHHHHHHHCCCEEEEEHHHHHHHHHCCCEEEEECEEECCCCCEECC
QTPTAFWYSVRHASPFTIGLNCALGANAMRAHIDELSAIADTLVCAYPNAGLPNEFGQYD
CCCCEEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHCCC
ESPEQMAAQIEGFARDGLVNVVGGCCGSTPAHIRAIAEAVAKYPPRRVPETERLMRLSGL
CCHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCC
EPFTLTDEIPFVNVGERTNVTGSAKFRKLITAGDYAAALEVARDQVANGAQIIDVNMDEG
CCEEECCCCCEEECCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEECCCCC
LIDSKQVMVEFLNLVASEPDIARVPVMIDSSKWEVIEAGLKCVQGKALVNSISLKEGEEA
CCCHHHHHHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHCCHHHHHHCCCCCCCHH
FLYHARLVRAYGAAVVVMAFDEKGQADTKTRKVEICRRAYRLLTEEVGFPPEDIIFDPNI
HHHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHEEECCCE
FAVATGIEEHDNYGVDFIEATHEIVAALPHVHISGGVSNLSFSFRGNEPVREAMHAVFLY
EEEEECCHHCCCCCCHHHHHHHHHHHHCCCEEEECCCCEEEEEECCCCHHHHHHHHHHHH
HAIQAGMDMGIVNAGQLAVYDAIDAELREACEDVVLNRRSDGTERLLEIAERYRGQGGSQ
HHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCC
GREKDLAWREWPVEKRLEHALVYGITEFIEADTEEARLSAERPLHVIEGPLMAGMNVVGD
CCCCCCCHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHCCHHHHHHHHHHH
LFGSGKMFLPQVVKSARVMKQAVAVLLPHMEAEKRANGGGEARESAGKILMATVKGDVHD
HHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHCCCCEEEEEECCCHHH
IGKNIVGVVLACNNYEIIDLGVMVSSARILEVAREQKVDIIGLSGLITPSLDEMAHVASE
HHHHHEEEEEEECCEEEEEEHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHH
LEREGFDLPLLIGGATTSRVHTAVKINPRYSLGQTVYVTDASRAVGVVSSLLSPEVRDGY
HHHCCCCCEEEECCCCCCCEEEEEEECCCCCCCCEEEEECCHHHHHHHHHHHCCHHHCCH
KETIRAEYLKVAEAHARNEAEKRRLPLSQARANAVKIDWEAHRPKVPSFLGTRVFDGWDL
HHHHHHHHHHHHHHHHHCHHHHHCCCHHHHCCCEEEEEECCCCCCCCHHHHHHHCCCCCH
AELARYIDWTPFFQTWEMKGVYPRILDDEHQGAAARQLFEDAQAMLAQIVAEKWFAPKAV
HHHHHHCCCCCCHHCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCE
VGFWPAGSVGDDVRLFTDETRKGELATLFTLRQQLVKRDGRPNVALADFVAPAESGKRDY
EEECCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEHHHHHCCCCCCCCCC
AGAFVVTAGIEEVAIAERFERANDDYSSIMVKALADRFAEAFAERMHEYVRKELWGYAAD
CCEEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
EAFTPQELIGEPYAGIRPAPGYPAQPDHTEKETLFRLLNAEAAIGVKLTESYAMWPGSSV
CCCCCHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHEEEEEECCEEECCCCCC
SGLYIGHPDSYYFGVAKIERDQVEDYAERKQMSVREVERWLSPVLNYVPAPEAEAAE
CEEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]