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The map label for this gene is vllY [H]

Identifier: 150398034

GI number: 150398034

Start: 2960806

End: 2961918

Strand: Direct

Name: vllY [H]

Synonym: Smed_2836

Alternate gene names: 150398034

Gene position: 2960806-2961918 (Clockwise)

Preceding gene: 150398032

Following gene: 150398036

Centisome position: 78.29

GC content: 59.39

Gene sequence:

>1113_bases
ATGGGCCCATTTCCACATGACGCACCGCCGCCGGCGATCTCGGCGGACAATCCCGCCGGAACCGACGGGTTCGAGTTCGT
CGAATTCGCCCATCCGGAACCGGAGAAGCTTGCGGAACTCTTCGGCCGCATGGGCTACGCACCGGTTGCCAGGCACAGGA
CGAAGGACATCACGATATGGCGACAGGGCGACATCAACTATGTCCTGAATGCTGAAGCCGGCTCGCATGCCATGCGCTTC
GTCGGAGAACACGGGCCCTGCGCCCCGTCGATGGCCTGGCGCGTCGTCGACGCGAAGCATGCCTTCGAGCACGCCGTATC
GAACGGCGCCGAGGCCTATACCGGCAACGACAAGAGCCTGGACGTACCGGCGATCGTCGGCATCGGCGGCTCGCTTCTCT
ATTTCGTGGAAGTTTACGGCGAGAAAGGGTCCGCTTACGATGCCGAGTTCGAATGGCTGCGCGAGCGTGATCCGAAGCCG
GCCGGCGTCGGCTTCTATTATCTCGACCACCTGACCCACAATGTCTATCGCGGCAATATGGACAAGTGGTGGGCCTTCTA
TCGCGAACTGTTCAATTTCAAACAGATCCATTTCTTCGACATCGACGGCCGCATCACCGGCCTCGTCAGCCGGGCGATCA
CCTCACCTTGCGGCAAGATTCGCATCCCACTGAACGAATCGAAGGACGACACCAGCCAGATCGAGGAATATCTGACGAAG
TACAAAGGCGAAGGCATACAGCACATCGCGGTCGGTACCGAGGCGATCTACGATGCGACCGACAAACTCGCGGCAAACGG
TCTGAAGTTCATGCCGGGACCGCCTGAAACCTATTATGAGATGTCCCACCAGCGCGTTCGCGGACACGACGAACCGATCG
ACCGGATGAAGAAACATGGCATCCTGATCGATGGAGAGGGTGTGGTGAATGGCGGCATGACGAAGATTCTGCTGCAGATC
TTCTCGCGCACCGTGATCGGACCAATCTTCTTCGAATTCATTCAGCGCAAGGGTGACGAAGGCTTCGGCGAGGGCAACTT
CAGAGCATTGTTCGAATCGATCGAGGCCGACCAGATCCGCCGCGGCGTACTTGGCCACGAGGCGGCCGAGTAG

Upstream 100 bases:

>100_bases
TTTCATGCAGAGATTCCGCTGAATCGCGCAAGAATACAAGCAACATGCATCGGAATTGCGTCATAATCCAGCAGAGTTTG
GACGTTGGAGGAGACTGACG

Downstream 100 bases:

>100_bases
AGCATGACCGGGAAAATACCGCCGCGAACGTGAGGCAACCGCGCGGCCGCGTAAAGGCCGCGCGGCTCCGGATGGCTGTC
AATTGCGCCAGCGCGTCGGC

Product: 4-hydroxyphenylpyruvate dioxygenase

Products: homogentisate; CO2

Alternate protein names: NA

Number of amino acids: Translated: 370; Mature: 369

Protein sequence:

>370_residues
MGPFPHDAPPPAISADNPAGTDGFEFVEFAHPEPEKLAELFGRMGYAPVARHRTKDITIWRQGDINYVLNAEAGSHAMRF
VGEHGPCAPSMAWRVVDAKHAFEHAVSNGAEAYTGNDKSLDVPAIVGIGGSLLYFVEVYGEKGSAYDAEFEWLRERDPKP
AGVGFYYLDHLTHNVYRGNMDKWWAFYRELFNFKQIHFFDIDGRITGLVSRAITSPCGKIRIPLNESKDDTSQIEEYLTK
YKGEGIQHIAVGTEAIYDATDKLAANGLKFMPGPPETYYEMSHQRVRGHDEPIDRMKKHGILIDGEGVVNGGMTKILLQI
FSRTVIGPIFFEFIQRKGDEGFGEGNFRALFESIEADQIRRGVLGHEAAE

Sequences:

>Translated_370_residues
MGPFPHDAPPPAISADNPAGTDGFEFVEFAHPEPEKLAELFGRMGYAPVARHRTKDITIWRQGDINYVLNAEAGSHAMRF
VGEHGPCAPSMAWRVVDAKHAFEHAVSNGAEAYTGNDKSLDVPAIVGIGGSLLYFVEVYGEKGSAYDAEFEWLRERDPKP
AGVGFYYLDHLTHNVYRGNMDKWWAFYRELFNFKQIHFFDIDGRITGLVSRAITSPCGKIRIPLNESKDDTSQIEEYLTK
YKGEGIQHIAVGTEAIYDATDKLAANGLKFMPGPPETYYEMSHQRVRGHDEPIDRMKKHGILIDGEGVVNGGMTKILLQI
FSRTVIGPIFFEFIQRKGDEGFGEGNFRALFESIEADQIRRGVLGHEAAE
>Mature_369_residues
GPFPHDAPPPAISADNPAGTDGFEFVEFAHPEPEKLAELFGRMGYAPVARHRTKDITIWRQGDINYVLNAEAGSHAMRFV
GEHGPCAPSMAWRVVDAKHAFEHAVSNGAEAYTGNDKSLDVPAIVGIGGSLLYFVEVYGEKGSAYDAEFEWLRERDPKPA
GVGFYYLDHLTHNVYRGNMDKWWAFYRELFNFKQIHFFDIDGRITGLVSRAITSPCGKIRIPLNESKDDTSQIEEYLTKY
KGEGIQHIAVGTEAIYDATDKLAANGLKFMPGPPETYYEMSHQRVRGHDEPIDRMKKHGILIDGEGVVNGGMTKILLQIF
SRTVIGPIFFEFIQRKGDEGFGEGNFRALFESIEADQIRRGVLGHEAAE

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI4504477, Length=356, Percent_Identity=27.8089887640449, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI285002264, Length=354, Percent_Identity=27.9661016949153, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI14249394, Length=378, Percent_Identity=24.8677248677249, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17555220, Length=324, Percent_Identity=32.4074074074074, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17550752, Length=307, Percent_Identity=25.0814332247557, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24667510, Length=335, Percent_Identity=31.044776119403, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI21356105, Length=305, Percent_Identity=31.1475409836066, Blast_Score=109, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: 1.13.11.27

Molecular weight: Translated: 41347; Mature: 41216

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGPFPHDAPPPAISADNPAGTDGFEFVEFAHPEPEKLAELFGRMGYAPVARHRTKDITIW
CCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHCCCCHHHHCCCCCEEEE
RQGDINYVLNAEAGSHAMRFVGEHGPCAPSMAWRVVDAKHAFEHAVSNGAEAYTGNDKSL
EECCCCEEEECCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEECCCCCCC
DVPAIVGIGGSLLYFVEVYGEKGSAYDAEFEWLRERDPKPAGVGFYYLDHLTHNVYRGNM
CCCEEECCCCCEEEEEEEECCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCH
DKWWAFYRELFNFKQIHFFDIDGRITGLVSRAITSPCGKIRIPLNESKDDTSQIEEYLTK
HHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHH
YKGEGIQHIAVGTEAIYDATDKLAANGLKFMPGPPETYYEMSHQRVRGHDEPIDRMKKHG
HCCCCEEEEEECHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHCC
ILIDGEGVVNGGMTKILLQIFSRTVIGPIFFEFIQRKGDEGFGEGNFRALFESIEADQIR
EEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
RGVLGHEAAE
HHHCCCCCCC
>Mature Secondary Structure 
GPFPHDAPPPAISADNPAGTDGFEFVEFAHPEPEKLAELFGRMGYAPVARHRTKDITIW
CCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHCCCCHHHHCCCCCEEEE
RQGDINYVLNAEAGSHAMRFVGEHGPCAPSMAWRVVDAKHAFEHAVSNGAEAYTGNDKSL
EECCCCEEEECCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEECCCCCCC
DVPAIVGIGGSLLYFVEVYGEKGSAYDAEFEWLRERDPKPAGVGFYYLDHLTHNVYRGNM
CCCEEECCCCCEEEEEEEECCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCH
DKWWAFYRELFNFKQIHFFDIDGRITGLVSRAITSPCGKIRIPLNESKDDTSQIEEYLTK
HHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHH
YKGEGIQHIAVGTEAIYDATDKLAANGLKFMPGPPETYYEMSHQRVRGHDEPIDRMKKHG
HCCCCEEEEEECHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHCC
ILIDGEGVVNGGMTKILLQIFSRTVIGPIFFEFIQRKGDEGFGEGNFRALFESIEADQIR
EEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
RGVLGHEAAE
HHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-hydroxyphenylpyruvate; O2

Specific reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA