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The map label for this gene is hmgA [H]

Identifier: 150398031

GI number: 150398031

Start: 2958275

End: 2959636

Strand: Reverse

Name: hmgA [H]

Synonym: Smed_2833

Alternate gene names: 150398031

Gene position: 2959636-2958275 (Counterclockwise)

Preceding gene: 150398033

Following gene: 150398030

Centisome position: 78.26

GC content: 61.82

Gene sequence:

>1362_bases
ATGTTGGAGAAGGCGGAAAGGCAGCGGAAGGCGGCCCCGGATCAGCAGCGCTCCGCCGGCTACATGCCGGGATTTGGCAA
CGACTTCGAGACGGAGAGCCTGCCCGGATCGCTGCCGCAGGGGCAGAACAGCCCGCAGAAGTGCAACTACGGCCTCTATG
CCGAACAGCTTTCCGGATCGCCCTTCACTGCACCGCGCGGCACCAATGAGCGCTCGTGGCTCTACCGCATCCGTCCAAGC
GTCCGGCATACGGGGCGCTTCACGAAGATCGATTATCCGCATTGGAAGACGGCGCCGCATACGCCAGAGCATTCCCTGGC
GCTCGGGCAATTGCGCTGGAGCCCTTTGCCGGCCCCCTCGCAGAGCCTGACCTTTCTTCAGGGTATACGCACCATGACGA
CCGCGGGCGACGCGCTGACGCAGGTCGGCATGGCCGCACATGCCTATGCCTTCAATGCCGATATGGTGGACGACTATTTC
TTCAACGCCGATGGCGAGCTGCTGATCGTTCCGGAAACGGGGGCATTCCAGGTCTTCACCGAACTCGGCAGGATCGACGT
GGAGCCGTCGGAAATCTGCCTCGTACCGCGGGGCATGATGTTCAAGGTTACACGCCTCGGCGATGAGAAGGTCTGGCGCG
GCTATATCTGCGAGAATTACGGAGCGAAGTTCACGCTGCCGGACCGCGGACCGATCGGCGCCAATTGCCTGGCCAATCCG
CGCGACTTCAAGACGCCGGTCGCCGCCTACGAGGACAAGGAGACGCCCTGCCGCGTACAGGTGAAATGGTGCGGCTCCTT
TCATACGGCCGAGATCGCCCACTCACCGCTCGATGTCGTCGCCTGGCATGGCAATTATGCGCCCTACAAATACGACCTCA
AGACCTTCTCACCTGTCGGTGCGATCCTGTTCGATCATCCCGACCCGTCGATCTTCACGGTGCTGACCGCGCCGTCCGGG
GAGGAAGGGACGGCCAATGTCGACTTCGTCATATTCCCGCCGCGCTGGCTGGTCGCCGAGCATACGTTCCGCCCGCCCTG
GTATCACCGCAACATCATGAGCGAGTTCATGGGCCTTATCCACGGGCGCTACGATGCGAAGGAGGAGGGTTTCGTGCCGG
GTGGCATGAGCCTGCACAACATGATGCTGGCGCACGGTCCGGATTTTTCCGGCTTCGAAAAGGCGTCGAACGGCGAACTG
AAGCCGGTAAAGCTCGACAACACCATGGCCTTCATGTTCGAAACCCGTTTCCCCCAGCAGCTGACGACGTTTGCCGCCGA
GCTCGAGACGCTGCAGGACGACTACATCGATTGCTGGTCAGGCCTCGAGCGCAAATTCGACGGCACTCCCGGAATCAAGT
GA

Upstream 100 bases:

>100_bases
CAGTTCGAACCGGTTCTCGGCCATGCTTCCTTCCTTGATAGTTACAAAATCGATAGTTACGATCGTAACTAATAGTCGAC
GGGAAGAGGAGGCTCAACCC

Downstream 100 bases:

>100_bases
CTTCCGCCGGCAAATCGTGACATGCTGCCGAAACGGGCAAAAAAATCTGCGCCGTCCGGCGCGGAGCAACAACGCATCGG
GAAACACCAATCCATGAAAC

Product: homogentisate 1,2-dioxygenase

Products: NA

Alternate protein names: Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase [H]

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MLEKAERQRKAAPDQQRSAGYMPGFGNDFETESLPGSLPQGQNSPQKCNYGLYAEQLSGSPFTAPRGTNERSWLYRIRPS
VRHTGRFTKIDYPHWKTAPHTPEHSLALGQLRWSPLPAPSQSLTFLQGIRTMTTAGDALTQVGMAAHAYAFNADMVDDYF
FNADGELLIVPETGAFQVFTELGRIDVEPSEICLVPRGMMFKVTRLGDEKVWRGYICENYGAKFTLPDRGPIGANCLANP
RDFKTPVAAYEDKETPCRVQVKWCGSFHTAEIAHSPLDVVAWHGNYAPYKYDLKTFSPVGAILFDHPDPSIFTVLTAPSG
EEGTANVDFVIFPPRWLVAEHTFRPPWYHRNIMSEFMGLIHGRYDAKEEGFVPGGMSLHNMMLAHGPDFSGFEKASNGEL
KPVKLDNTMAFMFETRFPQQLTTFAAELETLQDDYIDCWSGLERKFDGTPGIK

Sequences:

>Translated_453_residues
MLEKAERQRKAAPDQQRSAGYMPGFGNDFETESLPGSLPQGQNSPQKCNYGLYAEQLSGSPFTAPRGTNERSWLYRIRPS
VRHTGRFTKIDYPHWKTAPHTPEHSLALGQLRWSPLPAPSQSLTFLQGIRTMTTAGDALTQVGMAAHAYAFNADMVDDYF
FNADGELLIVPETGAFQVFTELGRIDVEPSEICLVPRGMMFKVTRLGDEKVWRGYICENYGAKFTLPDRGPIGANCLANP
RDFKTPVAAYEDKETPCRVQVKWCGSFHTAEIAHSPLDVVAWHGNYAPYKYDLKTFSPVGAILFDHPDPSIFTVLTAPSG
EEGTANVDFVIFPPRWLVAEHTFRPPWYHRNIMSEFMGLIHGRYDAKEEGFVPGGMSLHNMMLAHGPDFSGFEKASNGEL
KPVKLDNTMAFMFETRFPQQLTTFAAELETLQDDYIDCWSGLERKFDGTPGIK
>Mature_453_residues
MLEKAERQRKAAPDQQRSAGYMPGFGNDFETESLPGSLPQGQNSPQKCNYGLYAEQLSGSPFTAPRGTNERSWLYRIRPS
VRHTGRFTKIDYPHWKTAPHTPEHSLALGQLRWSPLPAPSQSLTFLQGIRTMTTAGDALTQVGMAAHAYAFNADMVDDYF
FNADGELLIVPETGAFQVFTELGRIDVEPSEICLVPRGMMFKVTRLGDEKVWRGYICENYGAKFTLPDRGPIGANCLANP
RDFKTPVAAYEDKETPCRVQVKWCGSFHTAEIAHSPLDVVAWHGNYAPYKYDLKTFSPVGAILFDHPDPSIFTVLTAPSG
EEGTANVDFVIFPPRWLVAEHTFRPPWYHRNIMSEFMGLIHGRYDAKEEGFVPGGMSLHNMMLAHGPDFSGFEKASNGEL
KPVKLDNTMAFMFETRFPQQLTTFAAELETLQDDYIDCWSGLERKFDGTPGIK

Specific function: Unknown

COG id: COG3508

COG function: function code Q; Homogentisate 1,2-dioxygenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homogentisate dioxygenase family [H]

Homologues:

Organism=Homo sapiens, GI115527117, Length=439, Percent_Identity=50.5694760820046, Blast_Score=419, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17507969, Length=435, Percent_Identity=51.7241379310345, Blast_Score=435, Evalue=1e-122,
Organism=Drosophila melanogaster, GI24583650, Length=441, Percent_Identity=49.8866213151927, Blast_Score=416, Evalue=1e-116,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR005708
- InterPro:   IPR022950 [H]

Pfam domain/function: PF04209 HgmA [H]

EC number: =1.13.11.5 [H]

Molecular weight: Translated: 50786; Mature: 50786

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEKAERQRKAAPDQQRSAGYMPGFGNDFETESLPGSLPQGQNSPQKCNYGLYAEQLSGS
CCCHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHCCCC
PFTAPRGTNERSWLYRIRPSVRHTGRFTKIDYPHWKTAPHTPEHSLALGQLRWSPLPAPS
CCCCCCCCCCCCEEEEECCCHHHCCCEEEECCCCCCCCCCCCCCCEEEECEECCCCCCCC
QSLTFLQGIRTMTTAGDALTQVGMAAHAYAFNADMVDDYFFNADGELLIVPETGAFQVFT
HHHHHHHHHHHHHHCCHHHHHHHHHHHEEEECCCCHHHEEECCCCCEEEEECCCHHHHHH
ELGRIDVEPSEICLVPRGMMFKVTRLGDEKVWRGYICENYGAKFTLPDRGPIGANCLANP
HHCCCCCCCCCEEEECCCCEEEEEECCCHHHHCCEEECCCCCEEECCCCCCCCCCCCCCC
RDFKTPVAAYEDKETPCRVQVKWCGSFHTAEIAHSPLDVVAWHGNYAPYKYDLKTFSPVG
HHCCCCCCCCCCCCCCEEEEEEECCCCCCHHHCCCCCEEEEECCCCCCEEECCCCCCCCC
AILFDHPDPSIFTVLTAPSGEEGTANVDFVIFPPRWLVAEHTFRPPWYHRNIMSEFMGLI
EEEEECCCCCEEEEEECCCCCCCCCEEEEEEECCCEEEECCCCCCCHHHHHHHHHHHHHH
HGRYDAKEEGFVPGGMSLHNMMLAHGPDFSGFEKASNGELKPVKLDNTMAFMFETRFPQQ
HCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEEEEEEECCCHHH
LTTFAAELETLQDDYIDCWSGLERKFDGTPGIK
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MLEKAERQRKAAPDQQRSAGYMPGFGNDFETESLPGSLPQGQNSPQKCNYGLYAEQLSGS
CCCHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHCCCC
PFTAPRGTNERSWLYRIRPSVRHTGRFTKIDYPHWKTAPHTPEHSLALGQLRWSPLPAPS
CCCCCCCCCCCCEEEEECCCHHHCCCEEEECCCCCCCCCCCCCCCEEEECEECCCCCCCC
QSLTFLQGIRTMTTAGDALTQVGMAAHAYAFNADMVDDYFFNADGELLIVPETGAFQVFT
HHHHHHHHHHHHHHCCHHHHHHHHHHHEEEECCCCHHHEEECCCCCEEEEECCCHHHHHH
ELGRIDVEPSEICLVPRGMMFKVTRLGDEKVWRGYICENYGAKFTLPDRGPIGANCLANP
HHCCCCCCCCCEEEECCCCEEEEEECCCHHHHCCEEECCCCCEEECCCCCCCCCCCCCCC
RDFKTPVAAYEDKETPCRVQVKWCGSFHTAEIAHSPLDVVAWHGNYAPYKYDLKTFSPVG
HHCCCCCCCCCCCCCCEEEEEEECCCCCCHHHCCCCCEEEEECCCCCCEEECCCCCCCCC
AILFDHPDPSIFTVLTAPSGEEGTANVDFVIFPPRWLVAEHTFRPPWYHRNIMSEFMGLI
EEEEECCCCCEEEEEECCCCCCCCCEEEEEEECCCEEEECCCCCCCHHHHHHHHHHHHHH
HGRYDAKEEGFVPGGMSLHNMMLAHGPDFSGFEKASNGELKPVKLDNTMAFMFETRFPQQ
HCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEEEEEEECCCHHH
LTTFAAELETLQDDYIDCWSGLERKFDGTPGIK
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10220173; 11481430 [H]