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The map label for this gene is ung [H]

Identifier: 150398018

GI number: 150398018

Start: 2944719

End: 2945444

Strand: Reverse

Name: ung [H]

Synonym: Smed_2820

Alternate gene names: 150398018

Gene position: 2945444-2944719 (Counterclockwise)

Preceding gene: 150398022

Following gene: 150398017

Centisome position: 77.88

GC content: 63.22

Gene sequence:

>726_bases
ATGGATTCGACGATACGGCTGGAAGAGAGCTGGAAAGCGGCCCTCGGCCCCGAGTTCCGCAACGGCTACATGACCGAGCT
CAAGCGTTTCCTGCTGGACGAAAAGCAACAGGGCCGACAGGTTTTTCCGAGGGGTGGCGAATATTTTCGCGCGCTCGATC
TTACCCCCCTCGACAGGGTTCGTGTCGTGATCCTCGGTCAGGATCCATATCATGGCGACGGGCAGGCGCACGGCCTCTGC
TTCAGTGTTCGTCCCGGCGTGCGTACACCGCCTTCGCTCGTCAACATCTACAAGGAGCTCAAGGAAGACCTCGGCATAGA
TCCGGCGCGCCACGGTTTTCTCGAAAGCTGGGCGCGCCAGGGCGTGTTGCTGCTGAACAGCGTGCTAACGGTGGAGCGCG
GCCGGGCGGCTTCGCATCAGGGCAGAGGATGGGAACGCTTTACCGATGCGGTCATCCGCGCCGTCAATGAGCAGGCGCAG
CCCGTCGTCTTCATGCTCTGGGGCTCTTATGCGCAACGCAAGGCGGCGTTCGTCGACCGCTCGCGCCATCTCGTGCTCAC
GGCGCCGCATCCGTCACCGCTTTCGGCGCATTCGGGCTTCTTCGGCTGCCGGCATTTCTCCAAGGCGAATGCCTTTCTCA
CGTCCAAGGGGCTCGACCCGATCGACTGGCGGTTGCCGGAAGATCCGCCCCTGGCAGTGGAACGGCCGACGCCGCCGAAC
TGCTGA

Upstream 100 bases:

>100_bases
ATCGAACGGTGAGGCAATGGGGCGAAGATTGCGCGACCGCTTGCGATAGACGCTCATGCGTCTAAATTCTGCAACGAGAG
CAAGCGAGGTGACGACCCAT

Downstream 100 bases:

>100_bases
CGCCCTCGTTCCGGCGCCCGTCGCGAATGGACCTTGCGCCCCCGGCTCCGATCCGTCAAAGACTGGCCCGAATAGGCAGG
CGACGCGATGGGAGACGGCA

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG [H]

Number of amino acids: Translated: 241; Mature: 241

Protein sequence:

>241_residues
MDSTIRLEESWKAALGPEFRNGYMTELKRFLLDEKQQGRQVFPRGGEYFRALDLTPLDRVRVVILGQDPYHGDGQAHGLC
FSVRPGVRTPPSLVNIYKELKEDLGIDPARHGFLESWARQGVLLLNSVLTVERGRAASHQGRGWERFTDAVIRAVNEQAQ
PVVFMLWGSYAQRKAAFVDRSRHLVLTAPHPSPLSAHSGFFGCRHFSKANAFLTSKGLDPIDWRLPEDPPLAVERPTPPN
C

Sequences:

>Translated_241_residues
MDSTIRLEESWKAALGPEFRNGYMTELKRFLLDEKQQGRQVFPRGGEYFRALDLTPLDRVRVVILGQDPYHGDGQAHGLC
FSVRPGVRTPPSLVNIYKELKEDLGIDPARHGFLESWARQGVLLLNSVLTVERGRAASHQGRGWERFTDAVIRAVNEQAQ
PVVFMLWGSYAQRKAAFVDRSRHLVLTAPHPSPLSAHSGFFGCRHFSKANAFLTSKGLDPIDWRLPEDPPLAVERPTPPN
C
>Mature_241_residues
MDSTIRLEESWKAALGPEFRNGYMTELKRFLLDEKQQGRQVFPRGGEYFRALDLTPLDRVRVVILGQDPYHGDGQAHGLC
FSVRPGVRTPPSLVNIYKELKEDLGIDPARHGFLESWARQGVLLLNSVLTVERGRAASHQGRGWERFTDAVIRAVNEQAQ
PVVFMLWGSYAQRKAAFVDRSRHLVLTAPHPSPLSAHSGFFGCRHFSKANAFLTSKGLDPIDWRLPEDPPLAVERPTPPN
C

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine [H]

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI19718751, Length=218, Percent_Identity=53.2110091743119, Blast_Score=229, Evalue=2e-60,
Organism=Homo sapiens, GI6224979, Length=218, Percent_Identity=53.2110091743119, Blast_Score=228, Evalue=4e-60,
Organism=Escherichia coli, GI1788934, Length=217, Percent_Identity=55.2995391705069, Blast_Score=248, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI17556304, Length=217, Percent_Identity=48.8479262672811, Blast_Score=227, Evalue=5e-60,
Organism=Saccharomyces cerevisiae, GI6323620, Length=236, Percent_Identity=41.1016949152542, Blast_Score=172, Evalue=6e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.27 [H]

Molecular weight: Translated: 27138; Mature: 27138

Theoretical pI: Translated: 9.18; Mature: 9.18

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSTIRLEESWKAALGPEFRNGYMTELKRFLLDEKQQGRQVFPRGGEYFRALDLTPLDRV
CCCCEECHHHHHHHCCCHHCCCHHHHHHHHHHCCHHCCCCCCCCCCCEEEEECCCCCCCE
RVVILGQDPYHGDGQAHGLCFSVRPGVRTPPSLVNIYKELKEDLGIDPARHGFLESWARQ
EEEEEECCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHC
GVLLLNSVLTVERGRAASHQGRGWERFTDAVIRAVNEQAQPVVFMLWGSYAQRKAAFVDR
CHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHCC
SRHLVLTAPHPSPLSAHSGFFGCRHFSKANAFLTSKGLDPIDWRLPEDPPLAVERPTPPN
CCEEEEECCCCCCCCCCCCCHHHHHHHHHCCEEECCCCCCCCCCCCCCCCCEEECCCCCC
C
C
>Mature Secondary Structure
MDSTIRLEESWKAALGPEFRNGYMTELKRFLLDEKQQGRQVFPRGGEYFRALDLTPLDRV
CCCCEECHHHHHHHCCCHHCCCHHHHHHHHHHCCHHCCCCCCCCCCCEEEEECCCCCCCE
RVVILGQDPYHGDGQAHGLCFSVRPGVRTPPSLVNIYKELKEDLGIDPARHGFLESWARQ
EEEEEECCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHC
GVLLLNSVLTVERGRAASHQGRGWERFTDAVIRAVNEQAQPVVFMLWGSYAQRKAAFVDR
CHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHCC
SRHLVLTAPHPSPLSAHSGFFGCRHFSKANAFLTSKGLDPIDWRLPEDPPLAVERPTPPN
CCEEEEECCCCCCCCCCCCCHHHHHHHHHCCEEECCCCCCCCCCCCCCCCCEEECCCCCC
C
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]