Click here to switch to the map view.

The map label for this gene is ldc [H]

Identifier: 150397970

GI number: 150397970

Start: 2891376

End: 2892509

Strand: Reverse

Name: ldc [H]

Synonym: Smed_2772

Alternate gene names: 150397970

Gene position: 2892509-2891376 (Counterclockwise)

Preceding gene: 150397974

Following gene: 150397969

Centisome position: 76.48

GC content: 62.79

Gene sequence:

>1134_bases
ATGACCACCGCACGTATCATCGACTTCCTCAACACCCGACGCCCGGAAGGTCCTTGCCTCGTCGTCGACCTCGACGTCGT
GCGCGATAATTTCAAGGCCTTCCGGCATGCCTTGCCCGACAGCGCAATCTACTATGCCGTGAAGGCGAATCCGGCGCCGG
AAGTTCTGCGTCTCCTCGCCAGTCTCGGCTCCAACTTCGATTGCGCGTCCGTCGCCGAAATCGAAATGGCCCTCGACGCT
GGCGCGACCCCGAACCGCATTTCCTATGGCAACACCATCAAGAAGGAGCGGGACGTTGCGCGCGCCCATACGCTGGGGAT
CAGCCTCTTTGCGGTGGACAGCCACGAAGAGGTCGAGAAGATCGCGCGCGCCGCTCCCGGTGCCCGAGTCTTCTGCCGCG
TGCTGACCGATGGCGAAGGCGCCGAATGGCCTCTGTCGCGCAAATTCGGCTGCGTGCCGCAGATGGCGGTCGACGTGCTC
GTCTATGCACACCAGCTCGGACTGGCATCCTACGGTGTTTCGTTCCATGTCGGCTCGCAGATGACGAAGCTCGATGCCTG
GGACGCGGCTCTTGCCGATGCCAAGCGGGTGTTCGTCCAGCTTGCCAAGCAGGGCATCGAGCTCAAGATGGTCAACATGG
GCGGCGGCTTCCCGACCAAATATCTCCGGGACGTTCCCTCGGCCGAGGCCTATGGCCAGGCGATCTTCGGCGCGCTGAAG
AAGCACTTCGGCAACAACATTCCGGAGACGATCATCGAGCCGGGCCGCGGCATGGTGGGCAATGCCGGCGTGATCAAGGC
GGAAGTCGTTCTCGTGTCGAAGAAGTCGGACAATGACAGCCACCGCTGGGTCTTTCTCGACATCGGCAAATTCGGCGGCC
TCGCCGAGACGATGGACGAGGCGATCCGCTATCCGATTCGCACCGCGCGCGATGCCGATGCGATGGAGCCCTGCGTGCTC
GCCGGGCCGACCTGCGACTCGGCCGACGTGCTCTACGAGAAGAACATGTATCCGCTGCCGATCTCGCTGACGATCGGCGA
CGAGGTTCTGATCGAAGGTACGGGCGCCTACACGACGACCTACTCGGCCGTCGCCTTCAACGGCTTCGAGCCGCTGAAAG
CCTATGTCATCTGA

Upstream 100 bases:

>100_bases
TGCATGGTTCCGGGGTCTCCACCGGCTGGTTCCTGTGCAAGCGTGCGTATGCCCTTTGTCCTCCACAGTCGTGGAGTTTA
ATGGATCGGGGAATATGGCC

Downstream 100 bases:

>100_bases
TCCTGCTCGCTCCCGGCTCAAACGGGAGCGGCAATTCACAATTCATGTCCGGTCCGCCTGAAGCGGTTTTGATGACGGGA
GGCCCCGATGGCCGCTGTTG

Product: Orn/DAP/Arg decarboxylase 2

Products: NA

Alternate protein names: LDC [H]

Number of amino acids: Translated: 377; Mature: 376

Protein sequence:

>377_residues
MTTARIIDFLNTRRPEGPCLVVDLDVVRDNFKAFRHALPDSAIYYAVKANPAPEVLRLLASLGSNFDCASVAEIEMALDA
GATPNRISYGNTIKKERDVARAHTLGISLFAVDSHEEVEKIARAAPGARVFCRVLTDGEGAEWPLSRKFGCVPQMAVDVL
VYAHQLGLASYGVSFHVGSQMTKLDAWDAALADAKRVFVQLAKQGIELKMVNMGGGFPTKYLRDVPSAEAYGQAIFGALK
KHFGNNIPETIIEPGRGMVGNAGVIKAEVVLVSKKSDNDSHRWVFLDIGKFGGLAETMDEAIRYPIRTARDADAMEPCVL
AGPTCDSADVLYEKNMYPLPISLTIGDEVLIEGTGAYTTTYSAVAFNGFEPLKAYVI

Sequences:

>Translated_377_residues
MTTARIIDFLNTRRPEGPCLVVDLDVVRDNFKAFRHALPDSAIYYAVKANPAPEVLRLLASLGSNFDCASVAEIEMALDA
GATPNRISYGNTIKKERDVARAHTLGISLFAVDSHEEVEKIARAAPGARVFCRVLTDGEGAEWPLSRKFGCVPQMAVDVL
VYAHQLGLASYGVSFHVGSQMTKLDAWDAALADAKRVFVQLAKQGIELKMVNMGGGFPTKYLRDVPSAEAYGQAIFGALK
KHFGNNIPETIIEPGRGMVGNAGVIKAEVVLVSKKSDNDSHRWVFLDIGKFGGLAETMDEAIRYPIRTARDADAMEPCVL
AGPTCDSADVLYEKNMYPLPISLTIGDEVLIEGTGAYTTTYSAVAFNGFEPLKAYVI
>Mature_376_residues
TTARIIDFLNTRRPEGPCLVVDLDVVRDNFKAFRHALPDSAIYYAVKANPAPEVLRLLASLGSNFDCASVAEIEMALDAG
ATPNRISYGNTIKKERDVARAHTLGISLFAVDSHEEVEKIARAAPGARVFCRVLTDGEGAEWPLSRKFGCVPQMAVDVLV
YAHQLGLASYGVSFHVGSQMTKLDAWDAALADAKRVFVQLAKQGIELKMVNMGGGFPTKYLRDVPSAEAYGQAIFGALKK
HFGNNIPETIIEPGRGMVGNAGVIKAEVVLVSKKSDNDSHRWVFLDIGKFGGLAETMDEAIRYPIRTARDADAMEPCVLA
GPTCDSADVLYEKNMYPLPISLTIGDEVLIEGTGAYTTTYSAVAFNGFEPLKAYVI

Specific function: Decarboxylates both L-lysine and L-ornithine with similar catalytic efficiency [H]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=374, Percent_Identity=32.620320855615, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI22538418, Length=368, Percent_Identity=26.0869565217391, Blast_Score=125, Evalue=8e-29,
Organism=Homo sapiens, GI21361583, Length=368, Percent_Identity=26.0869565217391, Blast_Score=125, Evalue=8e-29,
Organism=Homo sapiens, GI16506287, Length=355, Percent_Identity=30.1408450704225, Blast_Score=119, Evalue=3e-27,
Organism=Escherichia coli, GI1789203, Length=377, Percent_Identity=25.4641909814324, Blast_Score=81, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17562780, Length=374, Percent_Identity=32.3529411764706, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI25141365, Length=356, Percent_Identity=23.876404494382, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI25141367, Length=199, Percent_Identity=26.1306532663317, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6322664, Length=383, Percent_Identity=31.331592689295, Blast_Score=149, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24586472, Length=378, Percent_Identity=29.3650793650794, Blast_Score=155, Evalue=6e-38,
Organism=Drosophila melanogaster, GI24586474, Length=362, Percent_Identity=29.0055248618785, Blast_Score=120, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183
- InterPro:   IPR002433 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.17; =4.1.1.18 [H]

Molecular weight: Translated: 40855; Mature: 40724

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTARIIDFLNTRRPEGPCLVVDLDVVRDNFKAFRHALPDSAIYYAVKANPAPEVLRLLA
CCHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHH
SLGSNFDCASVAEIEMALDAGATPNRISYGNTIKKERDVARAHTLGISLFAVDSHEEVEK
HHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHEEEEEEEECCHHHHHH
IARAAPGARVFCRVLTDGEGAEWPLSRKFGCVPQMAVDVLVYAHQLGLASYGVSFHVGSQ
HHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCC
MTKLDAWDAALADAKRVFVQLAKQGIELKMVNMGGGFPTKYLRDVPSAEAYGQAIFGALK
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHCCCCHHHHHHHHHHHHH
KHFGNNIPETIIEPGRGMVGNAGVIKAEVVLVSKKSDNDSHRWVFLDIGKFGGLAETMDE
HHHCCCCCHHHHCCCCCCCCCCCEEEEEEEEEEECCCCCCCCEEEEECCCCCCHHHHHHH
AIRYPIRTARDADAMEPCVLAGPTCDSADVLYEKNMYPLPISLTIGDEVLIEGTGAYTTT
HHHCCCCCCCCCCCCCCEEEECCCCCCCCCEEECCCCCEEEEEEECCEEEEECCCCCEEE
YSAVAFNGFEPLKAYVI
EEEEEECCCCCHHEECC
>Mature Secondary Structure 
TTARIIDFLNTRRPEGPCLVVDLDVVRDNFKAFRHALPDSAIYYAVKANPAPEVLRLLA
CHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHH
SLGSNFDCASVAEIEMALDAGATPNRISYGNTIKKERDVARAHTLGISLFAVDSHEEVEK
HHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHEEEEEEEECCHHHHHH
IARAAPGARVFCRVLTDGEGAEWPLSRKFGCVPQMAVDVLVYAHQLGLASYGVSFHVGSQ
HHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCC
MTKLDAWDAALADAKRVFVQLAKQGIELKMVNMGGGFPTKYLRDVPSAEAYGQAIFGALK
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHCCCCHHHHHHHHHHHHH
KHFGNNIPETIIEPGRGMVGNAGVIKAEVVLVSKKSDNDSHRWVFLDIGKFGGLAETMDE
HHHCCCCCHHHHCCCCCCCCCCCEEEEEEEEEEECCCCCCCCEEEEECCCCCCHHHHHHH
AIRYPIRTARDADAMEPCVLAGPTCDSADVLYEKNMYPLPISLTIGDEVLIEGTGAYTTT
HHHCCCCCCCCCCCCCCEEEECCCCCCCCCEEECCCCCEEEEEEECCEEEEECCCCCEEE
YSAVAFNGFEPLKAYVI
EEEEEECCCCCHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11073919 [H]