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The map label for this gene is yciC [H]

Identifier: 150397965

GI number: 150397965

Start: 2887097

End: 2888206

Strand: Direct

Name: yciC [H]

Synonym: Smed_2767

Alternate gene names: 150397965

Gene position: 2887097-2888206 (Clockwise)

Preceding gene: 150397964

Following gene: 150397966

Centisome position: 76.34

GC content: 60.36

Gene sequence:

>1110_bases
ATGACCGAAACGACCCCGCAGAAGCCGATCCCCGTCACCGTGCTCACGGGCTATCTCGGCTCCGGCAAGACGACGCTTCT
CAACCGCATCCTCAGCGAAAATCACGGCCGCAAATATGCGGTCATCGTCAACGAATTCGGCGAGATCGGCATCGACAACG
ACCTGATCGTCGAGTCGGACGAAGAAATTTACGAGATGAACAACGGCTGCGTCTGCTGCACCGTTCGGGGCGACCTGATC
CGCGTCGTCGAAGGGCTGATGCGCCGGCCCGGGCGCTTCGACGCGATCATCGTCGAGACCACCGGCCTCGCAGATCCGGT
GCCGGTGGCGCAGACCTTCTTCATGGATGACGACGTCCGGGCCAAGACCGAGCTCGACGCCGTCGTCGCGCTCGTTGACG
CCAAGCACCTGCCGCTCCGCCTGAAGGACAGCCGGGAAGCCGAGGACCAGATCGCCTTTGCCGACGTCGTGCTGCTCAAC
AAGACCGATCTCGTAACGCCCGAGGAGCTCGAACGCGTCGAGGCAACGGTACGCGTCATCAATCCCTCGGCCCGCATCTA
TCGCACGCAGCGCTCCGAAATCGATCTTGCCAAAGTGCTCGATCAGGGAGCCTTCAACCTCGACAGGGCGCTGGAGAACG
ATCCGCACTTCCTCGATCACGACGATCACGACCACGTCTGTGGCCCCGATTGTGGTCATGATCATGATCATGACCACGGT
CACCATCATCACGATCATCATGGCCACCACCATGATCATGGTCATGATCACGACCACCATCACCACGATGCGCCCTCGCC
GATCCATGATGTGACGGTGCAGTCGATCTCGCTTCGCGGCGGTGAAATGAACCCGGATCGTTTCTTCCCCTGGATCCAGA
AGATCACCCAGACCGATGGCCCGAACATCCTGCGCCTCAAAGGCATCATCGCCTTTTCCGGCGACGGGGAGCGTTACGTC
GTTCAGGGCGTCCACATGATCATCGAAGGTGATCATCAGCGCCCCTGGAAAGAGGGCGAGAAGCGGGAAAGCAGGCTCGT
CTTCATTGGTCGCGATCTGGATCGAGAGAAGATCGAGCGCACCTTCAGGGCGTGTGAAGTCCAGGCATGA

Upstream 100 bases:

>100_bases
GCATCGTTTTTGTTCCGCACATTTGCGCATCGCTACCTCATCTCTTATATCAGGACCCAACCATCGATGCCTGCGGCGCA
TCGCCAACCTCGAGGTTCCC

Downstream 100 bases:

>100_bases
TCTTGAAAGATGGTGCCCGGCTTCGGAATAAGATCATGATGAAACAAGAGAGCCCGCCAAACTGATGCCGACCGTCGCTC
CGCTCGATCTCGAAGGCCAC

Product: cobalamin synthesis protein P47K

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 369; Mature: 368

Protein sequence:

>369_residues
MTETTPQKPIPVTVLTGYLGSGKTTLLNRILSENHGRKYAVIVNEFGEIGIDNDLIVESDEEIYEMNNGCVCCTVRGDLI
RVVEGLMRRPGRFDAIIVETTGLADPVPVAQTFFMDDDVRAKTELDAVVALVDAKHLPLRLKDSREAEDQIAFADVVLLN
KTDLVTPEELERVEATVRVINPSARIYRTQRSEIDLAKVLDQGAFNLDRALENDPHFLDHDDHDHVCGPDCGHDHDHDHG
HHHHDHHGHHHDHGHDHDHHHHDAPSPIHDVTVQSISLRGGEMNPDRFFPWIQKITQTDGPNILRLKGIIAFSGDGERYV
VQGVHMIIEGDHQRPWKEGEKRESRLVFIGRDLDREKIERTFRACEVQA

Sequences:

>Translated_369_residues
MTETTPQKPIPVTVLTGYLGSGKTTLLNRILSENHGRKYAVIVNEFGEIGIDNDLIVESDEEIYEMNNGCVCCTVRGDLI
RVVEGLMRRPGRFDAIIVETTGLADPVPVAQTFFMDDDVRAKTELDAVVALVDAKHLPLRLKDSREAEDQIAFADVVLLN
KTDLVTPEELERVEATVRVINPSARIYRTQRSEIDLAKVLDQGAFNLDRALENDPHFLDHDDHDHVCGPDCGHDHDHDHG
HHHHDHHGHHHDHGHDHDHHHHDAPSPIHDVTVQSISLRGGEMNPDRFFPWIQKITQTDGPNILRLKGIIAFSGDGERYV
VQGVHMIIEGDHQRPWKEGEKRESRLVFIGRDLDREKIERTFRACEVQA
>Mature_368_residues
TETTPQKPIPVTVLTGYLGSGKTTLLNRILSENHGRKYAVIVNEFGEIGIDNDLIVESDEEIYEMNNGCVCCTVRGDLIR
VVEGLMRRPGRFDAIIVETTGLADPVPVAQTFFMDDDVRAKTELDAVVALVDAKHLPLRLKDSREAEDQIAFADVVLLNK
TDLVTPEELERVEATVRVINPSARIYRTQRSEIDLAKVLDQGAFNLDRALENDPHFLDHDDHDHVCGPDCGHDHDHDHGH
HHHDHHGHHHDHGHDHDHHHHDAPSPIHDVTVQSISLRGGEMNPDRFFPWIQKITQTDGPNILRLKGIIAFSGDGERYVV
QGVHMIIEGDHQRPWKEGEKRESRLVFIGRDLDREKIERTFRACEVQA

Specific function: May bind GTP. Might act as metal chaperone (Potential). Contributes to optimal growth under starvation for zinc [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI33469141, Length=371, Percent_Identity=34.2318059299191, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI126722884, Length=371, Percent_Identity=33.9622641509434, Blast_Score=209, Evalue=4e-54,
Organism=Homo sapiens, GI148727351, Length=371, Percent_Identity=33.9622641509434, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI146231952, Length=374, Percent_Identity=33.4224598930481, Blast_Score=198, Evalue=7e-51,
Organism=Homo sapiens, GI223941776, Length=363, Percent_Identity=32.5068870523416, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI223941779, Length=196, Percent_Identity=44.8979591836735, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI119120938, Length=132, Percent_Identity=46.969696969697, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI310124599, Length=226, Percent_Identity=27.8761061946903, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI87082430, Length=362, Percent_Identity=31.4917127071823, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI1788499, Length=167, Percent_Identity=34.7305389221557, Blast_Score=95, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6324356, Length=391, Percent_Identity=27.3657289002558, Blast_Score=137, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 41785; Mature: 41654

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTETTPQKPIPVTVLTGYLGSGKTTLLNRILSENHGRKYAVIVNEFGEIGIDNDLIVESD
CCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCEEEECC
EEIYEMNNGCVCCTVRGDLIRVVEGLMRRPGRFDAIIVETTGLADPVPVAQTFFMDDDVR
HHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHEEECCCCCC
AKTELDAVVALVDAKHLPLRLKDSREAEDQIAFADVVLLNKTDLVTPEELERVEATVRVI
HHHHHHHHHHHHCCCCCCEEECCCCCHHHHHEEEEEEEECCCCCCCHHHHHHHHHEEEEE
NPSARIYRTQRSEIDLAKVLDQGAFNLDRALENDPHFLDHDDHDHVCGPDCGHDHDHDHG
CCCCEEEECCCCCHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
HHHHDHHGHHHDHGHDHDHHHHDAPSPIHDVTVQSISLRGGEMNPDRFFPWIQKITQTDG
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHEEEEEEECCCCCCHHHHHHHHHHHHHCCC
PNILRLKGIIAFSGDGERYVVQGVHMIIEGDHQRPWKEGEKRESRLVFIGRDLDREKIER
CCEEEEEEEEEECCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCEEEEEECCCCHHHHHH
TFRACEVQA
HHHHHCCCC
>Mature Secondary Structure 
TETTPQKPIPVTVLTGYLGSGKTTLLNRILSENHGRKYAVIVNEFGEIGIDNDLIVESD
CCCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCEEEECC
EEIYEMNNGCVCCTVRGDLIRVVEGLMRRPGRFDAIIVETTGLADPVPVAQTFFMDDDVR
HHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHEEECCCCCC
AKTELDAVVALVDAKHLPLRLKDSREAEDQIAFADVVLLNKTDLVTPEELERVEATVRVI
HHHHHHHHHHHHCCCCCCEEECCCCCHHHHHEEEEEEEECCCCCCCHHHHHHHHHEEEEE
NPSARIYRTQRSEIDLAKVLDQGAFNLDRALENDPHFLDHDDHDHVCGPDCGHDHDHDHG
CCCCEEEECCCCCHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
HHHHDHHGHHHDHGHDHDHHHHDAPSPIHDVTVQSISLRGGEMNPDRFFPWIQKITQTDG
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHEEEEEEECCCCCCHHHHHHHHHHHHHCCC
PNILRLKGIIAFSGDGERYVVQGVHMIIEGDHQRPWKEGEKRESRLVFIGRDLDREKIER
CCEEEEEEEEEECCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCEEEEEECCCCHHHHHH
TFRACEVQA
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377; 9811636 [H]