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The map label for this gene is hemH [H]

Identifier: 150397889

GI number: 150397889

Start: 2796292

End: 2797329

Strand: Direct

Name: hemH [H]

Synonym: Smed_2691

Alternate gene names: 150397889

Gene position: 2796292-2797329 (Clockwise)

Preceding gene: 150397888

Following gene: 150397900

Centisome position: 73.94

GC content: 60.98

Gene sequence:

>1038_bases
ATGACAGCCATGGAAGCCGAGCCGAACACCAACCACCCCGCCGTCAGCTATGGAAAGCTGGGCGTGCTCCTGGTCAATCT
CGGCACGCCTGACGGTACCGACGTCACCTCCATGCGCCGCTACCTCCGGGAATTCCTGAGCGACCGGCGCGTCATCGAAT
GGTCGCGCCTCTTCTGGTATCCGATCCTCTACGGCATCGTCCTCAACACGCGTCCGCGCAAGGTGGGCAAGGCTTACGAA
CTCATCTGGAACAAGGAACTGAATGAAAGCTGGCTCAGAACCTACACACGCAATCAGGCGGCCTTGATGACCGAGGCCTT
CGGCGGCCAGCCGCAGGTTATCGTCGACTGGGCGATGCGCTATGGTCGGCCCTCTATCGCCTCGCGGCTCGATGCGCTGC
AGAAAGCCGGATGCGAGCGAATTCTCGTATTCCCGCTCTATCCGCAATATGCCGCCGCCACGACAGCCACGGTCAACGAC
AAAGCCTTCGAGGCCCTGCTCGGGATGCGCTGGCAGCCCGCGCTCAGAACCGTGCCGCCTTATCACGACGACCCGGTCTA
CATCGATGCCCTGGCGACCTCCATCACCAAGCACCTCGCGACACTTGATTGGGAACCGGAGCTGGTTCTCGCCTCCTTCC
ACGGCATCCCGAAGAGCTATTTCGAGAAGGGCGATCCCTATTATTGCCAGTGCCAGAAGACGGCGCGGTTGCTGCGCGAA
AGACTCGGCTGGCCGAAAGAAAAGCTGCAGATCACCTTCCAATCGCGCTTCGGTCCCGAGGAGTGGCTCCAGCCTTATAC
CGACGCCACCGTGGAAAGACTGGCCAAGGAGGGCGTGAAGAAGATCGCCGTCATCAACCCCGGCTTCGTTTCGGACTGTC
TGGAAACGCTCGAGGAAATCGCCGGCCAGGCGGCGGAGAGTTTCCACCATAATGGCGGCGAGAAATTCGCCCATATTCCC
TGCCTGAACGACAGCCCCGAAGGCATGGCGGTGCTCAACCATGTGGTCCGCCGCGAATTGGAGGGATGGCTCTACTAG

Upstream 100 bases:

>100_bases
TTTCCCACCGGCGCGGGCTTTCCCGCGCCGGTATTTCTTTTTAGAAAGGTTTGAAATTGTAGGCAGCCGCGCAGTAACGT
GGCGCCCCACGAGGACCGAG

Downstream 100 bases:

>100_bases
GTAGACCAACCCAAAGACATCGTGAGCTGCAAGGAAGGCCGTTACGGCCTTTCCTGGAAGAGCTTAAATCCGGTCAAAAT
CGAAGGCGAGGGTGCCGCCG

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MTAMEAEPNTNHPAVSYGKLGVLLVNLGTPDGTDVTSMRRYLREFLSDRRVIEWSRLFWYPILYGIVLNTRPRKVGKAYE
LIWNKELNESWLRTYTRNQAALMTEAFGGQPQVIVDWAMRYGRPSIASRLDALQKAGCERILVFPLYPQYAAATTATVND
KAFEALLGMRWQPALRTVPPYHDDPVYIDALATSITKHLATLDWEPELVLASFHGIPKSYFEKGDPYYCQCQKTARLLRE
RLGWPKEKLQITFQSRFGPEEWLQPYTDATVERLAKEGVKKIAVINPGFVSDCLETLEEIAGQAAESFHHNGGEKFAHIP
CLNDSPEGMAVLNHVVRRELEGWLY

Sequences:

>Translated_345_residues
MTAMEAEPNTNHPAVSYGKLGVLLVNLGTPDGTDVTSMRRYLREFLSDRRVIEWSRLFWYPILYGIVLNTRPRKVGKAYE
LIWNKELNESWLRTYTRNQAALMTEAFGGQPQVIVDWAMRYGRPSIASRLDALQKAGCERILVFPLYPQYAAATTATVND
KAFEALLGMRWQPALRTVPPYHDDPVYIDALATSITKHLATLDWEPELVLASFHGIPKSYFEKGDPYYCQCQKTARLLRE
RLGWPKEKLQITFQSRFGPEEWLQPYTDATVERLAKEGVKKIAVINPGFVSDCLETLEEIAGQAAESFHHNGGEKFAHIP
CLNDSPEGMAVLNHVVRRELEGWLY
>Mature_344_residues
TAMEAEPNTNHPAVSYGKLGVLLVNLGTPDGTDVTSMRRYLREFLSDRRVIEWSRLFWYPILYGIVLNTRPRKVGKAYEL
IWNKELNESWLRTYTRNQAALMTEAFGGQPQVIVDWAMRYGRPSIASRLDALQKAGCERILVFPLYPQYAAATTATVNDK
AFEALLGMRWQPALRTVPPYHDDPVYIDALATSITKHLATLDWEPELVLASFHGIPKSYFEKGDPYYCQCQKTARLLRER
LGWPKEKLQITFQSRFGPEEWLQPYTDATVERLAKEGVKKIAVINPGFVSDCLETLEEIAGQAAESFHHNGGEKFAHIPC
LNDSPEGMAVLNHVVRRELEGWLY

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499021, Length=231, Percent_Identity=26.4069264069264, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI60499025, Length=231, Percent_Identity=26.4069264069264, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1786681, Length=318, Percent_Identity=43.0817610062893, Blast_Score=251, Evalue=4e-68,
Organism=Saccharomyces cerevisiae, GI6324750, Length=339, Percent_Identity=25.3687315634218, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17864156, Length=337, Percent_Identity=24.6290801186944, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 39339; Mature: 39208

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAMEAEPNTNHPAVSYGKLGVLLVNLGTPDGTDVTSMRRYLREFLSDRRVIEWSRLFWY
CCCCCCCCCCCCCCEEECCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHH
PILYGIVLNTRPRKVGKAYELIWNKELNESWLRTYTRNQAALMTEAFGGQPQVIVDWAMR
HHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHH
YGRPSIASRLDALQKAGCERILVFPLYPQYAAATTATVNDKAFEALLGMRWQPALRTVPP
CCCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHCCCCCHHHHHHHHCCCCCCHHCCCCC
YHDDPVYIDALATSITKHLATLDWEPELVLASFHGIPKSYFEKGDPYYCQCQKTARLLRE
CCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEHHCCCCHHHHHCCCCEEEEHHHHHHHHHH
RLGWPKEKLQITFQSRFGPEEWLQPYTDATVERLAKEGVKKIAVINPGFVSDCLETLEEI
HHCCCHHHEEEEEHHCCCHHHHHCCHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHH
AGQAAESFHHNGGEKFAHIPCLNDSPEGMAVLNHVVRRELEGWLY
HHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TAMEAEPNTNHPAVSYGKLGVLLVNLGTPDGTDVTSMRRYLREFLSDRRVIEWSRLFWY
CCCCCCCCCCCCCEEECCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHH
PILYGIVLNTRPRKVGKAYELIWNKELNESWLRTYTRNQAALMTEAFGGQPQVIVDWAMR
HHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHH
YGRPSIASRLDALQKAGCERILVFPLYPQYAAATTATVNDKAFEALLGMRWQPALRTVPP
CCCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHCCCCCHHHHHHHHCCCCCCHHCCCCC
YHDDPVYIDALATSITKHLATLDWEPELVLASFHGIPKSYFEKGDPYYCQCQKTARLLRE
CCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEHHCCCCHHHHHCCCCEEEEHHHHHHHHHH
RLGWPKEKLQITFQSRFGPEEWLQPYTDATVERLAKEGVKKIAVINPGFVSDCLETLEEI
HHCCCHHHEEEEEHHCCCHHHHHCCHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHH
AGQAAESFHHNGGEKFAHIPCLNDSPEGMAVLNHVVRRELEGWLY
HHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]