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The map label for this gene is purK [H]

Identifier: 150397871

GI number: 150397871

Start: 2775826

End: 2776875

Strand: Direct

Name: purK [H]

Synonym: Smed_2673

Alternate gene names: 150397871

Gene position: 2775826-2776875 (Clockwise)

Preceding gene: 150397870

Following gene: 150397872

Centisome position: 73.4

GC content: 66.38

Gene sequence:

>1050_bases
ATGAAGACGATCGGCATCATCGGCGGCGGCCAGCTCGGCCGCATGCTGGCCATGGCCGCTGCCCGCCTGAATTTTCGAAC
TGTCGTACTCGAGCCCCAGCCGGACTGTCCCGCCGCGCAGGTGGCCAACGAGCAGATCCTTGCCGCTTATGACGATCCGG
ACGCCTTGGCCGAGCTTGCCCGGGTGGCAGACCTCGTCACTTACGAATTCGAGAATGTCCCCGTCTCGGCCGCCGAACAG
CTCGCCCGTACGCGGCCGGTCTTCCCGCCGCCGAAGGCGCTGGAAGTGGCACAGGACCGTCTCGTCGAAAAGCGCTTCAT
CAACGGCTGCGGCATCGACACCGCCCGCTTCCGTTCCGTCGACAGCCAGGCCGACCTTGAGGCCGCCCTTTCCGACTTCG
GCGGGGCCGGCGTGCTCAAGACCCGCCGGTTCGGCTATGACGGCAAAGGTCAACGCGTCTTCCGTTCCGCCACCGACGAT
CCGGCGGGCGCCTATGTCGCGCTCGGGCAGGTCCCCCTGATCCTCGAAAGCCTCGTGTCCTTCGAGCGGGAGATCTCGGT
TATAGCCGCCCGCGCGGCCGACGGGACCACCGCCTGCTTCGACCCCGCAGAAAACATACATCGCCACGGCATTCTCCACA
CCTCGATCGTGCCCGCATCCGTCGGCGCGGCAACCACCGAAGCGGCCCGCAAGGCGGCTACCGGCATCCTTGCGGCGCTT
GGCTATGTGGGCGTCATCGGTGTCGAGTTTTTCGTTCTCGCCGACGGCAGCGTCGTCGCAAACGAGATCGCCCCGCGCGT
CCACAATTCCGGCCACTGGACGGAGGCCGCCTGTGTCGTTTCGCAATTCGAGCAGCATATCCGCGCGATTGCCGGGCTGC
CCCTCGGCGACCCGTCGCGCCATTCGGACTGCGTGATGCAGAACCTTATCGGCGACGACATCGCCGGCGTTGCGGACCTG
CTTGGAGAGCGCAACGTGCTTCTTCATCTCTACGGGAAGACCGAGGCGCGGCCCGGCCGCAAGATGGGGCATTTCACCCG
CCTGCTCTGA

Upstream 100 bases:

>100_bases
CAGCCGTCCTGGCTCTCAGCGACGACGACCTTGCCGACCGTCTCGACGATTGGCGCGAACAGCAGACCGTATCGGTCGCG
GAATATCCGGTAGACGAGGC

Downstream 100 bases:

>100_bases
TCCGGCCCTCATGAAACGGGGACACATGGAACGGGCACAGATGGGACGGGGAACAGGCGGCAAAATCCCCGGCGCGCGGT
TGACACGATTGGGACGACAC

Product: phosphoribosylaminoimidazole carboxylase ATPase

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MKTIGIIGGGQLGRMLAMAAARLNFRTVVLEPQPDCPAAQVANEQILAAYDDPDALAELARVADLVTYEFENVPVSAAEQ
LARTRPVFPPPKALEVAQDRLVEKRFINGCGIDTARFRSVDSQADLEAALSDFGGAGVLKTRRFGYDGKGQRVFRSATDD
PAGAYVALGQVPLILESLVSFEREISVIAARAADGTTACFDPAENIHRHGILHTSIVPASVGAATTEAARKAATGILAAL
GYVGVIGVEFFVLADGSVVANEIAPRVHNSGHWTEAACVVSQFEQHIRAIAGLPLGDPSRHSDCVMQNLIGDDIAGVADL
LGERNVLLHLYGKTEARPGRKMGHFTRLL

Sequences:

>Translated_349_residues
MKTIGIIGGGQLGRMLAMAAARLNFRTVVLEPQPDCPAAQVANEQILAAYDDPDALAELARVADLVTYEFENVPVSAAEQ
LARTRPVFPPPKALEVAQDRLVEKRFINGCGIDTARFRSVDSQADLEAALSDFGGAGVLKTRRFGYDGKGQRVFRSATDD
PAGAYVALGQVPLILESLVSFEREISVIAARAADGTTACFDPAENIHRHGILHTSIVPASVGAATTEAARKAATGILAAL
GYVGVIGVEFFVLADGSVVANEIAPRVHNSGHWTEAACVVSQFEQHIRAIAGLPLGDPSRHSDCVMQNLIGDDIAGVADL
LGERNVLLHLYGKTEARPGRKMGHFTRLL
>Mature_349_residues
MKTIGIIGGGQLGRMLAMAAARLNFRTVVLEPQPDCPAAQVANEQILAAYDDPDALAELARVADLVTYEFENVPVSAAEQ
LARTRPVFPPPKALEVAQDRLVEKRFINGCGIDTARFRSVDSQADLEAALSDFGGAGVLKTRRFGYDGKGQRVFRSATDD
PAGAYVALGQVPLILESLVSFEREISVIAARAADGTTACFDPAENIHRHGILHTSIVPASVGAATTEAARKAATGILAAL
GYVGVIGVEFFVLADGSVVANEIAPRVHNSGHWTEAACVVSQFEQHIRAIAGLPLGDPSRHSDCVMQNLIGDDIAGVADL
LGERNVLLHLYGKTEARPGRKMGHFTRLL

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=349, Percent_Identity=35.8166189111748, Blast_Score=184, Evalue=6e-48,
Organism=Escherichia coli, GI1788155, Length=357, Percent_Identity=26.890756302521, Blast_Score=106, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6324702, Length=363, Percent_Identity=33.8842975206612, Blast_Score=202, Evalue=4e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 37085; Mature: 37085

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTIGIIGGGQLGRMLAMAAARLNFRTVVLEPQPDCPAAQVANEQILAAYDDPDALAELA
CCEEEEECCHHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHCCCCEEEEECCHHHHHHHH
RVADLVTYEFENVPVSAAEQLARTRPVFPPPKALEVAQDRLVEKRFINGCGIDTARFRSV
HHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHCC
DSQADLEAALSDFGGAGVLKTRRFGYDGKGQRVFRSATDDPAGAYVALGQVPLILESLVS
CCHHHHHHHHHHCCCCCCEEHHCCCCCCCCCHHHHCCCCCCCCCEEECCCHHHHHHHHHH
FEREISVIAARAADGTTACFDPAENIHRHGILHTSIVPASVGAATTEAARKAATGILAAL
HHHHHHHHEEECCCCCCCCCCCHHHHHHCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHH
GYVGVIGVEFFVLADGSVVANEIAPRVHNSGHWTEAACVVSQFEQHIRAIAGLPLGDPSR
HHHHHHHHEEEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
HSDCVMQNLIGDDIAGVADLLGERNVLLHLYGKTEARPGRKMGHFTRLL
HHHHHHHHHHCCHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHCC
>Mature Secondary Structure
MKTIGIIGGGQLGRMLAMAAARLNFRTVVLEPQPDCPAAQVANEQILAAYDDPDALAELA
CCEEEEECCHHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHCCCCEEEEECCHHHHHHHH
RVADLVTYEFENVPVSAAEQLARTRPVFPPPKALEVAQDRLVEKRFINGCGIDTARFRSV
HHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHCC
DSQADLEAALSDFGGAGVLKTRRFGYDGKGQRVFRSATDDPAGAYVALGQVPLILESLVS
CCHHHHHHHHHHCCCCCCEEHHCCCCCCCCCHHHHCCCCCCCCCEEECCCHHHHHHHHHH
FEREISVIAARAADGTTACFDPAENIHRHGILHTSIVPASVGAATTEAARKAATGILAAL
HHHHHHHHEEECCCCCCCCCCCHHHHHHCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHH
GYVGVIGVEFFVLADGSVVANEIAPRVHNSGHWTEAACVVSQFEQHIRAIAGLPLGDPSR
HHHHHHHHEEEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
HSDCVMQNLIGDDIAGVADLLGERNVLLHLYGKTEARPGRKMGHFTRLL
HHHHHHHHHHCCHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11756688 [H]