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The map label for this gene is purE [H]

Identifier: 150397870

GI number: 150397870

Start: 2775365

End: 2775829

Strand: Direct

Name: purE [H]

Synonym: Smed_2672

Alternate gene names: 150397870

Gene position: 2775365-2775829 (Clockwise)

Preceding gene: 150397869

Following gene: 150397871

Centisome position: 73.39

GC content: 66.67

Gene sequence:

>465_bases
ATGGGAAGCCAGTCGGACTGGGAGACGATGAAGAACGCCGCTGACACGCTCGAGGCGCTCGACATCGCTTATGAAGCCCG
CATCGTTTCCGCCCATCGCACGCCCGACCGCCTCGTCCGCTTCGCCAAGGGCGCGCGCGACGAGGGTTTCCAGGTGATCA
TTGCCGGCGCCGGCGGCGCCGCGCACCTCCCGGGAATGTGCGCGGCCATGACGCCGCTTCCGGTCTTCGGTGTTCCGGTC
CAGTCGAGAGCGCTTTCCGGTCAGGACAGCCTGCTGTCGATCGTGCAGATGCCCGCCGGAATTCCGGTCGGCACGCTTGC
GATCGGCAGAGCAGGCGCCATCAACGCTGCGCTCCTGGCCGCAGCCGTCCTGGCTCTCAGCGACGACGACCTTGCCGACC
GTCTCGACGATTGGCGCGAACAGCAGACCGTATCGGTCGCGGAATATCCGGTAGACGAGGCATGA

Upstream 100 bases:

>100_bases
CAAGATCACCAAGATCGAAGACCAGATCATTCCAGACATAATCGCCTGAAAAACGGACCAAGACGTGACCGACACTACGC
CCCCTCCCGTCGCCATCATC

Downstream 100 bases:

>100_bases
AGACGATCGGCATCATCGGCGGCGGCCAGCTCGGCCGCATGCTGGCCATGGCCGCTGCCCGCCTGAATTTTCGAACTGTC
GTACTCGAGCCCCAGCCGGA

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 154; Mature: 153

Protein sequence:

>154_residues
MGSQSDWETMKNAADTLEALDIAYEARIVSAHRTPDRLVRFAKGARDEGFQVIIAGAGGAAHLPGMCAAMTPLPVFGVPV
QSRALSGQDSLLSIVQMPAGIPVGTLAIGRAGAINAALLAAAVLALSDDDLADRLDDWREQQTVSVAEYPVDEA

Sequences:

>Translated_154_residues
MGSQSDWETMKNAADTLEALDIAYEARIVSAHRTPDRLVRFAKGARDEGFQVIIAGAGGAAHLPGMCAAMTPLPVFGVPV
QSRALSGQDSLLSIVQMPAGIPVGTLAIGRAGAINAALLAAAVLALSDDDLADRLDDWREQQTVSVAEYPVDEA
>Mature_153_residues
GSQSDWETMKNAADTLEALDIAYEARIVSAHRTPDRLVRFAKGARDEGFQVIIAGAGGAAHLPGMCAAMTPLPVFGVPVQ
SRALSGQDSLLSIVQMPAGIPVGTLAIGRAGAINAALLAAAVLALSDDDLADRLDDWREQQTVSVAEYPVDEA

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=150, Percent_Identity=66, Blast_Score=167, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6324702, Length=146, Percent_Identity=50.6849315068493, Blast_Score=137, Evalue=7e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 16070; Mature: 15939

Theoretical pI: Translated: 4.26; Mature: 4.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSQSDWETMKNAADTLEALDIAYEARIVSAHRTPDRLVRFAKGARDEGFQVIIAGAGGA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCEEEEECCCCC
AHLPGMCAAMTPLPVFGVPVQSRALSGQDSLLSIVQMPAGIPVGTLAIGRAGAINAALLA
CCCCCHHHHHCCCCEECCCCHHHHCCCHHHHHHHHHCCCCCCCHHHHCCCCCCHHHHHHH
AAVLALSDDDLADRLDDWREQQTVSVAEYPVDEA
HHHHHCCCCHHHHHHHHHHHHHCCHHHCCCCCCC
>Mature Secondary Structure 
GSQSDWETMKNAADTLEALDIAYEARIVSAHRTPDRLVRFAKGARDEGFQVIIAGAGGA
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCEEEEECCCCC
AHLPGMCAAMTPLPVFGVPVQSRALSGQDSLLSIVQMPAGIPVGTLAIGRAGAINAALLA
CCCCCHHHHHCCCCEECCCCHHHHCCCHHHHHHHHHCCCCCCCHHHHCCCCCCHHHHHHH
AAVLALSDDDLADRLDDWREQQTVSVAEYPVDEA
HHHHHCCCCHHHHHHHHHHHHHCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11756688 [H]