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The map label for this gene is yeiA [H]

Identifier: 150397561

GI number: 150397561

Start: 2437744

End: 2439057

Strand: Direct

Name: yeiA [H]

Synonym: Smed_2361

Alternate gene names: 150397561

Gene position: 2437744-2439057 (Clockwise)

Preceding gene: 150397560

Following gene: 150397563

Centisome position: 64.46

GC content: 62.02

Gene sequence:

>1314_bases
ATGGCTGATCTTCGCAACAATTTCGTCGGCATCAAATCCCCCAACCCATTCTGGCTCGCCTCGGCGCCGCCGACGGACAA
AGCCTATAATGTCGAGCGCGCCTTCAAGGCGGGCTGGGGCGGAGTCGTCTGGAAGACGCTCGGCGAAGAGGGACCGCCGG
TGGTCAACGTCAACGGGCCGCGCTACGGCGCGATCTGGGGCGCCGACCGGCGGCTGCTGGGCTTGAACAATATCGAGCTT
ATCACCGATCGCGATCTCTATGTGAACCTGCGCGAAATGAAGCAGGTGAAGATGAACTGGCCGGATCGGGCATTGATCGC
TTCGATCATGGTGCCTTGCGAGGAGAATGCCTGGAAGGCGATCCTGCCCCTGGTCGAGGAGACGGGCGCAGACGGTATCG
AACTCAATTTCGGCTGTCCGCACGGCATGTCCGAGCGCGGCATGGGCTCGGCTGTCGGCCAGGTGCCTGAGTATATCGAG
ATGGTCGTGCGCTGGTGCAAGCAATATACGCGCATGCCCGTCATCACCAAGCTGACGCCCAATATCACCGACATCCGCAA
GCCAGCCCGCGCTGCCAGGGCCGGCGGCACCGATGCGGTGTCGCTGATCAACACGATCAATTCGATCACCGGGGTCAATC
TCGACACCTTCTCGCCGGAGCCCTCGATCGATGGCCGCGGCAGCCATGGCGGTTATTGCGGTCCGGCCGTTAAGCCGATC
GCGCTCAACATGGTCGCCGAGATCGCCCGTGATACGGAGACCCACGGCTTGCCGATTTCGGGCATTGGCGGCGTGACCAC
CTGGCGGGATGCGGCCGAATTCATGGCGCTCGGCGCCGGCAATGTGCAGGTCTGCACGGCGGCGATGACCTATGGCTTCA
AGATCGTCCAGGAGATGATTACCGGACTTTCCGACTGGATGGACGCCAAGGGACATCGCACGCTGGACGACATCAGTGGC
CGCGCCGTCCCCAACGTCACGGATTGGCAGTATCTCAACCTCAACTACATCACCAAGGCGAAGATCGATCAGGACGCCTG
CATCAAATGCGGCCGCTGTCACATCGCCTGCGAGGACACGTCGCATCAGGCCATCACCCAGTTGGTCAACGGCGTTCGCC
ATTTCGAGGTGATCGAGGAGGAATGCGTCGGCTGCAACCTCTGCGTCAATGTCTGTCCGGTCGACAACTGCATTACCATG
GAAACGTTGCCTGCCGGCACGCTCGACCGGCGCACGGGTAAACCGGTCGACCCGAACTACGCCAACTGGACGACCCATCC
CAACAACCCGATGGCCCGCCAGGCCGCCGAGTGA

Upstream 100 bases:

>100_bases
ACGCGATGCGGCCGGATCGATCGACCGGGCTTTCGCCGCGGCTCAACCGCTGGCGAGTGCCGTTGCCTGAGCGCGTAAAT
GGATCGAGAGGACGAGAACA

Downstream 100 bases:

>100_bases
AAGCCTGTTCAAGCCAAGGGGAAGGCCGCCGGCATCGCCGGCGGCCTTTTCCCTTGCCGTCGTCTCAGAACTCTATCACC
ACCTTGCCGAAGGGGCCGTG

Product: dihydropyrimidine dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 437; Mature: 436

Protein sequence:

>437_residues
MADLRNNFVGIKSPNPFWLASAPPTDKAYNVERAFKAGWGGVVWKTLGEEGPPVVNVNGPRYGAIWGADRRLLGLNNIEL
ITDRDLYVNLREMKQVKMNWPDRALIASIMVPCEENAWKAILPLVEETGADGIELNFGCPHGMSERGMGSAVGQVPEYIE
MVVRWCKQYTRMPVITKLTPNITDIRKPARAARAGGTDAVSLINTINSITGVNLDTFSPEPSIDGRGSHGGYCGPAVKPI
ALNMVAEIARDTETHGLPISGIGGVTTWRDAAEFMALGAGNVQVCTAAMTYGFKIVQEMITGLSDWMDAKGHRTLDDISG
RAVPNVTDWQYLNLNYITKAKIDQDACIKCGRCHIACEDTSHQAITQLVNGVRHFEVIEEECVGCNLCVNVCPVDNCITM
ETLPAGTLDRRTGKPVDPNYANWTTHPNNPMARQAAE

Sequences:

>Translated_437_residues
MADLRNNFVGIKSPNPFWLASAPPTDKAYNVERAFKAGWGGVVWKTLGEEGPPVVNVNGPRYGAIWGADRRLLGLNNIEL
ITDRDLYVNLREMKQVKMNWPDRALIASIMVPCEENAWKAILPLVEETGADGIELNFGCPHGMSERGMGSAVGQVPEYIE
MVVRWCKQYTRMPVITKLTPNITDIRKPARAARAGGTDAVSLINTINSITGVNLDTFSPEPSIDGRGSHGGYCGPAVKPI
ALNMVAEIARDTETHGLPISGIGGVTTWRDAAEFMALGAGNVQVCTAAMTYGFKIVQEMITGLSDWMDAKGHRTLDDISG
RAVPNVTDWQYLNLNYITKAKIDQDACIKCGRCHIACEDTSHQAITQLVNGVRHFEVIEEECVGCNLCVNVCPVDNCITM
ETLPAGTLDRRTGKPVDPNYANWTTHPNNPMARQAAE
>Mature_436_residues
ADLRNNFVGIKSPNPFWLASAPPTDKAYNVERAFKAGWGGVVWKTLGEEGPPVVNVNGPRYGAIWGADRRLLGLNNIELI
TDRDLYVNLREMKQVKMNWPDRALIASIMVPCEENAWKAILPLVEETGADGIELNFGCPHGMSERGMGSAVGQVPEYIEM
VVRWCKQYTRMPVITKLTPNITDIRKPARAARAGGTDAVSLINTINSITGVNLDTFSPEPSIDGRGSHGGYCGPAVKPIA
LNMVAEIARDTETHGLPISGIGGVTTWRDAAEFMALGAGNVQVCTAAMTYGFKIVQEMITGLSDWMDAKGHRTLDDISGR
AVPNVTDWQYLNLNYITKAKIDQDACIKCGRCHIACEDTSHQAITQLVNGVRHFEVIEEECVGCNLCVNVCPVDNCITME
TLPAGTLDRRTGKPVDPNYANWTTHPNNPMARQAAE

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=333, Percent_Identity=36.9369369369369, Blast_Score=218, Evalue=8e-57,
Organism=Escherichia coli, GI87082059, Length=398, Percent_Identity=41.7085427135678, Blast_Score=315, Evalue=5e-87,
Organism=Caenorhabditis elegans, GI71984108, Length=332, Percent_Identity=37.0481927710843, Blast_Score=215, Evalue=4e-56,
Organism=Saccharomyces cerevisiae, GI6322633, Length=327, Percent_Identity=26.2996941896024, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24640763, Length=320, Percent_Identity=37.8125, Blast_Score=219, Evalue=2e-57,
Organism=Drosophila melanogaster, GI18858217, Length=320, Percent_Identity=37.8125, Blast_Score=219, Evalue=2e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR012285 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: NA

Molecular weight: Translated: 47713; Mature: 47582

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADLRNNFVGIKSPNPFWLASAPPTDKAYNVERAFKAGWGGVVWKTLGEEGPPVVNVNGP
CCCCCCCEEEECCCCCEEEECCCCCCCCCCHHHHHHCCCCHHHHHHCCCCCCCEEEECCC
RYGAIWGADRRLLGLNNIELITDRDLYVNLREMKQVKMNWPDRALIASIMVPCEENAWKA
CEEEEECCCCEEECCCCEEEEECCHHEEEHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHH
ILPLVEETGADGIELNFGCPHGMSERGMGSAVGQVPEYIEMVVRWCKQYTRMPVITKLTP
HHHHHHHCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCC
NITDIRKPARAARAGGTDAVSLINTINSITGVNLDTFSPEPSIDGRGSHGGYCGPAVKPI
CHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHH
ALNMVAEIARDTETHGLPISGIGGVTTWRDAAEFMALGAGNVQVCTAAMTYGFKIVQEMI
HHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
TGLSDWMDAKGHRTLDDISGRAVPNVTDWQYLNLNYITKAKIDQDACIKCGRCHIACEDT
HHHHHHHHCCCCCCHHHCCCCCCCCCCCEEEEEEEEEEECCCCHHHHHCCCCEEEEECCC
SHQAITQLVNGVRHFEVIEEECVGCNLCVNVCPVDNCITMETLPAGTLDRRTGKPVDPNY
CHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCCC
ANWTTHPNNPMARQAAE
CCCCCCCCCCCHHCCCC
>Mature Secondary Structure 
ADLRNNFVGIKSPNPFWLASAPPTDKAYNVERAFKAGWGGVVWKTLGEEGPPVVNVNGP
CCCCCCEEEECCCCCEEEECCCCCCCCCCHHHHHHCCCCHHHHHHCCCCCCCEEEECCC
RYGAIWGADRRLLGLNNIELITDRDLYVNLREMKQVKMNWPDRALIASIMVPCEENAWKA
CEEEEECCCCEEECCCCEEEEECCHHEEEHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHH
ILPLVEETGADGIELNFGCPHGMSERGMGSAVGQVPEYIEMVVRWCKQYTRMPVITKLTP
HHHHHHHCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCC
NITDIRKPARAARAGGTDAVSLINTINSITGVNLDTFSPEPSIDGRGSHGGYCGPAVKPI
CHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHH
ALNMVAEIARDTETHGLPISGIGGVTTWRDAAEFMALGAGNVQVCTAAMTYGFKIVQEMI
HHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
TGLSDWMDAKGHRTLDDISGRAVPNVTDWQYLNLNYITKAKIDQDACIKCGRCHIACEDT
HHHHHHHHCCCCCCHHHCCCCCCCCCCCEEEEEEEEEEECCCCHHHHHCCCCEEEEECCC
SHQAITQLVNGVRHFEVIEEECVGCNLCVNVCPVDNCITMETLPAGTLDRRTGKPVDPNY
CHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCCC
ANWTTHPNNPMARQAAE
CCCCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 1719366 [H]