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The map label for this gene is bioA [C]

Identifier: 150397517

GI number: 150397517

Start: 2396850

End: 2398178

Strand: Direct

Name: bioA [C]

Synonym: Smed_2317

Alternate gene names: 150397517

Gene position: 2396850-2398178 (Clockwise)

Preceding gene: 150397510

Following gene: 150397518

Centisome position: 63.38

GC content: 61.25

Gene sequence:

>1329_bases
ATGTCCAACCGCCTGAATACGACGCCGAATGATTTGCGCGCATTCTGGATGCCCTTCACGGCCAACCGGCAGTTCAAGAA
GGAGCCGCGGCTCTTCGTTGGCGCCAAGGACATGTACTACACCACCCATGACGGACGGACGGTTCTCGATGGTACAGCCG
GACTCTGGTGCGTCAATGCCGGCCATTGTCGGCCGAAAATCACCGAAGCGATCCGCGAGCAGGCGGGCGAACTGGACTAC
GCGCCGGCCTTTCAGCTCGGTCACCCCAAGGCATTCGAACTCGCAAACCGGCTGGTCGATATCGCGCCCGAAGGCATGAA
CCACGTTCTCTACACCAATTCAGGCTCGGAATCGGTCGATACCGCGCTGAAGGTCGCGCTCGCTTATCACCGCGCCAAGG
GCAACGGCTCGCGCTTCCGCCTCATCGGCCGCGAGCGCGGCTATCATGGCGTCAACTTCGGCGGCATTTCGGTTGGCGGG
ATCGTCGCCAATCGCAAGATGTTCGGCACGCTGCTGACGGGCGTCGATCACCTTCCGCACACGCATTTGCCAGCCAAAAA
CGCCTTCAGCCGCGGCGAGCCCGAGCACGGCGCCGATCTCGCCGCCGAACTCGAGCGCATCGTCACGCTTCATGACGCCT
CGACGGTCGCGGCGGTCATCGTTGAACCCGTGGCCGGCTCGACCGGCGTTCTCATCCCGCCGAAGGGCTATCTTCAGAAA
CTGCGCGAAATCTGCACCAAACATGGCATCCTGCTGATCTTCGACGAGGTGATCACCGGCTATGGCCGGCTCGGCACGCC
CTTTGCCGCGCAATATTTCGACGTCAAGCCGGACATCATTACCACCGCCAAGGGCCTCACCAACGGCGTCATCCCGATGG
GCGCGGTCTTCGTGACATCGGAAATCCACGACGCCTTCATGACCGGTCCGGAGCACCTGATCGAGTTCTTCCACGGCTAT
ACCTATTCCGGCAACCCGATCGCCTCGGCAGCAGCACTCGGAACGCTGGACACCTACAAGGAGGAAGGCCTTCTGACGCG
CGCCGCCGAGCTTGCTTCCTATTGGGAGGAGGCGTTGCACGCGCTGAAGGACTGCCCCCATGTCATCGACATCCGCAATA
TCGGACTGATCGGCGCGATCGAGCTCGAGCCGATCGCCGGAGAGCCGACGAAGCGCGCCTTTTCCGCTTTCCTGAAGGCC
TATGAGAAGGGCCTTCTGATCCGCACCACAGGCGACATCATTGCGCTGTCACCGCCGCTGATCATCGAAAAACAGCAGAT
CGACGAGCTTTTCGACAAGCTACGCGACGTGCTGAAGAACAATATCTGA

Upstream 100 bases:

>100_bases
CGTTTACCGCATTTCTGCGATCCGGCGGTGGCAGGATATTGAATCGGTGCTACGTTCTGGCGGAGGCCAGCATCGCCACG
AATCGAGGAGGAGATGAGAC

Downstream 100 bases:

>100_bases
AGCGTTTCCTGCCATGTGCGAGGCCCTTTCCCCGACCGCGGGGAGAGGGTTATTGTCATGATCAGGATCAAGTGCGAGGT
GCATAGATGTCCGAAGCGCT

Product: omega amino acid--pyruvate transaminase

Products: NA

Alternate protein names: Omega-APT; Beta-alanine--pyruvate aminotransferase [H]

Number of amino acids: Translated: 442; Mature: 441

Protein sequence:

>442_residues
MSNRLNTTPNDLRAFWMPFTANRQFKKEPRLFVGAKDMYYTTHDGRTVLDGTAGLWCVNAGHCRPKITEAIREQAGELDY
APAFQLGHPKAFELANRLVDIAPEGMNHVLYTNSGSESVDTALKVALAYHRAKGNGSRFRLIGRERGYHGVNFGGISVGG
IVANRKMFGTLLTGVDHLPHTHLPAKNAFSRGEPEHGADLAAELERIVTLHDASTVAAVIVEPVAGSTGVLIPPKGYLQK
LREICTKHGILLIFDEVITGYGRLGTPFAAQYFDVKPDIITTAKGLTNGVIPMGAVFVTSEIHDAFMTGPEHLIEFFHGY
TYSGNPIASAAALGTLDTYKEEGLLTRAAELASYWEEALHALKDCPHVIDIRNIGLIGAIELEPIAGEPTKRAFSAFLKA
YEKGLLIRTTGDIIALSPPLIIEKQQIDELFDKLRDVLKNNI

Sequences:

>Translated_442_residues
MSNRLNTTPNDLRAFWMPFTANRQFKKEPRLFVGAKDMYYTTHDGRTVLDGTAGLWCVNAGHCRPKITEAIREQAGELDY
APAFQLGHPKAFELANRLVDIAPEGMNHVLYTNSGSESVDTALKVALAYHRAKGNGSRFRLIGRERGYHGVNFGGISVGG
IVANRKMFGTLLTGVDHLPHTHLPAKNAFSRGEPEHGADLAAELERIVTLHDASTVAAVIVEPVAGSTGVLIPPKGYLQK
LREICTKHGILLIFDEVITGYGRLGTPFAAQYFDVKPDIITTAKGLTNGVIPMGAVFVTSEIHDAFMTGPEHLIEFFHGY
TYSGNPIASAAALGTLDTYKEEGLLTRAAELASYWEEALHALKDCPHVIDIRNIGLIGAIELEPIAGEPTKRAFSAFLKA
YEKGLLIRTTGDIIALSPPLIIEKQQIDELFDKLRDVLKNNI
>Mature_441_residues
SNRLNTTPNDLRAFWMPFTANRQFKKEPRLFVGAKDMYYTTHDGRTVLDGTAGLWCVNAGHCRPKITEAIREQAGELDYA
PAFQLGHPKAFELANRLVDIAPEGMNHVLYTNSGSESVDTALKVALAYHRAKGNGSRFRLIGRERGYHGVNFGGISVGGI
VANRKMFGTLLTGVDHLPHTHLPAKNAFSRGEPEHGADLAAELERIVTLHDASTVAAVIVEPVAGSTGVLIPPKGYLQKL
REICTKHGILLIFDEVITGYGRLGTPFAAQYFDVKPDIITTAKGLTNGVIPMGAVFVTSEIHDAFMTGPEHLIEFFHGYT
YSGNPIASAAALGTLDTYKEEGLLTRAAELASYWEEALHALKDCPHVIDIRNIGLIGAIELEPIAGEPTKRAFSAFLKAY
EKGLLIRTTGDIIALSPPLIIEKQQIDELFDKLRDVLKNNI

Specific function: Catalyzes transamination between a variety of omega- amino acids, mono and diamines, and pyruvate. Plays a pivotal role in the metabolism of the omega amino acids [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=401, Percent_Identity=31.4214463840399, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI284507298, Length=320, Percent_Identity=31.875, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI37574042, Length=431, Percent_Identity=29.6983758700696, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI13994255, Length=434, Percent_Identity=28.3410138248848, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI226442709, Length=391, Percent_Identity=30.1790281329923, Blast_Score=132, Evalue=9e-31,
Organism=Homo sapiens, GI226442705, Length=427, Percent_Identity=29.03981264637, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI24119277, Length=442, Percent_Identity=26.2443438914027, Blast_Score=122, Evalue=6e-28,
Organism=Escherichia coli, GI1786991, Length=423, Percent_Identity=32.1513002364066, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI145693181, Length=402, Percent_Identity=30.5970149253731, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI1789759, Length=389, Percent_Identity=30.3341902313625, Blast_Score=156, Evalue=3e-39,
Organism=Escherichia coli, GI1789016, Length=399, Percent_Identity=31.077694235589, Blast_Score=154, Evalue=2e-38,
Organism=Escherichia coli, GI1787560, Length=410, Percent_Identity=30.9756097560976, Blast_Score=148, Evalue=9e-37,
Organism=Escherichia coli, GI1788044, Length=395, Percent_Identity=28.1012658227848, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1786349, Length=333, Percent_Identity=29.4294294294294, Blast_Score=93, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI32564660, Length=441, Percent_Identity=31.0657596371882, Blast_Score=172, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI25144271, Length=400, Percent_Identity=30.25, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI71992977, Length=435, Percent_Identity=29.4252873563218, Blast_Score=134, Evalue=9e-32,
Organism=Caenorhabditis elegans, GI25144274, Length=291, Percent_Identity=31.9587628865979, Blast_Score=127, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI17541228, Length=379, Percent_Identity=22.6912928759894, Blast_Score=75, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6323470, Length=438, Percent_Identity=31.2785388127854, Blast_Score=186, Evalue=9e-48,
Organism=Saccharomyces cerevisiae, GI6324432, Length=417, Percent_Identity=29.4964028776978, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6324386, Length=483, Percent_Identity=25.4658385093168, Blast_Score=129, Evalue=7e-31,
Organism=Saccharomyces cerevisiae, GI6321456, Length=306, Percent_Identity=27.4509803921569, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21357415, Length=403, Percent_Identity=31.0173697270471, Blast_Score=161, Evalue=7e-40,
Organism=Drosophila melanogaster, GI161085790, Length=467, Percent_Identity=28.6937901498929, Blast_Score=154, Evalue=8e-38,
Organism=Drosophila melanogaster, GI28574759, Length=450, Percent_Identity=29.3333333333333, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI21356575, Length=437, Percent_Identity=29.0617848970252, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI281366494, Length=426, Percent_Identity=22.0657276995305, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24667139, Length=426, Percent_Identity=22.0657276995305, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24667143, Length=426, Percent_Identity=22.0657276995305, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.18 [H]

Molecular weight: Translated: 48310; Mature: 48179

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNRLNTTPNDLRAFWMPFTANRQFKKEPRLFVGAKDMYYTTHDGRTVLDGTAGLWCVNA
CCCCCCCCHHHHEEEECCCCCCCCCCCCCCEEEECCCEEEEECCCCEEECCCCCEEEEEC
GHCRPKITEAIREQAGELDYAPAFQLGHPKAFELANRLVDIAPEGMNHVLYTNSGSESVD
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCHHHH
TALKVALAYHRAKGNGSRFRLIGRERGYHGVNFGGISVGGIVANRKMFGTLLTGVDHLPH
HHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCEEECCEEHHHHHHHHHHHHHHHCCC
THLPAKNAFSRGEPEHGADLAAELERIVTLHDASTVAAVIVEPVAGSTGVLIPPKGYLQK
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHEEEHEEECCCCCCCEEECCHHHHHH
LREICTKHGILLIFDEVITGYGRLGTPFAAQYFDVKPDIITTAKGLTNGVIPMGAVFVTS
HHHHHHHCCEEEEEHHHHHCCCCCCCCHHHHHCCCCCCHHHHHCCCCCCCCCCCCEEEHH
EIHDAFMTGPEHLIEFFHGYTYSGNPIASAAALGTLDTYKEEGLLTRAAELASYWEEALH
HHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
ALKDCPHVIDIRNIGLIGAIELEPIAGEPTKRAFSAFLKAYEKGLLIRTTGDIIALSPPL
HHHCCCCEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCEEEEECCCEEEECCCC
IIEKQQIDELFDKLRDVLKNNI
EEEHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SNRLNTTPNDLRAFWMPFTANRQFKKEPRLFVGAKDMYYTTHDGRTVLDGTAGLWCVNA
CCCCCCCHHHHEEEECCCCCCCCCCCCCCEEEECCCEEEEECCCCEEECCCCCEEEEEC
GHCRPKITEAIREQAGELDYAPAFQLGHPKAFELANRLVDIAPEGMNHVLYTNSGSESVD
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCHHHH
TALKVALAYHRAKGNGSRFRLIGRERGYHGVNFGGISVGGIVANRKMFGTLLTGVDHLPH
HHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCEEECCEEHHHHHHHHHHHHHHHCCC
THLPAKNAFSRGEPEHGADLAAELERIVTLHDASTVAAVIVEPVAGSTGVLIPPKGYLQK
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHEEEHEEECCCCCCCEEECCHHHHHH
LREICTKHGILLIFDEVITGYGRLGTPFAAQYFDVKPDIITTAKGLTNGVIPMGAVFVTS
HHHHHHHCCEEEEEHHHHHCCCCCCCCHHHHHCCCCCCHHHHHCCCCCCCCCCCCEEEHH
EIHDAFMTGPEHLIEFFHGYTYSGNPIASAAALGTLDTYKEEGLLTRAAELASYWEEALH
HHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
ALKDCPHVIDIRNIGLIGAIELEPIAGEPTKRAFSAFLKAYEKGLLIRTTGDIIALSPPL
HHHCCCCEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCEEEEECCCEEEECCCC
IIEKQQIDELFDKLRDVLKNNI
EEEHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1618757; 6822556; 2500426 [H]