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The map label for this gene is glxR [C]

Identifier: 150397432

GI number: 150397432

Start: 2312675

End: 2313541

Strand: Direct

Name: glxR [C]

Synonym: Smed_2232

Alternate gene names: 150397432

Gene position: 2312675-2313541 (Clockwise)

Preceding gene: 150397431

Following gene: 150397434

Centisome position: 61.15

GC content: 63.21

Gene sequence:

>867_bases
ATGAGCAGCATTTCAATTCTCGGCCTGGGCGCCATGGGGACGGCGCTCGCACAAACGCTTCTTAAGAACGGTCACACCGT
CACGATCTGGAATCGAACGGGCCGCCGCGCCGAGCCGCTTGCCGAGGCTGGCGCGAAAATCGCGGAAAGTCCGGCCGAAG
CGATCGCGGCGAGCGAGCTCACCATTCTCTGCGTCGTCGACTATCCCGCCGCACGTGCGGTGCTGACGCAGGCGGAGGGC
GTCCTCGCCGGCCGCGACCTTCTCAACCTCACCAACGGCACACCGGGTGACGCCAGGGAATTCGGCGCATGGCTGGCGGC
CAAGGGGGCGACCTATCTCGACGGCGGGATCATGGCGATCCCGCCGATGATCGGCGAGGCTGGCGCCCTGATTCTCTATA
GCGGCTCGCCTACGCTCTTCGAGCGGCACAGGAAAACGCTCGATGCGCTTGCCGAAAGCCGCCATCTCGGCGACGAAGTG
AGCCTCGCCTCACTCTACGACTTGGCGCTGCTTTCGGGAATGTACGGCCTCTTTTCGGGCTTCCTGCATGCGAGCGCGTT
GGTGACAAGCGCCGGAGGCAAAGCTGCCGACTTCCTGCCGCTGCTCCAACCGTGGATCCAGGCGATGAGCGGCACCCTTC
CCGACCTTGCCGACAAGGTCGACAGCGATATGCACGGCCGAAACGTCGTCTCCAATATCGCCATGCAGAAAGTCGCACTC
GAGAATATCGTAAGAGCGAGCGCAGAACAGGGCGTCGCTCCCGATTTCATCGAACCCATGTTGCGGCTGGCCGGCGGGCG
CATCGACAAAGGCGGTCATGATGAGGACATTTCCGCCGTCATCGAGGAGATCCGGCAACGAAAATGA

Upstream 100 bases:

>100_bases
AGGCCACCTTCACCACCGGCGCGAAGCTCGCCGTCGACGGCGGCCTCGGCCAGAAGCTCTCGACCGCCGCCTGAACGACC
TTCTTTGGAAAGGAACTTCC

Downstream 100 bases:

>100_bases
TTCCGTTTCAACGGCGTAGGATTGCTGATTGAACCGTATCCGGAGATCGCTGAATCAAGTTCTGAACATGAAAAAGCCCG
CCGATGGCGGGCTTTTTCAT

Product: 6-phosphogluconate dehydrogenase

Products: (R)-Glycerate; Nicotinamide adenine dinucleotide [C]

Alternate protein names: NA

Number of amino acids: Translated: 288; Mature: 287

Protein sequence:

>288_residues
MSSISILGLGAMGTALAQTLLKNGHTVTIWNRTGRRAEPLAEAGAKIAESPAEAIAASELTILCVVDYPAARAVLTQAEG
VLAGRDLLNLTNGTPGDAREFGAWLAAKGATYLDGGIMAIPPMIGEAGALILYSGSPTLFERHRKTLDALAESRHLGDEV
SLASLYDLALLSGMYGLFSGFLHASALVTSAGGKAADFLPLLQPWIQAMSGTLPDLADKVDSDMHGRNVVSNIAMQKVAL
ENIVRASAEQGVAPDFIEPMLRLAGGRIDKGGHDEDISAVIEEIRQRK

Sequences:

>Translated_288_residues
MSSISILGLGAMGTALAQTLLKNGHTVTIWNRTGRRAEPLAEAGAKIAESPAEAIAASELTILCVVDYPAARAVLTQAEG
VLAGRDLLNLTNGTPGDAREFGAWLAAKGATYLDGGIMAIPPMIGEAGALILYSGSPTLFERHRKTLDALAESRHLGDEV
SLASLYDLALLSGMYGLFSGFLHASALVTSAGGKAADFLPLLQPWIQAMSGTLPDLADKVDSDMHGRNVVSNIAMQKVAL
ENIVRASAEQGVAPDFIEPMLRLAGGRIDKGGHDEDISAVIEEIRQRK
>Mature_287_residues
SSISILGLGAMGTALAQTLLKNGHTVTIWNRTGRRAEPLAEAGAKIAESPAEAIAASELTILCVVDYPAARAVLTQAEGV
LAGRDLLNLTNGTPGDAREFGAWLAAKGATYLDGGIMAIPPMIGEAGALILYSGSPTLFERHRKTLDALAESRHLGDEVS
LASLYDLALLSGMYGLFSGFLHASALVTSAGGKAADFLPLLQPWIQAMSGTLPDLADKVDSDMHGRNVVSNIAMQKVALE
NIVRASAEQGVAPDFIEPMLRLAGGRIDKGGHDEDISAVIEEIRQRK

Specific function: Glyoxylate catabolism. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40556376, Length=288, Percent_Identity=24.6527777777778, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI28574115, Length=173, Percent_Identity=27.1676300578035, Blast_Score=82, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: 1.1.1.60 [C]

Molecular weight: Translated: 30226; Mature: 30095

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSISILGLGAMGTALAQTLLKNGHTVTIWNRTGRRAEPLAEAGAKIAESPAEAIAASEL
CCCCEEEECCHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHCCHHHHHHHCCE
TILCVVDYPAARAVLTQAEGVLAGRDLLNLTNGTPGDAREFGAWLAAKGATYLDGGIMAI
EEEEEECCCHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEECCCCEEC
PPMIGEAGALILYSGSPTLFERHRKTLDALAESRHLGDEVSLASLYDLALLSGMYGLFSG
CCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
FLHASALVTSAGGKAADFLPLLQPWIQAMSGTLPDLADKVDSDMHGRNVVSNIAMQKVAL
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHH
ENIVRASAEQGVAPDFIEPMLRLAGGRIDKGGHDEDISAVIEEIRQRK
HHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SSISILGLGAMGTALAQTLLKNGHTVTIWNRTGRRAEPLAEAGAKIAESPAEAIAASEL
CCCEEEECCHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHCCHHHHHHHCCE
TILCVVDYPAARAVLTQAEGVLAGRDLLNLTNGTPGDAREFGAWLAAKGATYLDGGIMAI
EEEEEECCCHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEECCCCEEC
PPMIGEAGALILYSGSPTLFERHRKTLDALAESRHLGDEVSLASLYDLALLSGMYGLFSG
CCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
FLHASALVTSAGGKAADFLPLLQPWIQAMSGTLPDLADKVDSDMHGRNVVSNIAMQKVAL
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHH
ENIVRASAEQGVAPDFIEPMLRLAGGRIDKGGHDEDISAVIEEIRQRK
HHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2-Hydroxy-3-oxopropanoate; H+; Nicotinamide adenine dinucleotide - reduced [C]

Specific reaction: 2-Hydroxy-3-oxopropanoate + H+ + Nicotinamide adenine dinucleotide - reduced --> (R)-Glycerate + Nicotinamide adenine dinucleotide [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA