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The map label for this gene is degP1 [H]

Identifier: 150397215

GI number: 150397215

Start: 2064642

End: 2066150

Strand: Reverse

Name: degP1 [H]

Synonym: Smed_2014

Alternate gene names: 150397215

Gene position: 2066150-2064642 (Counterclockwise)

Preceding gene: 150397216

Following gene: 150397212

Centisome position: 54.63

GC content: 61.37

Gene sequence:

>1509_bases
TTGTCGAAACGACCCGAATTCTTCCGCGGCCTGGCGCTCGCGGCCGCGACGGCACTCATTTTCACCAATACGGCGCTTGC
CCAGACGGCCACGTCACGGCCTCCGGCCGGTCCTCCATCCGTCGCGGATCTTGCCGAGGGACTGCTCGACGCAGTCGTCA
ACATATCGATTTCGCAGAACGTCAAGGGCGACGACGACAATGCGCCGATACCGCAGGTGCCGGAAGGGTCACCCCATCAG
GAGTTCTTCGACGAATTTTTCAGGGGTCCGGGAGGCGAGGGCGGCCGGCCGCGCACCGTCAATTCGCTGGGTTCAGGCTT
TATCATCGATCCCGCGGGCTACATTGTCACCAACAACCACGTGATCCAGGATGCCGACGATATCGAAATCAATTTCTCCG
ACGGCACGAAGCTGAAGGCGAAACTGGTCGGCATGGATACGAAAACCGACCTCGCCCTGCTGAAGGTCGAACCGAAAAAG
CCGCTCAAAGCCGTCTCTTTCGGTGATTCGCGAAAGATCAGGATCGGCGATTGGGTGATGGTGGTCGGCAATCCGTTCGG
TCTCGGCGTTTCCGTTTCCGTGGGCGTCGTCTCCGCACGCGGCCGCAATATCAATGCCGGCCCCTATGACAGTTTCATCC
AGACCGACGCGGCGATCAATCGCGGCAATTCGGGCGGACCGCTTTTCAACATGCAAGGCGAAGTCGTCGGCATCAATACG
GCGATCCTTTCGCAGACCGGCATGTCGGTCGGAATAGGCTTCGCCGTGCCGGCGGAGCTTGCCGTCAACGTTGTAAACCA
GCTCAAGGAATTCGGCGAAACCCGCCGCGGTTGGCTTGGCGTTCGAATCCAGCCCGTCACCGATGACATCGCCGAGAGCC
TGAAAATGGAGCTGCCGCGCGGCGCGCTCGTATCGGGCATCATCGAGGGCGGCCCGATTACCAAAGGTGAAATCAAGCCG
GGCGACATTATCATCCGCTTCGACGGAACGGATATCGCGGAGATTCGGGACCTCATGCGCACCGTCGGAGAGAGCCCCGT
CGGCAAGGCCGTCGATGTGGTGATCATCCGTGACGGCAAGGAGCAGTTGGTCCGCGTGACACTGGGCCGGCTGGAAGATG
GCGAGCAGCTCGCCAATGCGAAACCGGGTGAGATGCCGGAGAGCAGTGATGCGAAGCCCGGCGAACCGCCTGCCGCGCAA
CTGCCGGCAAGCGACACCGTGCTCGGCATGAAGCTCGCAGAGCTCGACACTGACCGCCGCCAGAGTTTCGGAATCGCCGA
AAACGTCAAAGGCGTCGTCATTACCGAGGTGCAGCCCAATTCGCCCGCGGCCGAGCGCCGGGTTGAGGTGGGCGAGGTGA
TCGTCGAACTTGGTCAGGAAGCAATGGAGACGCCGGAGGATGTCACCTCACGCGTCACGGAACTCAAGGCTGACGGGCGC
CGCAACGCTTTGCTGATGATCGCCAACAAAAGCGGCGAACTGCGCTTCGTGACGGTACGGATGGAGTGA

Upstream 100 bases:

>100_bases
GGCGCTGTAGTTCGTTGCAGCAAACCAAAGATCGTGCGTCATTTCCACCGGCCGACCTGAAGCCGGCGTGACGCAAGGGA
AATGATAGGAGCCTGGCGAC

Downstream 100 bases:

>100_bases
AACTCGCGGCGGCGTTCTGACGTACCAGAAACGGTCACGTTCAATTTTCAAGTCACCCGACTTAGAGCATTTCCGCTTTT
CCCCGATCCCGGAAACTCTC

Product: protease Do

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 502; Mature: 501

Protein sequence:

>502_residues
MSKRPEFFRGLALAAATALIFTNTALAQTATSRPPAGPPSVADLAEGLLDAVVNISISQNVKGDDDNAPIPQVPEGSPHQ
EFFDEFFRGPGGEGGRPRTVNSLGSGFIIDPAGYIVTNNHVIQDADDIEINFSDGTKLKAKLVGMDTKTDLALLKVEPKK
PLKAVSFGDSRKIRIGDWVMVVGNPFGLGVSVSVGVVSARGRNINAGPYDSFIQTDAAINRGNSGGPLFNMQGEVVGINT
AILSQTGMSVGIGFAVPAELAVNVVNQLKEFGETRRGWLGVRIQPVTDDIAESLKMELPRGALVSGIIEGGPITKGEIKP
GDIIIRFDGTDIAEIRDLMRTVGESPVGKAVDVVIIRDGKEQLVRVTLGRLEDGEQLANAKPGEMPESSDAKPGEPPAAQ
LPASDTVLGMKLAELDTDRRQSFGIAENVKGVVITEVQPNSPAAERRVEVGEVIVELGQEAMETPEDVTSRVTELKADGR
RNALLMIANKSGELRFVTVRME

Sequences:

>Translated_502_residues
MSKRPEFFRGLALAAATALIFTNTALAQTATSRPPAGPPSVADLAEGLLDAVVNISISQNVKGDDDNAPIPQVPEGSPHQ
EFFDEFFRGPGGEGGRPRTVNSLGSGFIIDPAGYIVTNNHVIQDADDIEINFSDGTKLKAKLVGMDTKTDLALLKVEPKK
PLKAVSFGDSRKIRIGDWVMVVGNPFGLGVSVSVGVVSARGRNINAGPYDSFIQTDAAINRGNSGGPLFNMQGEVVGINT
AILSQTGMSVGIGFAVPAELAVNVVNQLKEFGETRRGWLGVRIQPVTDDIAESLKMELPRGALVSGIIEGGPITKGEIKP
GDIIIRFDGTDIAEIRDLMRTVGESPVGKAVDVVIIRDGKEQLVRVTLGRLEDGEQLANAKPGEMPESSDAKPGEPPAAQ
LPASDTVLGMKLAELDTDRRQSFGIAENVKGVVITEVQPNSPAAERRVEVGEVIVELGQEAMETPEDVTSRVTELKADGR
RNALLMIANKSGELRFVTVRME
>Mature_501_residues
SKRPEFFRGLALAAATALIFTNTALAQTATSRPPAGPPSVADLAEGLLDAVVNISISQNVKGDDDNAPIPQVPEGSPHQE
FFDEFFRGPGGEGGRPRTVNSLGSGFIIDPAGYIVTNNHVIQDADDIEINFSDGTKLKAKLVGMDTKTDLALLKVEPKKP
LKAVSFGDSRKIRIGDWVMVVGNPFGLGVSVSVGVVSARGRNINAGPYDSFIQTDAAINRGNSGGPLFNMQGEVVGINTA
ILSQTGMSVGIGFAVPAELAVNVVNQLKEFGETRRGWLGVRIQPVTDDIAESLKMELPRGALVSGIIEGGPITKGEIKPG
DIIIRFDGTDIAEIRDLMRTVGESPVGKAVDVVIIRDGKEQLVRVTLGRLEDGEQLANAKPGEMPESSDAKPGEPPAAQL
PASDTVLGMKLAELDTDRRQSFGIAENVKGVVITEVQPNSPAAERRVEVGEVIVELGQEAMETPEDVTSRVTELKADGRR
NALLMIANKSGELRFVTVRME

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=282, Percent_Identity=32.6241134751773, Blast_Score=148, Evalue=2e-35,
Organism=Homo sapiens, GI4506141, Length=250, Percent_Identity=34.4, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI24308541, Length=263, Percent_Identity=31.9391634980989, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI7019477, Length=285, Percent_Identity=31.2280701754386, Blast_Score=124, Evalue=3e-28,
Organism=Escherichia coli, GI1786356, Length=453, Percent_Identity=36.4238410596026, Blast_Score=260, Evalue=2e-70,
Organism=Escherichia coli, GI1789629, Length=371, Percent_Identity=38.544474393531, Blast_Score=240, Evalue=2e-64,
Organism=Escherichia coli, GI1789630, Length=287, Percent_Identity=36.2369337979094, Blast_Score=171, Evalue=8e-44,
Organism=Drosophila melanogaster, GI24646839, Length=355, Percent_Identity=29.8591549295775, Blast_Score=142, Evalue=7e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 53314; Mature: 53183

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: PS50106 PDZ ; PS00211 ABC_TRANSPORTER_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKRPEFFRGLALAAATALIFTNTALAQTATSRPPAGPPSVADLAEGLLDAVVNISISQN
CCCCCHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHEEEEEECC
VKGDDDNAPIPQVPEGSPHQEFFDEFFRGPGGEGGRPRTVNSLGSGFIIDPAGYIVTNNH
CCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHCCCCEEECCCCEEEECCE
VIQDADDIEINFSDGTKLKAKLVGMDTKTDLALLKVEPKKPLKAVSFGDSRKIRIGDWVM
EEECCCCEEEEECCCCEEEEEEEECCCCCCEEEEEECCCCCCEEECCCCCCEEEECCEEE
VVGNPFGLGVSVSVGVVSARGRNINAGPYDSFIQTDAAINRGNSGGPLFNMQGEVVGINT
EECCCCCCCEEEEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCEEECCCCEEEEEH
AILSQTGMSVGIGFAVPAELAVNVVNQLKEFGETRRGWLGVRIQPVTDDIAESLKMELPR
HHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHCCCC
GALVSGIIEGGPITKGEIKPGDIIIRFDGTDIAEIRDLMRTVGESPVGKAVDVVIIRDGK
CHHHHHHCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCH
EQLVRVTLGRLEDGEQLANAKPGEMPESSDAKPGEPPAAQLPASDTVLGMKLAELDTDRR
HHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHCCCHHH
QSFGIAENVKGVVITEVQPNSPAAERRVEVGEVIVELGQEAMETPEDVTSRVTELKADGR
HHCCHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC
RNALLMIANKSGELRFVTVRME
CCEEEEEECCCCCEEEEEEEEC
>Mature Secondary Structure 
SKRPEFFRGLALAAATALIFTNTALAQTATSRPPAGPPSVADLAEGLLDAVVNISISQN
CCCCHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHEEEEEECC
VKGDDDNAPIPQVPEGSPHQEFFDEFFRGPGGEGGRPRTVNSLGSGFIIDPAGYIVTNNH
CCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHCCCCEEECCCCEEEECCE
VIQDADDIEINFSDGTKLKAKLVGMDTKTDLALLKVEPKKPLKAVSFGDSRKIRIGDWVM
EEECCCCEEEEECCCCEEEEEEEECCCCCCEEEEEECCCCCCEEECCCCCCEEEECCEEE
VVGNPFGLGVSVSVGVVSARGRNINAGPYDSFIQTDAAINRGNSGGPLFNMQGEVVGINT
EECCCCCCCEEEEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCEEECCCCEEEEEH
AILSQTGMSVGIGFAVPAELAVNVVNQLKEFGETRRGWLGVRIQPVTDDIAESLKMELPR
HHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHCCCC
GALVSGIIEGGPITKGEIKPGDIIIRFDGTDIAEIRDLMRTVGESPVGKAVDVVIIRDGK
CHHHHHHCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCH
EQLVRVTLGRLEDGEQLANAKPGEMPESSDAKPGEPPAAQLPASDTVLGMKLAELDTDRR
HHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHCCCHHH
QSFGIAENVKGVVITEVQPNSPAAERRVEVGEVIVELGQEAMETPEDVTSRVTELKADGR
HHCCHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC
RNALLMIANKSGELRFVTVRME
CCEEEEEECCCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550509; 11481430 [H]