Click here to switch to the map view.

The map label for this gene is czcD [H]

Identifier: 150396995

GI number: 150396995

Start: 1874699

End: 1875670

Strand: Reverse

Name: czcD [H]

Synonym: Smed_1792

Alternate gene names: 150396995

Gene position: 1875670-1874699 (Counterclockwise)

Preceding gene: 150396996

Following gene: 150396993

Centisome position: 49.6

GC content: 61.32

Gene sequence:

>972_bases
ATGACCGATATCCATTCACCGGCGCCTGCCGCCCACGATCATGTGTTTCTCGGCGACAATCACCAGCGCAATGAAAGGCG
AACGTGGTTCGTCATTGCGCTCACCGCGGGAATGATGGTCGCGGAAATCGCCGCGGGTACCTTCTACGGCTCGATGGCTC
TGGTCGCCGACGGCTGGCACATGTCGACGCATGCTGCAGCTCTGCTGATTGCGGCGCTCGCCTATCTCTATGCGCGGCGA
AACGCCCGCAACCCCCGGTTTACATTCGGTACCGGCAAACTCGGCGACCTTGCTGGTTTTTCCAGTGCGATCGTACTTGC
CCTGATCGCTCTGCTCATCGGCTGGGAAAGTCTTCTCCGGCTGGCCAATCCGGTGGCGATCAGTTTTCCGCAGGCCATTT
CGGTAGCCGTGCTTGGGCTTGTGGTCAATCTCGTCTGTGCCTGGCTGCTTCGCGAGGACCATTCGCATCACCACCATGGT
CACCATCACCACCACGGCCACGGGCACGATCACGATCACGGACACCACCACACCGCCGCCCAAGCCCGGGACAACAACCT
GCGTGCCGCCTATCTGCATGTGCTGGCGGATGCGCTGACCTCGGTTCTTGCGATTGTCGCGCTCGCAGCCGGCAGCGTCT
ACGGCTGGATATGGCTCGACCCGCTGATGGGTATTGTCGGCGCTCTGGTGATTGCCCGCTGGTCCATGGGGCTGATCCGG
GATAGCGGCAGCGTGCTGCTGGATTATATCCAGGCGGGCGAGGATCTGCCGGACGAGATACGTGCGGTAATCGAAAAGGA
CGGGGATCGGATTACGGATCTGCACGTGTGGCAGCTTGGGCCCGGTCACCATGGCGCCATCGTTTCGCTGGTGACGAAAA
ACCCGCAGAGCCCGTCGATCTACCGCCGGAAGCTTCAGCATATCCACGAGCTTTCACATGTGACGGTCGAGGTCGAGCCT
CTGGCTGCGTGA

Upstream 100 bases:

>100_bases
TAGAGGACCATATCCGAGGGCACGTCGCCGGCCATGATACGCAGGTCGAGCGCGAAGAAGGTGCTGCCGAACTGATTGAA
ATCGTCAGGAGATACCTGAA

Downstream 100 bases:

>100_bases
AGCGCCGTCTGTCTCCCAGATACTATCGAGCTTTGCGCCGCGGGTAGGGCGTCTCGCCCCGGCTCAGCATCCCGACATAT
TTATCGATGCGCGCAGCGCG

Product: cation diffusion facilitator family transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 323; Mature: 322

Protein sequence:

>323_residues
MTDIHSPAPAAHDHVFLGDNHQRNERRTWFVIALTAGMMVAEIAAGTFYGSMALVADGWHMSTHAAALLIAALAYLYARR
NARNPRFTFGTGKLGDLAGFSSAIVLALIALLIGWESLLRLANPVAISFPQAISVAVLGLVVNLVCAWLLREDHSHHHHG
HHHHHGHGHDHDHGHHHTAAQARDNNLRAAYLHVLADALTSVLAIVALAAGSVYGWIWLDPLMGIVGALVIARWSMGLIR
DSGSVLLDYIQAGEDLPDEIRAVIEKDGDRITDLHVWQLGPGHHGAIVSLVTKNPQSPSIYRRKLQHIHELSHVTVEVEP
LAA

Sequences:

>Translated_323_residues
MTDIHSPAPAAHDHVFLGDNHQRNERRTWFVIALTAGMMVAEIAAGTFYGSMALVADGWHMSTHAAALLIAALAYLYARR
NARNPRFTFGTGKLGDLAGFSSAIVLALIALLIGWESLLRLANPVAISFPQAISVAVLGLVVNLVCAWLLREDHSHHHHG
HHHHHGHGHDHDHGHHHTAAQARDNNLRAAYLHVLADALTSVLAIVALAAGSVYGWIWLDPLMGIVGALVIARWSMGLIR
DSGSVLLDYIQAGEDLPDEIRAVIEKDGDRITDLHVWQLGPGHHGAIVSLVTKNPQSPSIYRRKLQHIHELSHVTVEVEP
LAA
>Mature_322_residues
TDIHSPAPAAHDHVFLGDNHQRNERRTWFVIALTAGMMVAEIAAGTFYGSMALVADGWHMSTHAAALLIAALAYLYARRN
ARNPRFTFGTGKLGDLAGFSSAIVLALIALLIGWESLLRLANPVAISFPQAISVAVLGLVVNLVCAWLLREDHSHHHHGH
HHHHGHGHDHDHGHHHTAAQARDNNLRAAYLHVLADALTSVLAIVALAAGSVYGWIWLDPLMGIVGALVIARWSMGLIRD
SGSVLLDYIQAGEDLPDEIRAVIEKDGDRITDLHVWQLGPGHHGAIVSLVTKNPQSPSIYRRKLQHIHELSHVTVEVEPL
AA

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI20070323, Length=267, Percent_Identity=27.7153558052434, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI222080086, Length=298, Percent_Identity=24.8322147651007, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI40255009, Length=298, Percent_Identity=24.8322147651007, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI21359890, Length=260, Percent_Identity=26.1538461538462, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI52351208, Length=120, Percent_Identity=34.1666666666667, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1786966, Length=259, Percent_Identity=34.3629343629344, Blast_Score=102, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI32564488, Length=302, Percent_Identity=30.794701986755, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI193210990, Length=326, Percent_Identity=28.5276073619632, Blast_Score=95, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17555796, Length=316, Percent_Identity=26.2658227848101, Blast_Score=81, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17555794, Length=324, Percent_Identity=25.9259259259259, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323899, Length=165, Percent_Identity=28.4848484848485, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320411, Length=214, Percent_Identity=23.3644859813084, Blast_Score=63, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24645863, Length=308, Percent_Identity=28.2467532467532, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24656728, Length=284, Percent_Identity=28.5211267605634, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24656724, Length=284, Percent_Identity=28.5211267605634, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24656720, Length=284, Percent_Identity=28.5211267605634, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24656715, Length=284, Percent_Identity=28.5211267605634, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21357035, Length=284, Percent_Identity=28.5211267605634, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 35183; Mature: 35052

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDIHSPAPAAHDHVFLGDNHQRNERRTWFVIALTAGMMVAEIAAGTFYGSMALVADGWH
CCCCCCCCCCCCCEEEECCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCEEEEECCCC
MSTHAAALLIAALAYLYARRNARNPRFTFGTGKLGDLAGFSSAIVLALIALLIGWESLLR
HHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LANPVAISFPQAISVAVLGLVVNLVCAWLLREDHSHHHHGHHHHHGHGHDHDHGHHHTAA
HCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHH
QARDNNLRAAYLHVLADALTSVLAIVALAAGSVYGWIWLDPLMGIVGALVIARWSMGLIR
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DSGSVLLDYIQAGEDLPDEIRAVIEKDGDRITDLHVWQLGPGHHGAIVSLVTKNPQSPSI
CCCHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEEEEEEECCCCCCEEEEEEECCCCCHHH
YRRKLQHIHELSHVTVEVEPLAA
HHHHHHHHHHHHHEEEEEEECCC
>Mature Secondary Structure 
TDIHSPAPAAHDHVFLGDNHQRNERRTWFVIALTAGMMVAEIAAGTFYGSMALVADGWH
CCCCCCCCCCCCEEEECCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCEEEEECCCC
MSTHAAALLIAALAYLYARRNARNPRFTFGTGKLGDLAGFSSAIVLALIALLIGWESLLR
HHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LANPVAISFPQAISVAVLGLVVNLVCAWLLREDHSHHHHGHHHHHGHGHDHDHGHHHTAA
HCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHH
QARDNNLRAAYLHVLADALTSVLAIVALAAGSVYGWIWLDPLMGIVGALVIARWSMGLIR
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DSGSVLLDYIQAGEDLPDEIRAVIEKDGDRITDLHVWQLGPGHHGAIVSLVTKNPQSPSI
CCCHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEEEEEEECCCCCCEEEEEEECCCCCHHH
YRRKLQHIHELSHVTVEVEPLAA
HHHHHHHHHHHHHEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 9099864 [H]