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The map label for this gene is trxA [C]

Identifier: 150396838

GI number: 150396838

Start: 1725869

End: 1726573

Strand: Direct

Name: trxA [C]

Synonym: Smed_1632

Alternate gene names: 150396838

Gene position: 1725869-1726573 (Clockwise)

Preceding gene: 150396834

Following gene: 150396839

Centisome position: 45.63

GC content: 55.04

Gene sequence:

>705_bases
ATGAACACCACCACTCCCGATGAGCACCCCTCGGCTATTGTTAAAGTCGATACTTCCAATTTCTCGGAAGAAGTTCTGAA
GCCGGCCGAACCGGTCATCGCCATCTTCTCGTTCGATGGGTGCGGGCACTGCGCGATAATTGCACCTTTGCTCGAAGAAA
TCGCCACCGAGCTTGCTGGCAAGGTCAAGATCGTCAAGGTCAGCGACACTGAAAACCCCGAGCTCGCGAAGCAGTATGGC
ATATACGGCTTCCCAATGCTTGCCTTGTTCAAGGGTGGTGAAGTCAACGACATTTTCCTCGGAGCCGCACCACCTAATAT
TGAGACGAAACTCCGCTCCTGGATTTCCAAGACGGTTCAAACACCGAAGATGAACACCACTCCCGAGTACCCCACGGCTA
TTGTGGAAGGCGATGTTTCCGCTTTCCCGGAAGAAGGTCTGAAGTCGGCCGAAGCAGTCATCGTCCACTTCTGGGGAAAC
CGGTGCCCGCCGTTCGAGCTGATTGAACCCATCCTCGAACAAGTCGCCACCGAGCTTGCTGGCAAGGTCAAGGTCATCAA
GCTCAACATCGGGGAAAACCGCGATTTCGCGACGCAGTATGGCGTAGACGGCTTCCCAATGCTTGCCATGTTCAAGGGTG
GTGAAGTCGCCGGCATCTACGATGGAGGCTCACTCGGCTCCTGGATTTCGCACGCGATGGCTTGA

Upstream 100 bases:

>100_bases
CAAGGCTTTCCATGTTCAAGGGTGGGGAAGTCATCTACGTCGGAGGCGGCTCACTTCCCCTCCTGGATTTCGAAAATGGT
TCGAACACAAAGGAACCACG

Downstream 100 bases:

>100_bases
GTCACCGGTCTTCGGCTCATTCGATACCCCGAGCGATCAACCCCTTTTACCGGCGCATCTCTAACTGATCCGAATGCTCA
CCAACGTCCAACTCAATGGA

Product: thioredoxin domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MNTTTPDEHPSAIVKVDTSNFSEEVLKPAEPVIAIFSFDGCGHCAIIAPLLEEIATELAGKVKIVKVSDTENPELAKQYG
IYGFPMLALFKGGEVNDIFLGAAPPNIETKLRSWISKTVQTPKMNTTPEYPTAIVEGDVSAFPEEGLKSAEAVIVHFWGN
RCPPFELIEPILEQVATELAGKVKVIKLNIGENRDFATQYGVDGFPMLAMFKGGEVAGIYDGGSLGSWISHAMA

Sequences:

>Translated_234_residues
MNTTTPDEHPSAIVKVDTSNFSEEVLKPAEPVIAIFSFDGCGHCAIIAPLLEEIATELAGKVKIVKVSDTENPELAKQYG
IYGFPMLALFKGGEVNDIFLGAAPPNIETKLRSWISKTVQTPKMNTTPEYPTAIVEGDVSAFPEEGLKSAEAVIVHFWGN
RCPPFELIEPILEQVATELAGKVKVIKLNIGENRDFATQYGVDGFPMLAMFKGGEVAGIYDGGSLGSWISHAMA
>Mature_234_residues
MNTTTPDEHPSAIVKVDTSNFSEEVLKPAEPVIAIFSFDGCGHCAIIAPLLEEIATELAGKVKIVKVSDTENPELAKQYG
IYGFPMLALFKGGEVNDIFLGAAPPNIETKLRSWISKTVQTPKMNTTPEYPTAIVEGDVSAFPEEGLKSAEAVIVHFWGN
RCPPFELIEPILEQVATELAGKVKVIKLNIGENRDFATQYGVDGFPMLAMFKGGEVAGIYDGGSLGSWISHAMA

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI5031973, Length=233, Percent_Identity=26.1802575107296, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI42794771, Length=232, Percent_Identity=27.5862068965517, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI224493972, Length=235, Percent_Identity=27.6595744680851, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI4758304, Length=181, Percent_Identity=25.414364640884, Blast_Score=68, Evalue=7e-12,
Organism=Escherichia coli, GI87082331, Length=99, Percent_Identity=39.3939393939394, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1788936, Length=97, Percent_Identity=35.0515463917526, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI25144092, Length=211, Percent_Identity=26.5402843601896, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17556044, Length=237, Percent_Identity=24.0506329113924, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19921434, Length=229, Percent_Identity=26.2008733624454, Blast_Score=78, Evalue=6e-15,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 25229; Mature: 25229

Theoretical pI: Translated: 4.44; Mature: 4.44

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTTTPDEHPSAIVKVDTSNFSEEVLKPAEPVIAIFSFDGCGHCAIIAPLLEEIATELAG
CCCCCCCCCCCEEEEEECCCCHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHC
KVKIVKVSDTENPELAKQYGIYGFPMLALFKGGEVNDIFLGAAPPNIETKLRSWISKTVQ
CEEEEEECCCCCHHHHHHHCCCCCCHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHC
TPKMNTTPEYPTAIVEGDVSAFPEEGLKSAEAVIVHFWGNRCPPFELIEPILEQVATELA
CCCCCCCCCCCCEEEECCHHHCCHHHCCCHHEEEEEECCCCCCCHHHHHHHHHHHHHHHH
GKVKVIKLNIGENRDFATQYGVDGFPMLAMFKGGEVAGIYDGGSLGSWISHAMA
CCEEEEEEECCCCCCCHHHCCCCCCCEEEEECCCCEEEEECCCCHHHHHHHHCC
>Mature Secondary Structure
MNTTTPDEHPSAIVKVDTSNFSEEVLKPAEPVIAIFSFDGCGHCAIIAPLLEEIATELAG
CCCCCCCCCCCEEEEEECCCCHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHC
KVKIVKVSDTENPELAKQYGIYGFPMLALFKGGEVNDIFLGAAPPNIETKLRSWISKTVQ
CEEEEEECCCCCHHHHHHHCCCCCCHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHC
TPKMNTTPEYPTAIVEGDVSAFPEEGLKSAEAVIVHFWGNRCPPFELIEPILEQVATELA
CCCCCCCCCCCCEEEECCHHHCCHHHCCCHHEEEEEECCCCCCCHHHHHHHHHHHHHHHH
GKVKVIKLNIGENRDFATQYGVDGFPMLAMFKGGEVAGIYDGGSLGSWISHAMA
CCEEEEEEECCCCCCCHHHCCCCCCCEEEEECCCCEEEEECCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7021558 [H]