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The map label for this gene is bcr [H]

Identifier: 150396722

GI number: 150396722

Start: 1591199

End: 1592512

Strand: Direct

Name: bcr [H]

Synonym: Smed_1510

Alternate gene names: 150396722

Gene position: 1591199-1592512 (Clockwise)

Preceding gene: 150396721

Following gene: 150396731

Centisome position: 42.07

GC content: 60.43

Gene sequence:

>1314_bases
ATGTCTTCCGTTTCCCAGCAATCTTCACTCGGTGAGCAGTCATCCGGGCACAGCAATCAGGTCTCGGGTGCCGCGCGCCT
CGGAATGGGCCTCGTCGAATTCATCGTCACCATAGCGGTCATGACCGCAAGCATCGCGCTGGCGATCGACAGCATGCTGC
CGGCTTTGCCGGCCATCGGCCGGACGCTCAACGTTGCCAATGCCAACGACACGCAACTCGTGATCGGCGTCTTCTTTCTT
GGATTCGGTCTCTCCCAGATCTTTTTCGGAAGCCTCTCCGATACATTAGGTCGCCGGTCGGTGCTGCTTGCGGGCCTTGC
CCTCTTCAGCCTGTCGATGTTCGCCGCCTCCTGGGTCGAAAGCATCGAAGCGCTGCTGTTGCTCCGCTTCGTTCAGGGTA
TCGGCGGTGCCGCCGTGCGCATTACGACCATGGCGATCGTCCGCGACTGTTTCGGGGGCCGTGAGATGGCGCGCGTCATG
TCCTATGTCATGATCGTCTTCATGATCGTGCCGATCGTCGCCCCGACGCTTGGCCAGCTGGTGATCGCCTATGCCGATTG
GCACTGGATCTTCATCCTGATCGGCGTCGTCGGCGCGGCCCTTTTCGTTTGGGCACTTACCCGAATGAAAGAGTCGCTGC
CGAGGGAGGAGCGCCTGCCGCTTTCAGTCGGCGCGGTTTTGTCCGGTTTTCGTACGGTCCTTACAAACCGCATCACCTGT
GGCTACATGATCGGTATGACTCTGTTCACGGCCGTCATTTGCGCCTATGTCGTCAGCGTCCAGCAGGTCTTCGGTGAAGT
CTACAATCTCAGCGACTGGCTGCCGATCGCCTTTGCGGGCACCGCGGGCGGCATTGCGGTCGCGAACTTCGCCAATGGCT
ATTTCGTGCGCAGTTTCGGAATGCGGCGCATCTCGCACACAGCCATGATCCTCTTCACCGTCGTCGCGGCAATCGGATAC
GTTCTTTCGCTCGCGGGCACTCCGGCTTTCACCATCAGCTACCTGCTGTTTTCTCTTTTGCTGATGTTCTTTGCCGTCAT
CGCCACCAACTTCACCGCCATAAGCCTCGAACCCATGGGGCATCTCGCGGGAACAGCAACCGCGATCACCGGTTTCGTCT
CGACCACCGGCGGTGCGCTGATCGGCGGCGCCGTCGGCCAGCTCTTCAACGGCACGCTGCAGCCACTCTTCGGCGGCTAC
GCTCTTTTCGGAGTGCTGACCATCCTCGCAACGCTCTGGGCCGAAAACGGGAAGCTGTTCACCCATCCGGGCGATAGCGA
TACGACGCACGAACACGGCGGCGGCCATTTGTGA

Upstream 100 bases:

>100_bases
CTGTGTGCTGATCGCAGAGGGCGGAAAGCTATTCAAACCGCACAATCCGGCGGGTTAGCCGGATTCCCCAGTTTTCCCCA
TCCATTTCGGAATTTCAGAC

Downstream 100 bases:

>100_bases
CGAAAGAACCCGCCCGGCAATCGGGGCGGGTTCCATCTCGCCGGCGATGTCTTCCGATCAGACGGTGAAGACCTCTCGCC
GCAATTCCTGCCAGCTCTCC

Product: major facilitator transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Sulfonamide resistance protein [H]

Number of amino acids: Translated: 437; Mature: 436

Protein sequence:

>437_residues
MSSVSQQSSLGEQSSGHSNQVSGAARLGMGLVEFIVTIAVMTASIALAIDSMLPALPAIGRTLNVANANDTQLVIGVFFL
GFGLSQIFFGSLSDTLGRRSVLLAGLALFSLSMFAASWVESIEALLLLRFVQGIGGAAVRITTMAIVRDCFGGREMARVM
SYVMIVFMIVPIVAPTLGQLVIAYADWHWIFILIGVVGAALFVWALTRMKESLPREERLPLSVGAVLSGFRTVLTNRITC
GYMIGMTLFTAVICAYVVSVQQVFGEVYNLSDWLPIAFAGTAGGIAVANFANGYFVRSFGMRRISHTAMILFTVVAAIGY
VLSLAGTPAFTISYLLFSLLLMFFAVIATNFTAISLEPMGHLAGTATAITGFVSTTGGALIGGAVGQLFNGTLQPLFGGY
ALFGVLTILATLWAENGKLFTHPGDSDTTHEHGGGHL

Sequences:

>Translated_437_residues
MSSVSQQSSLGEQSSGHSNQVSGAARLGMGLVEFIVTIAVMTASIALAIDSMLPALPAIGRTLNVANANDTQLVIGVFFL
GFGLSQIFFGSLSDTLGRRSVLLAGLALFSLSMFAASWVESIEALLLLRFVQGIGGAAVRITTMAIVRDCFGGREMARVM
SYVMIVFMIVPIVAPTLGQLVIAYADWHWIFILIGVVGAALFVWALTRMKESLPREERLPLSVGAVLSGFRTVLTNRITC
GYMIGMTLFTAVICAYVVSVQQVFGEVYNLSDWLPIAFAGTAGGIAVANFANGYFVRSFGMRRISHTAMILFTVVAAIGY
VLSLAGTPAFTISYLLFSLLLMFFAVIATNFTAISLEPMGHLAGTATAITGFVSTTGGALIGGAVGQLFNGTLQPLFGGY
ALFGVLTILATLWAENGKLFTHPGDSDTTHEHGGGHL
>Mature_436_residues
SSVSQQSSLGEQSSGHSNQVSGAARLGMGLVEFIVTIAVMTASIALAIDSMLPALPAIGRTLNVANANDTQLVIGVFFLG
FGLSQIFFGSLSDTLGRRSVLLAGLALFSLSMFAASWVESIEALLLLRFVQGIGGAAVRITTMAIVRDCFGGREMARVMS
YVMIVFMIVPIVAPTLGQLVIAYADWHWIFILIGVVGAALFVWALTRMKESLPREERLPLSVGAVLSGFRTVLTNRITCG
YMIGMTLFTAVICAYVVSVQQVFGEVYNLSDWLPIAFAGTAGGIAVANFANGYFVRSFGMRRISHTAMILFTVVAAIGYV
LSLAGTPAFTISYLLFSLLLMFFAVIATNFTAISLEPMGHLAGTATAITGFVSTTGGALIGGAVGQLFNGTLQPLFGGYA
LFGVLTILATLWAENGKLFTHPGDSDTTHEHGGGHL

Specific function: Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance. Probable membrane translocase [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=390, Percent_Identity=26.4102564102564, Blast_Score=135, Evalue=6e-33,
Organism=Escherichia coli, GI1790146, Length=334, Percent_Identity=26.3473053892216, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI48994889, Length=159, Percent_Identity=34.5911949685535, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1790794, Length=192, Percent_Identity=28.6458333333333, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1790195, Length=181, Percent_Identity=29.2817679558011, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI87082312, Length=186, Percent_Identity=25.8064516129032, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787065, Length=293, Percent_Identity=24.9146757679181, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI87081738, Length=207, Percent_Identity=27.536231884058, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR004734 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 46202; Mature: 46071

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSVSQQSSLGEQSSGHSNQVSGAARLGMGLVEFIVTIAVMTASIALAIDSMLPALPAIG
CCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RTLNVANANDTQLVIGVFFLGFGLSQIFFGSLSDTLGRRSVLLAGLALFSLSMFAASWVE
CEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SIEALLLLRFVQGIGGAAVRITTMAIVRDCFGGREMARVMSYVMIVFMIVPIVAPTLGQL
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VIAYADWHWIFILIGVVGAALFVWALTRMKESLPREERLPLSVGAVLSGFRTVLTNRITC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHCCCHH
GYMIGMTLFTAVICAYVVSVQQVFGEVYNLSDWLPIAFAGTAGGIAVANFANGYFVRSFG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEEHHHHCCCHHHHHHH
MRRISHTAMILFTVVAAIGYVLSLAGTPAFTISYLLFSLLLMFFAVIATNFTAISLEPMG
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCH
HLAGTATAITGFVSTTGGALIGGAVGQLFNGTLQPLFGGYALFGVLTILATLWAENGKLF
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
THPGDSDTTHEHGGGHL
ECCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SSVSQQSSLGEQSSGHSNQVSGAARLGMGLVEFIVTIAVMTASIALAIDSMLPALPAIG
CCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RTLNVANANDTQLVIGVFFLGFGLSQIFFGSLSDTLGRRSVLLAGLALFSLSMFAASWVE
CEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SIEALLLLRFVQGIGGAAVRITTMAIVRDCFGGREMARVMSYVMIVFMIVPIVAPTLGQL
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VIAYADWHWIFILIGVVGAALFVWALTRMKESLPREERLPLSVGAVLSGFRTVLTNRITC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHCCCHH
GYMIGMTLFTAVICAYVVSVQQVFGEVYNLSDWLPIAFAGTAGGIAVANFANGYFVRSFG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEEHHHHCCCHHHHHHH
MRRISHTAMILFTVVAAIGYVLSLAGTPAFTISYLLFSLLLMFFAVIATNFTAISLEPMG
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCH
HLAGTATAITGFVSTTGGALIGGAVGQLFNGTLQPLFGGYALFGVLTILATLWAENGKLF
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
THPGDSDTTHEHGGGHL
ECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8486276; 9278503; 2694948 [H]