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The map label for this gene is sir2 [H]

Identifier: 150396320

GI number: 150396320

Start: 1170698

End: 1172371

Strand: Direct

Name: sir2 [H]

Synonym: Smed_1101

Alternate gene names: 150396320

Gene position: 1170698-1172371 (Clockwise)

Preceding gene: 150396319

Following gene: 150396321

Centisome position: 30.96

GC content: 60.93

Gene sequence:

>1674_bases
ATGTATCGTTACGACGAATTCGACCACACCTTCGTTTCCGCACGCGTCGAGCAGTTTCGCGACCAGGTCCAGCGGCGGCT
GTCCGGCGAACTCGCTGAGGATGCGTTCAAGCCGCTGCGCCTGATGAACGGCGTCTATCTGCAGCTCCATGCCTACATGC
TCCGCGTCGCAATTCCCTATGGGACCTTGTCGAGCCGACAGATGCGGATGCTCGCCCATATCGCCCGCAAATATGACCGC
GGCTACGGACATTTCACCACCCGGCAGAACATTCAGTACAACTGGCCGCGCCTTTCGGATACGCCTGATATCCTCCAGGA
ACTGGCAAGCGTCGAAATGCATGCGCTGCAGACATCCGGCAATTGCATTCGCAACGTCACGGCGGACCATTTCGCCGGTG
CGGCCGCCGACGAAGTTGCCGACCCGCGTCCCTATGCGGAAATCCTCAGGCAGTGGTCGAGCGTCCATCCGGAATTCTCC
TTCCTGCCGCGCAAGTTCAAGATCGCGGTCACGGGCGCCGAGCGCGACCGTGCCGCCATCCAGGTGCATGACATCGGCCT
TCACCTGAAAAAGGATGAGAACGGCAGGCTCGGTTTCGTCGTCTATGTCGGCGGCGGGCAGGGCCGCACTCCGATGATCG
CCAAGAAGATCCGCGACTTCCTTCCGGAAGAGGACCTGCTATCCTACACGACCGCGATCATGCGCGTTTACAATCTCCAT
GGCCGCCGTGACAACAAGTACAAGGCGCGCATCAAGATTCTGGTTCATGAAACGGGTGCCGAGGAACTGGCGCGCCAGGT
GGAGGCAGAGTTCGCCAATCTGAAGGACACGGAACTGAAGCTGCCGGATTCGGATATCCAGGCGATTGCCGCCTATTTCG
CCCCTGCAACGTTGCCGAACCGGCCGGAAGGCTGGGGCAACCTCGCCCGCTGGAAGAAGGCCGATCCGGAGTTTGCCCGT
TGGGTGCACCAGAACGTCCAGCCGCACAAGCATCCCGATTACGGCATGGTGACGATCTCGCTGAAGCCGATCGGCGGCAT
TCCGGGGGACGCCAGCGACGAGCAGATGGATATTGTCGCAGAAATCGCCGAGGAATATGCGTTCGACGAGATCCGCGTCA
GCCATGAGCAGAATCTGATCCTCCCGCATGTGGCGCTTGCCGATCTGGAGCCGGTCTACAGAGCCCTGGTCGCTGCCGGC
CTCGCCACCGCCAATGCAGGTCTGATAACCGATATCATTGCCTGTCCCGGGCTCGATTATTGCGCGCTCGCCAATGCGCG
TTCGATTCCGGTCGCGCAGGAGATTTCGAACCGTTTCGGTTCGGCGGAGCGGCAGGCTGAAATCGGCGAACTGAAGATCA
AGATTTCCGGCTGCATCAATGCCTGCGGGCATCATCACGTCGGCCATATCGGTCTTCTGGGTGTGGAGAAGAAGGGCGAG
GAGCTTTACCAGATCACGCTCGGCGGTTCCGGCGACGAACACACCTCGATCGGCGAGATCATCGGTCGCGGCTTCGAGCC
GGAAAAGGTCACCGACGCGGTCGAGAGGATCGTCGACACCTATCTCGGGCTGCGCCGGGACAAGTCGGAAACGTTTCTCG
AAGCCTACCGTCGTGTGGGGCCGCAGCCATTCAAGGATGCGCTCTATGGCGGCGGTGCCCAGGCAGCCGCGTGA

Upstream 100 bases:

>100_bases
GCGAACGCATACGCGCCGAGGGACCATCGATTCCCTACGCTCCGGGATATAATGGGCTTGCGGGCCCGAAAAACGTTGCT
GCCTGAGGACCTGAGAAGCC

Downstream 100 bases:

>100_bases
CTTAAGGATAACAAGAGATGACGAAAATCTGGAATGAAGCCGGCTTCGTGAGCGACGATCCCTGGGTCATCGAGAGCGAA
GACACCAAGGCCGGATCGAA

Product: nitrite/sulfite reductase hemoprotein subunit beta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 557; Mature: 557

Protein sequence:

>557_residues
MYRYDEFDHTFVSARVEQFRDQVQRRLSGELAEDAFKPLRLMNGVYLQLHAYMLRVAIPYGTLSSRQMRMLAHIARKYDR
GYGHFTTRQNIQYNWPRLSDTPDILQELASVEMHALQTSGNCIRNVTADHFAGAAADEVADPRPYAEILRQWSSVHPEFS
FLPRKFKIAVTGAERDRAAIQVHDIGLHLKKDENGRLGFVVYVGGGQGRTPMIAKKIRDFLPEEDLLSYTTAIMRVYNLH
GRRDNKYKARIKILVHETGAEELARQVEAEFANLKDTELKLPDSDIQAIAAYFAPATLPNRPEGWGNLARWKKADPEFAR
WVHQNVQPHKHPDYGMVTISLKPIGGIPGDASDEQMDIVAEIAEEYAFDEIRVSHEQNLILPHVALADLEPVYRALVAAG
LATANAGLITDIIACPGLDYCALANARSIPVAQEISNRFGSAERQAEIGELKIKISGCINACGHHHVGHIGLLGVEKKGE
ELYQITLGGSGDEHTSIGEIIGRGFEPEKVTDAVERIVDTYLGLRRDKSETFLEAYRRVGPQPFKDALYGGGAQAAA

Sequences:

>Translated_557_residues
MYRYDEFDHTFVSARVEQFRDQVQRRLSGELAEDAFKPLRLMNGVYLQLHAYMLRVAIPYGTLSSRQMRMLAHIARKYDR
GYGHFTTRQNIQYNWPRLSDTPDILQELASVEMHALQTSGNCIRNVTADHFAGAAADEVADPRPYAEILRQWSSVHPEFS
FLPRKFKIAVTGAERDRAAIQVHDIGLHLKKDENGRLGFVVYVGGGQGRTPMIAKKIRDFLPEEDLLSYTTAIMRVYNLH
GRRDNKYKARIKILVHETGAEELARQVEAEFANLKDTELKLPDSDIQAIAAYFAPATLPNRPEGWGNLARWKKADPEFAR
WVHQNVQPHKHPDYGMVTISLKPIGGIPGDASDEQMDIVAEIAEEYAFDEIRVSHEQNLILPHVALADLEPVYRALVAAG
LATANAGLITDIIACPGLDYCALANARSIPVAQEISNRFGSAERQAEIGELKIKISGCINACGHHHVGHIGLLGVEKKGE
ELYQITLGGSGDEHTSIGEIIGRGFEPEKVTDAVERIVDTYLGLRRDKSETFLEAYRRVGPQPFKDALYGGGAQAAA
>Mature_557_residues
MYRYDEFDHTFVSARVEQFRDQVQRRLSGELAEDAFKPLRLMNGVYLQLHAYMLRVAIPYGTLSSRQMRMLAHIARKYDR
GYGHFTTRQNIQYNWPRLSDTPDILQELASVEMHALQTSGNCIRNVTADHFAGAAADEVADPRPYAEILRQWSSVHPEFS
FLPRKFKIAVTGAERDRAAIQVHDIGLHLKKDENGRLGFVVYVGGGQGRTPMIAKKIRDFLPEEDLLSYTTAIMRVYNLH
GRRDNKYKARIKILVHETGAEELARQVEAEFANLKDTELKLPDSDIQAIAAYFAPATLPNRPEGWGNLARWKKADPEFAR
WVHQNVQPHKHPDYGMVTISLKPIGGIPGDASDEQMDIVAEIAEEYAFDEIRVSHEQNLILPHVALADLEPVYRALVAAG
LATANAGLITDIIACPGLDYCALANARSIPVAQEISNRFGSAERQAEIGELKIKISGCINACGHHHVGHIGLLGVEKKGE
ELYQITLGGSGDEHTSIGEIIGRGFEPEKVTDAVERIVDTYLGLRRDKSETFLEAYRRVGPQPFKDALYGGGAQAAA

Specific function: This Enzyme Catalyzes The 6-Electron Reduction Of Sulfite To Sulfide. This Is One Of Several Activities Required For The Biosynthesis Of L-Cysteine From Sulfate. [C]

COG id: COG0155

COG function: function code P; Sulfite reductase, beta subunit (hemoprotein)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nitrite and sulfite reductase 4Fe-4S domain family [H]

Homologues:

None

Paralogues:

None

Copy number: 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005117
- InterPro:   IPR006067
- InterPro:   IPR006066 [H]

Pfam domain/function: PF01077 NIR_SIR; PF03460 NIR_SIR_ferr [H]

EC number: =1.8.7.1 [H]

Molecular weight: Translated: 62174; Mature: 62174

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYRYDEFDHTFVSARVEQFRDQVQRRLSGELAEDAFKPLRLMNGVYLQLHAYMLRVAIPY
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GTLSSRQMRMLAHIARKYDRGYGHFTTRQNIQYNWPRLSDTPDILQELASVEMHALQTSG
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHCCC
NCIRNVTADHFAGAAADEVADPRPYAEILRQWSSVHPEFSFLPRKFKIAVTGAERDRAAI
CHHHCCCHHHHCCCCHHHCCCCCHHHHHHHHHHHCCCCHHCCCCEEEEEEECCCCCCCEE
QVHDIGLHLKKDENGRLGFVVYVGGGQGRTPMIAKKIRDFLPEEDLLSYTTAIMRVYNLH
EEEEEEEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
GRRDNKYKARIKILVHETGAEELARQVEAEFANLKDTELKLPDSDIQAIAAYFAPATLPN
CCCCCCEEEEEEEEEECCCHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHCCCCCCC
RPEGWGNLARWKKADPEFARWVHQNVQPHKHPDYGMVTISLKPIGGIPGDASDEQMDIVA
CCCCCCCHHHHCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHH
EIAEEYAFDEIRVSHEQNLILPHVALADLEPVYRALVAAGLATANAGLITDIIACPGLDY
HHHHHHHHHHHEECCCCCEEECHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCH
CALANARSIPVAQEISNRFGSAERQAEIGELKIKISGCINACGHHHVGHIGLLGVEKKGE
HHHCCCCCCCHHHHHHHHHCCHHHHCCCCEEEEEEHHHHHHCCCCCCCCEEEEECCCCCC
ELYQITLGGSGDEHTSIGEIIGRGFEPEKVTDAVERIVDTYLGLRRDKSETFLEAYRRVG
EEEEEEECCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCC
PQPFKDALYGGGAQAAA
CCCHHHHHCCCCCCCCC
>Mature Secondary Structure
MYRYDEFDHTFVSARVEQFRDQVQRRLSGELAEDAFKPLRLMNGVYLQLHAYMLRVAIPY
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GTLSSRQMRMLAHIARKYDRGYGHFTTRQNIQYNWPRLSDTPDILQELASVEMHALQTSG
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHCCC
NCIRNVTADHFAGAAADEVADPRPYAEILRQWSSVHPEFSFLPRKFKIAVTGAERDRAAI
CHHHCCCHHHHCCCCHHHCCCCCHHHHHHHHHHHCCCCHHCCCCEEEEEEECCCCCCCEE
QVHDIGLHLKKDENGRLGFVVYVGGGQGRTPMIAKKIRDFLPEEDLLSYTTAIMRVYNLH
EEEEEEEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
GRRDNKYKARIKILVHETGAEELARQVEAEFANLKDTELKLPDSDIQAIAAYFAPATLPN
CCCCCCEEEEEEEEEECCCHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHCCCCCCC
RPEGWGNLARWKKADPEFARWVHQNVQPHKHPDYGMVTISLKPIGGIPGDASDEQMDIVA
CCCCCCCHHHHCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHH
EIAEEYAFDEIRVSHEQNLILPHVALADLEPVYRALVAAGLATANAGLITDIIACPGLDY
HHHHHHHHHHHEECCCCCEEECHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCH
CALANARSIPVAQEISNRFGSAERQAEIGELKIKISGCINACGHHHVGHIGLLGVEKKGE
HHHCCCCCCCHHHHHHHHHCCHHHHCCCCEEEEEEHHHHHHCCCCCCCCEEEEECCCCCC
ELYQITLGGSGDEHTSIGEIIGRGFEPEKVTDAVERIVDTYLGLRRDKSETFLEAYRRVG
EEEEEEECCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCC
PQPFKDALYGGGAQAAA
CCCHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA