Click here to switch to the map view.

The map label for this gene is nhaA [H]

Identifier: 150395686

GI number: 150395686

Start: 497790

End: 498656

Strand: Direct

Name: nhaA [H]

Synonym: Smed_0461

Alternate gene names: 150395686

Gene position: 497790-498656 (Clockwise)

Preceding gene: 150395685

Following gene: 150395687

Centisome position: 13.16

GC content: 61.94

Gene sequence:

>867_bases
ATGGCCGGGTTCTTGAGAAAGCTAATGCCGAGGCGCTTCCGCAGGGATGGAGTGACGATCCCGGCGATCAGGCTGCATGG
CGCAATAATGGCAGGCGGCAGTCCTCTCCGTCCGGTTCTCAATCTCGCAACCGTTGCGCCGCTGCTCGAAAAGGCATTCT
CCGTCAAAGACGCTCCTGCCGTCGCCATCTCCATCAACTCTCCTGGCGGTTCGCCGGTGCAGTCCCGGCTGATTTATCAG
CGCATCCGGGATCTCGCACAGGAAAAGAGGAAGCGCGTGCTGATCTTCGTCGAGGACGTGGCAGCATCCGGCGGCTACAT
GATCGCACTGGCGGGCGACGAGATCATCGCCGATCCGACCTCGATCGTCGGTTCGATCGGCGTCGTTTCGGGCGGCTTCG
GTTTTCCCGATCTTCTCAAAAAGATCGGCGTGGAAAGACGCGTCTATACGGCCGGGGAAAACAAAGTGCTTCTCGATCCT
TTCCAGCCGGAGAAGGAGCGCGACATCGAGTTTCTCAAAGGCCTCCAGCTCGAAATCCACGACATCTTCATCCAGATGGT
AAAGAGCAGGCGCGGCTCGCTCCTGGCCGATCATCCGGACCTCTTCTCGGGGTTGTTCTGGACGGGACAGCGCGGCCAGG
AACTTGGCCTCGTCGATTCCCTCGGCGATATGCGGAGCGAGGTCAGGAAGCGCTATGGGGAAAAGGCGCGGCTCGAGCTG
ATCCAGCCGGCGCGGAGCCTTTTCGGGCGGCGCCAGCCTGGAGCGGCCGTGGCCGGAGCCATTGCCGCACCTCTCGTCGC
CTCGGCGGCCGCAGGTCTCGTCGATACCTTAGAGGAGAGGGCGCTCTGGGCCCGTTTCGGACTTTGA

Upstream 100 bases:

>100_bases
GCGGCCTATCATCGCAGGTGATTAACCGTAAGCACACCATTGCGTTTGCGGCGGCAGTGCATACATGCAGTGCTAAAATT
CGTATCGGGCAGGAGTTGAA

Downstream 100 bases:

>100_bases
GACGACGTATGCGCGCCGGCGGGAACAGCGTTTCGCAAAGAACGATGTCGCTGCATCTGGCCAGCGGGGCTTGGGCGCGC
TAACACTTCGAAGTGCTGCA

Product: peptidase S49

Products: NA

Alternate protein names: Sodium/proton antiporter nhaA [H]

Number of amino acids: Translated: 288; Mature: 287

Protein sequence:

>288_residues
MAGFLRKLMPRRFRRDGVTIPAIRLHGAIMAGGSPLRPVLNLATVAPLLEKAFSVKDAPAVAISINSPGGSPVQSRLIYQ
RIRDLAQEKRKRVLIFVEDVAASGGYMIALAGDEIIADPTSIVGSIGVVSGGFGFPDLLKKIGVERRVYTAGENKVLLDP
FQPEKERDIEFLKGLQLEIHDIFIQMVKSRRGSLLADHPDLFSGLFWTGQRGQELGLVDSLGDMRSEVRKRYGEKARLEL
IQPARSLFGRRQPGAAVAGAIAAPLVASAAAGLVDTLEERALWARFGL

Sequences:

>Translated_288_residues
MAGFLRKLMPRRFRRDGVTIPAIRLHGAIMAGGSPLRPVLNLATVAPLLEKAFSVKDAPAVAISINSPGGSPVQSRLIYQ
RIRDLAQEKRKRVLIFVEDVAASGGYMIALAGDEIIADPTSIVGSIGVVSGGFGFPDLLKKIGVERRVYTAGENKVLLDP
FQPEKERDIEFLKGLQLEIHDIFIQMVKSRRGSLLADHPDLFSGLFWTGQRGQELGLVDSLGDMRSEVRKRYGEKARLEL
IQPARSLFGRRQPGAAVAGAIAAPLVASAAAGLVDTLEERALWARFGL
>Mature_287_residues
AGFLRKLMPRRFRRDGVTIPAIRLHGAIMAGGSPLRPVLNLATVAPLLEKAFSVKDAPAVAISINSPGGSPVQSRLIYQR
IRDLAQEKRKRVLIFVEDVAASGGYMIALAGDEIIADPTSIVGSIGVVSGGFGFPDLLKKIGVERRVYTAGENKVLLDPF
QPEKERDIEFLKGLQLEIHDIFIQMVKSRRGSLLADHPDLFSGLFWTGQRGQELGLVDSLGDMRSEVRKRYGEKARLELI
QPARSLFGRRQPGAAVAGAIAAPLVASAAAGLVDTLEERALWARFGL

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1787527, Length=202, Percent_Identity=35.6435643564356, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1788064, Length=217, Percent_Identity=31.3364055299539, Blast_Score=71, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670
- InterPro:   IPR002142 [H]

Pfam domain/function: PF06965 Na_H_antiport_1; PF01343 Peptidase_S49 [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 31274; Mature: 31143

Theoretical pI: Translated: 10.56; Mature: 10.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGFLRKLMPRRFRRDGVTIPAIRLHGAIMAGGSPLRPVLNLATVAPLLEKAFSVKDAPA
CCHHHHHHHHHHHHHCCCCCCHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCE
VAISINSPGGSPVQSRLIYQRIRDLAQEKRKRVLIFVEDVAASGGYMIALAGDEIIADPT
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHCEEEEEEEEECCCCCEEEEEECCCHHCCHH
SIVGSIGVVSGGFGFPDLLKKIGVERRVYTAGENKVLLDPFQPEKERDIEFLKGLQLEIH
HHHHHHHHCCCCCCCHHHHHHHCCCCEEEECCCCEEEECCCCCCHHHHHHHHHCCHHHHH
DIFIQMVKSRRGSLLADHPDLFSGLFWTGQRGQELGLVDSLGDMRSEVRKRYGEKARLEL
HHHHHHHHHHCCCEECCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHH
IQPARSLFGRRQPGAAVAGAIAAPLVASAAAGLVDTLEERALWARFGL
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AGFLRKLMPRRFRRDGVTIPAIRLHGAIMAGGSPLRPVLNLATVAPLLEKAFSVKDAPA
CHHHHHHHHHHHHHCCCCCCHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCE
VAISINSPGGSPVQSRLIYQRIRDLAQEKRKRVLIFVEDVAASGGYMIALAGDEIIADPT
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHCEEEEEEEEECCCCCEEEEEECCCHHCCHH
SIVGSIGVVSGGFGFPDLLKKIGVERRVYTAGENKVLLDPFQPEKERDIEFLKGLQLEIH
HHHHHHHHCCCCCCCHHHHHHHCCCCEEEECCCCEEEECCCCCCHHHHHHHHHCCHHHHH
DIFIQMVKSRRGSLLADHPDLFSGLFWTGQRGQELGLVDSLGDMRSEVRKRYGEKARLEL
HHHHHHHHHHCCCEECCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHH
IQPARSLFGRRQPGAAVAGAIAAPLVASAAAGLVDTLEERALWARFGL
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA