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The map label for this gene is hisZ [H]

Identifier: 150395629

GI number: 150395629

Start: 434278

End: 435411

Strand: Direct

Name: hisZ [H]

Synonym: Smed_0404

Alternate gene names: 150395629

Gene position: 434278-435411 (Clockwise)

Preceding gene: 150395628

Following gene: 150395630

Centisome position: 11.48

GC content: 65.78

Gene sequence:

>1134_bases
ATGCCTCTCATTGATCTTCCCGGTTTCGCCGGCGACCTCCTTGCGGATTTCGAACGCCGGAACACGCTGCGCGTCGACAC
GCCGGTCATCCAGCCTGCCGAGCCTTTCCTCGACATGGCCGGGGAAGACCTGCGCCGGCGGATCTTCATGACCGAGAGCG
AAACCGGCGAGAGCCTGTGCCTGCGGCCGGAGTTCACCATCCCCGTCTGCCTGCGACATATCGAGACCGCAACCGGAACG
CCGCAACGCTACGCCTATCTGGGCGAGGTGTTCCGGCAGCGCCGCGACGGATCGAGCGAGTTCTACCAGGCGGGCATCGA
AGATCTGGGCGATCCGGATACGGCCGCCGCTGATGCGCGGGTGGTCGGTGATGCCTTGTTCGTCCTTTCCAATCGACTGC
CGGGCGAGCGGCTGAAGGTCACGCTTGGCGACCAGTCGGTCTTCGAAGCGGTGATTGCCGCCTGTGGCCTGCCCGGCGGT
TGGCAGAAACGGCTCATTCATGCCTTCGGGGATCAGAAGCAGTTGGACAGGCTCTTGGCCGAGCTGGCCGACCCGAAATC
GCCCGGCGTCTTCGGCCACGACGTCGAGCGCGTCGCAGCCTTGGGCATGCTCGACGACGAAGAGCGGCTCGTCGCTCATA
TCGGCGAGACGATGGAGGCGACCGGTTATTCGACCAATGCCAGCCGCTCGCCCCGCGATATCGCCCGGCGCCTGAAGGAA
AAGGTCGAACTTGCAGCCACCCGGCTGGACAAGGAAGCGCTTGCCGTCATGCGCGCGTTCCTCGCTCTTGATCTGCCGCT
CGCCGACGCTCCGGCCGCGCTCCACAGCTTCGCCGGCAAGGCGCGTCTGAGGATCGACGACGCGCTGGAACTCTTCGATG
CGCGCGTGGCTGCGCTCGCATTGGCGGGCGCCGATCCCGGCCCGATGCGTTACCGCGCCGCCTTCGGACGACCGCTCGAC
TATTACACGGGCCTCGTCTTCGAAATCCACGTCGAAGGCACCCCCGCAGTGCTCGCCGGCGGCGGCCGGTTCGACCGCCT
CCTCACCTTGCTCGGCGCTCGTGAGCATATTCCGGCCGTCGGCTTTTCTCTTTGGCTCGACCGGATAGAACAGGCTGCGG
GGAGAGAGAAATGA

Upstream 100 bases:

>100_bases
GTGCCGCTCAGATTTCCGTCCCGGAAGGCGAACTCGTCGTTAAGATTCGCGAAATTCTCGCGGACCAGGCCGAGGACCGG
AAAAGGGCGGGTTGACCGCG

Downstream 100 bases:

>100_bases
CCGTCACTATTGCGCTGCCCTCAAAGGGGCGGATGAAGGATGAGTCCTCGGCTATTTTCGAACGCGCCGGCATGAGGATC
ACGGCGGTTGGCAACGACCG

Product: ATP phosphoribosyltransferase regulatory subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 377; Mature: 376

Protein sequence:

>377_residues
MPLIDLPGFAGDLLADFERRNTLRVDTPVIQPAEPFLDMAGEDLRRRIFMTESETGESLCLRPEFTIPVCLRHIETATGT
PQRYAYLGEVFRQRRDGSSEFYQAGIEDLGDPDTAAADARVVGDALFVLSNRLPGERLKVTLGDQSVFEAVIAACGLPGG
WQKRLIHAFGDQKQLDRLLAELADPKSPGVFGHDVERVAALGMLDDEERLVAHIGETMEATGYSTNASRSPRDIARRLKE
KVELAATRLDKEALAVMRAFLALDLPLADAPAALHSFAGKARLRIDDALELFDARVAALALAGADPGPMRYRAAFGRPLD
YYTGLVFEIHVEGTPAVLAGGGRFDRLLTLLGAREHIPAVGFSLWLDRIEQAAGREK

Sequences:

>Translated_377_residues
MPLIDLPGFAGDLLADFERRNTLRVDTPVIQPAEPFLDMAGEDLRRRIFMTESETGESLCLRPEFTIPVCLRHIETATGT
PQRYAYLGEVFRQRRDGSSEFYQAGIEDLGDPDTAAADARVVGDALFVLSNRLPGERLKVTLGDQSVFEAVIAACGLPGG
WQKRLIHAFGDQKQLDRLLAELADPKSPGVFGHDVERVAALGMLDDEERLVAHIGETMEATGYSTNASRSPRDIARRLKE
KVELAATRLDKEALAVMRAFLALDLPLADAPAALHSFAGKARLRIDDALELFDARVAALALAGADPGPMRYRAAFGRPLD
YYTGLVFEIHVEGTPAVLAGGGRFDRLLTLLGAREHIPAVGFSLWLDRIEQAAGREK
>Mature_376_residues
PLIDLPGFAGDLLADFERRNTLRVDTPVIQPAEPFLDMAGEDLRRRIFMTESETGESLCLRPEFTIPVCLRHIETATGTP
QRYAYLGEVFRQRRDGSSEFYQAGIEDLGDPDTAAADARVVGDALFVLSNRLPGERLKVTLGDQSVFEAVIAACGLPGGW
QKRLIHAFGDQKQLDRLLAELADPKSPGVFGHDVERVAALGMLDDEERLVAHIGETMEATGYSTNASRSPRDIARRLKEK
VELAATRLDKEALAVMRAFLALDLPLADAPAALHSFAGKARLRIDDALELFDARVAALALAGADPGPMRYRAAFGRPLDY
YTGLVFEIHVEGTPAVLAGGGRFDRLLTLLGAREHIPAVGFSLWLDRIEQAAGREK

Specific function: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine [H]

COG id: COG3705

COG function: function code E; ATP phosphoribosyltransferase involved in histidine biosynthesis

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR004516 [H]

Pfam domain/function: PF00587 tRNA-synt_2b [H]

EC number: NA

Molecular weight: Translated: 41232; Mature: 41100

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLIDLPGFAGDLLADFERRNTLRVDTPVIQPAEPFLDMAGEDLRRRIFMTESETGESLC
CCCCCCCCCHHHHHHHHHHCCEEEECCCCCCCCHHHHHHCCHHHHHHEEECCCCCCCCEE
LRPEFTIPVCLRHIETATGTPQRYAYLGEVFRQRRDGSSEFYQAGIEDLGDPDTAAADAR
ECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHH
VVGDALFVLSNRLPGERLKVTLGDQSVFEAVIAACGLPGGWQKRLIHAFGDQKQLDRLLA
HHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHH
ELADPKSPGVFGHDVERVAALGMLDDEERLVAHIGETMEATGYSTNASRSPRDIARRLKE
HHCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHCCHHHHCCCCCCCCCCHHHHHHHHHH
KVELAATRLDKEALAVMRAFLALDLPLADAPAALHSFAGKARLRIDDALELFDARVAALA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCEEEHHHHHHHHHHHHHHHH
LAGADPGPMRYRAAFGRPLDYYTGLVFEIHVEGTPAVLAGGGRFDRLLTLLGAREHIPAV
HCCCCCCCCHHHHHCCCCHHHHCCEEEEEEECCCCEEEECCCHHHHHHHHHCCHHCCCHH
GFSLWLDRIEQAAGREK
HHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PLIDLPGFAGDLLADFERRNTLRVDTPVIQPAEPFLDMAGEDLRRRIFMTESETGESLC
CCCCCCCCHHHHHHHHHHCCEEEECCCCCCCCHHHHHHCCHHHHHHEEECCCCCCCCEE
LRPEFTIPVCLRHIETATGTPQRYAYLGEVFRQRRDGSSEFYQAGIEDLGDPDTAAADAR
ECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHH
VVGDALFVLSNRLPGERLKVTLGDQSVFEAVIAACGLPGGWQKRLIHAFGDQKQLDRLLA
HHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHH
ELADPKSPGVFGHDVERVAALGMLDDEERLVAHIGETMEATGYSTNASRSPRDIARRLKE
HHCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHCCHHHHCCCCCCCCCCHHHHHHHHHH
KVELAATRLDKEALAVMRAFLALDLPLADAPAALHSFAGKARLRIDDALELFDARVAALA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCEEEHHHHHHHHHHHHHHHH
LAGADPGPMRYRAAFGRPLDYYTGLVFEIHVEGTPAVLAGGGRFDRLLTLLGAREHIPAV
HCCCCCCCCHHHHHCCCCHHHHCCEEEEEEECCCCEEEECCCHHHHHHHHHCCHHCCCHH
GFSLWLDRIEQAAGREK
HHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]