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The map label for this gene is guaB [H]

Identifier: 150395604

GI number: 150395604

Start: 406307

End: 407809

Strand: Direct

Name: guaB [H]

Synonym: Smed_0379

Alternate gene names: 150395604

Gene position: 406307-407809 (Clockwise)

Preceding gene: 150395603

Following gene: 150395605

Centisome position: 10.74

GC content: 65.54

Gene sequence:

>1503_bases
ATGGCGCGCATCATTGAGACGGCAACCGGTCTGGAGGCATTGACCTTCGACGACGTTCTGCTCCAGCCGGGGCATTCCGA
AGTCATGCCCGGCCAGACGAACATCGCCACCCGCATCGCGCAGGACATCGACCTCAACCTTCCTATCCTCTCGGCCGCCA
TGGACACCGTTACCGAGGCGCGGCTCGCGATCGCCATGGCGCAGGCCGGCGGCATCGGCGTCATCCATCGCAATCTGACA
CCCGCCGAACAGGCGGAAGAAGTCCGGCAGGTCAAGAAATTCGAAAGCGGCATGGTCGTCAATCCGGTGACGATCGGACC
GGATGCGACGCTTGCGGATGCTCTGAGCCTGATGAAGACGCACGGCATTTCCGGCATCCCGGTCGTTGAAAACGGCGGGT
TGGGGGGGCAGACGCAGGGTCGCCTCGTCGGCATCCTCACCAACCGCGACGTCCGCTTCGCTTCCGATCCTTCCCAGAAG
ATCTATGAACTGATGACGCGGGAAAACCTCATCACCGTGAAGGAGAGCGTCGATCAGCAGGAAGCCAAGCGCTTGCTGCA
CAAGCACCGGATCGAGAAGCTCCTCGTCGTGGATCAGGATGGGCGCTGCGTCGGCCTGATCACGGTCAAGGACATGGAGA
AGTCGCAGCTGAACCCGAACGCCTCCAAGGACGCCCAGGGCAGGCTTCGCGCCGCCGCCGCTGTCAGCGTCGGTGACGAC
GGCTTCGAACGCGCCGAGCGGCTGATCGATGCGGGCGTGGACATGATCGTCATCGATACCGCCCACGGTCATTCGCAGCG
CGTGCTCGATGCGGTCGGCCGGGTGAAGAAGCTCTCCAATTCGGTGCGCATCATGGCGGGCAATGTCGCGACCGGCGACG
GCACCAAGGCGCTGATCGATGCCGGTGCGGACGCCGTCAAGGTCGGCATCGGACCGGGCTCTATCTGCACGACCCGCATC
GTCGCCGGCGTCGGCGTGCCGCAGCTCGCCGCGATCATGTCGGCCGTCGAGGCCGCGCAGGCCGCCGGCATCCCGATCAT
CGCCGATGGCGGCATCAAATATTCGGGCGATCTCGCCAAGGCCATCGCCGCTGGCGCTTCGGCCGTGATGATCGGCTCTC
TCCTCGCCGGCACCGAGGAAAGCCCGGGCGAGGTATTCCTCTACCAGGGCCGCTCCTTCAAGGCTTATCGCGGCATGGGC
TCCGTCGGCGCCATGGCCCGCGGTTCGGCCGACCGCTATTTCCAGGCTGAAGTCCGCGACACGCTGAAGCTCGTTCCGGA
AGGTATCGAAGGCCAGGTGCCCTACAAGGGCCCGGTCTCCGGCGTCCTGCACCAGCTCGCCGGCGGCCTCCGCGCCTCCA
TGGGCTATGTCGGCGGTGCGACGATCAAGGACTATCAGGAGCGCGCCAGCTTCGTGCGCATTTCCGGCGCGGGTCTGCGC
GAAAGCCACGCCCATGACGTAACGATCACCCGCGAGAGCCCGAACTATCCGGGCGGCGCCTGA

Upstream 100 bases:

>100_bases
CCAGCCCTCGCCAACTTCCAAGACAAGCCTTGAAGTCACCCGGCCGGACAAGTCGCTGAACGTCCCCGGGGATTTTCGTA
TATTTGAAGAGGAATTGGCC

Downstream 100 bases:

>100_bases
TGCTATTTTGCAGGGCGCCTTTCCTCCGGGGAACCTGCGCGCCCTGCGCCTTCTCCCTCAATTTCTGAAGAGCACCGATG
ACGGGCTTTGAAATCTTCTG

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 500; Mature: 499

Protein sequence:

>500_residues
MARIIETATGLEALTFDDVLLQPGHSEVMPGQTNIATRIAQDIDLNLPILSAAMDTVTEARLAIAMAQAGGIGVIHRNLT
PAEQAEEVRQVKKFESGMVVNPVTIGPDATLADALSLMKTHGISGIPVVENGGLGGQTQGRLVGILTNRDVRFASDPSQK
IYELMTRENLITVKESVDQQEAKRLLHKHRIEKLLVVDQDGRCVGLITVKDMEKSQLNPNASKDAQGRLRAAAAVSVGDD
GFERAERLIDAGVDMIVIDTAHGHSQRVLDAVGRVKKLSNSVRIMAGNVATGDGTKALIDAGADAVKVGIGPGSICTTRI
VAGVGVPQLAAIMSAVEAAQAAGIPIIADGGIKYSGDLAKAIAAGASAVMIGSLLAGTEESPGEVFLYQGRSFKAYRGMG
SVGAMARGSADRYFQAEVRDTLKLVPEGIEGQVPYKGPVSGVLHQLAGGLRASMGYVGGATIKDYQERASFVRISGAGLR
ESHAHDVTITRESPNYPGGA

Sequences:

>Translated_500_residues
MARIIETATGLEALTFDDVLLQPGHSEVMPGQTNIATRIAQDIDLNLPILSAAMDTVTEARLAIAMAQAGGIGVIHRNLT
PAEQAEEVRQVKKFESGMVVNPVTIGPDATLADALSLMKTHGISGIPVVENGGLGGQTQGRLVGILTNRDVRFASDPSQK
IYELMTRENLITVKESVDQQEAKRLLHKHRIEKLLVVDQDGRCVGLITVKDMEKSQLNPNASKDAQGRLRAAAAVSVGDD
GFERAERLIDAGVDMIVIDTAHGHSQRVLDAVGRVKKLSNSVRIMAGNVATGDGTKALIDAGADAVKVGIGPGSICTTRI
VAGVGVPQLAAIMSAVEAAQAAGIPIIADGGIKYSGDLAKAIAAGASAVMIGSLLAGTEESPGEVFLYQGRSFKAYRGMG
SVGAMARGSADRYFQAEVRDTLKLVPEGIEGQVPYKGPVSGVLHQLAGGLRASMGYVGGATIKDYQERASFVRISGAGLR
ESHAHDVTITRESPNYPGGA
>Mature_499_residues
ARIIETATGLEALTFDDVLLQPGHSEVMPGQTNIATRIAQDIDLNLPILSAAMDTVTEARLAIAMAQAGGIGVIHRNLTP
AEQAEEVRQVKKFESGMVVNPVTIGPDATLADALSLMKTHGISGIPVVENGGLGGQTQGRLVGILTNRDVRFASDPSQKI
YELMTRENLITVKESVDQQEAKRLLHKHRIEKLLVVDQDGRCVGLITVKDMEKSQLNPNASKDAQGRLRAAAAVSVGDDG
FERAERLIDAGVDMIVIDTAHGHSQRVLDAVGRVKKLSNSVRIMAGNVATGDGTKALIDAGADAVKVGIGPGSICTTRIV
AGVGVPQLAAIMSAVEAAQAAGIPIIADGGIKYSGDLAKAIAAGASAVMIGSLLAGTEESPGEVFLYQGRSFKAYRGMGS
VGAMARGSADRYFQAEVRDTLKLVPEGIEGQVPYKGPVSGVLHQLAGGLRASMGYVGGATIKDYQERASFVRISGAGLRE
SHAHDVTITRESPNYPGGA

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=491, Percent_Identity=37.8818737270876, Blast_Score=330, Evalue=2e-90,
Organism=Homo sapiens, GI217035146, Length=445, Percent_Identity=41.123595505618, Blast_Score=321, Evalue=1e-87,
Organism=Homo sapiens, GI34328928, Length=445, Percent_Identity=41.123595505618, Blast_Score=320, Evalue=2e-87,
Organism=Homo sapiens, GI156616279, Length=456, Percent_Identity=40.3508771929825, Blast_Score=320, Evalue=3e-87,
Organism=Homo sapiens, GI34328930, Length=456, Percent_Identity=40.3508771929825, Blast_Score=319, Evalue=3e-87,
Organism=Homo sapiens, GI217035152, Length=450, Percent_Identity=40.4444444444444, Blast_Score=314, Evalue=1e-85,
Organism=Homo sapiens, GI217035148, Length=445, Percent_Identity=40.2247191011236, Blast_Score=306, Evalue=2e-83,
Organism=Homo sapiens, GI217035150, Length=445, Percent_Identity=37.5280898876404, Blast_Score=275, Evalue=5e-74,
Organism=Homo sapiens, GI50541954, Length=246, Percent_Identity=41.4634146341463, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI50541952, Length=246, Percent_Identity=41.4634146341463, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI50541948, Length=246, Percent_Identity=41.4634146341463, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI50541956, Length=246, Percent_Identity=41.4634146341463, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI156104880, Length=240, Percent_Identity=40.4166666666667, Blast_Score=172, Evalue=8e-43,
Organism=Escherichia coli, GI1788855, Length=490, Percent_Identity=56.734693877551, Blast_Score=509, Evalue=1e-145,
Organism=Escherichia coli, GI1786293, Length=259, Percent_Identity=38.6100386100386, Blast_Score=173, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI71994385, Length=477, Percent_Identity=36.0587002096436, Blast_Score=280, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI71994389, Length=427, Percent_Identity=37.7049180327869, Blast_Score=268, Evalue=4e-72,
Organism=Caenorhabditis elegans, GI17560440, Length=289, Percent_Identity=36.3321799307958, Blast_Score=174, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6323585, Length=462, Percent_Identity=38.5281385281385, Blast_Score=320, Evalue=3e-88,
Organism=Saccharomyces cerevisiae, GI6322012, Length=456, Percent_Identity=38.1578947368421, Blast_Score=319, Evalue=6e-88,
Organism=Saccharomyces cerevisiae, GI6323464, Length=462, Percent_Identity=39.3939393939394, Blast_Score=315, Evalue=1e-86,
Organism=Saccharomyces cerevisiae, GI6319352, Length=341, Percent_Identity=36.6568914956012, Blast_Score=241, Evalue=1e-64,
Organism=Saccharomyces cerevisiae, GI6319353, Length=117, Percent_Identity=41.8803418803419, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24641071, Length=485, Percent_Identity=38.5567010309278, Blast_Score=328, Evalue=6e-90,
Organism=Drosophila melanogaster, GI24641073, Length=485, Percent_Identity=38.5567010309278, Blast_Score=328, Evalue=6e-90,
Organism=Drosophila melanogaster, GI28571163, Length=443, Percent_Identity=39.9548532731377, Blast_Score=301, Evalue=5e-82,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52294; Mature: 52162

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00318 HMG_COA_REDUCTASE_2 ; PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARIIETATGLEALTFDDVLLQPGHSEVMPGQTNIATRIAQDIDLNLPILSAAMDTVTEA
CCCHHHHHCCCEEEEECHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHH
RLAIAMAQAGGIGVIHRNLTPAEQAEEVRQVKKFESGMVVNPVTIGPDATLADALSLMKT
HHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCEECCEEECCCCHHHHHHHHHHH
HGISGIPVVENGGLGGQTQGRLVGILTNRDVRFASDPSQKIYELMTRENLITVKESVDQQ
CCCCCCCEEECCCCCCCCCCCEEEEEECCCEEECCCCHHHHHHHHHHCCEEEEHHHCCHH
EAKRLLHKHRIEKLLVVDQDGRCVGLITVKDMEKSQLNPNASKDAQGRLRAAAAVSVGDD
HHHHHHHHHHHCEEEEECCCCCEEEEEEECCCHHHCCCCCCCCCHHCCEEEEEEEECCCH
GFERAERLIDAGVDMIVIDTAHGHSQRVLDAVGRVKKLSNSVRIMAGNVATGDGTKALID
HHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEECCEECCCCCHHHHH
AGADAVKVGIGPGSICTTRIVAGVGVPQLAAIMSAVEAAQAAGIPIIADGGIKYSGDLAK
CCCCEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEECCCEEECCHHHH
AIAAGASAVMIGSLLAGTEESPGEVFLYQGRSFKAYRGMGSVGAMARGSADRYFQAEVRD
HHHCCCHHHHHHHHHCCCCCCCCCEEEECCCCCHHHCCCCCCCHHHCCCCCHHHHHHHHH
TLKLVPEGIEGQVPYKGPVSGVLHQLAGGLRASMGYVGGATIKDYQERASFVRISGAGLR
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCEEEEECCCCC
ESHAHDVTITRESPNYPGGA
CCCCCEEEEEECCCCCCCCC
>Mature Secondary Structure 
ARIIETATGLEALTFDDVLLQPGHSEVMPGQTNIATRIAQDIDLNLPILSAAMDTVTEA
CCHHHHHCCCEEEEECHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHH
RLAIAMAQAGGIGVIHRNLTPAEQAEEVRQVKKFESGMVVNPVTIGPDATLADALSLMKT
HHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCEECCEEECCCCHHHHHHHHHHH
HGISGIPVVENGGLGGQTQGRLVGILTNRDVRFASDPSQKIYELMTRENLITVKESVDQQ
CCCCCCCEEECCCCCCCCCCCEEEEEECCCEEECCCCHHHHHHHHHHCCEEEEHHHCCHH
EAKRLLHKHRIEKLLVVDQDGRCVGLITVKDMEKSQLNPNASKDAQGRLRAAAAVSVGDD
HHHHHHHHHHHCEEEEECCCCCEEEEEEECCCHHHCCCCCCCCCHHCCEEEEEEEECCCH
GFERAERLIDAGVDMIVIDTAHGHSQRVLDAVGRVKKLSNSVRIMAGNVATGDGTKALID
HHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEECCEECCCCCHHHHH
AGADAVKVGIGPGSICTTRIVAGVGVPQLAAIMSAVEAAQAAGIPIIADGGIKYSGDLAK
CCCCEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEECCCEEECCHHHH
AIAAGASAVMIGSLLAGTEESPGEVFLYQGRSFKAYRGMGSVGAMARGSADRYFQAEVRD
HHHCCCHHHHHHHHHCCCCCCCCCEEEECCCCCHHHCCCCCCCHHHCCCCCHHHHHHHHH
TLKLVPEGIEGQVPYKGPVSGVLHQLAGGLRASMGYVGGATIKDYQERASFVRISGAGLR
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCEEEEECCCCC
ESHAHDVTITRESPNYPGGA
CCCCCEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA