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The map label for this gene is cheA [H]

Identifier: 150395462

GI number: 150395462

Start: 258611

End: 260890

Strand: Direct

Name: cheA [H]

Synonym: Smed_0235

Alternate gene names: 150395462

Gene position: 258611-260890 (Clockwise)

Preceding gene: 150395461

Following gene: 150395463

Centisome position: 6.84

GC content: 62.02

Gene sequence:

>2280_bases
ATGGATATGAACGAAATCAAAGAGATCTTCTTCCAGGAATGCGAGGAGCAACTCGCGGAACTGGAAACGGGTCTCCTAAA
GCTCAATGACGGCGATCGCGACCCGGAAACGGTGAATGCCGTTTTCCGTGCGGTCCATTCCATCAAGGGTGGCGCCGGCG
CTTTCGGGCTCGACGATCTCGTCTCCTTCGCGCATGTATTCGAAACGACGCTCGACTGCGTTCGATCCAACAGGCTGGAA
CCCACTCAGGACGTTCTGAAAGTCATGCTGAGATCGGCGGATGTGCTCGCCGATCTGACCAATGCCGCCCGCGACGGCGG
CAGCGTCGACGGGGGGCGCAGCCGTCAGCTCATCAAGGAGCTCGAAGCGCTCGCCAATGGCGAATTGCCGCAGGCCGCTA
CCGAGCCTGTGCCGAAGGCGGTCCCGTCCGCCGCTGCCCCCGTTGCTCCCGTCGTCAACGAGGAAGGCTTCCAGCCGGTT
GCCTTCTCCTTCGACGATTTCGAAGCGGGCGACGAGCTGACCATCGAGCCGGTCGCCTATGAGATCGTCTTCAAGCCCAA
GTCCGACCTCTACGCCAAGGGCAATGATGCCACGCTGCTCCTGCGCGATCTGTCTCGGCTGGGCGAGATGAGCATCCATT
GTGACATGGACGGCCTGCCGCCGCTGGATCGGCTGAATCCGGAGGAGGCCTACTTCTCCTGGAAGATTTCGCTCAGCACC
GACAAGGGCGAGGAAGCGATACGCTCGGTGTTCGAATTCGCGGAGTGGGATTGCGACCTCGAGGTCGCGGTCGCCGGCGG
CTTGATCGGGATGGACGAGGAACTGCCGATGCAGCCCGTACCCTTCGATCTGTCGATCCTCGATGAAGAAGCCCAGATGC
CTGCCGGGGAAGAGGATCGGGCATATCCTCACGAGGGTGAGGCCCAAAATGCGACCATCCCGGCGGCAGAGACGGCGAGC
AACGTGCTGCAAATGGCGCAGTCCGCGGCGCGTGTCTCCCCGGAAAATGTCAGGAATCCGACATCGGCATCAACGGCGCA
GAACATTGCCGCGCAACAGGCCGCTTCGGCCGCGACCCCGACCATTCGCGTCGATCTCGATCGTGTCGATCGTCTGATCA
ACCTTGTCGGCGAACTCGTCATCAACCAGGCGATGCTGTCTCAGAGCGTAATCGAGAACGATACCAACGGCACGTCGTCG
ATCAATATGGGGCTGGAGGAGCTGCAGCAGCTTACGCGCGAAATCCAGGATAGCGTCATGGCGATCCGCGCGCAGCCGGT
AAAGCCGGTCTTCCAGCGCATGTCCCGCATTGTCCGCGAAATCGCCGACATGACCGGCAAATCCGTTCGTCTCATCACCG
AGGGTGAAAACACGGAAGTCGACAAGACGGTCATCGACAAGCTCGCCGAGCCGCTCACGCACATGATCCGCAACGCGGTC
GATCACGGCCTGGAAACGCCCGATAAGCGCATTGCCGCGGGCAAGAGCCCCGAAGGCACCGTGCGGCTCACGGCCAAGCA
TCGCTCCGGACGCATCGTCATCGAGCTGGCAGACGACGGCGCCGGCATCAATCGCGAAAAGGTGCGCCAGAAGGCGATCG
ACAATGATCTCATTGCGGCCGATGCAAACCTTTCCGACGAGGAGATCGATAACCTGATCTTCCATGCGGGTTTCTCCACG
GCCGACAAGATATCGGATATTTCCGGCCGCGGCGTCGGCATGGATGTCGTCAAGCGCTCCATCCAGGCGCTCGGCGGGCG
CATCAACATTTCGTCGAGGCCCGGCCAGGGTTCGATCTTCACCATGAGCCTCCCGCTGACGCTCGCCGTACTCGACGGCA
TGGTGGTGACCGTCGCGAACCAGACGCTCGTCGTGCCCCTGACGGCAATTGTCGAGACGCTGCAGCCGGAAGCCTCCGCT
ATTCACAGCTTCGGCGCCAGTCAGCGCCTGATTGCGATCCGCGACTCCTTCTGCCCGCTCGTCGACGTGGGCCGCATCCT
GAACTTCCGCGGAGCCCAGGCCAATCCGGTCGAGGGTGTGGCACTTCTCGTCGAATCCGAGGGCGGCGGCCAGCGCGCGC
TGATGGTCGATGCCATCCAGGGCCAGCGCCAAGTGGTGATCAAGAGCCTCGAAGCCAACTATACGCATGTGCCGGGCATT
GCCGCAGCCACCATTCTCGGCGACGGACGCGTGGCGCTCATCCTTGATGTGGACGCCATCGTTGCTGCATCGCGCGGACA
ATCCTTGAGACCCGAAATGCCTCTTGCTGCTGCCGGATGA

Upstream 100 bases:

>100_bases
CAGGCGGGTGCCACGGGCTGGATCGTGAAACCGTTCGACCCGACCAAGCTGATCGATGCCATCGAGCGCGTAACGGCCTG
AATCCGGGGACAGCCATCCA

Downstream 100 bases:

>100_bases
TGCCCATGACCAATGCCGCTAAACACCTGACAAATGGCGGACGGGAGCTGATCGCTTTCCGCGTCGGCGACCAGGAATTC
TGCGTGAACATCATGTCGGT

Product: CheA signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 759; Mature: 759

Protein sequence:

>759_residues
MDMNEIKEIFFQECEEQLAELETGLLKLNDGDRDPETVNAVFRAVHSIKGGAGAFGLDDLVSFAHVFETTLDCVRSNRLE
PTQDVLKVMLRSADVLADLTNAARDGGSVDGGRSRQLIKELEALANGELPQAATEPVPKAVPSAAAPVAPVVNEEGFQPV
AFSFDDFEAGDELTIEPVAYEIVFKPKSDLYAKGNDATLLLRDLSRLGEMSIHCDMDGLPPLDRLNPEEAYFSWKISLST
DKGEEAIRSVFEFAEWDCDLEVAVAGGLIGMDEELPMQPVPFDLSILDEEAQMPAGEEDRAYPHEGEAQNATIPAAETAS
NVLQMAQSAARVSPENVRNPTSASTAQNIAAQQAASAATPTIRVDLDRVDRLINLVGELVINQAMLSQSVIENDTNGTSS
INMGLEELQQLTREIQDSVMAIRAQPVKPVFQRMSRIVREIADMTGKSVRLITEGENTEVDKTVIDKLAEPLTHMIRNAV
DHGLETPDKRIAAGKSPEGTVRLTAKHRSGRIVIELADDGAGINREKVRQKAIDNDLIAADANLSDEEIDNLIFHAGFST
ADKISDISGRGVGMDVVKRSIQALGGRINISSRPGQGSIFTMSLPLTLAVLDGMVVTVANQTLVVPLTAIVETLQPEASA
IHSFGASQRLIAIRDSFCPLVDVGRILNFRGAQANPVEGVALLVESEGGGQRALMVDAIQGQRQVVIKSLEANYTHVPGI
AAATILGDGRVALILDVDAIVAASRGQSLRPEMPLAAAG

Sequences:

>Translated_759_residues
MDMNEIKEIFFQECEEQLAELETGLLKLNDGDRDPETVNAVFRAVHSIKGGAGAFGLDDLVSFAHVFETTLDCVRSNRLE
PTQDVLKVMLRSADVLADLTNAARDGGSVDGGRSRQLIKELEALANGELPQAATEPVPKAVPSAAAPVAPVVNEEGFQPV
AFSFDDFEAGDELTIEPVAYEIVFKPKSDLYAKGNDATLLLRDLSRLGEMSIHCDMDGLPPLDRLNPEEAYFSWKISLST
DKGEEAIRSVFEFAEWDCDLEVAVAGGLIGMDEELPMQPVPFDLSILDEEAQMPAGEEDRAYPHEGEAQNATIPAAETAS
NVLQMAQSAARVSPENVRNPTSASTAQNIAAQQAASAATPTIRVDLDRVDRLINLVGELVINQAMLSQSVIENDTNGTSS
INMGLEELQQLTREIQDSVMAIRAQPVKPVFQRMSRIVREIADMTGKSVRLITEGENTEVDKTVIDKLAEPLTHMIRNAV
DHGLETPDKRIAAGKSPEGTVRLTAKHRSGRIVIELADDGAGINREKVRQKAIDNDLIAADANLSDEEIDNLIFHAGFST
ADKISDISGRGVGMDVVKRSIQALGGRINISSRPGQGSIFTMSLPLTLAVLDGMVVTVANQTLVVPLTAIVETLQPEASA
IHSFGASQRLIAIRDSFCPLVDVGRILNFRGAQANPVEGVALLVESEGGGQRALMVDAIQGQRQVVIKSLEANYTHVPGI
AAATILGDGRVALILDVDAIVAASRGQSLRPEMPLAAAG
>Mature_759_residues
MDMNEIKEIFFQECEEQLAELETGLLKLNDGDRDPETVNAVFRAVHSIKGGAGAFGLDDLVSFAHVFETTLDCVRSNRLE
PTQDVLKVMLRSADVLADLTNAARDGGSVDGGRSRQLIKELEALANGELPQAATEPVPKAVPSAAAPVAPVVNEEGFQPV
AFSFDDFEAGDELTIEPVAYEIVFKPKSDLYAKGNDATLLLRDLSRLGEMSIHCDMDGLPPLDRLNPEEAYFSWKISLST
DKGEEAIRSVFEFAEWDCDLEVAVAGGLIGMDEELPMQPVPFDLSILDEEAQMPAGEEDRAYPHEGEAQNATIPAAETAS
NVLQMAQSAARVSPENVRNPTSASTAQNIAAQQAASAATPTIRVDLDRVDRLINLVGELVINQAMLSQSVIENDTNGTSS
INMGLEELQQLTREIQDSVMAIRAQPVKPVFQRMSRIVREIADMTGKSVRLITEGENTEVDKTVIDKLAEPLTHMIRNAV
DHGLETPDKRIAAGKSPEGTVRLTAKHRSGRIVIELADDGAGINREKVRQKAIDNDLIAADANLSDEEIDNLIFHAGFST
ADKISDISGRGVGMDVVKRSIQALGGRINISSRPGQGSIFTMSLPLTLAVLDGMVVTVANQTLVVPLTAIVETLQPEASA
IHSFGASQRLIAIRDSFCPLVDVGRILNFRGAQANPVEGVALLVESEGGGQRALMVDAIQGQRQVVIKSLEANYTHVPGI
AAATILGDGRVALILDVDAIVAASRGQSLRPEMPLAAAG

Specific function: Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylated; it can transfer its phosphate group to either CheB or CheY [H]

COG id: COG0643

COG function: function code NT; Chemotaxis protein histidine kinase and related kinases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HPt domain [H]

Homologues:

Organism=Escherichia coli, GI1788197, Length=394, Percent_Identity=47.2081218274112, Blast_Score=383, Evalue=1e-107,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002545
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR004105
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF01584 CheW; PF02895 H-kinase_dim; PF02518 HATPase_c; PF01627 Hpt [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 81448; Mature: 81448

Theoretical pI: Translated: 4.31; Mature: 4.31

Prosite motif: PS50851 CHEW ; PS50894 HPT ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDMNEIKEIFFQECEEQLAELETGLLKLNDGDRDPETVNAVFRAVHSIKGGAGAFGLDDL
CCHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHH
VSFAHVFETTLDCVRSNRLEPTQDVLKVMLRSADVLADLTNAARDGGSVDGGRSRQLIKE
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
LEALANGELPQAATEPVPKAVPSAAAPVAPVVNEEGFQPVAFSFDDFEAGDELTIEPVAY
HHHHHCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCEEEEEEEE
EIVFKPKSDLYAKGNDATLLLRDLSRLGEMSIHCDMDGLPPLDRLNPEEAYFSWKISLST
EEEECCCCCCEECCCCCCHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCEEEEEEEECC
DKGEEAIRSVFEFAEWDCDLEVAVAGGLIGMDEELPMQPVPFDLSILDEEAQMPAGEEDR
CCCHHHHHHHHHHHHCCCCEEEEEECCEECCCCCCCCCCCCCCCEEECHHHCCCCCCCCC
AYPHEGEAQNATIPAAETASNVLQMAQSAARVSPENVRNPTSASTAQNIAAQQAASAATP
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHHHCCCC
TIRVDLDRVDRLINLVGELVINQAMLSQSVIENDTNGTSSINMGLEELQQLTREIQDSVM
EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
AIRAQPVKPVFQRMSRIVREIADMTGKSVRLITEGENTEVDKTVIDKLAEPLTHMIRNAV
HHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
DHGLETPDKRIAAGKSPEGTVRLTAKHRSGRIVIELADDGAGINREKVRQKAIDNDLIAA
HCCCCCCCHHHCCCCCCCCEEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHCCCCEEEE
DANLSDEEIDNLIFHAGFSTADKISDISGRGVGMDVVKRSIQALGGRINISSRPGQGSIF
CCCCCHHHHHHHHEECCCCCHHHHHCCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCCEE
TMSLPLTLAVLDGMVVTVANQTLVVPLTAIVETLQPEASAIHSFGASQRLIAIRDSFCPL
EEECCHHHHHHCCEEEEEECCEEEEEHHHHHHHHCCHHHHHHHCCCCCCEEEECCCCCCH
VDVGRILNFRGAQANPVEGVALLVESEGGGQRALMVDAIQGQRQVVIKSLEANYTHVPGI
HHHHHHHHCCCCCCCCCCCEEEEEECCCCCCEEEEEEHHCCCHHHHHHHHCCCCCCCCCH
AAATILGDGRVALILDVDAIVAASRGQSLRPEMPLAAAG
HEEEEECCCCEEEEEEHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDMNEIKEIFFQECEEQLAELETGLLKLNDGDRDPETVNAVFRAVHSIKGGAGAFGLDDL
CCHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHH
VSFAHVFETTLDCVRSNRLEPTQDVLKVMLRSADVLADLTNAARDGGSVDGGRSRQLIKE
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
LEALANGELPQAATEPVPKAVPSAAAPVAPVVNEEGFQPVAFSFDDFEAGDELTIEPVAY
HHHHHCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCEEEEEEEE
EIVFKPKSDLYAKGNDATLLLRDLSRLGEMSIHCDMDGLPPLDRLNPEEAYFSWKISLST
EEEECCCCCCEECCCCCCHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCEEEEEEEECC
DKGEEAIRSVFEFAEWDCDLEVAVAGGLIGMDEELPMQPVPFDLSILDEEAQMPAGEEDR
CCCHHHHHHHHHHHHCCCCEEEEEECCEECCCCCCCCCCCCCCCEEECHHHCCCCCCCCC
AYPHEGEAQNATIPAAETASNVLQMAQSAARVSPENVRNPTSASTAQNIAAQQAASAATP
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHHHCCCC
TIRVDLDRVDRLINLVGELVINQAMLSQSVIENDTNGTSSINMGLEELQQLTREIQDSVM
EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
AIRAQPVKPVFQRMSRIVREIADMTGKSVRLITEGENTEVDKTVIDKLAEPLTHMIRNAV
HHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
DHGLETPDKRIAAGKSPEGTVRLTAKHRSGRIVIELADDGAGINREKVRQKAIDNDLIAA
HCCCCCCCHHHCCCCCCCCEEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHCCCCEEEE
DANLSDEEIDNLIFHAGFSTADKISDISGRGVGMDVVKRSIQALGGRINISSRPGQGSIF
CCCCCHHHHHHHHEECCCCCHHHHHCCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCCEE
TMSLPLTLAVLDGMVVTVANQTLVVPLTAIVETLQPEASAIHSFGASQRLIAIRDSFCPL
EEECCHHHHHHCCEEEEEECCEEEEEHHHHHHHHCCHHHHHHHCCCCCCEEEECCCCCCH
VDVGRILNFRGAQANPVEGVALLVESEGGGQRALMVDAIQGQRQVVIKSLEANYTHVPGI
HHHHHHHHCCCCCCCCCCCEEEEEECCCCCCEEEEEEHHCCCHHHHHHHHCCCCCCCCCH
AAATILGDGRVALILDVDAIVAASRGQSLRPEMPLAAAG
HEEEEECCCCEEEEEEHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7623670; 11481430 [H]