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The map label for this gene is sppA [H]

Identifier: 150395248

GI number: 150395248

Start: 17332

End: 18291

Strand: Direct

Name: sppA [H]

Synonym: Smed_0020

Alternate gene names: 150395248

Gene position: 17332-18291 (Clockwise)

Preceding gene: 150395247

Following gene: 150395249

Centisome position: 0.46

GC content: 63.23

Gene sequence:

>960_bases
ATGGACGAACTCGCCATAGCCGACCGCCGCAGCCTGCGCAGAAAGCTGAGCTTCTGGCGTTGGGCGGCGGCGGCCGTTCT
CTTCGCCGGCGGCCTTGCCCTGTTTGCCTTTTCCGGCTGGGGCGATGTGACGGAGCGCGCCCGCGATCACGTTGCGCGCG
TCGCCGTCACAGGTTTGATCCAGGACGACCGGGAACTGGTCGAGCGGCTGGAACGGATTGCCGAGAACCAGTCAGTCAAG
GCATTGATCGTGACGATCTCGTCCCCGGGGGGCACGACCTATGGGGGTGAGGTCATATACAAGGCGGTCCGCAAGGTGGC
CGCCAAAAAACCGGTGGTCTCGGACGTGCGCACGCTTGCCGCGTCGGCAGGCTACCTGATCGCGCTCGCGGGCGACCGTA
TCGTCGCCGGCGAGACGTCGATTACCGGTTCGATCGGCGTCATCTTCCAATATCCCCAGGTCAAGACCCTGATGGACAAG
CTCGGCGTGTCGCTCGAATCGATAAAGTCGAGGCCCCTCAAGGCCGAGCCCTCGCCGTTCCATCCTCCGAGCGACGAGGC
GAGGGCCATGATTCAGGCGATGATCGACGACAGCTACGGATGGTTCGTCGACCTGGTGGCGGAGCGGCGCAAACTGCCGC
GGGCGGAAGCGCTCGGCCTTGCGGATGGTCGGATCTTCACCGGCCGGCAGGCACTGGAAGGCAAGCTCGTCGACGAACTC
GGCGGCGATGATGAAATCAGGGCTTTCCTGGCCGAAAGGAAGGTCTCGAAGGACCTGCCCGTCCTCGATTGGGAAGCTCC
GAGCAGCACGCTGTCTTTCGGCCTCGGCTCGCTCCTGGCCGAAGCCGTCAAGGCGTTGGGATATGAGGCTTTTCCGGCAA
TGAAGGGCCTCGAAAAGACCGGCCTGGACAAGTTGTTTCTTGACGGTCTTCTTTCGGTTTGGCAGGTTGAAGGGCAATGA

Upstream 100 bases:

>100_bases
GCGTTCGACATAGAGACATGTAGTAGCTTGCCGCGGCTGAGGCAGATAGCATGTTCCGCAGGAAACTGACAGAACACCGC
ATCAGAAATCGGAGACACCC

Downstream 100 bases:

>100_bases
GGAAGGCGTGTGTGCTACCCGCGTCACGAGGCCGTAGCTGCAGGCGAGCCTTCCCGTATTCACAAACGCAGACAAAACAA
GCAAAAAACCAAGGGGGCGA

Product: signal peptide peptidase SppA, 36K type

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MDELAIADRRSLRRKLSFWRWAAAAVLFAGGLALFAFSGWGDVTERARDHVARVAVTGLIQDDRELVERLERIAENQSVK
ALIVTISSPGGTTYGGEVIYKAVRKVAAKKPVVSDVRTLAASAGYLIALAGDRIVAGETSITGSIGVIFQYPQVKTLMDK
LGVSLESIKSRPLKAEPSPFHPPSDEARAMIQAMIDDSYGWFVDLVAERRKLPRAEALGLADGRIFTGRQALEGKLVDEL
GGDDEIRAFLAERKVSKDLPVLDWEAPSSTLSFGLGSLLAEAVKALGYEAFPAMKGLEKTGLDKLFLDGLLSVWQVEGQ

Sequences:

>Translated_319_residues
MDELAIADRRSLRRKLSFWRWAAAAVLFAGGLALFAFSGWGDVTERARDHVARVAVTGLIQDDRELVERLERIAENQSVK
ALIVTISSPGGTTYGGEVIYKAVRKVAAKKPVVSDVRTLAASAGYLIALAGDRIVAGETSITGSIGVIFQYPQVKTLMDK
LGVSLESIKSRPLKAEPSPFHPPSDEARAMIQAMIDDSYGWFVDLVAERRKLPRAEALGLADGRIFTGRQALEGKLVDEL
GGDDEIRAFLAERKVSKDLPVLDWEAPSSTLSFGLGSLLAEAVKALGYEAFPAMKGLEKTGLDKLFLDGLLSVWQVEGQ
>Mature_319_residues
MDELAIADRRSLRRKLSFWRWAAAAVLFAGGLALFAFSGWGDVTERARDHVARVAVTGLIQDDRELVERLERIAENQSVK
ALIVTISSPGGTTYGGEVIYKAVRKVAAKKPVVSDVRTLAASAGYLIALAGDRIVAGETSITGSIGVIFQYPQVKTLMDK
LGVSLESIKSRPLKAEPSPFHPPSDEARAMIQAMIDDSYGWFVDLVAERRKLPRAEALGLADGRIFTGRQALEGKLVDEL
GGDDEIRAFLAERKVSKDLPVLDWEAPSSTLSFGLGSLLAEAVKALGYEAFPAMKGLEKTGLDKLFLDGLLSVWQVEGQ

Specific function: Digestion of cleaved signal peptides. Required for efficient processing of precursors under conditions of hyper-secretion [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1788064, Length=217, Percent_Identity=32.7188940092166, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI1787527, Length=172, Percent_Identity=27.906976744186, Blast_Score=77, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004635
- InterPro:   IPR002142 [H]

Pfam domain/function: PF01343 Peptidase_S49 [H]

EC number: 3.4.21.-

Molecular weight: Translated: 34587; Mature: 34587

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDELAIADRRSLRRKLSFWRWAAAAVLFAGGLALFAFSGWGDVTERARDHVARVAVTGLI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHH
QDDRELVERLERIAENQSVKALIVTISSPGGTTYGGEVIYKAVRKVAAKKPVVSDVRTLA
HHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHH
ASAGYLIALAGDRIVAGETSITGSIGVIFQYPQVKTLMDKLGVSLESIKSRPLKAEPSPF
HCCCEEEEEECCEEEECCCCCCCCEEEEEECCHHHHHHHHHCCCHHHHHCCCCCCCCCCC
HPPSDEARAMIQAMIDDSYGWFVDLVAERRKLPRAEALGLADGRIFTGRQALEGKLVDEL
CCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHCCCCCCCEECCHHHHHCHHHHHC
GGDDEIRAFLAERKVSKDLPVLDWEAPSSTLSFGLGSLLAEAVKALGYEAFPAMKGLEKT
CCCHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCHHHH
GLDKLFLDGLLSVWQVEGQ
CHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDELAIADRRSLRRKLSFWRWAAAAVLFAGGLALFAFSGWGDVTERARDHVARVAVTGLI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHH
QDDRELVERLERIAENQSVKALIVTISSPGGTTYGGEVIYKAVRKVAAKKPVVSDVRTLA
HHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHH
ASAGYLIALAGDRIVAGETSITGSIGVIFQYPQVKTLMDKLGVSLESIKSRPLKAEPSPF
HCCCEEEEEECCEEEECCCCCCCCEEEEEECCHHHHHHHHHCCCHHHHHCCCCCCCCCCC
HPPSDEARAMIQAMIDDSYGWFVDLVAERRKLPRAEALGLADGRIFTGRQALEGKLVDEL
CCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHCCCCCCCEECCHHHHHCHHHHHC
GGDDEIRAFLAERKVSKDLPVLDWEAPSSTLSFGLGSLLAEAVKALGYEAFPAMKGLEKT
CCCHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCHHHH
GLDKLFLDGLLSVWQVEGQ
CHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377; 10455123 [H]