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The map label for this gene is moaA

Identifier: 150401898

GI number: 150401898

Start: 1535368

End: 1536267

Strand: Direct

Name: moaA

Synonym: Maeo_1476

Alternate gene names: 150401898

Gene position: 1535368-1536267 (Clockwise)

Preceding gene: 150401897

Following gene: 150401901

Centisome position: 97.83

GC content: 27.78

Gene sequence:

>900_bases
ATGAAAGATTTACACAACCGAGAAATAAAATCGTTAAGAATTTCGATAACTCCCCAATGCAATTTAAATTGTTTTTACTG
CCATAAAGAAGGGCACAATATAGATAATAACAAATTAATGACCCCAACAGAAATAGGGGAAATGGTAAAATATTCTTTAA
AATATGGCATAAATAAAATTAAAATATCAGGGGGAGAACCACTTTTAAGGAACGATTTGCCCGAGATAATAAGAAATATA
AAAAATTTAAAAAATAATCAAATAAAAGATATATCTCTTACTACAAATGGAATATTGTTGGAAAAATATGCTCAAAAATT
AAAAGATGCAGGATTGGATAGAGTAAATGTTAGTTTGGATACCTTAGACCCGGAGCTATATAAAAAAATAACTGGTGGAA
ATGTTGAACTGGTTAAACGGGGAATAGAAAAGGCCGTAGAAGCTGGTTTAAAACCCATAAAAATAAATTTTGTTGTTATG
AGCAATACCGTAGGGGGATTAAATGATATTATGGATTATTGTAGAAAAATGGGAGTTATTTTACAAATAATAGAATTTAT
GCCAGTTGATGAAAAATTAAAAAAATACCATTATGATATAAATAAAATAGAGGAAGAAATAAGTAAAAAATCAGATAAAA
CCATGGTTAGAAAATTTATGCAAAATAGAAAAAAATATTTGGTTGATGGTTTGGAAATTGAATTTGTTAGGCCAATGGAT
AATACTGAATTTTGTAGCCATTGCACTAGGATAAGATTAACATATGATGGATTGTTAAAGCCCTGCTTACTTAGGGATGA
TAATTTAGTAGATGTTTTAACCCCATTACGAAATGGCGAAGATATTAACAAATGTTTTATTAAATGTATTGATAGAAGAG
AATTATATTTTAAAGAATAA

Upstream 100 bases:

>100_bases
TACATATATTTTATTTTTGTTTGCCATTAATTAAATTTAAATAATGTAAATATTATTAGTTAGATATAACTATATAGTTT
ATTAATTATTTGTGGTATTT

Downstream 100 bases:

>100_bases
AAAATAAAAATTTTATCTTATTTTATTACTTGATAAATAATAAACACCTTGACCAAAACAAATACCTCCATCCCCATTTG
GCACATTTTTATGATATAAA

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MKDLHNREIKSLRISITPQCNLNCFYCHKEGHNIDNNKLMTPTEIGEMVKYSLKYGINKIKISGGEPLLRNDLPEIIRNI
KNLKNNQIKDISLTTNGILLEKYAQKLKDAGLDRVNVSLDTLDPELYKKITGGNVELVKRGIEKAVEAGLKPIKINFVVM
SNTVGGLNDIMDYCRKMGVILQIIEFMPVDEKLKKYHYDINKIEEEISKKSDKTMVRKFMQNRKKYLVDGLEIEFVRPMD
NTEFCSHCTRIRLTYDGLLKPCLLRDDNLVDVLTPLRNGEDINKCFIKCIDRRELYFKE

Sequences:

>Translated_299_residues
MKDLHNREIKSLRISITPQCNLNCFYCHKEGHNIDNNKLMTPTEIGEMVKYSLKYGINKIKISGGEPLLRNDLPEIIRNI
KNLKNNQIKDISLTTNGILLEKYAQKLKDAGLDRVNVSLDTLDPELYKKITGGNVELVKRGIEKAVEAGLKPIKINFVVM
SNTVGGLNDIMDYCRKMGVILQIIEFMPVDEKLKKYHYDINKIEEEISKKSDKTMVRKFMQNRKKYLVDGLEIEFVRPMD
NTEFCSHCTRIRLTYDGLLKPCLLRDDNLVDVLTPLRNGEDINKCFIKCIDRRELYFKE
>Mature_299_residues
MKDLHNREIKSLRISITPQCNLNCFYCHKEGHNIDNNKLMTPTEIGEMVKYSLKYGINKIKISGGEPLLRNDLPEIIRNI
KNLKNNQIKDISLTTNGILLEKYAQKLKDAGLDRVNVSLDTLDPELYKKITGGNVELVKRGIEKAVEAGLKPIKINFVVM
SNTVGGLNDIMDYCRKMGVILQIIEFMPVDEKLKKYHYDINKIEEEISKKSDKTMVRKFMQNRKKYLVDGLEIEFVRPMD
NTEFCSHCTRIRLTYDGLLKPCLLRDDNLVDVLTPLRNGEDINKCFIKCIDRRELYFKE

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family

Homologues:

Organism=Homo sapiens, GI116734668, Length=305, Percent_Identity=32.1311475409836, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI22027536, Length=305, Percent_Identity=32.1311475409836, Blast_Score=135, Evalue=6e-32,
Organism=Escherichia coli, GI1786999, Length=286, Percent_Identity=30.4195804195804, Blast_Score=136, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17561210, Length=278, Percent_Identity=34.1726618705036, Blast_Score=136, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI32566331, Length=278, Percent_Identity=32.3741007194245, Blast_Score=128, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI32566329, Length=278, Percent_Identity=32.3741007194245, Blast_Score=128, Evalue=4e-30,
Organism=Drosophila melanogaster, GI28574490, Length=281, Percent_Identity=34.8754448398576, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI28574488, Length=281, Percent_Identity=34.8754448398576, Blast_Score=129, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MOAA_META3 (A6UX30)

Other databases:

- EMBL:   CP000743
- RefSeq:   YP_001325664.1
- ProteinModelPortal:   A6UX30
- SMR:   A6UX30
- STRING:   A6UX30
- GeneID:   5327538
- GenomeReviews:   CP000743_GR
- KEGG:   mae:Maeo_1476
- eggNOG:   arNOG05084
- HOGENOM:   HBG529885
- OMA:   NAVLMKQ
- ProtClustDB:   PRK00164
- BioCyc:   MAEO419665:MAEO_1476-MONOMER
- HAMAP:   MF_01225_A
- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013485
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197
- Gene3D:   G3DSA:3.20.20.70
- SMART:   SM00729
- TIGRFAMs:   TIGR02668

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM

EC number: NA

Molecular weight: Translated: 34664; Mature: 34664

Theoretical pI: Translated: 8.88; Mature: 8.88

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: BINDING 13-13 BINDING 26-26 BINDING 61-61 BINDING 65-65 BINDING 94-94 BINDING 118-118 BINDING 154-154

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDLHNREIKSLRISITPQCNLNCFYCHKEGHNIDNNKLMTPTEIGEMVKYSLKYGINKI
CCCCCCCCHHEEEEEECCCCCCEEEEEECCCCCCCCCCEECHHHHHHHHHHHHHHCCCEE
KISGGEPLLRNDLPEIIRNIKNLKNNQIKDISLTTNGILLEKYAQKLKDAGLDRVNVSLD
EECCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCEEEEEHH
TLDPELYKKITGGNVELVKRGIEKAVEAGLKPIKINFVVMSNTVGGLNDIMDYCRKMGVI
HCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHH
LQIIEFMPVDEKLKKYHYDINKIEEEISKKSDKTMVRKFMQNRKKYLVDGLEIEFVRPMD
HHHHHHCCCCHHHHHHHCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
NTEFCSHCTRIRLTYDGLLKPCLLRDDNLVDVLTPLRNGEDINKCFIKCIDRRELYFKE
CHHHHHHHHEEEEEHHHHHCHHHCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKDLHNREIKSLRISITPQCNLNCFYCHKEGHNIDNNKLMTPTEIGEMVKYSLKYGINKI
CCCCCCCCHHEEEEEECCCCCCEEEEEECCCCCCCCCCEECHHHHHHHHHHHHHHCCCEE
KISGGEPLLRNDLPEIIRNIKNLKNNQIKDISLTTNGILLEKYAQKLKDAGLDRVNVSLD
EECCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCEEEEEHH
TLDPELYKKITGGNVELVKRGIEKAVEAGLKPIKINFVVMSNTVGGLNDIMDYCRKMGVI
HCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHH
LQIIEFMPVDEKLKKYHYDINKIEEEISKKSDKTMVRKFMQNRKKYLVDGLEIEFVRPMD
HHHHHHCCCCHHHHHHHCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
NTEFCSHCTRIRLTYDGLLKPCLLRDDNLVDVLTPLRNGEDINKCFIKCIDRRELYFKE
CHHHHHHHHEEEEEHHHHHCHHHCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA