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The map label for this gene is dys [H]

Identifier: 150401895

GI number: 150401895

Start: 1532594

End: 1533622

Strand: Direct

Name: dys [H]

Synonym: Maeo_1473

Alternate gene names: 150401895

Gene position: 1532594-1533622 (Clockwise)

Preceding gene: 150401893

Following gene: 150401897

Centisome position: 97.65

GC content: 31.29

Gene sequence:

>1029_bases
ATGCGAGAAAAAGGTGAAAAAATTACTCAACCAAAAGATATAATATTAAAAAAAAGTGATGAAATTAATGGGTTAGAAGT
AGAAGGTCCATCATTGGACAACGATATTGATTTAAAAGATATAATTACAAATTATTATCAAAAAATAGGTTTTCAGGCAA
CGGCTGTTGGAAATGCCATAAATATATGGAAAAATATTGATAAAATAAAGCAGACAGACGAAATAACTGTTTTTATGGGA
TATACTTCAAATATGGTTTCATCTGGATTGCGAGAAATAATATCATATTTGGCAAAGCATAATAAAATAGATGTAATAGT
TACCACAGCAGGAGGGGTTGAGGAAGATTTTATAAAATGCTTAAAACCTTTTATCGTGGGAGAGTGGGATTTAGACGGAA
ATTATTTACGGGAAAAAGGAATTAATAGAATTGGGAATATATATGTTCCAAATGATAGATATATTGAATTTGAAACCTAT
ATGACGGAATTTTTTGAGCTATTGGACGAAAAACAGCAACAAACCAATAATATTATATCGGCACAGGAGTTTTGTTATGA
ATTGGGTAAATTTATGGATAGAAAATTGCCCGATGAAGCAAAAGAAAAATCCATTATTTACTGGGCATATAAAAATAATA
TTCCAATGTTTTGCCCTGCCATAACAGATGGTTCTATTGGAGATATGCTTTATTTCTATAAAATAGAAAGAAAATCAAAT
TTAAAAATAGATATTGCCGAAGATATTGTAAAATTAAATGATATTGCTGTAAATTCTAAAAAAACAGCCTGTATTGTGTT
GGGGGGCTCACTTCCAAAACACAGCATAATAAATGCAAATTTGTTCAGAGAGGGTACAGATTATGCTATATATATTACTA
CGGCCATTCCAAATGATGGCTCACTTAGTGGGGCTCCACCAGAAGAAGGAATTTCATGGGGGAAAATTCAGTCAAAAGCA
GATTTCGTTGAAGTGTGGGCCGACGCCACAATAGTATTTCCATTAATTGTTTATGGAGTATTTAAATAA

Upstream 100 bases:

>100_bases
ATACTATAAAATGTGGCGGTTATTTTATTGTTGTATAACTATATTAGTTATATATTGAAAACAATAATAAATAATAATAA
AAAAAATAATAATTTATTTT

Downstream 100 bases:

>100_bases
TTGGAGCTCCAATTCTTGGAGCCCCCAATAAATCTATAATTTATTTAAATCATTATGGGTATTCACATTTACAAAAGATT
TATGAGTTTCATCTATTTCA

Product: putative deoxyhypusine synthase

Products: NA

Alternate protein names: DHS [H]

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MREKGEKITQPKDIILKKSDEINGLEVEGPSLDNDIDLKDIITNYYQKIGFQATAVGNAINIWKNIDKIKQTDEITVFMG
YTSNMVSSGLREIISYLAKHNKIDVIVTTAGGVEEDFIKCLKPFIVGEWDLDGNYLREKGINRIGNIYVPNDRYIEFETY
MTEFFELLDEKQQQTNNIISAQEFCYELGKFMDRKLPDEAKEKSIIYWAYKNNIPMFCPAITDGSIGDMLYFYKIERKSN
LKIDIAEDIVKLNDIAVNSKKTACIVLGGSLPKHSIINANLFREGTDYAIYITTAIPNDGSLSGAPPEEGISWGKIQSKA
DFVEVWADATIVFPLIVYGVFK

Sequences:

>Translated_342_residues
MREKGEKITQPKDIILKKSDEINGLEVEGPSLDNDIDLKDIITNYYQKIGFQATAVGNAINIWKNIDKIKQTDEITVFMG
YTSNMVSSGLREIISYLAKHNKIDVIVTTAGGVEEDFIKCLKPFIVGEWDLDGNYLREKGINRIGNIYVPNDRYIEFETY
MTEFFELLDEKQQQTNNIISAQEFCYELGKFMDRKLPDEAKEKSIIYWAYKNNIPMFCPAITDGSIGDMLYFYKIERKSN
LKIDIAEDIVKLNDIAVNSKKTACIVLGGSLPKHSIINANLFREGTDYAIYITTAIPNDGSLSGAPPEEGISWGKIQSKA
DFVEVWADATIVFPLIVYGVFK
>Mature_342_residues
MREKGEKITQPKDIILKKSDEINGLEVEGPSLDNDIDLKDIITNYYQKIGFQATAVGNAINIWKNIDKIKQTDEITVFMG
YTSNMVSSGLREIISYLAKHNKIDVIVTTAGGVEEDFIKCLKPFIVGEWDLDGNYLREKGINRIGNIYVPNDRYIEFETY
MTEFFELLDEKQQQTNNIISAQEFCYELGKFMDRKLPDEAKEKSIIYWAYKNNIPMFCPAITDGSIGDMLYFYKIERKSN
LKIDIAEDIVKLNDIAVNSKKTACIVLGGSLPKHSIINANLFREGTDYAIYITTAIPNDGSLSGAPPEEGISWGKIQSKA
DFVEVWADATIVFPLIVYGVFK

Specific function: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine

COG id: COG1899

COG function: function code O; Deoxyhypusine synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the deoxyhypusine synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503325, Length=348, Percent_Identity=41.9540229885057, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI7108338, Length=348, Percent_Identity=35.632183908046, Blast_Score=201, Evalue=8e-52,
Organism=Homo sapiens, GI7108340, Length=348, Percent_Identity=33.3333333333333, Blast_Score=187, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17536927, Length=327, Percent_Identity=43.7308868501529, Blast_Score=276, Evalue=1e-74,
Organism=Saccharomyces cerevisiae, GI6321859, Length=352, Percent_Identity=41.4772727272727, Blast_Score=271, Evalue=1e-73,
Organism=Drosophila melanogaster, GI45550569, Length=357, Percent_Identity=45.0980392156863, Blast_Score=294, Evalue=5e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002773
- InterPro:   IPR022899 [H]

Pfam domain/function: PF01916 DS [H]

EC number: =2.5.1.46 [H]

Molecular weight: Translated: 38732; Mature: 38732

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREKGEKITQPKDIILKKSDEINGLEVEGPSLDNDIDLKDIITNYYQKIGFQATAVGNAI
CCCCCCCCCCCHHEEEECCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHCCEEECCCCHH
NIWKNIDKIKQTDEITVFMGYTSNMVSSGLREIISYLAKHNKIDVIVTTAGGVEEDFIKC
HHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHH
LKPFIVGEWDLDGNYLREKGINRIGNIYVPNDRYIEFETYMTEFFELLDEKQQQTNNIIS
HHHHEEEEECCCCHHHHHHCHHHHCCEEECCCCEEEHHHHHHHHHHHHHHHHHHHCCCHH
AQEFCYELGKFMDRKLPDEAKEKSIIYWAYKNNIPMFCPAITDGSIGDMLYFYKIERKSN
HHHHHHHHHHHHHHCCCCCHHHCCEEEEEEECCCCEEEECCCCCCCCCEEEEEEEECCCC
LKIDIAEDIVKLNDIAVNSKKTACIVLGGSLPKHSIINANLFREGTDYAIYITTAIPNDG
CEEEHHHHHHHHHHEEECCCCCEEEEECCCCCCCCEEECHHEECCCCEEEEEEEECCCCC
SLSGAPPEEGISWGKIQSKADFVEVWADATIVFPLIVYGVFK
CCCCCCCHHCCCCCCCCCCHHHHHHHHCHHHHHHHHHHHCCC
>Mature Secondary Structure
MREKGEKITQPKDIILKKSDEINGLEVEGPSLDNDIDLKDIITNYYQKIGFQATAVGNAI
CCCCCCCCCCCHHEEEECCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHCCEEECCCCHH
NIWKNIDKIKQTDEITVFMGYTSNMVSSGLREIISYLAKHNKIDVIVTTAGGVEEDFIKC
HHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHH
LKPFIVGEWDLDGNYLREKGINRIGNIYVPNDRYIEFETYMTEFFELLDEKQQQTNNIIS
HHHHEEEEECCCCHHHHHHCHHHHCCEEECCCCEEEHHHHHHHHHHHHHHHHHHHCCCHH
AQEFCYELGKFMDRKLPDEAKEKSIIYWAYKNNIPMFCPAITDGSIGDMLYFYKIERKSN
HHHHHHHHHHHHHHCCCCCHHHCCEEEEEEECCCCEEEECCCCCCCCCEEEEEEEECCCC
LKIDIAEDIVKLNDIAVNSKKTACIVLGGSLPKHSIINANLFREGTDYAIYITTAIPNDG
CEEEHHHHHHHHHHEEECCCCCEEEEECCCCCCCCEEECHHEECCCCEEEEEEEECCCCC
SLSGAPPEEGISWGKIQSKADFVEVWADATIVFPLIVYGVFK
CCCCCCCHHCCCCCCCCCCHHHHHHHHCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA