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The map label for this gene is purP

Identifier: 150401749

GI number: 150401749

Start: 1389737

End: 1390822

Strand: Reverse

Name: purP

Synonym: Maeo_1327

Alternate gene names: 150401749

Gene position: 1390822-1389737 (Counterclockwise)

Preceding gene: 150401750

Following gene: 150401743

Centisome position: 88.62

GC content: 33.33

Gene sequence:

>1086_bases
ATGATTTCAAAAGAGGAAATATTGAGCATATATGAAGGATACAACAAGGAAGAAATAACAATTGTTACTGTTGGTAGTCA
TACATCACTCCATATATTAAAGGGAGCAAAATTAGAAGGATTTTCAACAGCAGTGATTACAACAAAAGATAGGGCTACAC
CATACAAAAGATTTGGAGTTGCAGACAAATATATTTATGTAGATAATTTTTCAGACATATCAAATGAAGAAATACAGAAG
CAATTAATAGAAATGAATGCAATTATTATTCCTCATGGTTCATTTATAGCATATTGTGGATTAGATAATTTAGAAAACAA
CTTTAAAGTGCCAATGTTTGGAAACAGACAGATATTAAGATGGGAAGCTGAAAGAGATTTAGAAGGAAAACTATTAAAAG
AAAGCGGGTTAAGAATACCTAAAAAACTCAATAGCCCAGATGAAATAAACTGCCCAGTTATGGTAAAATTCCCTGGGGCT
CGGGGAGGTAGAGGATATTTCCCATGTTCCACCACAGAAGAATTTTGGAAAAAAGTTGAAATATTTAAAGAAAGAGGAAT
TTTAACAGATGAGGATGTGGGTAATGCCCACATTGAAGAATATGTTGTTGGAACAAATTATTGTATTCATTACTTCTACT
CGCCATTAAAAAACCAGGTTGAATTAATGGGCATAGACAGCAGATATGAAAGTAATATTGATGGAATAGTTAGAGTTCCT
GCAAAAGACCAGATGGAATTAGATATTAATCCATCATATGTAATAAGTGGAAACTTCCCAGTTGTAATAAGGGAAAGTCT
TCTCCCACAAGTATTTGATATGGGAGATAAATTAGTAGCAAAGGCAGAGGAAATGGTTGCACCGGGAATGATAGGACCAT
TCTGTCTTCAATCATTATGTAATGATAGCCTTGAATTGGTTGTATTTGAAATGAGTGCAAGAATAGATGGAGGAACAAAC
TCCTTTATGAATGGAAGTGCCTATTCATGCCTATACTCTGGTGAGCCATTGAGCATGGGACAAAGAATAGCAAAAGAGAT
AAAATTAGCATTGGAATTAGATATGATGGATAAAATATTATATTAA

Upstream 100 bases:

>100_bases
ATAATATATATTCTTTACTATTCGGTTCTTGTAATAAATAATATATAGGCTCATGACATAATATAACAATGTTAATTTAA
ATCGTAAAAAGGTGAAATAA

Downstream 100 bases:

>100_bases
ATAAAAAAAATAAATATAATTATTTCAATTTTTCTTTTAATTTTTCGTTTTCTTGTTTTAATTTTTCTTTTAATTTAGTG
TATTCCCCTGAATTCAGCCC

Product: 5-formaminoimidazole-4-carboxamide-1-(beta)-D- ribofuranosyl 5'-monophosphate synthetase

Products: NA

Alternate protein names: 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate--formate ligase

Number of amino acids: Translated: 361; Mature: 361

Protein sequence:

>361_residues
MISKEEILSIYEGYNKEEITIVTVGSHTSLHILKGAKLEGFSTAVITTKDRATPYKRFGVADKYIYVDNFSDISNEEIQK
QLIEMNAIIIPHGSFIAYCGLDNLENNFKVPMFGNRQILRWEAERDLEGKLLKESGLRIPKKLNSPDEINCPVMVKFPGA
RGGRGYFPCSTTEEFWKKVEIFKERGILTDEDVGNAHIEEYVVGTNYCIHYFYSPLKNQVELMGIDSRYESNIDGIVRVP
AKDQMELDINPSYVISGNFPVVIRESLLPQVFDMGDKLVAKAEEMVAPGMIGPFCLQSLCNDSLELVVFEMSARIDGGTN
SFMNGSAYSCLYSGEPLSMGQRIAKEIKLALELDMMDKILY

Sequences:

>Translated_361_residues
MISKEEILSIYEGYNKEEITIVTVGSHTSLHILKGAKLEGFSTAVITTKDRATPYKRFGVADKYIYVDNFSDISNEEIQK
QLIEMNAIIIPHGSFIAYCGLDNLENNFKVPMFGNRQILRWEAERDLEGKLLKESGLRIPKKLNSPDEINCPVMVKFPGA
RGGRGYFPCSTTEEFWKKVEIFKERGILTDEDVGNAHIEEYVVGTNYCIHYFYSPLKNQVELMGIDSRYESNIDGIVRVP
AKDQMELDINPSYVISGNFPVVIRESLLPQVFDMGDKLVAKAEEMVAPGMIGPFCLQSLCNDSLELVVFEMSARIDGGTN
SFMNGSAYSCLYSGEPLSMGQRIAKEIKLALELDMMDKILY
>Mature_361_residues
MISKEEILSIYEGYNKEEITIVTVGSHTSLHILKGAKLEGFSTAVITTKDRATPYKRFGVADKYIYVDNFSDISNEEIQK
QLIEMNAIIIPHGSFIAYCGLDNLENNFKVPMFGNRQILRWEAERDLEGKLLKESGLRIPKKLNSPDEINCPVMVKFPGA
RGGRGYFPCSTTEEFWKKVEIFKERGILTDEDVGNAHIEEYVVGTNYCIHYFYSPLKNQVELMGIDSRYESNIDGIVRVP
AKDQMELDINPSYVISGNFPVVIRESLLPQVFDMGDKLVAKAEEMVAPGMIGPFCLQSLCNDSLELVVFEMSARIDGGTN
SFMNGSAYSCLYSGEPLSMGQRIAKEIKLALELDMMDKILY

Specific function: Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'- monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1- beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates

COG id: COG1759

COG function: function code R; ATP-utilizing enzymes of ATP-grasp superfamily (probably carboligases)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURP_META3 (A6UWN1)

Other databases:

- EMBL:   CP000743
- RefSeq:   YP_001325515.1
- ProteinModelPortal:   A6UWN1
- SMR:   A6UWN1
- STRING:   A6UWN1
- GeneID:   5327694
- GenomeReviews:   CP000743_GR
- KEGG:   mae:Maeo_1327
- eggNOG:   arNOG04185
- HOGENOM:   HBG392202
- OMA:   VFEISAR
- ProtClustDB:   PRK13278
- BioCyc:   MAEO419665:MAEO_1327-MONOMER
- HAMAP:   MF_01163
- InterPro:   IPR011761
- InterPro:   IPR013816
- InterPro:   IPR009720
- InterPro:   IPR010672
- InterPro:   IPR013817
- Gene3D:   G3DSA:3.30.470.20
- Gene3D:   G3DSA:3.40.50.20

Pfam domain/function: PF06849 DUF1246; PF06973 DUF1297

EC number: NA

Molecular weight: Translated: 40663; Mature: 40663

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS50975 ATP_GRASP

Important sites: BINDING 27-27 BINDING 94-94 BINDING 230-230 BINDING 258-258

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISKEEILSIYEGYNKEEITIVTVGSHTSLHILKGAKLEGFSTAVITTKDRATPYKRFGV
CCCHHHHHHHHCCCCCCEEEEEEECCCCEEEEEECCEECCCEEEEEEECCCCCCHHHHCC
ADKYIYVDNFSDISNEEIQKQLIEMNAIIIPHGSFIAYCGLDNLENNFKVPMFGNRQILR
CCEEEEEECCCCCCHHHHHHHHHHHCEEEEECCCEEEEECCCCCCCCEECCEECCCEEEE
WEAERDLEGKLLKESGLRIPKKLNSPDEINCPVMVKFPGARGGRGYFPCSTTEEFWKKVE
EECCCCCCCHHHHHCCCCCCHHCCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHH
IFKERGILTDEDVGNAHIEEYVVGTNYCIHYFYSPLKNQVELMGIDSRYESNIDGIVRVP
HHHHCCCCCCCCCCCCHHHHEEECCHHHHHHHHHHHCCCEEEEEECCHHCCCCCCEEECC
AKDQMELDINPSYVISGNFPVVIRESLLPQVFDMGDKLVAKAEEMVAPGMIGPFCLQSLC
CCCCEEEECCCCEEEECCCCEEEHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHC
NDSLELVVFEMSARIDGGTNSFMNGSAYSCLYSGEPLSMGQRIAKEIKLALELDMMDKIL
CCCEEEEEEEEEECCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHC
Y
C
>Mature Secondary Structure
MISKEEILSIYEGYNKEEITIVTVGSHTSLHILKGAKLEGFSTAVITTKDRATPYKRFGV
CCCHHHHHHHHCCCCCCEEEEEEECCCCEEEEEECCEECCCEEEEEEECCCCCCHHHHCC
ADKYIYVDNFSDISNEEIQKQLIEMNAIIIPHGSFIAYCGLDNLENNFKVPMFGNRQILR
CCEEEEEECCCCCCHHHHHHHHHHHCEEEEECCCEEEEECCCCCCCCEECCEECCCEEEE
WEAERDLEGKLLKESGLRIPKKLNSPDEINCPVMVKFPGARGGRGYFPCSTTEEFWKKVE
EECCCCCCCHHHHHCCCCCCHHCCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHH
IFKERGILTDEDVGNAHIEEYVVGTNYCIHYFYSPLKNQVELMGIDSRYESNIDGIVRVP
HHHHCCCCCCCCCCCCHHHHEEECCHHHHHHHHHHHCCCEEEEEECCHHCCCCCCEEECC
AKDQMELDINPSYVISGNFPVVIRESLLPQVFDMGDKLVAKAEEMVAPGMIGPFCLQSLC
CCCCEEEECCCCEEEECCCCEEEHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHC
NDSLELVVFEMSARIDGGTNSFMNGSAYSCLYSGEPLSMGQRIAKEIKLALELDMMDKIL
CCCEEEEEEEEEECCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHC
Y
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA