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The map label for this gene is thrS

Identifier: 150401612

GI number: 150401612

Start: 1255951

End: 1257843

Strand: Reverse

Name: thrS

Synonym: Maeo_1189

Alternate gene names: 150401612

Gene position: 1257843-1255951 (Counterclockwise)

Preceding gene: 150401613

Following gene: 150401610

Centisome position: 80.14

GC content: 33.28

Gene sequence:

>1893_bases
TTGAAAGTTTTATTGATTCACTCAGATTATTTGGAATTTGAAGCAAAACAAAAAACAAAAATTGCAGAAGATACAGACAT
ATTAAATGGAAAAATGGAGGAATGTTTAACTGTTTTTATGGCTGTTGAGAAAGAGGATGAAGAAAATCCGCAAAATGTAA
TATATAATACAGTAGATGAGATAATAAAAACAGCCGAAAACTTAAAAATTAATAATGTGGTTGTTTATCCTTATGCCCAT
TTATCAAGTGAGTTAAGCTCCCCAAAGGTTGCAAAAGAAGTTTTACAGAAAATTGAAGAAGAATTAAAACAAAAAAATTA
TTCTGTTTTGAGAGCTCCATTTGGCTGGTATAAATCATTTAAGATTAGCTGTAAAGGACATCCATTAAGTGAATTATCTA
GAAAAATAACCACAGAACGGAAAGAGGAAAAAGGAGAAACGGAGGCAAAAGACAGACCCAAAAATAAATTCTACATCCTT
GATGGAGAAAAAGGAGAGGAAGGATTAAAAGAATTAGATGAAAAAAAGGTTAAAAAATTAAAAGATAAAGGTTTAAAATC
CGTAGCCATGCATGAAATGGGAATAAAGCATGGAGGTAAAGAAAAGGATATAGAGCCACCACATGTTAAATTTATTACGG
AAAAAGAAATCTGCGACTATGAACCTTCTTCCGATGCCGGACATTTTAGATGGTATCCAAAGGGGAAACTCATAAGAGAC
CTTTTGCAGGATTATGTTTATAATATGGTTGTAGAAAACAACGGTATGCCTGTTGAAACACCTGTAATGTATGATTTGGG
AAATAAAGCAATAAAAGAACATGCAGATAAATTTGGAGAAAGACAGTACAGATTTAAACAGGGAAACAAGGATTTAATGC
TTAGATTTGCGGCATGTTTTGGACAATTTATGATGAAAAAGGATATGTACATACTTCCAAAACATTTGCCTTTAAAATTA
TATGAGCTCAGCACATACAGTTTTAGATATGAACAAAGAGGGGAGCTCGTAGGATTAAAAAGGCTTAGGGGCTTCACCAT
GCCAGATATGCATACTGTTTGTAAAGATACCAAACAGACAATAGAGGAATTTGAAAATCAATTCTGGATGTGCTTAAAAA
CAGGAGATGACCTTAATACGCCATATTCTACAATATTTAGATTTACAGAGGATTTCTTTGAAGAAAATAAAGAATGGTTC
TTTAAAGTGGCAAAAGAATATAAAGAAAAATATGGAAAAGATGTAATTCTTGAATTGATTCCAGAAAGAAAACACTACTG
GGTAGGAAAAGTAGATATGGCTGTTATAGATAGCTTTGGAAGACCTATTGAAAATCCAACTGTTCAAATTGATGTTGAAA
GTGCAAAAAGATTCAATATAGTTGTGCATGATGGAAATGAAAAAACCTATCCAGTCATACTTCACTGTTCCCCAACTGGA
AGTATAGAAAGAGTATTATGCGGACTTTTGGAAAAGGCTTCATTAGATGCAGATGCAGGAGCTCCACCAATGTTGCCAGT
TTGGTTATCCCCAATACAGGCAAGAGTAATACCTGTGGCTGATGCACATTCTGAATATGCCCTATCAGTTGCCAAAAAAC
TAAGAGAAAACGGAATAAGAGCAGACTTTGACGATAGAGAAGAAAGTGTCGGTAAAAAAATAAGAAATGCTGGTAAGGAC
TGGGTGCCATTTGTTATAGTTATAGGGGATAAAGAGGTTGAGAATAATATATTAACAACCACAATAAGAGAAAAATCCAC
ATTAAAAAAGCCAGTTAAGGAAAATTTGACTGTTGAAGAGTTAATCGAAAAAATAAAAGAAGAAACCAAAGGATTCCCAT
ACAGGCCATTAAGTTTGCCTTTATATTGCTCATTACAGCCAATATTTAGATAA

Upstream 100 bases:

>100_bases
TAAATAATTTAAAGTTTATAAAGTTTATATAATTGAAACGCATATATTTTTAAAATAACTATAATTTTATAACCATGACA
AATTTTATAAGAGGGATAAT

Downstream 100 bases:

>100_bases
AATATTTAAATAAGTATAATATCAAATCAATTCTATTTCTTACTTTTAATTTCTTACTTTTGTTTTTAATTTTTTAATTA
ATTATTTCCCCATATAAACC

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS

Number of amino acids: Translated: 630; Mature: 630

Protein sequence:

>630_residues
MKVLLIHSDYLEFEAKQKTKIAEDTDILNGKMEECLTVFMAVEKEDEENPQNVIYNTVDEIIKTAENLKINNVVVYPYAH
LSSELSSPKVAKEVLQKIEEELKQKNYSVLRAPFGWYKSFKISCKGHPLSELSRKITTERKEEKGETEAKDRPKNKFYIL
DGEKGEEGLKELDEKKVKKLKDKGLKSVAMHEMGIKHGGKEKDIEPPHVKFITEKEICDYEPSSDAGHFRWYPKGKLIRD
LLQDYVYNMVVENNGMPVETPVMYDLGNKAIKEHADKFGERQYRFKQGNKDLMLRFAACFGQFMMKKDMYILPKHLPLKL
YELSTYSFRYEQRGELVGLKRLRGFTMPDMHTVCKDTKQTIEEFENQFWMCLKTGDDLNTPYSTIFRFTEDFFEENKEWF
FKVAKEYKEKYGKDVILELIPERKHYWVGKVDMAVIDSFGRPIENPTVQIDVESAKRFNIVVHDGNEKTYPVILHCSPTG
SIERVLCGLLEKASLDADAGAPPMLPVWLSPIQARVIPVADAHSEYALSVAKKLRENGIRADFDDREESVGKKIRNAGKD
WVPFVIVIGDKEVENNILTTTIREKSTLKKPVKENLTVEELIEKIKEETKGFPYRPLSLPLYCSLQPIFR

Sequences:

>Translated_630_residues
MKVLLIHSDYLEFEAKQKTKIAEDTDILNGKMEECLTVFMAVEKEDEENPQNVIYNTVDEIIKTAENLKINNVVVYPYAH
LSSELSSPKVAKEVLQKIEEELKQKNYSVLRAPFGWYKSFKISCKGHPLSELSRKITTERKEEKGETEAKDRPKNKFYIL
DGEKGEEGLKELDEKKVKKLKDKGLKSVAMHEMGIKHGGKEKDIEPPHVKFITEKEICDYEPSSDAGHFRWYPKGKLIRD
LLQDYVYNMVVENNGMPVETPVMYDLGNKAIKEHADKFGERQYRFKQGNKDLMLRFAACFGQFMMKKDMYILPKHLPLKL
YELSTYSFRYEQRGELVGLKRLRGFTMPDMHTVCKDTKQTIEEFENQFWMCLKTGDDLNTPYSTIFRFTEDFFEENKEWF
FKVAKEYKEKYGKDVILELIPERKHYWVGKVDMAVIDSFGRPIENPTVQIDVESAKRFNIVVHDGNEKTYPVILHCSPTG
SIERVLCGLLEKASLDADAGAPPMLPVWLSPIQARVIPVADAHSEYALSVAKKLRENGIRADFDDREESVGKKIRNAGKD
WVPFVIVIGDKEVENNILTTTIREKSTLKKPVKENLTVEELIEKIKEETKGFPYRPLSLPLYCSLQPIFR
>Mature_630_residues
MKVLLIHSDYLEFEAKQKTKIAEDTDILNGKMEECLTVFMAVEKEDEENPQNVIYNTVDEIIKTAENLKINNVVVYPYAH
LSSELSSPKVAKEVLQKIEEELKQKNYSVLRAPFGWYKSFKISCKGHPLSELSRKITTERKEEKGETEAKDRPKNKFYIL
DGEKGEEGLKELDEKKVKKLKDKGLKSVAMHEMGIKHGGKEKDIEPPHVKFITEKEICDYEPSSDAGHFRWYPKGKLIRD
LLQDYVYNMVVENNGMPVETPVMYDLGNKAIKEHADKFGERQYRFKQGNKDLMLRFAACFGQFMMKKDMYILPKHLPLKL
YELSTYSFRYEQRGELVGLKRLRGFTMPDMHTVCKDTKQTIEEFENQFWMCLKTGDDLNTPYSTIFRFTEDFFEENKEWF
FKVAKEYKEKYGKDVILELIPERKHYWVGKVDMAVIDSFGRPIENPTVQIDVESAKRFNIVVHDGNEKTYPVILHCSPTG
SIERVLCGLLEKASLDADAGAPPMLPVWLSPIQARVIPVADAHSEYALSVAKKLRENGIRADFDDREESVGKKIRNAGKD
WVPFVIVIGDKEVENNILTTTIREKSTLKKPVKENLTVEELIEKIKEETKGFPYRPLSLPLYCSLQPIFR

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI38570111, Length=416, Percent_Identity=27.8846153846154, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI38202255, Length=418, Percent_Identity=27.7511961722488, Blast_Score=128, Evalue=2e-29,
Organism=Homo sapiens, GI20070344, Length=411, Percent_Identity=24.5742092457421, Blast_Score=99, Evalue=1e-20,
Organism=Escherichia coli, GI1788013, Length=406, Percent_Identity=26.3546798029557, Blast_Score=124, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71984192, Length=410, Percent_Identity=25.8536585365854, Blast_Score=122, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI71984184, Length=410, Percent_Identity=25.8536585365854, Blast_Score=121, Evalue=9e-28,
Organism=Saccharomyces cerevisiae, GI6322112, Length=441, Percent_Identity=26.0770975056689, Blast_Score=106, Evalue=9e-24,
Organism=Saccharomyces cerevisiae, GI6322654, Length=327, Percent_Identity=28.7461773700306, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24583842, Length=408, Percent_Identity=26.4705882352941, Blast_Score=129, Evalue=6e-30,
Organism=Drosophila melanogaster, GI28574141, Length=408, Percent_Identity=26.4705882352941, Blast_Score=129, Evalue=6e-30,
Organism=Drosophila melanogaster, GI24583839, Length=409, Percent_Identity=26.4058679706601, Blast_Score=129, Evalue=7e-30,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYT_META3 (A6UW94)

Other databases:

- EMBL:   CP000743
- RefSeq:   YP_001325378.1
- ProteinModelPortal:   A6UW94
- SMR:   A6UW94
- STRING:   A6UW94
- GeneID:   5327250
- GenomeReviews:   CP000743_GR
- KEGG:   mae:Maeo_1189
- eggNOG:   arNOG04477
- HOGENOM:   HBG392335
- OMA:   ETPVMYD
- ProtClustDB:   PRK03991
- BioCyc:   MAEO419665:MAEO_1189-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00184_A
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR002320
- InterPro:   IPR015011
- Gene3D:   G3DSA:3.40.50.800
- PRINTS:   PR01047
- ProDom:   PD016189
- TIGRFAMs:   TIGR00418

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; PF08915 tRNA-Thr_ED; SSF52954 Anticodon_bd

EC number: =6.1.1.3

Molecular weight: Translated: 72954; Mature: 72954

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLLIHSDYLEFEAKQKTKIAEDTDILNGKMEECLTVFMAVEKEDEENPQNVIYNTVDE
CEEEEEECCHHHHCCHHHHCCCCHHHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
IIKTAENLKINNVVVYPYAHLSSELSSPKVAKEVLQKIEEELKQKNYSVLRAPFGWYKSF
HHHHHHCCEECCEEEEEHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCE
KISCKGHPLSELSRKITTERKEEKGETEAKDRPKNKFYILDGEKGEEGLKELDEKKVKKL
EEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHH
KDKGLKSVAMHEMGIKHGGKEKDIEPPHVKFITEKEICDYEPSSDAGHFRWYPKGKLIRD
HHCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCEEECCCHHHHHH
LLQDYVYNMVVENNGMPVETPVMYDLGNKAIKEHADKFGERQYRFKQGNKDLMLRFAACF
HHHHHHHHEEECCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
GQFMMKKDMYILPKHLPLKLYELSTYSFRYEQRGELVGLKRLRGFTMPDMHTVCKDTKQT
HHHHHHCCCEECCCCCCEEEEEECEEEEEHHHCCCCHHHHHHCCCCCCHHHHHHHHHHHH
IEEFENQFWMCLKTGDDLNTPYSTIFRFTEDFFEENKEWFFKVAKEYKEKYGKDVILELI
HHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHC
PERKHYWVGKVDMAVIDSFGRPIENPTVQIDVESAKRFNIVVHDGNEKTYPVILHCSPTG
CCCCCEEECCHHHHHHHHCCCCCCCCEEEEEECCCCEEEEEEECCCCCCEEEEEEECCCC
SIERVLCGLLEKASLDADAGAPPMLPVWLSPIQARVIPVADAHSEYALSVAKKLRENGIR
CHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCHHEEEEEECCCCHHHHHHHHHHHHHCCCC
ADFDDREESVGKKIRNAGKDWVPFVIVIGDKEVENNILTTTIREKSTLKKPVKENLTVEE
CCCCHHHHHHHHHHHHCCCCCCCEEEEECCCHHCCCEEEEEHHHHHHHHHHHHHCCCHHH
LIEKIKEETKGFPYRPLSLPLYCSLQPIFR
HHHHHHHHHCCCCCCCCCCCEEECCCCCCC
>Mature Secondary Structure
MKVLLIHSDYLEFEAKQKTKIAEDTDILNGKMEECLTVFMAVEKEDEENPQNVIYNTVDE
CEEEEEECCHHHHCCHHHHCCCCHHHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
IIKTAENLKINNVVVYPYAHLSSELSSPKVAKEVLQKIEEELKQKNYSVLRAPFGWYKSF
HHHHHHCCEECCEEEEEHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCE
KISCKGHPLSELSRKITTERKEEKGETEAKDRPKNKFYILDGEKGEEGLKELDEKKVKKL
EEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHH
KDKGLKSVAMHEMGIKHGGKEKDIEPPHVKFITEKEICDYEPSSDAGHFRWYPKGKLIRD
HHCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCEEECCCHHHHHH
LLQDYVYNMVVENNGMPVETPVMYDLGNKAIKEHADKFGERQYRFKQGNKDLMLRFAACF
HHHHHHHHEEECCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
GQFMMKKDMYILPKHLPLKLYELSTYSFRYEQRGELVGLKRLRGFTMPDMHTVCKDTKQT
HHHHHHCCCEECCCCCCEEEEEECEEEEEHHHCCCCHHHHHHCCCCCCHHHHHHHHHHHH
IEEFENQFWMCLKTGDDLNTPYSTIFRFTEDFFEENKEWFFKVAKEYKEKYGKDVILELI
HHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHC
PERKHYWVGKVDMAVIDSFGRPIENPTVQIDVESAKRFNIVVHDGNEKTYPVILHCSPTG
CCCCCEEECCHHHHHHHHCCCCCCCCEEEEEECCCCEEEEEEECCCCCCEEEEEEECCCC
SIERVLCGLLEKASLDADAGAPPMLPVWLSPIQARVIPVADAHSEYALSVAKKLRENGIR
CHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCHHEEEEEECCCCHHHHHHHHHHHHHCCCC
ADFDDREESVGKKIRNAGKDWVPFVIVIGDKEVENNILTTTIREKSTLKKPVKENLTVEE
CCCCHHHHHHHHHHHHCCCCCCCEEEEECCCHHCCCEEEEEHHHHHHHHHHHHHCCCHHH
LIEKIKEETKGFPYRPLSLPLYCSLQPIFR
HHHHHHHHHCCCCCCCCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA