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The map label for this gene is pyrC [H]

Identifier: 150401534

GI number: 150401534

Start: 1156909

End: 1158189

Strand: Direct

Name: pyrC [H]

Synonym: Maeo_1111

Alternate gene names: 150401534

Gene position: 1156909-1158189 (Clockwise)

Preceding gene: 150401533

Following gene: 150401535

Centisome position: 73.71

GC content: 27.48

Gene sequence:

>1281_bases
ATGCTTTTAAAAAATTGTAAAATTATAAAAAATAATTCTATTATTGAAGCCGATATATTAATCGAAAATGATAAAATTAA
AAAAATAAGTAAAAATATATCAAATAATGAAAATAGCGATAAAAATAATACCATTGATTTAAAAAATAAAATTGTAATGA
GCGGAATTATTGATTCCCATGTTCATTTTAGATATGGGCAACCACAAAAAGAAGATTTTATAAGTGGAAGCAAAGCAGGT
ATTAACGGTGGAGTGGCTTATGCAATAGACATGCCAAATAGCAACCCCCCAACCACCACAAAAGAAGAATTTGAAAAGAA
ATACAAAGAGGGAAAAGAAAAAAGCAAAATAAATATAGAATTTAATTATGGAATTACTGAAAATAACTATTTAGATAGTA
TAAAAAATGCAAAATCATATAAAATTTTTATGGTAAAATCTGTTGGAGACTTATTTATAAGCGATTATTCAAAATTAAAG
GACATATTAAACCAAAATAAATTATTTACCATTCATGCGGAGCATAAAAACATAATAGCCGAAAACTCAAAAAAATACCC
ATTAAATAGCTGGACTAACCACACAAAAATAAGAGATAGTAGAAGTGAAGTTGAGGCAATAAAAGAAATAATAAAAAACT
TAGAAATTGTTGAAAAATTAAACCAAAATAAACCACGAATACATATATGCCATTTATCCACAAAAGAAGGACTAAATTTA
ATAAATAATGCCAAAAAAACATTTAAAAATGTGAAAATAACAACCGAAGTTGCACCACATCATTTATTTTTAAATAAAGA
AGATGCCGAAAAATTAAAGGGAATGGGAAAGTTCAATCCACCACTTAGAACAAAAGAAGACTGCAAAGCACTAATAAATG
GAATTGTAAATAAAACGGTGGATATAATTGCAACAGACCACGCACCACATAATATTGACGAAAAAAATAATCCTGTTGAA
AGTTGCCCTTCTGGAATTCCGGGAATAGAAACCCTTGTTCCTTTGACTCTGGATTTAGTTAATAAAAATATTATAAATAT
ATTTGATGTTGAAAGGTTATTAAGTGGAGCTCCTTCAAAAATATTTAATATTGATAATGAAATAAGGGGGGGAAATAATG
CAAATTTATCAATTATTGATTTAGACAAAGATGTGACAATTAAGGGGGAAACATTTAAATCTAAGGCTAAATTTACACCA
TTTGAAAGTTGGAAAGTTAAGGGAGCTCCGATATATACTATTATTAATGGAGAAGTGTATGATGCATGTGGAAACATTTA
A

Upstream 100 bases:

>100_bases
TTTATTATGGGAGCTCCTTTTATGACTTTTTTTATATATTGTTATACAATATTTTATTAATAATATTTTATTACGATATT
ATCTATTTTAGGGGGATATT

Downstream 100 bases:

>100_bases
ATATTACAAATATTAAATAGTAAATATTAGATATATAAATGTAAAAGTAGTATTAAGGGGAGGTACTTATGAAATTTGAC
AGTGAATTAATGTTAAAACC

Product: dihydroorotase, multifunctional complex type

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MLLKNCKIIKNNSIIEADILIENDKIKKISKNISNNENSDKNNTIDLKNKIVMSGIIDSHVHFRYGQPQKEDFISGSKAG
INGGVAYAIDMPNSNPPTTTKEEFEKKYKEGKEKSKINIEFNYGITENNYLDSIKNAKSYKIFMVKSVGDLFISDYSKLK
DILNQNKLFTIHAEHKNIIAENSKKYPLNSWTNHTKIRDSRSEVEAIKEIIKNLEIVEKLNQNKPRIHICHLSTKEGLNL
INNAKKTFKNVKITTEVAPHHLFLNKEDAEKLKGMGKFNPPLRTKEDCKALINGIVNKTVDIIATDHAPHNIDEKNNPVE
SCPSGIPGIETLVPLTLDLVNKNIINIFDVERLLSGAPSKIFNIDNEIRGGNNANLSIIDLDKDVTIKGETFKSKAKFTP
FESWKVKGAPIYTIINGEVYDACGNI

Sequences:

>Translated_426_residues
MLLKNCKIIKNNSIIEADILIENDKIKKISKNISNNENSDKNNTIDLKNKIVMSGIIDSHVHFRYGQPQKEDFISGSKAG
INGGVAYAIDMPNSNPPTTTKEEFEKKYKEGKEKSKINIEFNYGITENNYLDSIKNAKSYKIFMVKSVGDLFISDYSKLK
DILNQNKLFTIHAEHKNIIAENSKKYPLNSWTNHTKIRDSRSEVEAIKEIIKNLEIVEKLNQNKPRIHICHLSTKEGLNL
INNAKKTFKNVKITTEVAPHHLFLNKEDAEKLKGMGKFNPPLRTKEDCKALINGIVNKTVDIIATDHAPHNIDEKNNPVE
SCPSGIPGIETLVPLTLDLVNKNIINIFDVERLLSGAPSKIFNIDNEIRGGNNANLSIIDLDKDVTIKGETFKSKAKFTP
FESWKVKGAPIYTIINGEVYDACGNI
>Mature_426_residues
MLLKNCKIIKNNSIIEADILIENDKIKKISKNISNNENSDKNNTIDLKNKIVMSGIIDSHVHFRYGQPQKEDFISGSKAG
INGGVAYAIDMPNSNPPTTTKEEFEKKYKEGKEKSKINIEFNYGITENNYLDSIKNAKSYKIFMVKSVGDLFISDYSKLK
DILNQNKLFTIHAEHKNIIAENSKKYPLNSWTNHTKIRDSRSEVEAIKEIIKNLEIVEKLNQNKPRIHICHLSTKEGLNL
INNAKKTFKNVKITTEVAPHHLFLNKEDAEKLKGMGKFNPPLRTKEDCKALINGIVNKTVDIIATDHAPHNIDEKNNPVE
SCPSGIPGIETLVPLTLDLVNKNIINIFDVERLLSGAPSKIFNIDNEIRGGNNANLSIIDLDKDVTIKGETFKSKAKFTP
FESWKVKGAPIYTIINGEVYDACGNI

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=376, Percent_Identity=29.5212765957447, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI4503379, Length=458, Percent_Identity=23.7991266375546, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI4503375, Length=452, Percent_Identity=23.2300884955752, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI19923821, Length=454, Percent_Identity=24.0088105726872, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI4503051, Length=459, Percent_Identity=22.4400871459695, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI62422571, Length=459, Percent_Identity=22.4400871459695, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI4503377, Length=453, Percent_Identity=24.2825607064018, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI1786722, Length=445, Percent_Identity=23.5955056179775, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI87082175, Length=446, Percent_Identity=25.1121076233184, Blast_Score=124, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI193204318, Length=373, Percent_Identity=29.2225201072386, Blast_Score=137, Evalue=9e-33,
Organism=Caenorhabditis elegans, GI17539558, Length=461, Percent_Identity=22.7765726681128, Blast_Score=89, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI71989490, Length=459, Percent_Identity=22.4400871459695, Blast_Score=83, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6322218, Length=422, Percent_Identity=25.1184834123223, Blast_Score=120, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24642586, Length=374, Percent_Identity=32.3529411764706, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI221377917, Length=462, Percent_Identity=23.1601731601732, Blast_Score=88, Evalue=9e-18,
Organism=Drosophila melanogaster, GI17137462, Length=455, Percent_Identity=23.0769230769231, Blast_Score=86, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 47957; Mature: 47957

Theoretical pI: Translated: 9.27; Mature: 9.27

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLKNCKIIKNNSIIEADILIENDKIKKISKNISNNENSDKNNTIDLKNKIVMSGIIDSH
CCCCCCEEEECCCEEEEEEEEECCHHHHHHHHCCCCCCCCCCCEEEHHHHEEEHHHHCCC
VHFRYGQPQKEDFISGSKAGINGGVAYAIDMPNSNPPTTTKEEFEKKYKEGKEKSKINIE
EEEECCCCCHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCEEEEE
FNYGITENNYLDSIKNAKSYKIFMVKSVGDLFISDYSKLKDILNQNKLFTIHAEHKNIIA
EEECCCCCCHHHHHCCCCCEEEEEEECHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHH
ENSKKYPLNSWTNHTKIRDSRSEVEAIKEIIKNLEIVEKLNQNKPRIHICHLSTKEGLNL
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHH
INNAKKTFKNVKITTEVAPHHLFLNKEDAEKLKGMGKFNPPLRTKEDCKALINGIVNKTV
HHHHHHHHHCEEEEEEECCCEEEECCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCE
DIIATDHAPHNIDEKNNPVESCPSGIPGIETLVPLTLDLVNKNIINIFDVERLLSGAPSK
EEEEECCCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHCCCHHHHEEHHHHHCCCCHH
IFNIDNEIRGGNNANLSIIDLDKDVTIKGETFKSKAKFTPFESWKVKGAPIYTIINGEVY
EECCCCHHCCCCCCCEEEEECCCCEEEECCCCCCCCCCCCCCCCEECCCEEEEEECCCHH
DACGNI
HCCCCC
>Mature Secondary Structure
MLLKNCKIIKNNSIIEADILIENDKIKKISKNISNNENSDKNNTIDLKNKIVMSGIIDSH
CCCCCCEEEECCCEEEEEEEEECCHHHHHHHHCCCCCCCCCCCEEEHHHHEEEHHHHCCC
VHFRYGQPQKEDFISGSKAGINGGVAYAIDMPNSNPPTTTKEEFEKKYKEGKEKSKINIE
EEEECCCCCHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCEEEEE
FNYGITENNYLDSIKNAKSYKIFMVKSVGDLFISDYSKLKDILNQNKLFTIHAEHKNIIA
EEECCCCCCHHHHHCCCCCEEEEEEECHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHH
ENSKKYPLNSWTNHTKIRDSRSEVEAIKEIIKNLEIVEKLNQNKPRIHICHLSTKEGLNL
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHH
INNAKKTFKNVKITTEVAPHHLFLNKEDAEKLKGMGKFNPPLRTKEDCKALINGIVNKTV
HHHHHHHHHCEEEEEEECCCEEEECCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCE
DIIATDHAPHNIDEKNNPVESCPSGIPGIETLVPLTLDLVNKNIINIFDVERLLSGAPSK
EEEEECCCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHCCCHHHHEEHHHHHCCCCHH
IFNIDNEIRGGNNANLSIIDLDKDVTIKGETFKSKAKFTPFESWKVKGAPIYTIINGEVY
EECCCCHHCCCCCCCEEEEECCCCEEEECCCCCCCCCCCCCCCCEECCCEEEEEECCCHH
DACGNI
HCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]