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The map label for this gene is top6A [H]

Identifier: 150401437

GI number: 150401437

Start: 1039513

End: 1040604

Strand: Direct

Name: top6A [H]

Synonym: Maeo_1013

Alternate gene names: 150401437

Gene position: 1039513-1040604 (Clockwise)

Preceding gene: 150401432

Following gene: 150401438

Centisome position: 66.23

GC content: 33.88

Gene sequence:

>1092_bases
GTGATTTCTAAAAGAGAATTGGCAAAAGAAAAAATTATAGATGTCTCCAATGCCATGTATAATGATATCCTCGAAGGCAG
AAGGCCAAAACTTAAATTTCCAGTTCGAAGTTTGGCTAATGCCAGATTTGATAAAGAAAAGGGAACTTTTGTATTAATTG
GAAAAGAAAAGGAAAGGGCTCTAACAGTTAATCAGGCAAAAATATTTGCTCAAACTGTAAAAATGATGGAGTTTTCAAAA
GAATTACTTATTACAAACGATTTCTCAACTCTAAGGGAGGCGTATTATGTTTCAAAAAATTGGGGGGAGGCGAGATTTGA
TGACCAGCAACCTTCAAACAGCGTAATAGAAGATATAGAAGCGTCTTTGAATTTTTTAAGAGAAGAACTTGGATTTATAC
CCGAGGAAGATGGTGCCTCTGTGGTAGGACCTTTAAAAATAGTGGATAAATCAGAAAAAAACGAAGAATTAAAAATAGAT
TGTGCGAGATTAGGTAGTGGAGCATACAATATTCCAAATGACATTACTAAATTAGAATTTGAGACAGATGCCGAGTTTAT
ACTTGCAATAGAAACAGCTGGTATGTTTGCGAGACTAAATGCAGAAAAATTCTGGAAAAAACATAATTGTATATTAATAT
CATTAAAAGGAGTGCCTGCGAGAGCGACAAGACAATTTACAAAAAGATTAAATGAAGAACATAATCTACCTGTTTTAGTA
TTCACAGATGGGGATCCATATGGATATCTTAACATTTACCGAACACTAAAAGTAGGCAGTGGTAAATCTGTACATTTGGC
AGATAAACTTTCAATACCTTCGGCGAGGTTAATAGGAGTAACTCCTCAGGACATTAATGATTATGACCTTCCAACACACC
CATTAAAAGACCACGATATTAAAAGATTAAAAGATGGTTTAAAAAATGATGATTTTGTAAAAAGTCACCCAGAATGGCAA
AAAGCTATTAATCATATGATAGAATCAAAAGAAAGGGCCGAGCAACAGTCTTTGGCAAAATATGGTTTAAAATATGTTGT
TGAAGAATATCTTCCCGCGAAAATAGAAGATAAAAGCACTTGGCTACCTTAA

Upstream 100 bases:

>100_bases
ATATTTATTATATTTATTGTGGTATATTTGCTATTTATTTTATATGGCCCCATATTAATATTAATACTATCATAACACAT
AATTAATCAATGGTGAGAAT

Downstream 100 bases:

>100_bases
TTTATAATTATTTATAGTTAATTAAAAAAACAATAAAATAATTAATATAGTGAAAAAATGGCTAAAAAACCTATAATAGC
AAAACTTTCAGAAGATAGGG

Product: DNA topoisomerase VI subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 363; Mature: 363

Protein sequence:

>363_residues
MISKRELAKEKIIDVSNAMYNDILEGRRPKLKFPVRSLANARFDKEKGTFVLIGKEKERALTVNQAKIFAQTVKMMEFSK
ELLITNDFSTLREAYYVSKNWGEARFDDQQPSNSVIEDIEASLNFLREELGFIPEEDGASVVGPLKIVDKSEKNEELKID
CARLGSGAYNIPNDITKLEFETDAEFILAIETAGMFARLNAEKFWKKHNCILISLKGVPARATRQFTKRLNEEHNLPVLV
FTDGDPYGYLNIYRTLKVGSGKSVHLADKLSIPSARLIGVTPQDINDYDLPTHPLKDHDIKRLKDGLKNDDFVKSHPEWQ
KAINHMIESKERAEQQSLAKYGLKYVVEEYLPAKIEDKSTWLP

Sequences:

>Translated_363_residues
MISKRELAKEKIIDVSNAMYNDILEGRRPKLKFPVRSLANARFDKEKGTFVLIGKEKERALTVNQAKIFAQTVKMMEFSK
ELLITNDFSTLREAYYVSKNWGEARFDDQQPSNSVIEDIEASLNFLREELGFIPEEDGASVVGPLKIVDKSEKNEELKID
CARLGSGAYNIPNDITKLEFETDAEFILAIETAGMFARLNAEKFWKKHNCILISLKGVPARATRQFTKRLNEEHNLPVLV
FTDGDPYGYLNIYRTLKVGSGKSVHLADKLSIPSARLIGVTPQDINDYDLPTHPLKDHDIKRLKDGLKNDDFVKSHPEWQ
KAINHMIESKERAEQQSLAKYGLKYVVEEYLPAKIEDKSTWLP
>Mature_363_residues
MISKRELAKEKIIDVSNAMYNDILEGRRPKLKFPVRSLANARFDKEKGTFVLIGKEKERALTVNQAKIFAQTVKMMEFSK
ELLITNDFSTLREAYYVSKNWGEARFDDQQPSNSVIEDIEASLNFLREELGFIPEEDGASVVGPLKIVDKSEKNEELKID
CARLGSGAYNIPNDITKLEFETDAEFILAIETAGMFARLNAEKFWKKHNCILISLKGVPARATRQFTKRLNEEHNLPVLV
FTDGDPYGYLNIYRTLKVGSGKSVHLADKLSIPSARLIGVTPQDINDYDLPTHPLKDHDIKRLKDGLKNDDFVKSHPEWQ
KAINHMIESKERAEQQSLAKYGLKYVVEEYLPAKIEDKSTWLP

Specific function: Relaxes both positive and negative superturns and exhibits a strong decatenase activity [H]

COG id: COG1697

COG function: function code L; DNA topoisomerase VI, subunit A

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TOP6A family [H]

Homologues:

Organism=Homo sapiens, GI38201680, Length=297, Percent_Identity=29.2929292929293, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI6912680, Length=297, Percent_Identity=29.2929292929293, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI45552753, Length=195, Percent_Identity=28.2051282051282, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002815
- InterPro:   IPR013049
- InterPro:   IPR004085
- InterPro:   IPR022904
- InterPro:   IPR011991 [H]

Pfam domain/function: PF04406 TP6A_N [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 41438; Mature: 41438

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISKRELAKEKIIDVSNAMYNDILEGRRPKLKFPVRSLANARFDKEKGTFVLIGKEKERA
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCHHHHHHCCCCCCCCCEEEEECCCCCE
LTVNQAKIFAQTVKMMEFSKELLITNDFSTLREAYYVSKNWGEARFDDQQPSNSVIEDIE
EEHHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHH
ASLNFLREELGFIPEEDGASVVGPLKIVDKSEKNEELKIDCARLGSGAYNIPNDITKLEF
HHHHHHHHHHCCCCCCCCCCEECCEEEECCCCCCCCEEEEHHHCCCCCCCCCCCCEEEEE
ETDAEFILAIETAGMFARLNAEKFWKKHNCILISLKGVPARATRQFTKRLNEEHNLPVLV
ECCCEEEEEEECCCHHEECCHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCEEE
FTDGDPYGYLNIYRTLKVGSGKSVHLADKLSIPSARLIGVTPQDINDYDLPTHPLKDHDI
EECCCCCEEEEEEEEEEECCCCEEEEHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCHH
KRLKDGLKNDDFVKSHPEWQKAINHMIESKERAEQQSLAKYGLKYVVEEYLPAKIEDKST
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
WLP
CCC
>Mature Secondary Structure
MISKRELAKEKIIDVSNAMYNDILEGRRPKLKFPVRSLANARFDKEKGTFVLIGKEKERA
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCHHHHHHCCCCCCCCCEEEEECCCCCE
LTVNQAKIFAQTVKMMEFSKELLITNDFSTLREAYYVSKNWGEARFDDQQPSNSVIEDIE
EEHHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHH
ASLNFLREELGFIPEEDGASVVGPLKIVDKSEKNEELKIDCARLGSGAYNIPNDITKLEF
HHHHHHHHHHCCCCCCCCCCEECCEEEECCCCCCCCEEEEHHHCCCCCCCCCCCCEEEEE
ETDAEFILAIETAGMFARLNAEKFWKKHNCILISLKGVPARATRQFTKRLNEEHNLPVLV
ECCCEEEEEEECCCHHEECCHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCEEE
FTDGDPYGYLNIYRTLKVGSGKSVHLADKLSIPSARLIGVTPQDINDYDLPTHPLKDHDI
EECCCCCEEEEEEEEEEECCCCEEEEHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCHH
KRLKDGLKNDDFVKSHPEWQKAINHMIESKERAEQQSLAKYGLKYVVEEYLPAKIEDKST
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
WLP
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087; 10545127 [H]