Definition Methanococcus aeolicus Nankai-3, complete genome.
Accession NC_009635
Length 1,569,500

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The map label for this gene is mfnA

Identifier: 150401432

GI number: 150401432

Start: 1035059

End: 1036231

Strand: Direct

Name: mfnA

Synonym: Maeo_1008

Alternate gene names: 150401432

Gene position: 1035059-1036231 (Clockwise)

Preceding gene: 150401431

Following gene: 150401437

Centisome position: 65.95

GC content: 32.14

Gene sequence:

>1173_bases
ATGGACGAAAGAGCGGTTTTAGAAGAGTTAAAGAAATATAGAAAAATGGATTTAAAATATGAAGATGGTGCAATTTTGGG
GTCTATGTGCACAAAACCACACCCAATCACAAAAAAAATAAGCGATATGTTTTTTGAGACCAATTTAGGAGACCCTGGGC
TATTTAGGGGAACAAAAAAATTGGAGGATGAAGTAATAAATAATATTGGAAAATTTTTAAATAATCCAAATCCTTTTGGA
TATATTATTTCAGGCGGAACTGAGGCAAATATTACGGCAATGAGGGCAATAAACAATATTGCCAAAGCTAAACGGAAAAA
TCATAAAACAACAGTTATCATGCCAGAAACAGCCCATTTTTCATTTGAAAAAGCCCGGGAAATGATGGATTTAAATCTGA
TAACCCCTCCACTAACTAAATATTATACAATGGATTTAAAATATATTAATGATTTTATAGAGGATAGGAATAATAAAAAT
GACATCTCTGTTGACGGAATAGTTGGCATAGCTGGATGTACGGAGCTTGGGGCAATTGATAATATAAAGGAGCTCTCAAA
AATAGCCGAACAAAATAATATATTTTTGCATGTTGATGCGGCATTTGGTGGTTTCGTAATACCATTTTTAGATGACAAAT
ATAAATTAGACAATTATTGTTATGAATTTGATTTCTCATTAAATGGTGTTAAATCCATGACAGTAGACCCTCACAAAATG
GGATTAGCTCCAATTCCTGCTGGGGGCATATTATTTAGAGATAAATCATTTAAAAAATATTTAGATGTGGAAGCTCCCTA
TTTAACTGACATACATCAGGCAACGATAATAGGAACAAGAAGTGGAGTTGGAGTTGCATCTACATGGGGAGTTATGAAAT
TATTTGGGGAAGAAGGATATAAAAATTTAGCTTCTGAATGCATGGATAAAACCCACTATTTAGTAAAAGAAGCTAAAAAA
TTAGGATTTAAACCAGTTATAGACCCAGTTTTAAATATTGTAGCGTTGGAGGATGATAATCCAGAAGAAACTAGTTTAAA
ACTTAGAAAAATGGGCTGGTTTATATCTATTTGTAAATGTGTTAAAGCTCTTAGAATAATAGTTATGCCCCATGTTGAAA
AAGAACATATTGATAAATTTTTGGGAGCCCTAACCGAAGTTAAAAAAAATTAA

Upstream 100 bases:

>100_bases
AAAAAGTGCTTAATGCTATGATAGAATTTGAAAAACAATATTAATTACATATTATGGAATTATTATTTTATTATTTATTT
TATTTTAATATTGGGAAAAT

Downstream 100 bases:

>100_bases
CACCAAAATTGTATAATTTTTATTCTTTTTATTCTTTTTAATTTATTATGGCTAATCTTCGGTCTTTTTCACTAAACCGT
CTCAAAATCGCAAAGCGATT

Product: L-tyrosine decarboxylase

Products: NA

Alternate protein names: TDC

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MDERAVLEELKKYRKMDLKYEDGAILGSMCTKPHPITKKISDMFFETNLGDPGLFRGTKKLEDEVINNIGKFLNNPNPFG
YIISGGTEANITAMRAINNIAKAKRKNHKTTVIMPETAHFSFEKAREMMDLNLITPPLTKYYTMDLKYINDFIEDRNNKN
DISVDGIVGIAGCTELGAIDNIKELSKIAEQNNIFLHVDAAFGGFVIPFLDDKYKLDNYCYEFDFSLNGVKSMTVDPHKM
GLAPIPAGGILFRDKSFKKYLDVEAPYLTDIHQATIIGTRSGVGVASTWGVMKLFGEEGYKNLASECMDKTHYLVKEAKK
LGFKPVIDPVLNIVALEDDNPEETSLKLRKMGWFISICKCVKALRIIVMPHVEKEHIDKFLGALTEVKKN

Sequences:

>Translated_390_residues
MDERAVLEELKKYRKMDLKYEDGAILGSMCTKPHPITKKISDMFFETNLGDPGLFRGTKKLEDEVINNIGKFLNNPNPFG
YIISGGTEANITAMRAINNIAKAKRKNHKTTVIMPETAHFSFEKAREMMDLNLITPPLTKYYTMDLKYINDFIEDRNNKN
DISVDGIVGIAGCTELGAIDNIKELSKIAEQNNIFLHVDAAFGGFVIPFLDDKYKLDNYCYEFDFSLNGVKSMTVDPHKM
GLAPIPAGGILFRDKSFKKYLDVEAPYLTDIHQATIIGTRSGVGVASTWGVMKLFGEEGYKNLASECMDKTHYLVKEAKK
LGFKPVIDPVLNIVALEDDNPEETSLKLRKMGWFISICKCVKALRIIVMPHVEKEHIDKFLGALTEVKKN
>Mature_390_residues
MDERAVLEELKKYRKMDLKYEDGAILGSMCTKPHPITKKISDMFFETNLGDPGLFRGTKKLEDEVINNIGKFLNNPNPFG
YIISGGTEANITAMRAINNIAKAKRKNHKTTVIMPETAHFSFEKAREMMDLNLITPPLTKYYTMDLKYINDFIEDRNNKN
DISVDGIVGIAGCTELGAIDNIKELSKIAEQNNIFLHVDAAFGGFVIPFLDDKYKLDNYCYEFDFSLNGVKSMTVDPHKM
GLAPIPAGGILFRDKSFKKYLDVEAPYLTDIHQATIIGTRSGVGVASTWGVMKLFGEEGYKNLASECMDKTHYLVKEAKK
LGFKPVIDPVLNIVALEDDNPEETSLKLRKMGWFISICKCVKALRIIVMPHVEKEHIDKFLGALTEVKKN

Specific function: Specifically catalyzes the decarboxylation of L-tyrosine to produce tyramine

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family. Archaeal L-tyrosine decarboxylase subfamily

Homologues:

Organism=Homo sapiens, GI31982936, Length=408, Percent_Identity=28.6764705882353, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17543922, Length=380, Percent_Identity=28.9473684210526, Blast_Score=138, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI25148342, Length=300, Percent_Identity=29.3333333333333, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17557272, Length=273, Percent_Identity=30.03663003663, Blast_Score=108, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6320500, Length=351, Percent_Identity=28.4900284900285, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6323905, Length=288, Percent_Identity=23.9583333333333, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21355963, Length=375, Percent_Identity=25.8666666666667, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24654344, Length=375, Percent_Identity=25.8666666666667, Blast_Score=126, Evalue=2e-29,

Paralogues:

None

Copy number: 3820 Molecules/Cell In: Early Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): MFNA_META3 (A6UVR4)

Other databases:

- EMBL:   CP000743
- RefSeq:   YP_001325198.1
- ProteinModelPortal:   A6UVR4
- STRING:   A6UVR4
- GeneID:   5326526
- GenomeReviews:   CP000743_GR
- KEGG:   mae:Maeo_1008
- eggNOG:   arNOG04425
- HOGENOM:   HBG497871
- OMA:   ILGSMCT
- ProtClustDB:   PRK13520
- BioCyc:   MAEO419665:MAEO_1008-MONOMER
- HAMAP:   MF_01610
- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR021115
- InterPro:   IPR020931
- Gene3D:   G3DSA:3.40.640.10
- PANTHER:   PTHR11999
- TIGRFAMs:   TIGR03812

Pfam domain/function: PF00282 Pyridoxal_deC; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =4.1.1.25

Molecular weight: Translated: 43927; Mature: 43927

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: PS00392 DDC_GAD_HDC_YDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MDERAVLEELKKYRKMDLKYEDGAILGSMCTKPHPITKKISDMFFETNLGDPGLFRGTKK
CCHHHHHHHHHHHHHCCCCCCCCCEEHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHH
LEDEVINNIGKFLNNPNPFGYIISGGTEANITAMRAINNIAKAKRKNHKTTVIMPETAHF
HHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCC
SFEKAREMMDLNLITPPLTKYYTMDLKYINDFIEDRNNKNDISVDGIVGIAGCTELGAID
CHHHHHHHHHCCCCCCCCHHHEEHHHHHHHHHHHCCCCCCCEEECCEEEECCCHHHCCCC
NIKELSKIAEQNNIFLHVDAAFGGFVIPFLDDKYKLDNYCYEFDFSLNGVKSMTVDPHKM
CHHHHHHHHHHCCEEEEEECCCCCEEEEECCCCEECCCEEEEEECCCCCCEECEECHHHC
GLAPIPAGGILFRDKSFKKYLDVEAPYLTDIHQATIIGTRSGVGVASTWGVMKLFGEEGY
CCCCCCCCCEEEECCCHHHHHCCCCCCHHCCHHEEEEECCCCCCCHHHHHHHHHHHHHHH
KNLASECMDKTHYLVKEAKKLGFKPVIDPVLNIVALEDDNPEETSLKLRKMGWFISICKC
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHH
VKALRIIVMPHVEKEHIDKFLGALTEVKKN
HHHHHHHHCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDERAVLEELKKYRKMDLKYEDGAILGSMCTKPHPITKKISDMFFETNLGDPGLFRGTKK
CCHHHHHHHHHHHHHCCCCCCCCCEEHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHH
LEDEVINNIGKFLNNPNPFGYIISGGTEANITAMRAINNIAKAKRKNHKTTVIMPETAHF
HHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCC
SFEKAREMMDLNLITPPLTKYYTMDLKYINDFIEDRNNKNDISVDGIVGIAGCTELGAID
CHHHHHHHHHCCCCCCCCHHHEEHHHHHHHHHHHCCCCCCCEEECCEEEECCCHHHCCCC
NIKELSKIAEQNNIFLHVDAAFGGFVIPFLDDKYKLDNYCYEFDFSLNGVKSMTVDPHKM
CHHHHHHHHHHCCEEEEEECCCCCEEEEECCCCEECCCEEEEEECCCCCCEECEECHHHC
GLAPIPAGGILFRDKSFKKYLDVEAPYLTDIHQATIIGTRSGVGVASTWGVMKLFGEEGY
CCCCCCCCCEEEECCCHHHHHCCCCCCHHCCHHEEEEECCCCCCCHHHHHHHHHHHHHHH
KNLASECMDKTHYLVKEAKKLGFKPVIDPVLNIVALEDDNPEETSLKLRKMGWFISICKC
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHH
VKALRIIVMPHVEKEHIDKFLGALTEVKKN
HHHHHHHHCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA