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The map label for this gene is guaAA

Identifier: 150401297

GI number: 150401297

Start: 896024

End: 896590

Strand: Reverse

Name: guaAA

Synonym: Maeo_0869

Alternate gene names: 150401297

Gene position: 896590-896024 (Counterclockwise)

Preceding gene: 150401298

Following gene: 150401295

Centisome position: 57.13

GC content: 33.16

Gene sequence:

>567_bases
ATGATTGTAATTCTTAACAATGGCGGTCAATATGTCCATAGAATTCACAGAAGTTTAAGATATTTAAAAATACCTTCAAA
AATAATTCCAAACAGCACACCATTGGCGGAAATTGAAGAAAATAAAGAAATAAAAGGAATTATATTAAGCGGGGGTCCAG
ATATCGAAAAAGCAAGTAATTGTTTGGACATAGCTTTAAACTCAAAACTCCCAATATTGGGGATATGTTTGGGACATCAG
ATAATAGCAAAAGCATACGGCGGAGAAATAGGTAGGGCAGAATCTGAGGAATATGCCCATTCCAAAATATTTGTAAAAGA
AGAAAATGATTTATTTAAAAATGTTCCAAAAGAATTTACAGCTTGGGCGTCTCATAAAGATGAAGTTGTAGGAGCTCCCC
TTAATTTTGAAATATTGGCTTATTCTAATATTTGCGAAGTTGAGGCAATGAAACACAAAGAAAAACCAATTTATGGGGTT
CAATTCCATCCAGAAGTATCTCATACGGAAAATGGGGCAGAAATATTAAAAAATTTCTGTAAAGTTTGTGGATTATTGGG
GGAATAA

Upstream 100 bases:

>100_bases
ACAATTTATATTGGAGAAGATAAAATAGAAATAATTACAAAATAAAAGGAATATATAAGAATATATGCAGAATATAATAC
AAATATAAGTTGGTGATTAT

Downstream 100 bases:

>100_bases
TATATATGCCATATTATCTTTTATTCTTTTAACATTTTTTCGGCTAATTCAATATGTTTTTCACTGCCTACTTTTTTAAT
GGTTTTAAAATAATAATTCA

Product: GMP synthase subunit A

Products: NA

Alternate protein names: Glutamine amidotransferase

Number of amino acids: Translated: 188; Mature: 188

Protein sequence:

>188_residues
MIVILNNGGQYVHRIHRSLRYLKIPSKIIPNSTPLAEIEENKEIKGIILSGGPDIEKASNCLDIALNSKLPILGICLGHQ
IIAKAYGGEIGRAESEEYAHSKIFVKEENDLFKNVPKEFTAWASHKDEVVGAPLNFEILAYSNICEVEAMKHKEKPIYGV
QFHPEVSHTENGAEILKNFCKVCGLLGE

Sequences:

>Translated_188_residues
MIVILNNGGQYVHRIHRSLRYLKIPSKIIPNSTPLAEIEENKEIKGIILSGGPDIEKASNCLDIALNSKLPILGICLGHQ
IIAKAYGGEIGRAESEEYAHSKIFVKEENDLFKNVPKEFTAWASHKDEVVGAPLNFEILAYSNICEVEAMKHKEKPIYGV
QFHPEVSHTENGAEILKNFCKVCGLLGE
>Mature_188_residues
MIVILNNGGQYVHRIHRSLRYLKIPSKIIPNSTPLAEIEENKEIKGIILSGGPDIEKASNCLDIALNSKLPILGICLGHQ
IIAKAYGGEIGRAESEEYAHSKIFVKEENDLFKNVPKEFTAWASHKDEVVGAPLNFEILAYSNICEVEAMKHKEKPIYGV
QFHPEVSHTENGAEILKNFCKVCGLLGE

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0518

COG function: function code F; GMP synthase - Glutamine amidotransferase domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=182, Percent_Identity=38.4615384615385, Blast_Score=105, Evalue=3e-23,
Organism=Escherichia coli, GI1788854, Length=191, Percent_Identity=30.8900523560209, Blast_Score=108, Evalue=2e-25,
Organism=Escherichia coli, GI1789760, Length=184, Percent_Identity=29.3478260869565, Blast_Score=84, Evalue=4e-18,
Organism=Escherichia coli, GI1787517, Length=183, Percent_Identity=28.4153005464481, Blast_Score=70, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI133901714, Length=192, Percent_Identity=35.9375, Blast_Score=99, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71992717, Length=192, Percent_Identity=35.9375, Blast_Score=99, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71992710, Length=192, Percent_Identity=35.9375, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6323873, Length=183, Percent_Identity=37.1584699453552, Blast_Score=123, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6322638, Length=145, Percent_Identity=27.5862068965517, Blast_Score=63, Evalue=3e-11,
Organism=Drosophila melanogaster, GI281365319, Length=188, Percent_Identity=36.7021276595745, Blast_Score=107, Evalue=7e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAAA_META3 (A6UVC9)

Other databases:

- EMBL:   CP000743
- RefSeq:   YP_001325063.1
- ProteinModelPortal:   A6UVC9
- SMR:   A6UVC9
- STRING:   A6UVC9
- GeneID:   5326839
- GenomeReviews:   CP000743_GR
- KEGG:   mae:Maeo_0869
- eggNOG:   arNOG05587
- HOGENOM:   HBG292341
- OMA:   GQYVHRI
- ProtClustDB:   PRK00758
- BioCyc:   MAEO419665:MAEO_0869-MONOMER
- HAMAP:   MF_01510
- InterPro:   IPR006220
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR004739
- PRINTS:   PR00097
- PRINTS:   PR00096
- TIGRFAMs:   TIGR00888

Pfam domain/function: PF00117 GATase

EC number: =6.3.5.2

Molecular weight: Translated: 20877; Mature: 20877

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 76-76 ACT_SITE 163-163 ACT_SITE 165-165

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVILNNGGQYVHRIHRSLRYLKIPSKIIPNSTPLAEIEENKEIKGIILSGGPDIEKASN
CEEEECCCCHHHHHHHHHHHEEECCHHHCCCCCCCHHCCCCCCEEEEEEECCCCHHHHCC
CLDIALNSKLPILGICLGHQIIAKAYGGEIGRAESEEYAHSKIFVKEENDLFKNVPKEFT
EEEEEECCCCCEEEEHHHHHHHHHHHCCCCCCCCCHHHHCEEEEEECCCHHHHHCCHHHH
AWASHKDEVVGAPLNFEILAYSNICEVEAMKHKEKPIYGVQFHPEVSHTENGAEILKNFC
HHCCCCCCEECCCCCEEEEEECCCHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHH
KVCGLLGE
HHHHCCCC
>Mature Secondary Structure
MIVILNNGGQYVHRIHRSLRYLKIPSKIIPNSTPLAEIEENKEIKGIILSGGPDIEKASN
CEEEECCCCHHHHHHHHHHHEEECCHHHCCCCCCCHHCCCCCCEEEEEEECCCCHHHHCC
CLDIALNSKLPILGICLGHQIIAKAYGGEIGRAESEEYAHSKIFVKEENDLFKNVPKEFT
EEEEEECCCCCEEEEHHHHHHHHHHHCCCCCCCCCHHHHCEEEEEECCCHHHHHCCHHHH
AWASHKDEVVGAPLNFEILAYSNICEVEAMKHKEKPIYGVQFHPEVSHTENGAEILKNFC
HHCCCCCCEECCCCCEEEEEECCCHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHH
KVCGLLGE
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA