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The map label for this gene is thrB

Identifier: 150401261

GI number: 150401261

Start: 862886

End: 863824

Strand: Direct

Name: thrB

Synonym: Maeo_0833

Alternate gene names: 150401261

Gene position: 862886-863824 (Clockwise)

Preceding gene: 150401259

Following gene: 150401263

Centisome position: 54.98

GC content: 35.25

Gene sequence:

>939_bases
ATGAAAATGGTTAAAATATGTTCTCCTGCAACTTCTGCAAATTTAGGTCCTGGTTATGATGTTTTTGGATTAGCACTAAA
TAATCCTTATGACACAATTACGGTGAGTATAGTAGAAGAAAAAGGAGGAAATGAAACCCTCTCAAATGAAAAAATAACCA
TATCAATGGAAGGAGAGAAATGCGAAGAGATACCTACGGCAGTAGATGAAAATACTGCGGGAGTTGTAGCAAAAAAAATG
ATGGAAGATTTCAATATAGATAAAAATATACAAATCCACATAGAAAAAGGAATAAAGCCCGGAAGTGGTTTAGGTAGTAG
CTCGGCATCTTGTGCAGGAGTTGCCGTTGCAATAAATGAACTATTTGGTTTGGAGCTCCCAAAATTAGAGTTGGTAAAAT
ATGCATCATTGGGAGAAGCTGTTGCCGCAGGAGCTCCACATGCTGACAATGTTGCACCTGCAATATATGGCGGTTTTACA
ATGGTGGTAAATCAAGACCCCTTGGAAATAATACATATTCCAGTAGAATTTGAAGTATTGGTGGCACTACCAAATATACA
AATATCTACAAAAGAGGCAAGGGAATTAGTTCCAAAAGAAATTCCAATAAAAGATATGGTAAATAATGTAGGAAAAGCCT
GTGGAATGATTTATTCATTACATGATAACAATGTAGAATTATTTGGAAAATATATGATGCAGGATGCCGTAGTTGAACCA
TGTAGGGCTACGCTAATTGATAATTATTCAGAAGTCAAGGAAAAAGTAAAAGATTTAGTATATGGAATTACCATAAGTGG
CTCAGGTCCTGCAATAATCTCATTACCTAAAAAAGAATGCGTATTAGAAGTTAAAAAAATATTTAAAGAAACTTGGGATT
GTCCAATATACTATACTACGCTGGGGGCTGGGGCATATGTAGTAAAGGAAGAAGAATAA

Upstream 100 bases:

>100_bases
TCATCCATTTTTCCCCCATGATCCTTAATCTTTTATATATTAATGACGAATAGATACATACTATAATATAAAATATTTAT
TATATATGGTTGGTGATTTT

Downstream 100 bases:

>100_bases
CAGACATATAGTTAATATTATTCTTTTATTATATGATTATATTATATTTTTACAACATTCCTAAATATTTGTGGATTTGT
GATGTGCATATTACGCTATC

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MKMVKICSPATSANLGPGYDVFGLALNNPYDTITVSIVEEKGGNETLSNEKITISMEGEKCEEIPTAVDENTAGVVAKKM
MEDFNIDKNIQIHIEKGIKPGSGLGSSSASCAGVAVAINELFGLELPKLELVKYASLGEAVAAGAPHADNVAPAIYGGFT
MVVNQDPLEIIHIPVEFEVLVALPNIQISTKEARELVPKEIPIKDMVNNVGKACGMIYSLHDNNVELFGKYMMQDAVVEP
CRATLIDNYSEVKEKVKDLVYGITISGSGPAIISLPKKECVLEVKKIFKETWDCPIYYTTLGAGAYVVKEEE

Sequences:

>Translated_312_residues
MKMVKICSPATSANLGPGYDVFGLALNNPYDTITVSIVEEKGGNETLSNEKITISMEGEKCEEIPTAVDENTAGVVAKKM
MEDFNIDKNIQIHIEKGIKPGSGLGSSSASCAGVAVAINELFGLELPKLELVKYASLGEAVAAGAPHADNVAPAIYGGFT
MVVNQDPLEIIHIPVEFEVLVALPNIQISTKEARELVPKEIPIKDMVNNVGKACGMIYSLHDNNVELFGKYMMQDAVVEP
CRATLIDNYSEVKEKVKDLVYGITISGSGPAIISLPKKECVLEVKKIFKETWDCPIYYTTLGAGAYVVKEEE
>Mature_312_residues
MKMVKICSPATSANLGPGYDVFGLALNNPYDTITVSIVEEKGGNETLSNEKITISMEGEKCEEIPTAVDENTAGVVAKKM
MEDFNIDKNIQIHIEKGIKPGSGLGSSSASCAGVAVAINELFGLELPKLELVKYASLGEAVAAGAPHADNVAPAIYGGFT
MVVNQDPLEIIHIPVEFEVLVALPNIQISTKEARELVPKEIPIKDMVNNVGKACGMIYSLHDNNVELFGKYMMQDAVVEP
CRATLIDNYSEVKEKVKDLVYGITISGSGPAIISLPKKECVLEVKKIFKETWDCPIYYTTLGAGAYVVKEEE

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily

Homologues:

Organism=Escherichia coli, GI1786184, Length=279, Percent_Identity=29.0322580645161, Blast_Score=120, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6321814, Length=323, Percent_Identity=26.3157894736842, Blast_Score=100, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KHSE_META3 (A6UV93)

Other databases:

- EMBL:   CP000743
- RefSeq:   YP_001325027.1
- ProteinModelPortal:   A6UV93
- SMR:   A6UV93
- STRING:   A6UV93
- GeneID:   5327004
- GenomeReviews:   CP000743_GR
- KEGG:   mae:Maeo_0833
- eggNOG:   arNOG05905
- HOGENOM:   HBG646290
- OMA:   GSAHADN
- ProtClustDB:   PRK01212
- BioCyc:   MAEO419665:MAEO_0833-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00384
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.230.10
- PIRSF:   PIRSF000676
- PRINTS:   PR00958
- TIGRFAMs:   TIGR00191

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.39

Molecular weight: Translated: 33661; Mature: 33661

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMVKICSPATSANLGPGYDVFGLALNNPYDTITVSIVEEKGGNETLSNEKITISMEGEK
CCEEEECCCCCCCCCCCCCCEEEEEECCCCCEEEEEEEECCCCCCCCCCCEEEEEECCCH
CEEIPTAVDENTAGVVAKKMMEDFNIDKNIQIHIEKGIKPGSGLGSSSASCAGVAVAINE
HHHCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHH
LFGLELPKLELVKYASLGEAVAAGAPHADNVAPAIYGGFTMVVNQDPLEIIHIPVEFEVL
HHCCCCCHHHHHHHHHHCHHHHCCCCCCCCCCHHHCCCEEEEEECCCEEEEEECEEEEEE
VALPNIQISTKEARELVPKEIPIKDMVNNVGKACGMIYSLHDNNVELFGKYMMQDAVVEP
EEECCCEEECHHHHHCCCCCCCHHHHHHHHHHHHCEEEEEECCCHHHHHHHHHHHHHHHH
CRATLIDNYSEVKEKVKDLVYGITISGSGPAIISLPKKECVLEVKKIFKETWDCPIYYTT
HHHHHHCCHHHHHHHHHHHHEEEEECCCCCEEEECCHHHHHHHHHHHHHHCCCCCEEEEE
LGAGAYVVKEEE
ECCCEEEEEECC
>Mature Secondary Structure
MKMVKICSPATSANLGPGYDVFGLALNNPYDTITVSIVEEKGGNETLSNEKITISMEGEK
CCEEEECCCCCCCCCCCCCCEEEEEECCCCCEEEEEEEECCCCCCCCCCCEEEEEECCCH
CEEIPTAVDENTAGVVAKKMMEDFNIDKNIQIHIEKGIKPGSGLGSSSASCAGVAVAINE
HHHCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHH
LFGLELPKLELVKYASLGEAVAAGAPHADNVAPAIYGGFTMVVNQDPLEIIHIPVEFEVL
HHCCCCCHHHHHHHHHHCHHHHCCCCCCCCCCHHHCCCEEEEEECCCEEEEEECEEEEEE
VALPNIQISTKEARELVPKEIPIKDMVNNVGKACGMIYSLHDNNVELFGKYMMQDAVVEP
EEECCCEEECHHHHHCCCCCCCHHHHHHHHHHHHCEEEEEECCCHHHHHHHHHHHHHHHH
CRATLIDNYSEVKEKVKDLVYGITISGSGPAIISLPKKECVLEVKKIFKETWDCPIYYTT
HHHHHHCCHHHHHHHHHHHHEEEEECCCCCEEEECCHHHHHHHHHHHHHHCCCCCEEEEE
LGAGAYVVKEEE
ECCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA