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The map label for this gene is mvk [H]

Identifier: 150401204

GI number: 150401204

Start: 797318

End: 798388

Strand: Reverse

Name: mvk [H]

Synonym: Maeo_0775

Alternate gene names: 150401204

Gene position: 798388-797318 (Counterclockwise)

Preceding gene: 150401205

Following gene: 150401199

Centisome position: 50.87

GC content: 27.82

Gene sequence:

>1071_bases
ATGAATAATATTGGTAATATTAATAATATTAAATATGACGGCAACAACAATGATAGCAAAATAACCACAATAGAAACGCC
TTCAAAAGTCATATTATTTGGTGAGCATGCCGTAGTGGGTGGATATATGGCACTTTCAATGGCAGTTGATTTAAAAATTA
GTGGGTTATTGGAGTGTTATGATTATATTATCAACAACCAACAACCAACAACACCAGAACCAATAATAATTGATTTAATT
GATTTAAACAAAAAAGTAGAAATAAATCCGCAGGATATTCTAAATATAAATCTAAGCAACTACGATAATGATTTAAAATA
TGTGGCATCTACTCTAAAAAATACAGTTAATTACTTAATGGATAAAAATTTAATGAAATTAAATCCTATAAATAATAATA
TAAAGCCATTTAAATTAACCATCACTTCAAATATTCCCATTAGTTGTGGGTTGGGTTCTTCGGCATCAATTATAATAACT
ATTATTAAATCTATTTTAACAGTGCATAATTTAATATTATCAAAAGAAGAAATATCAAAAATAGCATATACCGTAGAAAA
AGAGGTTCAAGGTATAGCAAGTATAACGGACACATCCACCATAATATATGGGGGAGCTCTGAAAATAAAAGACAACAAAA
TTAAACCAATTGAAAATAATGATTTTAATAATTTATTGGCAGGTTGTCAATTTTTAATAGTGCATTCCGAACGAAGAATT
AAAAAAACAGCCGAATTAGTAAATGAAGTGGCAAAACATCCACAAAAAAGGCAGATATTTAAACAGATTGGAGAAATTGT
AGAAAAAGCCGAATTTGTGAAAAATAAGGAAGAGTTAGGAAAATTAATGGTGGAAAATCATAAATTATTAAATAAATTGG
GAGTATCCACTGAAAAACTAAATAAAATCGTAGAAATTGGGCAAAAATTAGGATATGGTGCTAAATTATCTGGTGCGGGG
GGAGGCGGAATTGCCATAATATTAATAAATGAAAATAAAAAAGAAGATTTATTAAATGAATTAAATGATTTGGGAGTTTT
GGGAATCTATGACTGCATAATTAAATATTAA

Upstream 100 bases:

>100_bases
AAAACACATTTGGGACAAAAGGATATTTAACGGCTGATTTTGATGGTGAAGTTAGCAATAAAGATAAAGTAATTTTAAAT
AGGCTTAGACGGTGGGGATA

Downstream 100 bases:

>100_bases
TTTTTTTATTTTTTGAATAAAAGGGATTTTTTGAATAAAAGGAGCTCCATTTTATATTTTAGTTTTAGTCATTACCGTCT
TTTTCACTAAAAATATTATA

Product: mevalonate kinase

Products: NA

Alternate protein names: MK [H]

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MNNIGNINNIKYDGNNNDSKITTIETPSKVILFGEHAVVGGYMALSMAVDLKISGLLECYDYIINNQQPTTPEPIIIDLI
DLNKKVEINPQDILNINLSNYDNDLKYVASTLKNTVNYLMDKNLMKLNPINNNIKPFKLTITSNIPISCGLGSSASIIIT
IIKSILTVHNLILSKEEISKIAYTVEKEVQGIASITDTSTIIYGGALKIKDNKIKPIENNDFNNLLAGCQFLIVHSERRI
KKTAELVNEVAKHPQKRQIFKQIGEIVEKAEFVKNKEELGKLMVENHKLLNKLGVSTEKLNKIVEIGQKLGYGAKLSGAG
GGGIAIILINENKKEDLLNELNDLGVLGIYDCIIKY

Sequences:

>Translated_356_residues
MNNIGNINNIKYDGNNNDSKITTIETPSKVILFGEHAVVGGYMALSMAVDLKISGLLECYDYIINNQQPTTPEPIIIDLI
DLNKKVEINPQDILNINLSNYDNDLKYVASTLKNTVNYLMDKNLMKLNPINNNIKPFKLTITSNIPISCGLGSSASIIIT
IIKSILTVHNLILSKEEISKIAYTVEKEVQGIASITDTSTIIYGGALKIKDNKIKPIENNDFNNLLAGCQFLIVHSERRI
KKTAELVNEVAKHPQKRQIFKQIGEIVEKAEFVKNKEELGKLMVENHKLLNKLGVSTEKLNKIVEIGQKLGYGAKLSGAG
GGGIAIILINENKKEDLLNELNDLGVLGIYDCIIKY
>Mature_356_residues
MNNIGNINNIKYDGNNNDSKITTIETPSKVILFGEHAVVGGYMALSMAVDLKISGLLECYDYIINNQQPTTPEPIIIDLI
DLNKKVEINPQDILNINLSNYDNDLKYVASTLKNTVNYLMDKNLMKLNPINNNIKPFKLTITSNIPISCGLGSSASIIIT
IIKSILTVHNLILSKEEISKIAYTVEKEVQGIASITDTSTIIYGGALKIKDNKIKPIENNDFNNLLAGCQFLIVHSERRI
KKTAELVNEVAKHPQKRQIFKQIGEIVEKAEFVKNKEELGKLMVENHKLLNKLGVSTEKLNKIVEIGQKLGYGAKLSGAG
GGGIAIILINENKKEDLLNELNDLGVLGIYDCIIKY

Specific function: Unknown

COG id: COG1577

COG function: function code I; Mevalonate kinase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Mevalonate kinase subfamily [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6323864, Length=363, Percent_Identity=27.5482093663912, Blast_Score=76, Evalue=9e-15,
Organism=Drosophila melanogaster, GI78707210, Length=365, Percent_Identity=27.3972602739726, Blast_Score=72, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006205
- InterPro:   IPR006206
- InterPro:   IPR022937
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.36 [H]

Molecular weight: Translated: 39419; Mature: 39419

Theoretical pI: Translated: 7.94; Mature: 7.94

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNIGNINNIKYDGNNNDSKITTIETPSKVILFGEHAVVGGYMALSMAVDLKISGLLECY
CCCCCCCCCEEECCCCCCCEEEEEECCCEEEEEECCHHHHHHHHHHHEEEHHHHHHHHHH
DYIINNQQPTTPEPIIIDLIDLNKKVEINPQDILNINLSNYDNDLKYVASTLKNTVNYLM
HHHHCCCCCCCCCCEEEEEEECCCEEEECHHHEEEEECCCCCHHHHHHHHHHHHHHHHHH
DKNLMKLNPINNNIKPFKLTITSNIPISCGLGSSASIIITIIKSILTVHNLILSKEEISK
CCCCEEECCCCCCCCEEEEEEECCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCHHHHHH
IAYTVEKEVQGIASITDTSTIIYGGALKIKDNKIKPIENNDFNNLLAGCQFLIVHSERRI
HHHHHHHHHHHHHHHCCCCEEEECCEEEEECCCCCCCCCCCHHHHHHHHEEEEEECHHHH
KKTAELVNEVAKHPQKRQIFKQIGEIVEKAEFVKNKEELGKLMVENHKLLNKLGVSTEKL
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHH
NKIVEIGQKLGYGAKLSGAGGGGIAIILINENKKEDLLNELNDLGVLGIYDCIIKY
HHHHHHHHHCCCCCEECCCCCCEEEEEEECCCCHHHHHHHHHHCCHHHHHHHHHCC
>Mature Secondary Structure
MNNIGNINNIKYDGNNNDSKITTIETPSKVILFGEHAVVGGYMALSMAVDLKISGLLECY
CCCCCCCCCEEECCCCCCCEEEEEECCCEEEEEECCHHHHHHHHHHHEEEHHHHHHHHHH
DYIINNQQPTTPEPIIIDLIDLNKKVEINPQDILNINLSNYDNDLKYVASTLKNTVNYLM
HHHHCCCCCCCCCCEEEEEEECCCEEEECHHHEEEEECCCCCHHHHHHHHHHHHHHHHHH
DKNLMKLNPINNNIKPFKLTITSNIPISCGLGSSASIIITIIKSILTVHNLILSKEEISK
CCCCEEECCCCCCCCEEEEEEECCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCHHHHHH
IAYTVEKEVQGIASITDTSTIIYGGALKIKDNKIKPIENNDFNNLLAGCQFLIVHSERRI
HHHHHHHHHHHHHHHCCCCEEEECCEEEEECCCCCCCCCCCHHHHHHHHEEEEEECHHHH
KKTAELVNEVAKHPQKRQIFKQIGEIVEKAEFVKNKEELGKLMVENHKLLNKLGVSTEKL
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHH
NKIVEIGQKLGYGAKLSGAGGGGIAIILINENKKEDLLNELNDLGVLGIYDCIIKY
HHHHHHHHHCCCCCEECCCCCCEEEEEEECCCCHHHHHHHHHHCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087; 10497066 [H]