Click here to switch to the map view.

The map label for this gene is truD

Identifier: 150401185

GI number: 150401185

Start: 777782

End: 778990

Strand: Direct

Name: truD

Synonym: Maeo_0756

Alternate gene names: 150401185

Gene position: 777782-778990 (Clockwise)

Preceding gene: 150401183

Following gene: 150401189

Centisome position: 49.56

GC content: 28.37

Gene sequence:

>1209_bases
ATGCCATTAAATTTAAATTGCTATTTGCTTAATTTAAAAATAGATGGAGTCATGAAAAAATATCCTGAAGATTTTATAGT
TGAAGAAATAACTCCAGAAGGGATAGTTTTGGAAGCTGGAAAAGACATAGGATTTAAAGAGGAAAATAAACATGATTGGA
ATGGTTCATTTATCCATTTTACGATGGAAAAAATAAACTGGAATACTATGGACGCTATAAGGGAGTTGGCAAGAAGAACA
AAAACTAAACGGAAAAATTTTGGTTTTGCTGGAACAAAAGATAAATTTGCCTTAACTACTCAAAGAGTAGGCTGTTTTGG
CATAAAACCAGAGAAACTTGAAGAGATAAAAAACTCCATCAAAGATATAACCATAAGAGACATTCAAAAAACAAACATAA
AATTAAGAATGGGCCATTTATGGGGCAATAAATTTACAATAAAAATAAGATTAAATGAAACCGATAAATATTATAATGAT
ATTTCTAAATATGAAGAAATATTGAAAAATAAAAATTTAGACTATATTTTAAATTACTATGGAACTCAAAGATTTGGAAC
ATTCCGACCCATTACGCATATTGTGGGTAAATTTATATATAATCGGGATTTTGAAAGTGCTTTTTATACATACTGTGGAG
CTCCAATAAATGAAACAGGCGTTGTAAAGGAAGCTCGAGAGATGGTAGATAATGGAGAATTTGAGAAGGCTTTAAAATTA
TTCCCTAAAAAAAGTTATTATAATGAAATAAAAATGATAAGACACTACATTAAAACAGGGAATTATAAAGAATGTTTTAA
AGTATTACCTCCACAATTAAGTAGTATGTTTGTAAATGCATATCAATCATATTTATTCAATGAAATGATAAATATTAGAC
ATAGGGATTATTCATTTGATATTCTTGATGGAGATGTGGTGGAGGAGGGAGCTCCCACAGGGAATATACTTGGTAGTGAT
ACAATATTAAGTGATGGAATTCAAGGAGATATTGAAAAATATATTATTGAAAAAGAAAATCTTGATTTAAAAAAGTTTAA
AATTGAAGATTATGGAAACTTCCCTGGAACTCGCCGAAAATTAATCACAAAAATTTATGATTTTGAAAGTTCAATAGATA
AAGACAATAATATAATCTCCATATCATTTAAAATGGAGCGAGGAAATTATGCTACGGTTGTATTGAGAGAAATCATATCT
GAGATTTAA

Upstream 100 bases:

>100_bases
AAGGCAAAATAAACAGGAAACTGCCAAAAACATAGCAAAAGTTAGAAATAAAAAATTAAAGAAATACAGGGAGCTCCGAA
TAAATTCACTATTGGAGGAA

Downstream 100 bases:

>100_bases
ATGGAGAGTGAAAAGGGAGCTCCCCTATAATGCACCATATAATTTAAAATTAAAAAATAATATATATTTTTCAGTATATG
GCTAACGCCACCCTGTTTTT

Product: tRNA pseudouridine synthase D TruD

Products: NA

Alternate protein names: tRNA pseudouridylate synthase D; tRNA-uridine isomerase D

Number of amino acids: Translated: 402; Mature: 401

Protein sequence:

>402_residues
MPLNLNCYLLNLKIDGVMKKYPEDFIVEEITPEGIVLEAGKDIGFKEENKHDWNGSFIHFTMEKINWNTMDAIRELARRT
KTKRKNFGFAGTKDKFALTTQRVGCFGIKPEKLEEIKNSIKDITIRDIQKTNIKLRMGHLWGNKFTIKIRLNETDKYYND
ISKYEEILKNKNLDYILNYYGTQRFGTFRPITHIVGKFIYNRDFESAFYTYCGAPINETGVVKEAREMVDNGEFEKALKL
FPKKSYYNEIKMIRHYIKTGNYKECFKVLPPQLSSMFVNAYQSYLFNEMINIRHRDYSFDILDGDVVEEGAPTGNILGSD
TILSDGIQGDIEKYIIEKENLDLKKFKIEDYGNFPGTRRKLITKIYDFESSIDKDNNIISISFKMERGNYATVVLREIIS
EI

Sequences:

>Translated_402_residues
MPLNLNCYLLNLKIDGVMKKYPEDFIVEEITPEGIVLEAGKDIGFKEENKHDWNGSFIHFTMEKINWNTMDAIRELARRT
KTKRKNFGFAGTKDKFALTTQRVGCFGIKPEKLEEIKNSIKDITIRDIQKTNIKLRMGHLWGNKFTIKIRLNETDKYYND
ISKYEEILKNKNLDYILNYYGTQRFGTFRPITHIVGKFIYNRDFESAFYTYCGAPINETGVVKEAREMVDNGEFEKALKL
FPKKSYYNEIKMIRHYIKTGNYKECFKVLPPQLSSMFVNAYQSYLFNEMINIRHRDYSFDILDGDVVEEGAPTGNILGSD
TILSDGIQGDIEKYIIEKENLDLKKFKIEDYGNFPGTRRKLITKIYDFESSIDKDNNIISISFKMERGNYATVVLREIIS
EI
>Mature_401_residues
PLNLNCYLLNLKIDGVMKKYPEDFIVEEITPEGIVLEAGKDIGFKEENKHDWNGSFIHFTMEKINWNTMDAIRELARRTK
TKRKNFGFAGTKDKFALTTQRVGCFGIKPEKLEEIKNSIKDITIRDIQKTNIKLRMGHLWGNKFTIKIRLNETDKYYNDI
SKYEEILKNKNLDYILNYYGTQRFGTFRPITHIVGKFIYNRDFESAFYTYCGAPINETGVVKEAREMVDNGEFEKALKLF
PKKSYYNEIKMIRHYIKTGNYKECFKVLPPQLSSMFVNAYQSYLFNEMINIRHRDYSFDILDGDVVEEGAPTGNILGSDT
ILSDGIQGDIEKYIIEKENLDLKKFKIEDYGNFPGTRRKLITKIYDFESSIDKDNNIISISFKMERGNYATVVLREIISE
I

Specific function: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs

COG id: COG0585

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TRUD domain

Homologues:

Organism=Homo sapiens, GI50727002, Length=420, Percent_Identity=26.4285714285714, Blast_Score=118, Evalue=9e-27,
Organism=Homo sapiens, GI148762985, Length=399, Percent_Identity=24.5614035087719, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI148762961, Length=399, Percent_Identity=24.5614035087719, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI148762948, Length=399, Percent_Identity=24.5614035087719, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17557232, Length=264, Percent_Identity=26.5151515151515, Blast_Score=92, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6324817, Length=312, Percent_Identity=28.525641025641, Blast_Score=109, Evalue=8e-25,
Organism=Drosophila melanogaster, GI21355799, Length=258, Percent_Identity=24.8062015503876, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRUD_META3 (A6UV17)

Other databases:

- EMBL:   CP000743
- RefSeq:   YP_001324951.1
- ProteinModelPortal:   A6UV17
- SMR:   A6UV17
- STRING:   A6UV17
- GeneID:   5327206
- GenomeReviews:   CP000743_GR
- KEGG:   mae:Maeo_0756
- eggNOG:   arNOG05422
- HOGENOM:   HBG541221
- OMA:   NEMINIR
- ProtClustDB:   CLSK876256
- BioCyc:   MAEO419665:MAEO_0756-MONOMER
- HAMAP:   MF_01082
- InterPro:   IPR020103
- InterPro:   IPR001656
- InterPro:   IPR020119
- InterPro:   IPR011760
- PANTHER:   PTHR13326
- TIGRFAMs:   TIGR00094

Pfam domain/function: PF01142 TruD; SSF55120 PsdUridine_synth_cat_dom

EC number: NA

Molecular weight: Translated: 47014; Mature: 46882

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: PS50984 TRUD; PS01268 UPF0024

Important sites: ACT_SITE 94-94

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLNLNCYLLNLKIDGVMKKYPEDFIVEEITPEGIVLEAGKDIGFKEENKHDWNGSFIHF
CCCCEEEEEEEEEECHHHHHCCHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCEEEE
TMEKINWNTMDAIRELARRTKTKRKNFGFAGTKDKFALTTQRVGCFGIKPEKLEEIKNSI
EEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCEECCCHHHHHHHHHHH
KDITIRDIQKTNIKLRMGHLWGNKFTIKIRLNETDKYYNDISKYEEILKNKNLDYILNYY
HCCEEEEEEECCEEEEEEEECCCEEEEEEEECCCHHHHHHHHHHHHHHHCCCCCEEEECC
GTQRFGTFRPITHIVGKFIYNRDFESAFYTYCGAPINETGVVKEAREMVDNGEFEKALKL
CCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHH
FPKKSYYNEIKMIRHYIKTGNYKECFKVLPPQLSSMFVNAYQSYLFNEMINIRHRDYSFD
CCCHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
ILDGDVVEEGAPTGNILGSDTILSDGIQGDIEKYIIEKENLDLKKFKIEDYGNFPGTRRK
ECCCCHHHCCCCCCCCCCCCHHHCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHH
LITKIYDFESSIDKDNNIISISFKMERGNYATVVLREIISEI
HHHHHHHHHHCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHC
>Mature Secondary Structure 
PLNLNCYLLNLKIDGVMKKYPEDFIVEEITPEGIVLEAGKDIGFKEENKHDWNGSFIHF
CCCEEEEEEEEEECHHHHHCCHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCEEEE
TMEKINWNTMDAIRELARRTKTKRKNFGFAGTKDKFALTTQRVGCFGIKPEKLEEIKNSI
EEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCEECCCHHHHHHHHHHH
KDITIRDIQKTNIKLRMGHLWGNKFTIKIRLNETDKYYNDISKYEEILKNKNLDYILNYY
HCCEEEEEEECCEEEEEEEECCCEEEEEEEECCCHHHHHHHHHHHHHHHCCCCCEEEECC
GTQRFGTFRPITHIVGKFIYNRDFESAFYTYCGAPINETGVVKEAREMVDNGEFEKALKL
CCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHH
FPKKSYYNEIKMIRHYIKTGNYKECFKVLPPQLSSMFVNAYQSYLFNEMINIRHRDYSFD
CCCHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
ILDGDVVEEGAPTGNILGSDTILSDGIQGDIEKYIIEKENLDLKKFKIEDYGNFPGTRRK
ECCCCHHHCCCCCCCCCCCCHHHCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHH
LITKIYDFESSIDKDNNIISISFKMERGNYATVVLREIISEI
HHHHHHHHHHCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA